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$62+ Cheap flights from St. Louis (STL) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from St. Louis to South Carolina

Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$120
(CheapOair)

One-way from

$62
(Mytrip)

Popular in

December

Cheapest in

October

Average price

$411

Good round-trip deal

$317 or less
Provider with most accurate pricing for Lambert-St Louis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Myrtle Beach Intl flights.
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From Lambert-St Louis to South Carolina
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One-way flight from Lambert-St Louis to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Price to beat on a round-trip flight from Lambert-St Louis to South Carolina.
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Find flight deals from St. Louis to South Carolina

Cheapest flights from St. Louis to South Carolina
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:47 pmSTL - CLT
1 stop14h 10mFrontier
Thu 5/810:36 pmCLT - STL
1 stop26h 30mFrontier
Deal found 2/19$120
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:11 pmSTL - CHS
1 stop23h 34mSpirit Airlines
Tue 4/2911:14 amCHS - STL
1 stop7h 02mSpirit Airlines
Deal found 2/19$123
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/115:38 pmSTL - CLT
1 stop22h 29mMultiple Airlines
Thu 3/137:19 pmCLT - STL
1 stop5h 30mMultiple Airlines
Deal found 2/19$139
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:11 pmSTL - CLT
1 stop14h 24mSpirit Airlines
Wed 4/235:21 pmCLT - STL
1 stop24h 55mSpirit Airlines
Deal found 2/20$147
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/89:50 amSTL - CHS
3 stops31h 18mMultiple Airlines
Mon 5/126:11 pmCHS - STL
1 stop25h 21mMultiple Airlines
Deal found 2/20$242
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/127:29 amSTL - CAE
1 stop7h 58mAmerican Airlines
Mon 3/178:05 pmCAE - STL
1 stop4h 51mAmerican Airlines
Deal found 2/19$249
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/61:35 pmSTL - CAE
1 stop8h 08mDelta
Mon 3/106:00 amCAE - STL
1 stop6h 58mDelta
Deal found 2/19$259
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1912:15 pmSTL - MYR
3 stops18h 39mMultiple Airlines
Wed 3/263:50 pmMYR - STL
1 stop27h 02mMultiple Airlines
Deal found 2/19$283
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/185:06 amSTL - HHH
1 stop4h 18mAmerican Airlines
Thu 3/275:59 pmHHH - STL
1 stop6h 57mAmerican Airlines
Deal found 2/20$284
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/155:00 amSTL - CLT
Nonstop1h 56mAmerican Airlines
Wed 4/234:30 pmCLT - STL
1 stop8h 03mAmerican Airlines
Deal found 2/19$285
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/251:48 pmSTL - GSP
1 stop7h 07mDelta
Tue 4/15:47 amGSP - STL
1 stop4h 27mDelta
Deal found 2/19$287
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/222:20 pmSTL - CHS
Nonstop2h 00mSouthwest
Tue 4/295:55 pmCHS - STL
Nonstop2h 20mSouthwest
Deal found 2/19$287

Find flights from St. Louis to South Carolina within your budget

Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

St. Louis

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 5/7

5:47 pm-5:56 pm

1 stop23h 09m

Charlotte Douglas

Thu 5/8

10:36 pm-12:06 am

1 stop26h 30m

$120

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Tue 4/22

6:11 pm-6:45 pm

1 stop23h 34m

Charleston

Tue 4/29

11:14 am-5:16 pm

1 stop7h 02m

$123

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 4/3

6:47 pm-4:30 pm

1 stop20h 43m

Charlotte Douglas

Mon 4/7

8:08 am-11:46 pm

1 stop16h 38m

$145

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 4/15

6:11 pm-9:35 am

1 stop14h 24m

Charlotte Douglas

Wed 4/23

5:21 pm-5:16 pm

1 stop24h 55m

$147

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Thu 5/8

9:50 am-6:08 pm

3 stops31h 18m

Charleston

Mon 5/12

6:11 pm-6:32 pm

1 stop25h 21m

$242

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 3/12

6:00 am-1:12 pm

1 stop6h 12m

Columbia Metropolitan

Mon 3/17

8:05 pm-11:56 pm

1 stop4h 51m

$249

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Thu 3/6

1:35 pm-10:43 pm

1 stop8h 08m

Columbia Metropolitan

Mon 3/10

6:00 am-11:58 am

1 stop6h 58m

$259

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Wed 3/19

12:15 pm-7:54 am

3 stops18h 39m

Myrtle Beach Intl

Wed 3/26

3:50 pm-5:52 pm

1 stop27h 02m

$283

St. LouisHilton Head Island

STL - HHH

STLHHH

Lambert-St Louis

Tue 3/18

5:06 am-10:24 am

1 stop4h 18m

Hilton Head Island

Thu 3/27

5:59 pm-11:56 pm

1 stop6h 57m

$284

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 3/18

11:55 am-8:35 pm

1 stop7h 40m

Charlotte Douglas

Thu 3/20

10:50 pm-11:56 pm

Nonstop2h 06m

$285

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 55 results
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2
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Best time to book a flight from St. Louis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from St. Louis to South Carolina

Get recent, data-driven insights about flights from St. Louis to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from St. Louis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $217). Flying from St. Louis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SC?

Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 20, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from St. Louis to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Spirit Airlines
6.3
Okay
8,013 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South Carolina?

    For a flight from St. Louis to South Carolina, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this St. Louis to South Carolina flight route?

    Within the past month, 4 users have taken a look at flights from Lambert-St Louis to South Carolina.

  • What are the cheapest airlines to fly from St. Louis to South Carolina one-way?

    The cheapest airlines for a one-way flight from St. Louis to South Carolina are Frontier ($62), Spirit Airlines ($74), and Delta ($137).

  • What are the most popular routes from St. Louis to South Carolina?

    While some choose either Lambert-St Louis - Charleston or Lambert-St Louis - Savannah/Hilton Head, Lambert-St Louis - Charlotte Douglas is the most popular route from St. Louis to South Carolina.

  • What are the cheapest flights from St. Louis to South Carolina?

    Looking for the cheapest flight from St. Louis to South Carolina? While on average our users pay $393, our data indicates the cheapest price to be $287. The most popular route (Lambert-St Louis - Charlotte Douglas), is priced around $139.

  • Can I find deals for flights from St. Louis to South Carolina that include hotel bookings?

    Yes. In addition to deals on St. Louis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South Carolina.

  • Can I find deals for business class flights from St. Louis to South Carolina?

    Yes. Cheapflights offers flight deals from St. Louis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $217). Flying from St. Louis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from St. Louis to South Carolina

Discover the top 5 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$165Average$199FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$188Average$378FlexibilityNo cancel feeOn-time71%
DeltaCheapest$227Average$395FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$307Average$410FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$367Average$640FlexibilityNo cancel feeOn-time69%
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