What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?

Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Delta and Southwest, starting at $141 and $148 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

The most flights from DTW to STL are scheduled on a Monday (16 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (11 on average).

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

On average you can expect to pay $222 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $42 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $152.

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), Aeromexico (89%) or Spirit Airlines (88%) as they are the most reliable in getting you off to your destination on time.

What are the most popular airlines that fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Before booking your flight from Detroit Metropolitan Wayne County Airport to St. Louis check out the most popular airlines for this route: Delta, Spirit Airlines or United Airlines.

What is the cheapest day to fly round-trip from Detroit Metropolitan Wayne County Airport to St. Louis?

Sunday flights are found to be more expensive to fly from Detroit Metropolitan Wayne County Airport to St. Louis. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to St. Louis.

What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Flights from Detroit Metropolitan Wayne County Airport to St. Louis lean towards being more expensive in October. Prices are generally better when you fly from Detroit Metropolitan Wayne County Airport to St. Louis in August, with the cheapest ticket starting at $60.

What airports do I use to fly from Detroit to St. Louis?

If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 35m for a nonstop flight. There are 13 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Detroit to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.

Can I find deals for business class flights from Detroit to St. Louis?

Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$71+ Flights from Detroit Metropolitan Wayne County Airport to St. Louis

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Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

Round-trip from	$164 (Kiwi.com)
One-way from	$71 (Kiwi.com)
Popular in	December
Cheapest in	July
Average price	$299
Good round-trip deal	$218 or less
Good one-way deal	$120 or less

From Detroit Metropolitan Wayne County to Lambert-St Louis

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One-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis

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Highest demand for flights based on searches. 16% potential increase in price ($54 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($7 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

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Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Sun 9/287:20 amDTW - STL

1 stop8h 44mMultiple Airlines

Thu 10/24:00 pmSTL - DTW

1 stop21h 46mMultiple Airlines

Deal found 9/13

$164

Fri 10/31:36 pmDTW - STL

1 stop8h 01mFrontier

Sun 10/51:57 pmSTL - DTW

1 stop17h 47mFrontier

Deal found 9/15

$174

Sat 9/278:00 amDTW - STL

1 stop26h 06mFrontier

Tue 9/307:55 pmSTL - DTW

1 stop27h 51mFrontier

Deal found 9/13

$181

Wed 10/87:00 amDTW - STL

1 stop7h 44mAmerican Airlines

Wed 10/156:00 amSTL - DTW

1 stop10h 34mAmerican Airlines

Deal found 9/14

$183

Sun 9/2810:29 pmDTW - STL

2 stops17h 35mFrontier

Thu 10/24:00 pmSTL - DTW

1 stop16h 59mFrontier

Deal found 9/13

$197

Fri 10/31:36 pmDTW - STL

1 stop8h 01mMultiple Airlines

Sun 10/54:00 pmSTL - DTW

1 stop15h 16mMultiple Airlines

Deal found 9/13

$205

Thu 10/23:42 pmDTW - STL

2 stops18h 24mMultiple Airlines

Sun 10/54:00 pmSTL - DTW

1 stop15h 16mMultiple Airlines

Deal found 9/13

$207

Wed 10/153:42 pmDTW - STL

1 stop19h 55mMultiple Airlines

Wed 10/227:52 pmSTL - DTW

2 stops20h 58mMultiple Airlines

Deal found 9/15

$213

Mon 11/35:14 pmDTW - STL

1 stop16h 53mMultiple Airlines

Tue 11/47:45 pmSTL - DTW

2 stops14h 16mMultiple Airlines

Deal found 9/14

$214

Best flights from Detroit to St. Louis
Discover carefully curated flight deals from Detroit to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Fri 10/31:36 pmDTW - STL

