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St. Louis

$64+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:26 pmCLT - STL
Nonstop2h 04mAmerican Airlines
Thu 12/257:05 amSTL - CLT
Nonstop2h 02mAmerican Airlines
Deal found 12/10$217
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:05 pmCLT - STL
1 stop5h 36mDelta
Thu 12/2510:04 amSTL - CLT
1 stop4h 57mDelta
Deal found 12/10$237
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:24 amCLT - STL
Nonstop2h 11mAmerican Airlines
Sat 1/103:54 pmSTL - CLT
Nonstop1h 50mAmerican Airlines
Deal found 12/10$252
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:05 pmCLT - STL
1 stop4h 45mSouthwest
Thu 1/11:50 pmSTL - CLT
1 stop6h 00mSouthwest
Deal found 12/10$272
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:26 pmCLT - STL
Nonstop2h 04mAmerican Airlines
Tue 1/66:52 amSTL - CLT
Nonstop1h 50mAmerican Airlines
Deal found 12/11$276
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:09 pmCLT - STL
1 stop6h 34mUnited Airlines
Sat 1/108:05 amSTL - CLT
2 stops12h 11mUnited Airlines
Deal found 12/10$277
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2412:55 pmCLT - STL
Nonstop2h 10mSouthwest
Thu 12/251:50 pmSTL - CLT
1 stop6h 00mSouthwest
Deal found 12/10$280
This Booking.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:04 pmCLT - STL
1 stop26h 29mFrontier
Mon 12/224:27 pmSTL - CLT
1 stop27h 02mFrontier
Deal found 12/9$281
This Frontier deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:22 pmCLT - STL
1 stop9h 11mFrontier
Mon 12/229:07 amSTL - CLT
1 stop6h 54mFrontier
Deal found 12/10$283
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:10 pmCLT - STL
Nonstop2h 08mAmerican Airlines
Sat 12/137:12 amSTL - CLT
Nonstop1h 57mAmerican Airlines
Deal found 12/10$287
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:45 amGSP - STL
1 stop4h 29mAmerican Airlines
Mon 12/296:00 pmSTL - GSP
1 stop5h 51mAmerican Airlines
Deal found 12/10$351
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:35 amSAV - STL
1 stop7h 06mAmerican Airlines
Sat 12/135:02 amSTL - SAV
1 stop4h 40mAmerican Airlines
Deal found 12/11$375

Find flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$128
(Expedia)

One-way from

$64
(Priceline)

Popular in

December

Cheapest in

August

Average price

$529
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From South Carolina to Lambert-St Louis
Search Deals
One-way flight from South Carolina to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 1/6

9:34 pm-10:33 pm

1 stop25h 59m

Lambert-St Louis

Wed 1/14

8:32 pm-8:18 am

2 stops34h 46m

$146

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 1/8

8:46 pm-7:50 am

1 stop12h 04m

Lambert-St Louis

Sat 1/10

7:43 pm-10:17 am

2 stops13h 34m

$188

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Thu 1/22

3:01 pm-10:23 am

1 stop20h 22m

Lambert-St Louis

Sun 1/25

5:42 pm-5:36 pm

2 stops22h 54m

$208

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 1/6

8:25 am-9:35 am

Nonstop2h 10m

Lambert-St Louis

Wed 1/14

2:30 pm-5:15 pm

Nonstop1h 45m

$217

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 1/14

1:59 pm-3:04 pm

Nonstop2h 05m

Lambert-St Louis

Wed 1/21

6:52 am-9:50 am

Nonstop1h 58m

$217

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 1/6

8:25 am-9:35 am

Nonstop2h 10m

Lambert-St Louis

Thu 1/8

2:30 pm-5:15 pm

Nonstop1h 45m

$228

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 1/12

8:25 am-9:35 am

Nonstop2h 10m

Lambert-St Louis

Wed 1/14

2:30 pm-5:15 pm

Nonstop1h 45m

$228

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 1/9

6:50 pm-10:02 am

1 stop16h 12m

Lambert-St Louis

Sun 1/11

3:43 pm-8:11 am

2 stops15h 28m

$232

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 2/7

12:59 pm-4:37 pm

1 stop4h 38m

Lambert-St Louis

Wed 2/11

7:10 am-1:38 pm

1 stop5h 28m

$237

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/29

5:30 am-10:45 am

1 stop6h 15m

Lambert-St Louis

Wed 5/13

6:45 am-12:03 pm

1 stop4h 18m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in November is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 16% on airfare.

What is the cheapest day to fly from South Carolina to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to St. Louis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to St. Louis flight should consider departing on Saturday mornings when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this South Carolina to St. Louis flight route?

    Within the past month, 9 users have taken a look at flights from South Carolina to Lambert-St Louis.

  • How long is the flight from South Carolina to St. Louis?

    Departing from South Carolina to St. Louis will take you 2h 05m. South Carolina and St. Louis are separated by a distance of 574 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Volaris, which is currently one of the cheapest options available, starting at $124. Frontier flights start at $164 while deals on Delta start at $193 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Savannah/Hilton Head - Lambert-St Louis.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in November is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Swansea
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Top 3 airlines flying from South Carolina to St. Louis

Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$360FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$229Average$387FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$287Average$394FlexibilityNo cancel feeOn-time63%

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