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$296+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Apr 7 — Apr 141
Mon 4/7
Mon 4/14
1 adult, Economy
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Cheap flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated April 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$449
(Delta)

One-way from

$296
(Delta)

Popular in

January

Cheapest in

March

Average price

$614
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
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From Panama to Lambert-St Louis
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One-way flight from Panama to Lambert-St Louis
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Highest demand for flights based on searches. 4% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/62:20 pmPTY - STL
1 stop9h 16mDelta
Tue 5/136:00 amSTL - PTY
1 stop6h 48mDelta
Deal found 4/1$449
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1910:00 amPTY - STL
1 stop29h 49mUnited Airlines
Sat 6/75:27 pmSTL - PTY
2 stops20h 47mUnited Airlines
Deal found 3/31$493
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/191:20 pmPTY - STL
1 stop28h 09mAmerican Airlines
Sat 6/78:05 pmSTL - PTY
2 stops18h 20mAmerican Airlines
Deal found 4/1$506
This Expedia deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/243:20 amPTY - STL
2 stops35h 56mMultiple Airlines
Tue 7/2910:00 amSTL - PTY
2 stops24h 25mMultiple Airlines
Deal found 4/1$1,694
This Avianca deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/53:25 amPTY - STL
2 stops13h 58mAvianca
Tue 5/138:25 amSTL - PTY
2 stops15h 45mAvianca
Deal found 4/1$3,228

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 5/6

2:20 pm-11:36 pm

1 stop9h 16m

Lambert-St Louis

Tue 5/13

6:00 am-12:48 pm

1 stop6h 48m

$449

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/19

10:00 am-3:49 pm

1 stop29h 49m

Lambert-St Louis

Sat 6/7

5:27 pm-2:14 pm

2 stops20h 47m

$493

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/19

1:20 pm-5:29 pm

1 stop28h 09m

Lambert-St Louis

Sat 6/7

8:05 pm-2:25 pm

2 stops18h 20m

$506

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 7/24

3:20 am-3:16 pm

2 stops35h 56m

Lambert-St Louis

Tue 7/29

10:00 am-10:25 am

2 stops24h 25m

$1,694

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/5

3:25 am-5:23 pm

2 stops13h 58m

Lambert-St Louis

Tue 5/13

8:25 am-12:10 am

2 stops15h 45m

$3,228

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 5/11

8:00 am-4:35 pm

1 stop8h 35m

$296

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 5/11

3:20 pm-3:47 pm

2 stops24h 27m

$302

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 5/11

9:34 am-12:06 am

3 stops14h 32m

$370

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest time of day to fly from PA to STL?

Find hourly flight availability from Panama to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to St. Louis as you normally would.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 2, 2025.
Delta
8.0
Very good
7,898 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,898 reviews
Delta
8.0
Very good
7,898 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,615 reviews
Delta
8.0
Very good
7,898 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,898 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,302 reviews
Delta
8.0
Very good
7,898 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama to St. Louis (average of $311). Flying from Panama to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama?

Book flights to Panama if you plan to visit one of these locations
Fenton
Maryland Heights
Fairview Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington
Chesterfield

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama to St. Louis

Discover the top 2 airlines that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$460Average$563FlexibilityNo cancel feeOn-time69%

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