1 stop8h 01mFrontier

Sun 10/51:57 pmSTL - DTW

1 stop17h 47mFrontier

Deal found 9/15

$174

Wed 11/196:45 amDTW - STL

1 stop9h 17mAmerican Airlines

Sat 11/228:39 amSTL - DTW

1 stop9h 04mAmerican Airlines

Deal found 9/14

$183

Wed 10/153:42 pmDTW - STL

1 stop19h 55mMultiple Airlines

Wed 10/227:52 pmSTL - DTW

2 stops20h 58mMultiple Airlines

Deal found 9/15

$213

Mon 11/36:45 pmDTW - STL

Nonstop1h 40mSouthwest

Tue 11/46:10 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 9/14

$255

Wed 10/812:45 pmDTW - STL

Nonstop1h 37mDelta

Wed 10/156:40 amSTL - DTW

Nonstop1h 32mDelta

Deal found 9/14

$255

Wed 10/157:00 amDTW - STL

1 stop7h 44mAmerican Airlines

Wed 10/228:42 amSTL - DTW

1 stop7h 52mAmerican Airlines

Deal found 9/15

$183

Sat 10/118:18 pmDTW - STL

1 stop14h 04mMultiple Airlines

Mon 10/137:52 pmSTL - DTW

2 stops20h 58mMultiple Airlines

Deal found 9/13

$220

Fri 10/36:10 amDTW - STL

1 stop27h 56mFrontier

Mon 10/67:55 pmSTL - DTW

1 stop28h 04mFrontier

Deal found 9/12

$231

Sat 11/225:40 pmDTW - STL

1 stop6h 40mSouthwest

Mon 11/248:10 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 9/14

$265

Wed 10/153:42 pmDTW - STL

2 stops18h 40mMultiple Airlines

Sun 10/1910:57 amSTL - DTW

1 stop21h 57mMultiple Airlines

Deal found 9/15

$242

Mon 11/38:30 amDTW - STL

1 stop5h 45mAmerican Airlines

Tue 11/46:00 amSTL - DTW

1 stop12h 14mAmerican Airlines

Deal found 9/14

$242

Sat 11/17:00 amDTW - STL

1 stop7h 35mAmerican Airlines

Sun 11/27:30 amSTL - DTW

1 stop3h 40mAmerican Airlines

Deal found 9/13

$261

Last-minute flights from Detroit to St. Louis
Discover last-minute flight deals from Detroit to St. Louis. Data last updated September 15, 2025 and is based on user searches.

Fri 9/263:42 pmDTW - STL

2 stops18h 24mFrontier

Mon 9/294:00 pmSTL - DTW

1 stop21h 07mFrontier

Deal found 9/13

$220

Sat 9/278:00 amDTW - STL

1 stop26h 06mFrontier

Tue 9/307:55 pmSTL - DTW

1 stop27h 51mFrontier

Deal found 9/13

$181

Sun 9/287:20 amDTW - STL

1 stop8h 44mMultiple Airlines

Thu 10/24:00 pmSTL - DTW

1 stop21h 46mMultiple Airlines

Deal found 9/13

$164

Sun 9/2810:29 pmDTW - STL

2 stops17h 35mFrontier

Thu 10/24:00 pmSTL - DTW

1 stop16h 59mFrontier

Deal found 9/13

$197

Thu 10/23:42 pmDTW - STL

2 stops18h 24mMultiple Airlines

Sun 10/54:00 pmSTL - DTW

1 stop15h 16mMultiple Airlines

Deal found 9/13

$207

Fri 10/31:36 pmDTW - STL

1 stop8h 01mFrontier

Sun 10/51:57 pmSTL - DTW

1 stop17h 47mFrontier

Deal found 9/15

$174

Fri 10/31:36 pmDTW - STL

1 stop8h 01mMultiple Airlines

Sun 10/54:00 pmSTL - DTW

1 stop15h 16mMultiple Airlines

Deal found 9/13

$205

Wed 10/87:00 amDTW - STL

1 stop7h 44mAmerican Airlines

Wed 10/156:00 amSTL - DTW

1 stop10h 34mAmerican Airlines

Deal found 9/14

$183

Fri 10/315:14 pmDTW - STL

1 stop16h 53mMultiple Airlines

Sun 11/27:45 pmSTL - DTW

2 stops21h 05mMultiple Airlines

Deal found 9/13

$221

One-way flights from Detroit to St. Louis
Search for one-way flight options from Detroit to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Wed 11/129:20 pmDTW - STL

