What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

Flying on Delta is currently your cheapest option to St. Louis, with prices starting at $300. Additional round-trip tickets that might be worth considering are offered by United Airlines and American Airlines, with the lowest prices starting at $305 and $310, respectively. Delta is 34% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $134. However, be on the lookout for offers from Southwest and American Airlines, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

What is the cheapest day to fly from Panama City, Florida to St. Louis?

Travelers seeking maximum savings on their Panama City, Florida to St. Louis flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from Panama City, Florida to St. Louis?

Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $380, our data indicates the cheapest price to be $149. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $300.

What are the most popular airlines that fly from Panama City, Florida to St. Louis?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Panama City, Florida to St. Louis.

What is the cheapest day to fly round-trip from Panama City, Florida to St. Louis?

Users have found that leaving on a Tuesday can be a cost-effective option. It’s possible to save up to 28% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City, Florida to St. Louis?

Our data shows that July tends to be the cheapest month to fly to St. Louis from Panama City, Florida. Users have commonly found prices around $460 for the month, but tickets can be as low as $237. Due to multiple factors, prepare for potentially higher prices in February.

Most accurate provider : When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$134+ Flights from Panama City, FL to St. Louis

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1. Tell us where you want to go

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Cheap flight deals from Panama City to St. Louis

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$300 (Delta)
One-way from	$134 (Delta)
Popular in	February
Cheapest in	July
Average price	$426
Good round-trip deal	$400 or less
Good one-way deal	$213 or less

Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.

Search Deals

From Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

One-way flight from Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 19% potential increase in price ($112 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 7% potential price decrease ($33 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.

Search Deals

Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.

Search Deals

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

Wed 4/309:13 amECP - STL

1 stop5h 59mDelta

Mon 5/54:05 pmSTL - ECP

1 stop3h 35mDelta

Deal found 4/4

$300

Wed 4/303:14 pmECP - STL

1 stop6h 55mUnited Airlines

Mon 5/510:39 amSTL - ECP

2 stops9h 40mUnited Airlines

Deal found 4/4

$305

Wed 4/3010:13 amECP - STL

2 stops10h 34mAmerican Airlines

Mon 5/56:45 amSTL - ECP

2 stops9h 14mAmerican Airlines

Deal found 4/4

$310

Wed 4/307:50 amECP - STL

Nonstop1h 50mSouthwest

Mon 5/59:00 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 4/4

$338

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2025.

Wed 4/309:13 amECP - STL

1 stop5h 59mDelta

Mon 5/54:05 pmSTL - ECP

1 stop3h 35mDelta

Deal found 4/4

$300

Wed 4/303:14 pmECP - STL

1 stop6h 55mUnited Airlines

Mon 5/510:39 amSTL - ECP

2 stops9h 40mUnited Airlines

Deal found 4/4

$305

Wed 4/3010:13 amECP - STL

2 stops10h 34mAmerican Airlines

Mon 5/56:45 amSTL - ECP

2 stops9h 14mAmerican Airlines

Deal found 4/4

$310

Wed 4/307:50 amECP - STL

Nonstop1h 50mSouthwest

Mon 5/59:00 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 4/4

$338

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated April 4, 2025 and is based on user searches.

Fri 4/116:00 amECP - STL

1 stop3h 36mDelta

Sun 4/137:12 pmSTL - ECP

1 stop3h 53mDelta

Deal found 4/3

$499

Fri 4/115:05 pmECP - STL

1 stop4h 55mSouthwest

Sun 4/1310:15 amSTL - ECP

2 stops7h 25mSouthwest

Deal found 4/3

$504

Wed 4/309:13 amECP - STL

1 stop5h 59mDelta

Mon 5/54:05 pmSTL - ECP

1 stop3h 35mDelta

Deal found 4/4

$300

Wed 4/303:14 pmECP - STL

1 stop6h 55mUnited Airlines

Mon 5/510:39 amSTL - ECP

2 stops9h 40mUnited Airlines

Deal found 4/4

$305

Wed 4/3010:13 amECP - STL

2 stops10h 34mAmerican Airlines

Mon 5/56:45 amSTL - ECP

2 stops9h 14mAmerican Airlines

Deal found 4/4

$310

Wed 4/307:50 amECP - STL

Nonstop1h 50mSouthwest

Mon 5/59:00 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 4/4

$338

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 4, 2025.

Tue 5/66:00 amECP - STL

1 stop5h 45mDelta

Deal found 4/4

$134

Tue 5/67:50 amECP - STL

Nonstop1h 50mSouthwest

Deal found 4/3

$139

Wed 6/1112:33 pmECP - STL

2 stops7h 57mAmerican Airlines

Deal found 4/3

$154

Fri 6/133:20 pmECP - STL

1 stop6h 57mUnited Airlines

Deal found 4/4

$185

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 4/30

9:13 am-3:12 pm

1 stop5h 59m

Lambert-St Louis

Mon 5/5

4:05 pm-7:40 pm

1 stop3h 35m

$300

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 4/30

7:50 am-9:40 am

Nonstop1h 50m

Lambert-St Louis

Mon 5/5

3:45 pm-9:50 pm

1 stop6h 05m

$305

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 4/30

10:13 am-8:47 pm

2 stops10h 34m

Lambert-St Louis

Mon 5/5

6:45 am-3:59 pm

2 stops9h 14m

$310

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 5/24

5:07 pm-10:27 pm

1 stop5h 20m

Lambert-St Louis

Mon 5/26

8:25 am-4:20 pm

1 stop7h 55m

$351

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 5/6

6:00 am-11:45 am

1 stop5h 45m

$134

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 5/6

7:50 am-9:40 am

Nonstop1h 50m

$139

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 6/11

12:33 pm-8:30 pm

2 stops7h 57m

$154

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 6/13

3:20 pm-10:17 pm

1 stop6h 57m

$185

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/4

Compare providers for flights from Panama City to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 6% on your trip compared to booking a flight in the afternoon.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta and United Airlines from Panama City to St. Louis. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,276 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest

8.0

Very good

4,276 reviews

Southwest

8.0

Very good

4,276 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta

8.0

Very good

7,899 reviews

Southwest

8.0

Very good

4,276 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines

7.4

Good

8,618 reviews

Southwest

8.0

Very good

4,276 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,276 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?
Flying on Delta is currently your cheapest option to St. Louis, with prices starting at $300. Additional round-trip tickets that might be worth considering are offered by United Airlines and American Airlines, with the lowest prices starting at $305 and $310, respectively. Delta is 34% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?
The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $134. However, be on the lookout for offers from Southwest and American Airlines, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.
What are the cheapest flights from Panama City, Florida to St. Louis?
Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $380, our data indicates the cheapest price to be $149. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $300.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fenton

Maryland Heights

Fairview Heights

Collinsville

Wentzville

Eureka

St. Peters

Festus

Glencoe

Alton

Farmington

Chesterfield

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Top 3 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$206	Average$326	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$290	Average$446	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$343	Average$466	FlexibilityNo cancel fee	On-time63%

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$134+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in April.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta and United Airlines from Panama City to St. Louis. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

What are the cheapest flights from Panama City, Florida to St. Louis?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Traveling to a place near Panama City?

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Alternative routes for Panama City to St. Louis

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Top 3 airlines flying from Panama City to St. Louis

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Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.