How long is the flight from Santiago to St. Louis?

A quick flight from Santiago to St. Louis can take about 20h 18m. American Airlines provides one of the quickest options available for as low as $764. The distance between Santiago and St. Louis is about 5137 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Santiago to St. Louis round-trip?

According to our current data, Delta ($877), and American Airlines ($948) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 11% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What is the cheapest time of day to fly from SCL to STL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to St. Louis as you normally would.

Most accurate provider : When it comes to deals on Santiago-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

Can I find deals for business class flights from Santiago to St. Louis?

Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$412+ Flights from Santiago to St. Louis

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1. Tell us where you want to go

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2. Select your favorite providers

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Cheap flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Thu 12/2511:10 pmSCL - STL

1 stop20h 18mLATAM Airlines

Mon 12/296:00 amSTL - SCL

1 stop22h 40mLATAM Airlines

Deal found 12/11

$764

Thu 12/2510:45 pmSCL - STL

2 stops18h 41mUnited Airlines

Mon 12/299:55 amSTL - SCL

2 stops19h 55mUnited Airlines

Deal found 12/10

$964

Best flights from Santiago to St. Louis
Discover carefully curated flight deals from Santiago to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Mon 3/2310:15 pmSCL - STL

1 stop20h 58mAmerican Airlines

Tue 3/313:22 pmSTL - SCL

1 stop14h 43mAmerican Airlines

Deal found 12/10

$764

Thu 12/2511:10 pmSCL - STL

1 stop20h 18mLATAM Airlines

Mon 12/296:00 amSTL - SCL

1 stop22h 40mLATAM Airlines

Deal found 12/9

$764

Wed 5/278:40 pmSCL - STL

1 stop17h 14mDelta

Thu 6/1111:51 amSTL - SCL

1 stop18h 09mDelta

Deal found 12/9

$795

Wed 5/2711:00 pmSCL - STL

2 stops20h 02mLATAM Airlines

Thu 6/1111:51 amSTL - SCL

1 stop18h 09mLATAM Airlines

Deal found 12/9

$792

Last-minute flights from Santiago to St. Louis
Discover last-minute flight deals from Santiago to St. Louis. Data last updated December 12, 2025 and is based on user searches.

Thu 12/2511:10 pmSCL - STL

1 stop20h 18mLATAM Airlines

Mon 12/296:00 amSTL - SCL

1 stop22h 40mLATAM Airlines

Deal found 12/11

$764

Thu 12/2510:45 pmSCL - STL

2 stops18h 41mUnited Airlines

Mon 12/299:55 amSTL - SCL

2 stops19h 55mUnited Airlines

Deal found 12/10

$964

Sat 1/104:35 pmSCL - STL

2 stops28h 15mLATAM Airlines

Sat 1/176:00 amSTL - SCL

1 stop22h 40mLATAM Airlines

Deal found 12/11

$1,314

Sat 1/107:25 amSCL - STL

3 stops30h 37mMultiple Airlines

Sat 1/174:05 pmSTL - SCL

3 stops30h 04mMultiple Airlines

Deal found 12/11

$2,128

One-way flights from Santiago to St. Louis
Search for one-way flight options from Santiago to St. Louis. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Mon 3/231:35 amSCL - STL

2 stops23h 44mMultiple Airlines

Deal found 12/10

$412

Fri 3/204:35 amSCL - STL

2 stops28h 32mMultiple Airlines

Deal found 12/10

$567

Tue 3/2410:10 pmSCL - STL

1 stop19h 43mDelta

Deal found 12/10

$577

Fri 3/2010:10 pmSCL - STL

1 stop19h 47mDelta

Deal found 12/10

$617

Sun 12/214:25 pmSCL - STL

2 stops26h 04mMultiple Airlines

Deal found 12/11

$2,156

Sun 12/219:30 pmSCL - STL

1 stop20h 02mDelta

Deal found 12/11

$2,652

Sun 12/216:39 pmSCL - STL

3 stops30h 04mLATAM Airlines

Deal found 12/11

$2,672

Find flight deals from Santiago to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$764 (LATAM Airlines)
One-way from	$412 (Kiwi.com)
Popular in	March
Cheapest in	August
Average price	$795

Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.

Search Deals

From Santiago Arturo Merino Benitez to Lambert-St Louis

Search Deals

One-way flight from Santiago Arturo Merino Benitez to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($107 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/23

10:15 pm-5:13 pm

1 stop20h 58m

Lambert-St Louis

Tue 3/31

3:22 pm-8:05 am

1 stop14h 43m

$764

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 12/25

11:10 pm-4:28 pm

1 stop20h 18m

Lambert-St Louis

Mon 12/29

6:00 am-7:40 am

1 stop22h 40m

$764

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 5/27

11:00 pm-6:02 pm

2 stops20h 02m

Lambert-St Louis

Thu 6/11

11:51 am-7:00 am

1 stop18h 09m

$792

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 5/27

8:40 pm-12:54 pm

1 stop17h 14m

Lambert-St Louis

Thu 6/11

11:51 am-7:00 am

1 stop18h 09m

$795

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/23

1:35 am-11:19 pm

2 stops23h 44m

$412

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Fri 3/20

4:35 am-7:07 am

2 stops28h 32m

$567

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 3/24

10:10 pm-3:53 pm

1 stop19h 43m

$577

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Fri 3/20

10:10 pm-3:57 pm

1 stop19h 47m

$617

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 12/21

4:25 pm-3:29 pm

2 stops26h 04m

$2,156

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 12/21

9:30 pm-2:32 pm

1 stop20h 02m

$2,652

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 11 results

Compare providers for flights from Santiago to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to St. Louis in December.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santiago-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Santiago to St. Louis?
A quick flight from Santiago to St. Louis can take about 20h 18m. American Airlines provides one of the quickest options available for as low as $764. The distance between Santiago and St. Louis is about 5137 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Santiago to St. Louis round-trip?
According to our current data, Delta ($877), and American Airlines ($948) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 11% less than the average price by searching for these airlines.
Can I find deals for flights from Santiago to St. Louis that include hotel bookings?
Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.
Can I find deals for business class flights from Santiago to St. Louis?
Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Other flights to St. Louis

Top 2 airlines flying from Santiago to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$877	Average$1,065	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$948	Average$1,150	FlexibilityNo cancel fee	On-time71%

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$412+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. LouisExplore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Santiago to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Compare providers for flights from Santiago to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to St. Louis in December.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santiago to St. Louis?

What are the cheapest airlines flying from Santiago to St. Louis round-trip?

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

How can I find direct flights from Santiago to St. Louis?

Can I find deals for business class flights from Santiago to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Santiago to St. Louis

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Book with Flexibility

Travel Smart

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.