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$443+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated February 20, 2025.

Round-trip from

$683
(KLM)

One-way from

$443
(Air Europa)

Popular in

July

Cheapest in

May

Average price

$790

Good round-trip deal

$711 or less

Good one-way deal

$611 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 7% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This KLM deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/266:50 pmPTY - MAD
1 stop35h 50mKLM
Mon 6/166:00 amMAD - PTY
1 stop17h 50mKLM
Deal found 2/19$676
This KLM deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/198:50 pmPTY - MAD
1 stop14h 10mMultiple Airlines
Tue 3/1811:00 amMAD - PTY
1 stop35h 25mMultiple Airlines
Deal found 2/19$682
This Booking.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/175:35 pmPTY - MAD
Nonstop9h 50mIberia
Sat 5/2412:00 pmMAD - PTY
Nonstop11h 05mIberia
Deal found 2/19$687
This Gotogate deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/249:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Mon 5/123:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 2/19$704
This Air France deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/108:05 amPTY - MAD
1 stop18h 30mAir France
Sun 6/110:05 amMAD - PTY
1 stop14h 40mAir France
Deal found 2/19$710
This Iberia deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/125:35 pmPTY - BCN
1 stop22h 15mIberia
Sat 5/319:15 amBCN - PTY
1 stop13h 50mIberia
Deal found 2/19$714
This KLM deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/206:45 pmPTY - BCN
1 stop35h 30mKLM
Tue 3/41:00 pmBCN - PTY
1 stop33h 25mKLM
Deal found 2/20$744
This Air Europa deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/128:25 pmPTY - BCN
1 stop13h 10mAir Europa
Sat 4/2611:50 amBCN - PTY
1 stop13h 50mAir Europa
Deal found 2/19$747
This KLM deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:55 pmPTY - AGP
1 stop16h 05mMultiple Airlines
Thu 10/3010:40 amAGP - PTY
1 stop35h 45mMultiple Airlines
Deal found 2/19$758
This Iberia deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:20 pmPTY - AGP
1 stop16h 45mIberia
Thu 10/239:10 amAGP - PTY
1 stop13h 30mIberia
Deal found 2/19$782
This KLM deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/206:45 pmPTY - BCN
1 stop22h 20mMultiple Airlines
Fri 2/286:00 amBCN - PTY
1 stop18h 50mMultiple Airlines
Deal found 2/20$807
This KLM deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/66:50 pmPTY - AGP
1 stop31h 55mKLM
Sun 4/139:05 pmAGP - PTY
1 stop26h 45mKLM
Deal found 2/20$811

Find flights from Panama City to Spain within your budget

Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/5

6:45 pm-10:15 am

1 stop33h 30m

Madrid Barajas

Wed 3/26

1:00 pm-4:25 pm

1 stop33h 25m

$683

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/17

5:35 pm-10:25 am

Nonstop9h 50m

Madrid Barajas

Sat 5/24

12:00 pm-4:05 pm

Nonstop11h 05m

$687

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/18

7:55 pm-4:45 pm

1 stop13h 50m

Madrid Barajas

Wed 5/28

10:20 am-4:50 pm

1 stop37h 30m

$692

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/24

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Mon 5/12

3:05 pm-6:40 pm

Nonstop10h 35m

$704

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/10

8:05 am-9:35 am

1 stop18h 30m

Madrid Barajas

Sun 6/1

10:05 am-5:45 pm

1 stop14h 40m

$710

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Mon 5/12

5:35 pm-10:50 pm

1 stop22h 15m

Barcelona-El Prat

Sat 5/31

9:15 am-4:05 pm

1 stop13h 50m

$714

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Sat 4/12

8:25 pm-4:35 pm

1 stop13h 10m

Barcelona-El Prat

Sat 4/26

11:50 am-6:40 pm

1 stop13h 50m

$747

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Tue 4/29

6:50 pm-8:40 am

1 stop30h 50m

Barcelona-El Prat

Sun 5/18

6:20 am-5:45 pm

2 stops18h 25m

$782

Panama CityBarcelona

PTY - BCN

PTYBCN

Panama City Tocumen Intl

Tue 4/1

7:55 pm-10:40 pm

1 stop19h 45m

Barcelona-El Prat

Mon 4/14

6:20 am-4:50 pm

1 stop17h 30m

$807

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 4/6

6:50 pm-9:45 am

1 stop31h 55m

Malaga

Sun 4/13

9:05 pm-4:50 pm

1 stop26h 45m

$811

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 38 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City to Spain

Get recent, data-driven insights about flights from Panama City to Spain including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,124). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Rainfall in Spain by month

Plan your trip to Spain by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Spain ranges from 0.8 - 3.6 inches per month. October is typically the wettest month, when rainfall can reach 3.6 in. July is typically the driest time to visit Spain when rainfall is around 0.8 in.

Temperature in Spain by month

Plan your trip to Spain by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Spain, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated February 20, 2025.
See what other customers who have flown with KLM, Air France and United Airlines from Panama City to Spain have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

KLM
7.8
Good
1,333 reviews
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

Air France
7.4
Good
1,449 reviews
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

United Airlines
7.4
Good
8,766 reviews
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

Turkish Airlines
7.3
Good
3,832 reviews
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

Iberia
7.0
Good
2,639 reviews
KLM
7.8
Good
1,333 reviews

Crew

8.4

Food

7.3

Comfort

7.7

Overall

7.8

Boarding

7.8

Entertainment

7.2

Reviews

1 / 20

8.0
Excellent

Anonymous,Dec 2024

YWG - YYZ

I could not select a seat prior to check in as systems not integrated. Different PNRs should be on reservation which would make process easier.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Air Europa, which is currently one of the cheapest options available, starting at $443. Avianca flights start at $552 while deals on Iberia start at $637 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Santa Cruz de Tenerife Tenerife-Norte when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider China Eastern (100%), Air Europa (90%) or Etihad Airways (90%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,332 for a flight from Panama City to Spain. The cheapest flight overall is $566 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $691.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,124). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$777FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$589Average$827FlexibilityNo cancel feeOn-time83%
United AirlinesCheapest$601Average$772FlexibilityNo cancel feeOn-time69%
IberiaCheapest$633Average$892FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$666Average$815FlexibilityNo cancel feeOn-time77%
KLMCheapest$670Average$875FlexibilityNo cancel feeOn-time75%
Turkish AirlinesCheapest$728Average$776FlexibilityNo cancel feeOn-time77%
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