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St. Louis

$79+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Apr 9 — Apr 161
Mi 4/9
Mi 4/16
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated April 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$160
(CheapOair)

One-way from

$79
(Cheapflightsfares)

Popular in

April

Cheapest in

July

Average price

$432

Good round-trip deal

$336 or less

Good one-way deal

$154 or less
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
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From South Carolina to Lambert-St Louis
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One-way flight from South Carolina to Lambert-St Louis
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Highest demand for flights based on searches. 6% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from South Carolina to Lambert-St Louis.
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Price to beat on a one-way flight from South Carolina to Lambert-St Louis.
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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

This CheapOair deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 4/266:33 pmCLT - STL
1 stop6h 31mFrontier
Mo 4/286:58 pmSTL - CLT
1 stop20h 04mFrontier
Deal found 4/3$160
This Cheapflightsfares deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 4/296:58 amCLT - STL
1 stop11h 17mSpirit Airlines
Di 5/66:10 pmSTL - CLT
1 stop5h 17mSpirit Airlines
Deal found 4/2$183
This CheapOair deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/94:21 pmCLT - STL
1 stop8h 53mMultiple Airlines
So 5/1110:10 amSTL - CLT
1 stop8h 47mMultiple Airlines
Deal found 4/3$188
This Trip.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 4/255:59 pmMYR - STL
1 stop7h 05mMultiple Airlines
So 4/275:41 pmSTL - MYR
1 stop13h 13mMultiple Airlines
Deal found 4/4$217
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 4/307:30 pmCHS - STL
1 stop22h 45mSpirit Airlines
So 5/46:10 pmSTL - CHS
1 stop14h 26mSpirit Airlines
Deal found 4/3$218
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/93:55 pmGSP - STL
1 stop18h 20mMultiple Airlines
So 5/1110:10 amSTL - GSP
1 stop27h 55mMultiple Airlines
Deal found 4/4$226
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/225:55 pmCAE - STL
1 stop3h 44mDelta
So 5/2510:05 amSTL - CAE
1 stop5h 54mDelta
Deal found 4/2$233
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/226:10 amCAE - STL
1 stop5h 33mAmerican Airlines
So 5/257:10 amSTL - CAE
1 stop4h 16mAmerican Airlines
Deal found 4/3$254
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 4/297:35 amCLT - STL
Nonstop1h 55mAmerican Airlines
Di 5/65:12 amSTL - CLT
Nonstop1h 58mAmerican Airlines
Deal found 4/2$255
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/110:25 amCHS - STL
1 stop7h 50mMultiple Airlines
Sa 5/39:50 amSTL - CHS
3 stops29h 06mMultiple Airlines
Deal found 4/3$261
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 4/303:40 pmCLT - STL
Nonstop2h 05mSouthwest
Mo 5/53:15 pmSTL - CLT
Nonstop1h 50mSouthwest
Deal found 4/2$271
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/2212:11 pmSAV - STL
1 stop24h 14mSun Country Air
So 5/2510:20 amSTL - SAV
1 stop23h 43mSun Country Air
Deal found 4/4$272

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sa 4/26

6:33 pm-12:04 am

1 stop6h 31m

Lambert-St Louis

Mo 4/28

6:58 pm-4:02 pm

1 stop20h 04m

$160

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Di 4/29

6:58 am-5:15 pm

1 stop11h 17m

Lambert-St Louis

Di 5/6

6:10 pm-12:27 am

1 stop5h 17m

$183

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fr 5/9

4:21 pm-12:14 am

1 stop8h 53m

Lambert-St Louis

So 5/11

10:10 am-7:57 pm

1 stop8h 47m

$188

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fr 4/25

5:59 pm-12:04 am

1 stop7h 05m

Lambert-St Louis

So 4/27

5:41 pm-7:54 am

1 stop13h 13m

$217

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Mi 4/30

7:30 pm-5:15 pm

1 stop22h 45m

Lambert-St Louis

So 5/4

6:10 pm-9:36 am

1 stop14h 26m

$218

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fr 5/9

3:55 pm-9:15 am

1 stop18h 20m

Lambert-St Louis

So 5/11

10:10 am-3:05 pm

1 stop27h 55m

$226

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Do 5/22

5:55 pm-8:39 pm

1 stop3h 44m

Lambert-St Louis

So 5/25

10:05 am-4:59 pm

1 stop5h 54m

$233

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Do 5/22

6:10 am-10:43 am

1 stop5h 33m

Lambert-St Louis

So 5/25

7:10 am-12:26 pm

1 stop4h 16m

$254

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Di 4/29

7:35 am-8:30 am

Nonstop1h 55m

Lambert-St Louis

Di 5/6

5:12 am-8:10 am

Nonstop1h 58m

$255

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Do 5/1

10:25 am-5:15 pm

1 stop7h 50m

Lambert-St Louis

Sa 5/3

9:50 am-3:56 pm

3 stops29h 06m

$261

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/3

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 4, 2025.
Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,276 reviews
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,900 reviews
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,618 reviews
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Sun Country Air
6.9
Okay
349 reviews
Southwest
8.0
Very good
4,276 reviews

Overall

8.0

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $79. Spirit Airlines flights start at $86 while deals on Delta start at $123 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Greenville - Lambert-St Louis.

  • What are the cheapest flights from South Carolina to St. Louis?

    On average you can expect to pay $323 for a flight from South Carolina to St. Louis. The cheapest flight overall is $143 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $178.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Fenton
Maryland Heights
Fairview Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington
Chesterfield

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to St. Louis

Discover the top 4 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$139Average$201FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$172Average$355FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$363FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$363FlexibilityNo cancel feeOn-time63%

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