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$55+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Feb 4 — Feb 111
Tue 2/4
Tue 2/11
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$127
(CheapOair)

One-way from

$55
(Frontier)

Popular in

March

Cheapest in

June

Average price

$401
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
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From South Carolina to Lambert-St Louis
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One-way flight from South Carolina to Lambert-St Louis
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Highest demand for flights based on searches. 17% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in January 2025
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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2025.

This CheapOair deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/57:47 pmCLT - STL
1 stop16h 50mFrontier
Tue 4/84:57 pmSTL - CLT
1 stop23h 49mFrontier
Deal found 1/30$127
This FlightHub deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/257:15 amCHS - STL
1 stop8h 27mSpirit Airlines
Tue 3/44:00 pmSTL - CHS
1 stop16h 53mSpirit Airlines
Deal found 1/29$127
This FlightHub deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/276:40 amCLT - STL
1 stop9h 02mMultiple Airlines
Mon 3/35:20 pmSTL - CLT
1 stop12h 48mMultiple Airlines
Deal found 1/28$137
This FlightHub deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/276:40 amCLT - STL
1 stop9h 02mSpirit Airlines
Sun 3/24:00 pmSTL - CLT
1 stop6h 41mSpirit Airlines
Deal found 1/28$143
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/156:01 pmCAE - STL
1 stop6h 55mAmerican Airlines
Sat 2/226:00 amSTL - CAE
1 stop6h 02mAmerican Airlines
Deal found 1/29$198
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1510:45 amCAE - STL
1 stop5h 49mDelta
Tue 2/187:15 amSTL - CAE
1 stop6h 32mDelta
Deal found 1/29$248
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/156:27 pmAGS - STL
1 stop6h 29mAmerican Airlines
Sat 2/229:13 amSTL - AGS
1 stop3h 59mAmerican Airlines
Deal found 1/29$270
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/208:40 pmGSP - STL
1 stop4h 16mAmerican Airlines
Mon 2/241:52 pmSTL - GSP
1 stop4h 14mAmerican Airlines
Deal found 1/29$285
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/257:10 amCLT - STL
Nonstop1h 59mAmerican Airlines
Thu 3/275:06 amSTL - CLT
Nonstop1h 55mAmerican Airlines
Deal found 1/28$287
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/43:14 pmGSP - STL
1 stop3h 47mDelta
Tue 3/111:48 pmSTL - GSP
1 stop7h 07mDelta
Deal found 1/29$287
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/202:15 pmGSP - STL
2 stops9h 15mSouthwest
Mon 2/247:20 amSTL - GSP
1 stop5h 20mSouthwest
Deal found 1/29$292
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/46:14 pmCLT - STL
1 stop4h 35mDelta
Thu 3/66:43 amSTL - CLT
1 stop4h 21mDelta
Deal found 1/29$307

Find flights from South Carolina to St. Louis within your budget

Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 4/5

7:47 pm-11:37 am

1 stop16h 50m

Lambert-St Louis

Tue 4/8

4:57 pm-5:46 pm

1 stop23h 49m

$127

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 2/25

7:15 am-2:42 pm

1 stop8h 27m

Lambert-St Louis

Tue 3/4

4:00 pm-9:53 am

1 stop16h 53m

$127

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 2/27

6:40 am-2:42 pm

1 stop9h 02m

Lambert-St Louis

Tue 3/4

5:20 pm-7:08 am

1 stop12h 48m

$136

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 2/27

6:40 am-2:42 pm

1 stop9h 02m

Lambert-St Louis

Sun 3/2

4:00 pm-11:41 pm

1 stop6h 41m

$143

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 2/15

6:01 pm-11:56 pm

1 stop6h 55m

Lambert-St Louis

Sat 2/22

6:00 am-1:02 pm

1 stop6h 02m

$198

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 2/15

10:45 am-3:34 pm

1 stop5h 49m

Lambert-St Louis

Tue 2/18

7:15 am-2:47 pm

1 stop6h 32m

$248

AugustaSt. Louis

AGS - STL

AGSSTL

Augusta Bush Field

Sat 2/15

6:27 pm-11:56 pm

1 stop6h 29m

Lambert-St Louis

Sat 2/22

9:13 am-2:12 pm

1 stop3h 59m

$270

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 2/20

8:40 pm-11:56 pm

1 stop4h 16m

Lambert-St Louis

Mon 2/24

1:52 pm-7:06 pm

1 stop4h 14m

$285

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 3/4

3:14 pm-6:01 pm

1 stop3h 47m

Lambert-St Louis

Tue 3/11

1:48 pm-9:55 pm

1 stop7h 07m

$287

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 3/18

7:10 am-8:09 am

Nonstop1h 59m

Lambert-St Louis

Tue 3/25

6:32 pm-9:22 pm

Nonstop1h 50m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/30

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to St. Louis

Get recent, data-driven insights about flights from South Carolina to St. Louis including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2025.

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 30, 2025.
Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Southwest, Alaska Airlines and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,585 reviews
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Alaska Airlines
8.0
Very good
9,688 reviews
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,454 reviews
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,913 reviews
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,585 reviews

Crew

8.7

Food

7.1

Entertainment

7.7

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $55. Spirit Airlines flights start at $60 while deals on American Airlines start at $100 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Columbia Metropolitan - Lambert-St Louis and Greenville - Lambert-St Louis.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Fenton
Fairview Heights
Maryland Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Alton
Farmington
Chesterfield

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Alternative routes for South Carolina to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to St. Louis

Discover the top 4 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$147Average$250FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$172Average$361FlexibilityNo cancel feeOn-time71%
DeltaCheapest$224Average$363FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$280Average$367FlexibilityNo cancel feeOn-time63%
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