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South Carolina

$229+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Feb 27 — Mar 61
Thu 2/27
Thu 3/6
1 adult, Economy
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Cheap flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated February 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$436
(Delta)

One-way from

$229
(Avianca Connect)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
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From Panama to South Carolina
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One-way flight from Panama to South Carolina
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Find flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2025.

This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/32:20 pmPTY - CHS
1 stop7h 23mDelta
Wed 5/145:30 amCHS - PTY
1 stop8h 21mDelta
Deal found 2/21$436
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/31:05 pmPTY - CHS
2 stops18h 29mAmerican Airlines
Wed 5/147:00 amCHS - PTY
1 stop6h 15mAmerican Airlines
Deal found 2/21$450
This Avianca Connect deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/93:25 amPTY - CLT
2 stops19h 03mMultiple Airlines
Thu 5/156:50 amCLT - PTY
2 stops18h 20mMultiple Airlines
Deal found 2/22$457
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/292:20 pmPTY - CLT
1 stop23h 34mDelta
Sun 5/48:37 pmCLT - PTY
1 stop17h 18mDelta
Deal found 2/21$460
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/151:20 pmPTY - CLT
1 stop9h 28mAmerican Airlines
Sun 5/188:19 pmCLT - PTY
1 stop16h 56mAmerican Airlines
Deal found 2/21$469
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/251:05 pmPTY - MYR
2 stops19h 47mAmerican Airlines
Tue 5/67:32 pmMYR - PTY
2 stops17h 43mAmerican Airlines
Deal found 2/22$474
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/243:30 pmPTY - CAE
2 stops20h 42mAmerican Airlines
Mon 4/76:32 pmCAE - PTY
2 stops18h 43mAmerican Airlines
Deal found 2/21$474
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/3010:55 pmPTY - CLT
1 stop9h 33mUnited Airlines
Mon 5/56:30 amCLT - PTY
1 stop13h 07mUnited Airlines
Deal found 2/21$481
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/32:23 pmPTY - GSP
1 stop8h 15mDelta
Tue 4/85:46 amGSP - PTY
1 stop8h 12mDelta
Deal found 2/21$492
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2811:55 pmPTY - CHS
1 stop8h 46mUnited Airlines
Tue 3/411:00 amCHS - PTY
1 stop9h 02mUnited Airlines
Deal found 2/21$515
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/31:05 pmPTY - GSP
2 stops19h 48mAmerican Airlines
Tue 4/86:00 amGSP - PTY
1 stop7h 15mAmerican Airlines
Deal found 2/21$516
This Avianca Connect deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/273:19 amPTY - CHS
2 stops18h 00mMultiple Airlines
Tue 3/47:15 amCHS - PTY
2 stops17h 05mMultiple Airlines
Deal found 2/21$530

Find flights from Panama to South Carolina within your budget

Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.

Fly from

Panama

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 5/3

2:20 pm-10:43 pm

1 stop7h 23m

Charleston

Wed 5/14

5:30 am-12:51 pm

1 stop8h 21m

$436

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 5/3

1:05 pm-8:34 am

2 stops18h 29m

Charleston

Wed 5/14

7:00 am-12:15 pm

1 stop6h 15m

$450

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 5/9

3:25 am-11:28 pm

2 stops19h 03m

Charlotte Douglas

Thu 5/15

6:50 am-12:10 am

2 stops18h 20m

$457

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 4/29

2:20 pm-2:54 pm

1 stop23h 34m

Charlotte Douglas

Sun 5/4

8:37 pm-12:55 pm

1 stop17h 18m

$460

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 5/15

1:20 pm-11:48 pm

1 stop9h 28m

Charlotte Douglas

Sun 5/18

8:19 pm-12:15 pm

1 stop16h 56m

$469

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Tue 3/25

1:05 pm-9:52 am

2 stops19h 47m

Myrtle Beach Intl

Tue 5/6

7:32 pm-12:15 pm

2 stops17h 43m

$474

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Mon 3/24

3:30 pm-1:12 pm

2 stops20h 42m

Columbia Metropolitan

Mon 4/7

6:32 pm-12:15 pm

2 stops18h 43m

$474

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 4/30

10:55 pm-9:28 am

1 stop9h 33m

Charlotte Douglas

Mon 5/5

6:30 am-6:37 pm

1 stop13h 07m

$481

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/3

2:23 pm-11:38 pm

1 stop8h 15m

Greenville

Tue 4/8

5:46 am-12:58 pm

1 stop8h 12m

$492

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/3

1:05 pm-9:53 am

2 stops19h 48m

Greenville

Tue 4/8

6:00 am-12:15 pm

1 stop7h 15m

$516

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 17 results
1
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama to South Carolina

Get recent, data-driven insights about flights from Panama to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest time of day to fly from PA to SC?

Find hourly flight availability from Panama to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 22, 2025.
Read reviews from past customers who have flown Delta, United Airlines and American Airlines from Panama to South Carolina. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,203 reviews

Comfort

8.0

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,203 reviews
Delta
8.0
Very good
8,203 reviews

Comfort

8.0

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,754 reviews
Delta
8.0
Very good
8,203 reviews

Comfort

8.0

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,203 reviews

Comfort

8.0

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca
6.8
Okay
2,425 reviews
Delta
8.0
Very good
8,203 reviews

Comfort

8.0

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Panama to South Carolina one-way?

    $284 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $295 and $584, respectively.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to South Carolina

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