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St. Louis

$119+ Cheap flights from Mesa, AZ to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — STL
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in June or July, booked 89 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Cheap flight deals from Mesa to St. Louis

Keep the following information in mind while searching for Mesa to St. Louis flight deals. Data was last updated March 28, 2025.

Round-trip from

$248
(Booking.com)

One-way from

$119
(Frontier)

Popular in

January

Cheapest in

June

Average price

$401
From Mesa to Lambert-St Louis
Search Deals
One-way flight from Mesa to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($94 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Mesa to St. Louis

Cheapest flights from Mesa to St. Louis
Explore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This Booking.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/247:35 pmPHX - STL
1 stop12h 26mFrontier
Thu 5/14:07 pmSTL - PHX
1 stop9h 48mFrontier
Deal found 3/27$248
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/291:04 amPHX - STL
1 stop8h 20mAmerican Airlines
Wed 4/302:27 pmSTL - PHX
Nonstop3h 31mAmerican Airlines
Deal found 3/27$259
This Sun Country Air deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sun Country Air is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:25 pmPHX - STL
1 stop15h 12mSun Country Air
Sun 5/187:30 amSTL - PHX
1 stop27h 25mSun Country Air
Deal found 3/27$265
This Trip.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/311:49 pmPHX - STL
1 stop21h 57mMultiple Airlines
Sun 4/66:35 amSTL - PHX
1 stop8h 24mMultiple Airlines
Deal found 3/28$272
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:16 pmPHX - STL
1 stop14h 33mSpirit Airlines
Sun 11/28:44 amSTL - PHX
1 stop7h 27mSpirit Airlines
Deal found 3/27$299
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:00 amPHX - STL
1 stop4h 47mUnited Airlines
Wed 4/305:35 pmSTL - PHX
1 stop6h 16mUnited Airlines
Deal found 3/27$334
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1012:45 amPHX - STL
1 stop8h 02mDelta
Tue 5/136:05 pmSTL - PHX
1 stop7h 41mDelta
Deal found 3/28$349
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/285:05 pmPHX - STL
Nonstop2h 55mSouthwest
Mon 5/58:50 amSTL - PHX
1 stop5h 25mSouthwest
Deal found 3/27$365
This Alaska Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:00 amPHX - STL
1 stop15h 59mAlaska Airlines
Sat 4/196:44 amSTL - PHX
2 stops15h 10mAlaska Airlines
Deal found 3/27$391

Cheapflights Fare Finder

Customize your flight search to find flights from Mesa to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Mesa to St. Louis that are best for you.

Fly from

Mesa

Fly to

St. Louis

Route

Depart

Return

Price

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/24

7:35 pm-10:01 am

1 stop12h 26m

Lambert-St Louis

Thu 5/1

4:07 pm-11:55 pm

1 stop9h 48m

$248

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Tue 4/29

1:04 am-11:24 am

1 stop8h 20m

Lambert-St Louis

Wed 4/30

2:27 pm-3:58 pm

Nonstop3h 31m

$259

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 5/15

6:25 pm-11:37 am

1 stop15h 12m

Lambert-St Louis

Sun 5/18

7:30 am-8:55 am

1 stop27h 25m

$265

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 5/21

5:54 pm-1:40 pm

1 stop17h 46m

Lambert-St Louis

Sun 5/25

10:20 am-9:07 am

1 stop24h 47m

$274

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Wed 4/30

6:00 am-12:47 pm

1 stop4h 47m

Lambert-St Louis

Wed 4/30

5:35 pm-9:51 pm

1 stop6h 16m

$334

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Sat 5/10

12:45 am-10:47 am

1 stop8h 02m

Lambert-St Louis

Tue 5/13

6:05 pm-11:46 pm

1 stop7h 41m

$349

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Mon 4/28

5:05 pm-10:00 pm

Nonstop2h 55m

Lambert-St Louis

Mon 5/5

8:50 am-12:15 pm

1 stop5h 25m

$365

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Thu 4/17

6:00 am-11:59 pm

1 stop15h 59m

Lambert-St Louis

Sat 4/19

6:44 am-7:54 pm

2 stops15h 10m

$391

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 4/18

7:51 am-5:43 pm

1 stop7h 52m

$119

PhoenixSt. Louis

PHX - STL

PHXSTL

Phoenix Sky Harbor Intl

Fri 5/9

9:19 am-9:15 am

2 stops21h 56m

$133

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 17 results
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Best time to book a flight from Mesa to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to St. Louis

How far ahead should I book a flight from Mesa to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to St. Louis. Price data was last updated on March 21, 2025.

Booking 89 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mesa to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $311). Flying from Mesa to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to STL?

Find hourly flight availability from Mesa to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

When flying from Mesa to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from Mesa to St. Louis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to St. Louis

Explore weekly flight availability from Mesa to St. Louis. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated March 28, 2025.

The most flights from MS9 to STL are scheduled on a Tuesday (10 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 28, 2025.
To help decide which airline to fly from Mesa to St. Louis, see what other customers have to say about Southwest, Alaska Airlines and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.1
Very good
4,273 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Alaska Airlines
8.0
Very good
9,798 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,896 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,603 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Mesa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Mesa?

    For a flight from Mesa to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city. Lambert-St Louis is the only St. Louis airport and it handles 7 inbound flights from Mesa per day. 5 airlines have flights to Lambert-St Louis from Mesa on a regular basis.

  • What are the cheapest airlines to fly from Mesa to St. Louis one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $119. Users have also found prices from $133 and $160 on Spirit Airlines and American Airlines, respectively.

  • What are the most reliable airlines from Mesa to St. Louis?

    No one likes to see their flight delayed. When booking a flight from Mesa to St. Louis consider choosing American Airlines (91%), Alaska Airlines (91%) or SkyWest Airlines (85%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mesa to St. Louis?

    On average you can expect to pay $406 for a flight from Mesa to St. Louis. The cheapest flight overall is $99 while the most popular route, (Phoenix Sky Harbor Intl - Lambert-St Louis) is currently priced at $265.

  • Can I find deals for flights from Mesa to St. Louis that include hotel bookings?

    Yes. In addition to deals on Mesa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to St. Louis.

  • Can I find deals for business class flights from Mesa to St. Louis?

    Yes. Cheapflights offers flight deals from Mesa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Mesa to St. Louis (average of $311). Flying from Mesa to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mesa?

Book flights to Mesa if you plan to visit one of these locations
Fenton
Fairview Heights
Maryland Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington
Chesterfield

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Mesa to St. Louis

Discover the top 5 airlines that operate flights from Mesa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$78Average$153FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$131Average$325FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$290FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$263Average$352FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$302Average$447FlexibilityNo cancel feeOn-time63%
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