What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $251 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $258 and $326 round-trip. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

What is the cheapest day to fly from Des Moines to Syracuse?

Travelers seeking maximum savings on their Des Moines to Syracuse flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Des Moines to Syracuse?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Des Moines to Syracuse.

What is the cheapest day to fly round-trip from Des Moines to Syracuse?

It’s generally more expensive to depart on a Tuesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.

What is the cheapest month to fly from Des Moines to Syracuse?

The best pricing can be found in the month of May. Prices to Syracuse from Des Moines average $401. You can even find prices in May for less than $401, as users have found deals to Syracuse from as low as $128. The month of March appears to be one of the more expensive times to travel to Syracuse from Des Moines. Flying in the targeted month can save you up to 54%.

What is the cheapest time of day to fly from DSM to SYR?

It’s typically best to fly out from Des Moines to Syracuse in the morning. Doing so could potentially save you 25% on the flight price compared to flying at noon, which is usually more expensive.

Most accurate provider : When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Syracuse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

Can I find deals for business class flights from Des Moines to Syracuse?

Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$129+ Flights from Des Moines to Syracuse

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1. Tell us where you want to go

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Cheap flight deals from Des Moines to Syracuse

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$251 (American Airlines)
One-way from	$129 (Delta)
Popular in	March
Cheapest in	May
Average price	$307

Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.

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From Des Moines to Syracuse Hancock Intl

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One-way flight from Des Moines to Syracuse Hancock Intl

Search Deals

Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Sat 5/311:54 amDSM - SYR

1 stop4h 43mAmerican Airlines

Sat 5/105:25 amSYR - DSM

1 stop7h 53mAmerican Airlines

Deal found 4/10

$251

Fri 5/305:50 pmDSM - SYR

1 stop4h 13mDelta

Mon 6/212:20 pmSYR - DSM

1 stop7h 46mDelta

Deal found 4/10

$258

Sat 5/38:48 amDSM - SYR

2 stops11h 32mUnited Airlines

Sat 5/106:30 amSYR - DSM

1 stop5h 04mUnited Airlines

Deal found 4/10

$326

Best flights from Des Moines to Syracuse
Discover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2025.

Sat 5/311:54 amDSM - SYR

1 stop4h 43mAmerican Airlines

Sat 5/105:25 amSYR - DSM

1 stop7h 53mAmerican Airlines

Deal found 4/10

$251

Fri 5/305:50 pmDSM - SYR

1 stop4h 13mDelta

Mon 6/212:20 pmSYR - DSM

1 stop7h 46mDelta

Deal found 4/10

$258

Sat 5/38:48 amDSM - SYR

2 stops11h 32mUnited Airlines

Sat 5/106:30 amSYR - DSM

1 stop5h 04mUnited Airlines

Deal found 4/10

$326

Last-minute flights from Des Moines to Syracuse
Discover last-minute flight deals from Des Moines to Syracuse. Data last updated April 11, 2025 and is based on user searches.

Sat 5/311:54 amDSM - SYR

1 stop4h 43mAmerican Airlines

Sat 5/105:25 amSYR - DSM

1 stop7h 53mAmerican Airlines

Deal found 4/10

$251

Sat 5/38:48 amDSM - SYR

2 stops11h 32mUnited Airlines

Sat 5/106:30 amSYR - DSM

1 stop5h 04mUnited Airlines

Deal found 4/10

$326

Fri 5/305:50 pmDSM - SYR

1 stop4h 13mDelta

Mon 6/212:20 pmSYR - DSM

1 stop7h 46mDelta

Deal found 4/10

$258

One-way flights from Des Moines to Syracuse
Search for one-way flight options from Des Moines to Syracuse. Find affordable one-way fares based on user searches. Data last updated April 11, 2025.

Fri 7/43:41 pmDSM - SYR

1 stop6h 36mDelta

Deal found 4/10

$129

Fri 7/46:00 amDSM - SYR

2 stops6h 22mAmerican Airlines

Deal found 4/10

$175

Fri 7/42:00 pmDSM - SYR

3 stops18h 33mMultiple Airlines

Deal found 4/10

$223

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 5/3

11:54 am-5:37 pm

1 stop4h 43m

Syracuse Hancock Intl

Sat 5/10

5:25 am-12:18 pm

1 stop7h 53m

$251

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 5/30

5:50 pm-11:03 pm

1 stop4h 13m

Syracuse Hancock Intl

Mon 6/2

12:20 pm-7:06 pm

1 stop7h 46m

$258

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 5/3

8:48 am-9:20 pm

2 stops11h 32m

Syracuse Hancock Intl

Sat 5/10

6:30 am-10:34 am

1 stop5h 04m

$326

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/4

3:41 pm-11:17 pm

1 stop6h 36m

$129

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/4

6:00 am-1:22 pm

2 stops6h 22m

$175

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/4

2:00 pm-9:33 am

3 stops18h 33m

$223

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Compare providers for flights from Des Moines to Syracuse

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars
CheapOair	Price Accuracy1 star	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $395). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Syracuse by month

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

Temperature in Syracuse by month

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Syracuse

Delta

8.0

Very good

7,910 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Delta

8.0

Very good

7,910 reviews

Delta

8.0

Very good

7,910 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

United Airlines

7.4

Good

8,636 reviews

Delta

8.0

Very good

7,910 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,910 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

What are the cheapest airlines flying from Des Moines to Syracuse round-trip?
Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $251 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $258 and $326 round-trip. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?
Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Syracuse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.
Can I find deals for business class flights from Des Moines to Syracuse?
Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Syracuse?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $395). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Other flights to Syracuse

Top 3 airlines flying from Des Moines to Syracuse

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$128	Average$326	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$236	Average$397	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$374	Average$542	FlexibilityNo cancel fee	On-time69%

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$129+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Syracuse with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Syracuse

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to SyracuseExplore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in April.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Rainfall in Syracuse by month

Plan your trip to Syracuse by taking into account the average rainfall totals by month.

Temperature in Syracuse by month

Plan your trip to Syracuse by taking into account the average temperature totals by month.

Reviews of airlines servicing Syracuse

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

How can I find direct flights from Des Moines to Syracuse?

Can I find deals for business class flights from Des Moines to Syracuse?

What is the cheapest month to book a flight from Des Moines to Syracuse?

Traveling to a place near Des Moines?

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Alternative routes for Des Moines to Syracuse

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Top 3 airlines flying from Des Moines to Syracuse

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Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.