1 stop13h 52mMultiple Airlines

Deal found 9/13

$71

Sat 10/119:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Deal found 9/13

$72

Fri 10/172:56 pmDTW - STL

1 stop8h 18mFrontier

Deal found 9/14

$80

Thu 11/66:00 amDTW - STL

1 stop5h 12mMultiple Airlines

Deal found 9/12

$82

Sun 10/59:05 pmDTW - STL

1 stop18h 59mMultiple Airlines

Deal found 9/13

$84

Sun 11/99:15 pmDTW - STL

1 stop12h 52mFrontier

Deal found 9/13

$86

Tue 10/147:25 pmDTW - STL

Nonstop1h 35mSouthwest

Deal found 9/12

$88

Sat 10/188:18 pmDTW - STL

1 stop14h 04mFrontier

Deal found 9/12

$89

Thu 10/166:00 amDTW - STL

1 stop28h 07mFrontier

Deal found 9/14

$90

Thu 10/26:10 amDTW - STL

1 stop27h 56mFrontier

Deal found 9/13

$91

Sat 11/156:45 amDTW - STL

1 stop10h 27mAmerican Airlines

Deal found 9/12

$97

Tue 10/2112:57 pmDTW - STL

1 stop6h 49mAmerican Airlines

Deal found 9/12

$98

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 10/3

1:36 pm-8:37 pm

1 stop8h 01m

Lambert-St Louis

Sun 10/5

1:57 pm-8:44 am

1 stop17h 47m

$174

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 11/19

6:45 am-3:02 pm

1 stop9h 17m

Lambert-St Louis

Sat 11/22

8:39 am-6:43 pm

1 stop9h 04m

$183

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/15

7:00 am-1:44 pm

1 stop7h 44m

Lambert-St Louis

Wed 10/22

8:42 am-5:34 pm

1 stop7h 52m

$183

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/15

3:42 pm-10:37 am

1 stop19h 55m

Lambert-St Louis

Wed 10/22

7:52 pm-5:50 pm

2 stops20h 58m

$213

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 10/11

8:18 pm-9:22 am

1 stop14h 04m

Lambert-St Louis

Mon 10/13

7:52 pm-5:50 pm

2 stops20h 58m

$220

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 10/3

6:10 am-9:06 am

1 stop27h 56m

Lambert-St Louis

Mon 10/6

7:55 pm-12:59 am

1 stop28h 04m

$231

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/15

3:42 pm-9:22 am

2 stops18h 40m

Lambert-St Louis

Sun 10/19

10:57 am-9:54 am

1 stop21h 57m

$242

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/3

8:30 am-1:15 pm

1 stop5h 45m

Lambert-St Louis

Tue 11/4

6:00 am-7:14 pm

1 stop12h 14m

$242

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/3

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Tue 11/4

6:10 pm-8:40 pm

Nonstop1h 30m

$255

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/8

12:45 pm-1:22 pm

Nonstop1h 37m

Lambert-St Louis

Wed 10/15

6:40 am-9:12 am

Nonstop1h 32m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 24 results

The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to St. Louis trip

Airports

DTW

At DTW, security lines are generally short, with waits rarely exceeding 10 minutes in McNamara Terminal, making it efficient for business travelers.

STL

Use the MetroLink light rail from STL for a convenient, economical ride to downtown St. Louis, taking about 40 minutes.

Our travel experts

Brandon Schultz

Expert on DTW

Taryn White

Expert on STL

Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

Prices

Airlines

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

The price you pay for your flight from Detroit Metropolitan Wayne County Airport to St. Louis may vary depending on when you book. For the best chance of a lower fare, look to book 54 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $311). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to STL?

Unlike in the morning, when flights are generally more expensive, you can save up to 21% on flights from Detroit Metropolitan Wayne County Airport to St. Louis by exploring options for tickets at noon.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to St. Louis flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,242 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,954 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

United Airlines

7.4

Good

8,929 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Spirit Airlines

6.3

Okay

8,016 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airports do I use to fly from Detroit to St. Louis?
If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 35m for a nonstop flight. There are 13 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.
How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?
For as low as $174, Frontier can have you in St. Louis from Detroit Metropolitan Wayne County Airport in 8h 01m. Airlines will cover a distance of 439 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?
Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Delta and Southwest, starting at $141 and $148 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.
What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?
No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), Aeromexico (89%) or Spirit Airlines (88%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?
On average you can expect to pay $222 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $42 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $152.
Can I find deals for flights from Detroit to St. Louis that include hotel bookings?
Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Detroit to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.
Can I find deals for business class flights from Detroit to St. Louis?
Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $311). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Edwardsville

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Maryland Heights

Collinsville

Eureka

Glencoe

St. Peters

Chesterfield

Alton

Farmington

Festus

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Top 4 airlines flying from Detroit to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$36	Average$101	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$141	Average$303	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$148	Average$300	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$313	Average$476	FlexibilityNo cancel fee	On-time69%

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$71+ Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis (DTW - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Detroit to St. Louis with Cheapflights

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3. Compare prices and book

Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

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One-way from

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Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. LouisExplore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to St. Louis trip

Airports

DTW

STL

Our travel experts

Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What is the cheapest time of day to fly from DTW to STL?

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

Reviews of airlines servicing St. Louis

Related info for your journey

Find useful and relevant information for your journey from Detroit to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Detroit to St. Louis?

How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

How can I find direct flights from Detroit to St. Louis?

Can I find deals for business class flights from Detroit to St. Louis?

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

Traveling to a place near St. Louis?

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Alternative routes for Detroit to St. Louis

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Top 4 airlines flying from Detroit to St. Louis

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Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.