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$271+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Feb 27 — Mar 61
Thu 2/27
Thu 3/6
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$447
(United Airlines)

One-way from

$271
(American Airlines)

Popular in

February

Cheapest in

October

Average price

$676
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
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From Panama City Tocumen Intl to Lambert-St Louis
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One-way flight from Panama City Tocumen Intl to Lambert-St Louis
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Highest demand for flights based on searches. 10% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2025.

This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/610:55 pmPTY - STL
2 stops13h 24mUnited Airlines
Tue 5/138:30 amSTL - PTY
1 stop10h 07mUnited Airlines
Deal found 2/21$447
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/61:20 pmPTY - STL
1 stop9h 00mAmerican Airlines
Tue 5/135:13 amSTL - PTY
1 stop7h 02mAmerican Airlines
Deal found 2/21$465
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/232:20 pmPTY - STL
1 stop9h 11mDelta
Wed 3/266:00 amSTL - PTY
1 stop6h 55mDelta
Deal found 2/22$706
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/273:19 amPTY - STL
2 stops21h 24mMultiple Airlines
Sun 3/24:00 pmSTL - PTY
1 stop27h 19mMultiple Airlines
Deal found 2/21$840
This KAYAK deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/263:20 amPTY - STL
2 stops15h 13mAvianca
Fri 9/58:25 amSTL - PTY
2 stops32h 05mAvianca
Deal found 2/21$2,196

Find flights from Panama City to St. Louis within your budget

Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 5/6

10:55 pm-12:19 pm

2 stops13h 24m

Lambert-St Louis

Tue 5/13

8:30 am-6:37 pm

1 stop10h 07m

$447

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 5/6

1:20 pm-10:20 pm

1 stop9h 00m

Lambert-St Louis

Tue 5/13

5:13 am-12:15 pm

1 stop7h 02m

$465

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 3/23

2:20 pm-11:31 pm

1 stop9h 11m

Lambert-St Louis

Wed 3/26

6:00 am-12:55 pm

1 stop6h 55m

$706

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 3/23

7:24 am-11:31 pm

1 stop16h 07m

Lambert-St Louis

Sat 5/17

8:30 am-6:37 pm

1 stop10h 07m

$868

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/5

3:25 am-9:58 am

2 stops30h 33m

Lambert-St Louis

Tue 5/13

8:25 am-12:35 pm

3 stops28h 10m

$3,854

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 3/20

1:05 pm-8:09 am

2 stops19h 04m

$271

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 3/20

3:40 pm-3:16 pm

1 stop23h 36m

$325

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 3/19

3:19 am-8:10 pm

3 stops40h 51m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City to St. Louis

Get recent, data-driven insights about flights from Panama City to St. Louis including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama City to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2025.

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 7% versus a flight in the morning.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 22, 2025.
Delta
8.0
Very good
8,203 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,203 reviews
Delta
8.0
Very good
8,203 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,754 reviews
Delta
8.0
Very good
8,203 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,203 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca
6.8
Okay
2,425 reviews
Delta
8.0
Very good
8,203 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $447 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $465 and $706 round-trip. You may be able to fly from Panama City to St. Louis for 23% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Fenton
Fairview Heights
Maryland Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Alton
Farmington
Chesterfield

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$460Average$563FlexibilityNo cancel feeOn-time69%
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