HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$57+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Mar 9 — Mar 161
Sun 3/9
Sun 3/16
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to St. Louis with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated March 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$137
(CheapOair)

One-way from

$57
(Cheapflightsfares)

Popular in

February

Cheapest in

July

Average price

$381

Good round-trip deal

$330 or less

Good one-way deal

$208 or less
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From South Carolina to Lambert-St Louis
Search Deals
One-way flight from South Carolina to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2025
Search Deals
Price to beat on a round-trip flight from South Carolina to Lambert-St Louis.
Search Deals
Price to beat on a one-way flight from South Carolina to Lambert-St Louis.
Search Deals

Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 4, 2025.

This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/25:35 pmCLT - STL
1 stop25h 17mSpirit Airlines
Tue 4/86:47 pmSTL - CLT
1 stop28h 40mSpirit Airlines
Deal found 3/4$137
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/28:31 amCLT - STL
1 stop16h 15mFrontier
Wed 4/94:57 pmSTL - CLT
1 stop27h 12mFrontier
Deal found 3/4$150
This CheapOair deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/96:36 pmCLT - STL
1 stop6h 10mMultiple Airlines
Sun 4/136:10 pmSTL - CLT
1 stop5h 17mMultiple Airlines
Deal found 3/3$158
This Mytrip deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/147:00 amCHS - STL
3 stops35h 15mMultiple Airlines
Sun 4/206:10 pmSTL - CHS
1 stop14h 26mMultiple Airlines
Deal found 3/3$201
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/205:10 amCAE - STL
1 stop4h 20mAmerican Airlines
Sat 4/263:44 pmSTL - CAE
1 stop6h 10mAmerican Airlines
Deal found 3/3$224
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1612:23 pmCAE - STL
1 stop6h 39mDelta
Tue 4/226:00 amSTL - CAE
1 stop4h 43mDelta
Deal found 3/3$249
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/175:59 pmHHH - STL
1 stop6h 57mAmerican Airlines
Sun 3/235:06 amSTL - HHH
1 stop4h 18mAmerican Airlines
Deal found 3/3$259
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2711:40 amCHS - STL
1 stop7h 12mSpirit Airlines
Sun 3/306:47 pmSTL - CHS
1 stop13h 46mSpirit Airlines
Deal found 3/4$266
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3110:50 pmCLT - STL
Nonstop2h 06mAmerican Airlines
Tue 4/110:12 amSTL - CLT
1 stop8h 27mAmerican Airlines
Deal found 3/4$270
This Mytrip deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/196:15 amMYR - STL
3 stops11h 30mMultiple Airlines
Sun 3/236:47 pmSTL - MYR
1 stop25h 45mMultiple Airlines
Deal found 3/3$275
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/175:46 amGSP - STL
1 stop4h 50mDelta
Thu 4/245:32 pmSTL - GSP
1 stop5h 21mDelta
Deal found 3/3$277
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/175:40 amGSP - STL
1 stop6h 52mAmerican Airlines
Sun 4/206:00 amSTL - GSP
1 stop4h 14mAmerican Airlines
Deal found 3/3$282

Find flights from South Carolina to St. Louis within your budget

Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2025.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/2

