What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $218. Other airlines that can offer you cheap pricing are Delta, from $229, and American Airlines, from $234. These flights start at 30% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Knoxville to St. Louis one-way?

For one-way options, check prices for Delta. According to our data, you can fly for as low as $126. Users have also found prices from $201 and $393 on American Airlines and United Airlines, respectively.

What is the cheapest day to fly from Knoxville to St. Louis?

Travelers seeking maximum savings on their Knoxville to St. Louis flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Knoxville to St. Louis?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Knoxville to St. Louis.

What is the cheapest day to fly round-trip from Knoxville to St. Louis?

Sunday flights are found to be more expensive to fly from Knoxville to St. Louis. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to St. Louis.

What is the cheapest month to fly from Knoxville to St. Louis?

The best pricing can be found in the month of June. Prices to St. Louis from Knoxville average $314. You can even find prices in June for less than $314, as users have found deals to St. Louis from as low as $221. The month of March appears to be one of the more expensive times to travel to St. Louis from Knoxville. Flying in the targeted month can save you up to 72%.

Most accurate provider : When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

Can I find deals for business class flights from Knoxville to St. Louis?

Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$96+ Flights from Knoxville to St. Louis

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1. Tell us where you want to go

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Cheap flight deals from Knoxville to St. Louis

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$218 (Booking.com)
One-way from	$96 (Mytrip)
Popular in	March
Cheapest in	June
Average price	$286

Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.

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From Knoxville McGhee Tyson to Lambert-St Louis

Search Deals

One-way flight from Knoxville McGhee Tyson to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($61 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 7% potential price decrease ($21 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Thu 5/295:30 pmTYS - STL

1 stop16h 39mFrontier

Sat 5/317:55 pmSTL - TYS

1 stop19h 34mFrontier

Deal found 4/21

$218

Tue 6/105:45 amTYS - STL

1 stop3h 38mDelta

Sat 6/145:23 pmSTL - TYS

1 stop5h 36mDelta

Deal found 4/21

$229

Mon 5/266:10 amTYS - STL

1 stop5h 33mAmerican Airlines

Sat 5/315:19 amSTL - TYS

1 stop5h 22mAmerican Airlines

Deal found 4/22

$234

Tue 5/207:00 amTYS - STL

1 stop6h 19mUnited Airlines

Tue 5/275:00 amSTL - TYS

1 stop4h 07mUnited Airlines

Deal found 4/22

$289

Fri 6/610:59 amTYS - STL

1 stop25h 26mMultiple Airlines

Fri 6/1311:28 amSTL - TYS

1 stop20h 06mMultiple Airlines

Deal found 4/22

$311

Best flights from Knoxville to St. Louis
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2025.

Thu 5/295:30 pmTYS - STL

1 stop16h 39mFrontier

Sat 5/317:55 pmSTL - TYS

1 stop19h 34mFrontier

Deal found 4/21

$218

Tue 6/105:45 amTYS - STL

1 stop3h 38mDelta

Sat 6/145:23 pmSTL - TYS

1 stop5h 36mDelta

Deal found 4/21

$229

Mon 5/266:10 amTYS - STL

1 stop5h 33mAmerican Airlines

Sat 5/315:19 amSTL - TYS

1 stop5h 22mAmerican Airlines

Deal found 4/22

$234

Tue 5/207:00 amTYS - STL

1 stop6h 19mUnited Airlines

Tue 5/275:00 amSTL - TYS

1 stop4h 07mUnited Airlines

Deal found 4/22

$289

Fri 6/610:59 amTYS - STL

1 stop25h 26mMultiple Airlines

Fri 6/1311:28 amSTL - TYS

1 stop20h 06mMultiple Airlines

Deal found 4/22

$311

Last-minute flights from Knoxville to St. Louis
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated April 22, 2025 and is based on user searches.

