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$120+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Apr 30 — May 71
Wed 4/30
Wed 5/7
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$297
(Delta)

One-way from

$120
(American Airlines)

Popular in

February

Cheapest in

May

Average price

$448

Good round-trip deal

$380 or less

Good one-way deal

$211 or less
Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.
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From Panama City NW Florida Beaches to Lambert-St Louis
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One-way flight from Panama City NW Florida Beaches to Lambert-St Louis
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Highest demand for flights based on searches. 19% potential increase in price ($110 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.
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Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2025.

This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/19:16 amECP - STL
1 stop5h 21mDelta
Fri 7/45:23 pmSTL - ECP
1 stop5h 58mDelta
Deal found 4/24$297
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/27:02 pmECP - STL
1 stop4h 57mAmerican Airlines
Tue 7/85:27 pmSTL - ECP
1 stop4h 36mAmerican Airlines
Deal found 4/24$309
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/237:00 amECP - STL
1 stop6h 00mSouthwest
Mon 6/234:40 pmSTL - ECP
1 stop5h 35mSouthwest
Deal found 4/24$333
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/111:10 amECP - STL
1 stop7h 43mUnited Airlines
Fri 7/48:00 amSTL - ECP
2 stops10h 59mUnited Airlines
Deal found 4/24$372

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/1

9:16 am-2:37 pm

1 stop5h 21m

Lambert-St Louis

Fri 7/4

5:23 pm-11:21 pm

1 stop5h 58m

$297

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 7/2

7:02 pm-11:59 pm

1 stop4h 57m

Lambert-St Louis

Tue 7/8

5:27 pm-10:03 pm

1 stop4h 36m

$309

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 6/23

7:00 am-1:00 pm

1 stop6h 00m

Lambert-St Louis

Mon 6/23

4:40 pm-10:15 pm

1 stop5h 35m

$333

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/1

11:10 am-6:53 pm

1 stop7h 43m

Lambert-St Louis

Fri 7/4

8:00 am-6:59 pm

2 stops10h 59m

$372

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 6/17

9:36 am-4:39 pm

1 stop7h 03m

$120

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sun 5/25

7:35 am-9:25 am

Nonstop1h 50m

$139

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 5/24

1:59 pm-8:39 pm

1 stop6h 40m

$149

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 6/21

11:10 am-10:45 pm

2 stops11h 35m

$208

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 25, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 6% on your trip compared to booking a flight in the afternoon.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 25, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Panama City to St. Louis. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,289 reviews

Comfort

8.0

Food

7.1

Overall

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,289 reviews
Southwest
8.0
Very good
4,289 reviews

Comfort

8.0

Food

7.1

Overall

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,289 reviews

Comfort

8.0

Food

7.1

Overall

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,685 reviews
Southwest
8.0
Very good
4,289 reviews

Comfort

8.0

Food

7.1

Overall

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,289 reviews

Comfort

8.0

Food

7.1

Overall

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

    Flying on Delta is currently your cheapest option to St. Louis, with prices starting at $297. Additional round-trip tickets that might be worth considering are offered by American Airlines and Southwest, with the lowest prices starting at $309 and $333, respectively. Delta is 35% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $120. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

  • What are the cheapest flights from Panama City, Florida to St. Louis?

    Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $338, our data indicates the cheapest price to be $189. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $333.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Fenton
Maryland Heights
Fairview Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington

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Top 3 airlines flying from Panama City to St. Louis

Discover the top 3 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$206Average$326FlexibilityNo cancel feeOn-time71%
DeltaCheapest$309Average$446FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$343Average$438FlexibilityNo cancel feeOn-time63%

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