5:35 pm-5:52 pm

1 stop25h 17m

Lambert-St Louis

Tue 4/8

6:47 pm-12:27 am

1 stop28h 40m

$137

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/2

8:31 am-11:46 pm

1 stop16h 15m

Lambert-St Louis

Wed 4/9

4:57 pm-9:09 pm

1 stop27h 12m

$150

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/9

6:36 pm-11:46 pm

1 stop6h 10m

Lambert-St Louis

Sun 4/13

6:10 pm-12:27 am

1 stop5h 17m

$158

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Mon 4/14

7:00 am-5:15 pm

3 stops35h 15m

Lambert-St Louis

Sun 4/20

6:10 pm-9:36 am

1 stop14h 26m

$201

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sun 4/20

5:10 am-8:30 am

1 stop4h 20m

Lambert-St Louis

Sat 4/26

3:44 pm-10:54 pm

1 stop6h 10m

$224

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Wed 4/16

12:23 pm-6:02 pm

1 stop6h 39m

Lambert-St Louis

Tue 4/22

6:00 am-11:43 am

1 stop4h 43m

$249

Hilton Head IslandSt. Louis

HHH - STL

HHHSTL

Hilton Head Island

Mon 3/17

5:59 pm-11:56 pm

1 stop6h 57m

Lambert-St Louis

Sun 3/23

5:06 am-10:24 am

1 stop4h 18m

$259

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Thu 3/27

11:40 am-5:52 pm

1 stop7h 12m

Lambert-St Louis

Sun 3/30

6:47 pm-9:33 am

1 stop13h 46m

$266

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 3/31

10:50 pm-11:56 pm

Nonstop2h 06m

Lambert-St Louis

Tue 4/1

10:12 am-7:39 pm

1 stop8h 27m

$270

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 3/19

6:15 am-4:45 pm

3 stops11h 30m

Lambert-St Louis

Sun 3/23

6:47 pm-9:32 pm

1 stop25h 45m

$275

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/4

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to St. Louis

Get recent, data-driven insights about flights from South Carolina to St. Louis including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 4, 2025.

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 4, 2025.
Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Southwest, Alaska Airlines and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest
8.1
Very good
4,330 reviews
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Alaska Airlines
8.0
Very good
9,713 reviews
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta
8.0
Very good
8,061 reviews
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines
7.4
Good
8,678 reviews
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,330 reviews

Boarding

8.2

Crew

8.7

Entertainment

7.6

Comfort

8.1

Food

7.1

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $57. Frontier flights start at $75 while deals on American Airlines start at $137 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Columbia Metropolitan - Lambert-St Louis and Greenville - Lambert-St Louis.

  • What are the cheapest flights from South Carolina to St. Louis?

    On average you can expect to pay $283 for a flight from South Carolina to St. Louis. The cheapest flight overall is $193 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $178.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Fenton
Fairview Heights
Maryland Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Alton
Farmington
Chesterfield

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Newark to St. Louis flights
LaGuardia to St. Louis flights
John F Kennedy Intl to Kansas City flights
Seattle to Kansas City flights
John F Kennedy Intl to St. Louis flights
Dulles Intl to St. Louis flights
Seattle to St. Louis flights
Newark to Kansas City flights
Dulles Intl to Kansas City flights
Boston to St. Louis flights
Los Angeles to St. Louis flights
Dallas/Fort Worth to St. Louis flights
Los Angeles to Kansas City flights
O'Hare Intl to Kansas City flights
Denver to Kansas City flights
Dallas/Fort Worth to Kansas City flights
Reagan-National to St. Louis flights
Boston to Kansas City flights
LaGuardia to Kansas City flights
Denver to St. Louis flights
Baltimore to St. Louis flights
San Francisco to St. Louis flights
Sky Harbor Intl to St. Louis flights
Reagan-National to Kansas City flights
Philadelphia to St. Louis flights
Atlanta to Kansas City flights
Sky Harbor Intl to Kansas City flights
Minneapolis to St. Louis flights
O'Hare Intl to St. Louis flights
Atlanta to St. Louis flights
Baltimore to Kansas City flights
Minneapolis to Kansas City flights
San Francisco to Kansas City flights
Detroit to St. Louis flights
Orlando to St. Louis flights
Ontario to St. Louis flights
Portland to Kansas City flights
Ontario to Kansas City flights
Hobby to St. Louis flights
Philadelphia to Kansas City flights
Love Field to St. Louis flights
Detroit to Kansas City flights
Salt Lake City to St. Louis flights
George Bush Intcntl to St. Louis flights
Salt Lake City to Kansas City flights
Portland to St. Louis flights
Hobby to Kansas City flights
Denver to Springfield flights
Orlando to Kansas City flights
Fort Lauderdale to St. Louis flights

Top 4 airlines flying from South Carolina to St. Louis

Discover the top 4 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$147Average$250FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$172Average$352FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$363FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$371FlexibilityNo cancel feeOn-time63%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.