Tue 4/225:30 amTYS - STL

1 stop5h 06mDelta

Tue 4/2910:42 amSTL - TYS

1 stop4h 32mDelta

Deal found 4/21

$279

Mon 4/286:17 amTYS - STL

1 stop9h 28mAmerican Airlines

Wed 4/3010:48 amSTL - TYS

1 stop7h 12mAmerican Airlines

Deal found 4/21

$561

Mon 4/285:00 pmTYS - STL

1 stop4h 39mDelta

Wed 4/306:50 amSTL - TYS

1 stop4h 13mDelta

Deal found 4/21

$564

Mon 4/2810:00 amTYS - STL

2 stops32h 15mMultiple Airlines

Fri 5/21:00 pmSTL - TYS

3 stops26h 03mMultiple Airlines

Deal found 4/22

$591

Mon 4/281:57 pmTYS - STL

1 stop4h 26mUnited Airlines

Fri 5/24:50 pmSTL - TYS

2 stops16h 15mUnited Airlines

Deal found 4/22

$803

Sun 5/41:43 pmTYS - STL

3 stops29h 58mMultiple Airlines

Tue 5/66:10 pmSTL - TYS

1 stop18h 23mMultiple Airlines

Deal found 4/21

$391

Tue 5/207:00 amTYS - STL

1 stop6h 19mUnited Airlines

Tue 5/275:00 amSTL - TYS

1 stop4h 07mUnited Airlines

Deal found 4/22

$289

Mon 5/266:10 amTYS - STL

1 stop5h 33mAmerican Airlines

Sat 5/315:19 amSTL - TYS

1 stop5h 22mAmerican Airlines

Deal found 4/22

$234

Thu 5/295:30 pmTYS - STL

1 stop16h 39mFrontier

Sat 5/317:55 pmSTL - TYS

1 stop19h 34mFrontier

Deal found 4/21

$218

One-way flights from Knoxville to St. Louis
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 22, 2025.

Wed 5/145:02 pmTYS - STL

1 stop17h 13mMultiple Airlines

Deal found 4/20

$96

Wed 7/165:15 pmTYS - STL

1 stop4h 15mDelta

Deal found 4/22

$126

Tue 4/2912:14 pmTYS - STL

1 stop5h 22mAmerican Airlines

Deal found 4/22

$201

Wed 7/169:35 amTYS - STL

2 stops13h 15mUnited Airlines

Deal found 4/22

$393

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 5/29

5:30 pm-9:09 am

1 stop16h 39m

Lambert-St Louis

Sat 5/31

7:55 pm-4:29 pm

1 stop19h 34m

$218

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 6/10

5:45 am-8:23 am

1 stop3h 38m

Lambert-St Louis

Sat 6/14

5:23 pm-11:59 pm

1 stop5h 36m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 5/26

6:10 am-10:43 am

1 stop5h 33m

Lambert-St Louis

Sat 5/31

5:19 am-11:41 am

1 stop5h 22m

$234

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/20

7:00 am-12:19 pm

1 stop6h 19m

Lambert-St Louis

Tue 5/27

5:00 am-10:07 am

1 stop4h 07m

$289

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 6/6

10:59 am-11:25 am

1 stop25h 26m

Lambert-St Louis

Fri 6/13

11:28 am-8:34 am

1 stop20h 06m

$311

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/14

5:02 pm-9:15 am

1 stop17h 13m

$96

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 7/16

5:15 pm-8:30 pm

1 stop4h 15m

$126

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 4/29

12:14 pm-4:36 pm

1 stop5h 22m

$201

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 7/16

9:35 am-9:50 pm

2 stops13h 15m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/20

Compare providers for flights from Knoxville to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 8% on your trip compared to booking a flight in the morning.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Knoxville to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,920 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,683 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Frontier

6.0

Okay

3,283 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?
Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $218. Other airlines that can offer you cheap pricing are Delta, from $229, and American Airlines, from $234. These flights start at 30% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Knoxville to St. Louis one-way?
For one-way options, check prices for Delta. According to our data, you can fly for as low as $126. Users have also found prices from $201 and $393 on American Airlines and United Airlines, respectively.
Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?
Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.
Can I find deals for business class flights from Knoxville to St. Louis?
Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Wentzville

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Glencoe

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Farmington

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Other flights to St. Louis

Top 3 airlines flying from Knoxville to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$282	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$213	Average$288	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$227	Average$305	FlexibilityNo cancel fee	On-timeN/A

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$96+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Compare providers for flights from Knoxville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in April.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Knoxville to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

What are the cheapest airlines to fly from Knoxville to St. Louis one-way?

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

How can I find direct flights from Knoxville to St. Louis?

Can I find deals for business class flights from Knoxville to St. Louis?

What is the cheapest month to book a flight from Knoxville to St. Louis?

Traveling to a place near Knoxville?

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Top 3 airlines flying from Knoxville to St. Louis

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Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.