South Carolina

$284+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Apr 29 — May 61
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Cheap flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$428
(Avianca Connect)

One-way from

$284
(Delta)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
From Panama to South Carolina
One-way flight from Panama to South Carolina

Find flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Avianca Connect deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/153:40 pmPTY - CLT
2 stops18h 23mMultiple Airlines
Sun 5/186:00 amCLT - PTY
2 stops16h 10mMultiple Airlines
Deal found 4/23$428
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/283:20 pmPTY - FLO
2 stops18h 19mAmerican Airlines
Sun 7/62:34 pmFLO - PTY
2 stops23h 20mAmerican Airlines
Deal found 4/23$460
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/11:50 pmPTY - AGS
2 stops26h 59mAmerican Airlines
Thu 7/242:38 pmAGS - PTY
2 stops24h 37mAmerican Airlines
Deal found 4/22$472
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/12:12 pmPTY - CLT
1 stop8h 42mDelta
Wed 11/55:30 amCLT - PTY
1 stop8h 17mDelta
Deal found 4/23$481
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2910:55 pmPTY - CLT
1 stop9h 51mUnited Airlines
Thu 6/127:00 amCLT - PTY
1 stop12h 37mUnited Airlines
Deal found 4/23$503
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/63:20 pmPTY - MYR
2 stops17h 47mAmerican Airlines
Fri 6/136:14 pmMYR - PTY
2 stops19h 46mAmerican Airlines
Deal found 4/21$503
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/291:20 pmPTY - CLT
2 stops16h 08mAmerican Airlines
Thu 6/129:20 pmCLT - PTY
1 stop16h 40mAmerican Airlines
Deal found 4/23$516
This Avianca Connect deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/53:20 amPTY - MYR
2 stops16h 45mMultiple Airlines
Fri 6/136:10 amMYR - PTY
2 stops16h 00mMultiple Airlines
Deal found 4/21$533
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/32:20 pmPTY - CHS
1 stop7h 26mDelta
Wed 5/145:35 amCHS - PTY
1 stop8h 13mDelta
Deal found 4/23$540
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/183:16 pmPTY - CAE
2 stops21h 52mAmerican Airlines
Mon 8/257:54 pmCAE - PTY
2 stops19h 21mAmerican Airlines
Deal found 4/22$545
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/31:05 pmPTY - CHS
2 stops18h 29mAmerican Airlines
Wed 5/147:30 amCHS - PTY
1 stop5h 49mAmerican Airlines
Deal found 4/23$553
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2510:00 amPTY - CHS
1 stop11h 00mUnited Airlines
Wed 4/305:10 pmCHS - PTY
1 stop26h 27mUnited Airlines
Deal found 4/22$558

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Panama

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 5/15

3:40 pm-11:03 am

2 stops18h 23m

Charlotte Douglas

Sun 5/18

6:00 am-9:10 pm

2 stops16h 10m

$428

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sat 6/28

3:20 pm-10:39 am

2 stops18h 19m

Florence

Sun 7/6

2:34 pm-12:54 pm

2 stops23h 20m

$460

Panama CityAugusta

PTY - AGS

PTYAGS

Panama City Tocumen Intl

Tue 7/1

1:50 pm-5:49 pm

2 stops26h 59m

Augusta Bush Field

Thu 7/24

2:38 pm-2:15 pm

2 stops24h 37m

$472

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 5/29

10:55 pm-9:46 am

1 stop9h 51m

Charlotte Douglas

Thu 6/12

7:00 am-6:37 pm

1 stop12h 37m

$503

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Fri 6/6

3:20 pm-10:07 am

2 stops17h 47m

Myrtle Beach Intl

Fri 6/13

6:14 pm-1:00 pm

2 stops19h 46m

$503

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 5/29

1:20 pm-6:28 am

2 stops16h 08m

Charlotte Douglas

Thu 6/12

9:20 pm-1:00 pm

1 stop16h 40m

$516

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Thu 6/5

3:20 am-9:05 pm

2 stops16h 45m

Myrtle Beach Intl

Fri 6/13

6:10 am-9:10 pm

2 stops16h 00m

$533

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sun 6/8

10:55 pm-8:47 am

1 stop8h 52m

Charleston

Sun 6/15

7:00 am-4:12 pm

1 stop10h 12m

$564

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 5/6

2:20 pm-11:46 pm

1 stop8h 26m

Charlotte Douglas

Sun 5/11

5:40 am-12:48 pm

1 stop8h 08m

$599

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Fri 6/6

10:55 pm-9:07 am

1 stop9h 12m

Myrtle Beach Intl

Fri 6/13

11:58 am-7:31 pm

1 stop8h 33m

$699

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 19 results
1
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SC?

Find hourly flight availability from Panama to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 24, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines and United Airlines from Panama to South Carolina. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$423Average$501FlexibilityNo cancel feeOn-time71%

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