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$62+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$120
(CheapOair)

One-way from

$62
(Mytrip)

Good round-trip deal

$317 or less
Provider with most accurate pricing for Kansas City Downtown-Myrtle Beach Intl flight deals.
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From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:47 pmSTL - CLT
1 stop14h 10mFrontier
Thu 5/810:36 pmCLT - STL
1 stop26h 30mFrontier
Deal found 2/19$120
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:11 pmSTL - CHS
1 stop23h 34mSpirit Airlines
Tue 4/2911:14 amCHS - STL
1 stop7h 02mSpirit Airlines
Deal found 2/19$123
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/115:38 pmSTL - CLT
1 stop22h 29mMultiple Airlines
Thu 3/137:19 pmCLT - STL
1 stop5h 30mMultiple Airlines
Deal found 2/19$139
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:11 pmSTL - CLT
1 stop14h 24mSpirit Airlines
Wed 4/235:21 pmCLT - STL
1 stop24h 55mSpirit Airlines
Deal found 2/20$147
This FlightHub deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/254:59 pmMCI - CHS
1 stop16h 13mSpirit Airlines
Mon 4/2811:06 amCHS - MCI
1 stop5h 58mSpirit Airlines
Deal found 2/20$181
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/65:12 pmMCI - MYR
1 stop13h 42mSpirit Airlines
Thu 3/136:30 amMYR - MCI
1 stop10h 47mSpirit Airlines
Deal found 2/20$188
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/65:12 pmMCI - GSP
1 stop21h 41mMultiple Airlines
Mon 3/104:35 pmGSP - MCI
1 stop17h 40mMultiple Airlines
Deal found 2/19$212
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/74:21 pmMCI - SAV
1 stop5h 52mMultiple Airlines
Wed 4/912:27 pmSAV - MCI
1 stop21h 33mMultiple Airlines
Deal found 2/20$219
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/163:59 pmMCI - CHS
2 stops17h 09mMultiple Airlines
Sat 4/196:34 pmCHS - MCI
2 stops23h 50mMultiple Airlines
Deal found 2/19$238
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/89:50 amSTL - CHS
3 stops31h 18mMultiple Airlines
Mon 5/126:11 pmCHS - STL
1 stop25h 21mMultiple Airlines
Deal found 2/20$242
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/96:59 pmSGF - SAV
1 stop4h 00mDelta
Wed 4/162:37 pmSAV - SGF
1 stop4h 34mDelta
Deal found 2/20$249
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/56:38 pmSGF - SAV
1 stop4h 11mAmerican Airlines
Wed 4/94:24 pmSAV - SGF
2 stops8h 24mAmerican Airlines
Deal found 2/19$254

Find flights from Missouri to South Carolina within your budget

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 5/7

5:47 pm-5:56 pm

1 stop23h 09m

Charlotte Douglas

Thu 5/8

10:36 pm-12:06 am

1 stop26h 30m

$120

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Tue 4/22

6:11 pm-6:45 pm

1 stop23h 34m

Charleston

Tue 4/29

11:14 am-5:16 pm

1 stop7h 02m

$123

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 4/3

6:47 pm-4:30 pm

1 stop20h 43m

Charlotte Douglas

Mon 4/7

8:08 am-11:46 pm

1 stop16h 38m

$145

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 4/15

6:11 pm-9:35 am

1 stop14h 24m

Charlotte Douglas

Wed 4/23

5:21 pm-5:16 pm

1 stop24h 55m

$147

Kansas CityCharleston

MCI - CHS

MCICHS

Kansas City

Fri 4/25

4:59 pm-10:12 am

1 stop16h 13m

Charleston

Mon 4/28

11:06 am-4:04 pm

1 stop5h 58m

$181

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Thu 3/6

5:12 pm-7:54 am

1 stop13h 42m

Myrtle Beach Intl

Thu 3/13

6:30 am-4:17 pm

1 stop10h 47m

$188

Kansas CityGreenville

MCI - GSP

MCIGSP

Kansas City

Thu 3/6

5:12 pm-3:53 pm

1 stop21h 41m

Greenville

Mon 3/10

4:35 pm-9:15 am

1 stop17h 40m

$212

Kansas CitySavannah

MCI - SAV

MCISAV

Kansas City

Mon 4/7

4:21 pm-11:13 pm

1 stop5h 52m

Savannah/Hilton Head

Wed 4/9

12:27 pm-9:00 am

1 stop21h 33m

$219

Kansas CityCharleston

MCI - CHS

MCICHS

Kansas City

Wed 4/16

3:59 pm-10:08 am

2 stops17h 09m

Charleston

Sat 4/19

6:34 pm-5:24 pm

2 stops23h 50m

$238

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Thu 5/8

9:50 am-6:08 pm

3 stops31h 18m

Charleston

Mon 5/12

6:11 pm-6:32 pm

1 stop25h 21m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to South Carolina

Get recent, data-driven insights about flights from Missouri to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 20, 2025.
Read reviews from past customers who have flown Southwest, Alaska Airlines and Delta from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,697 reviews
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,219 reviews
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,765 reviews
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,411 reviews

Comfort

8.1

Entertainment

7.6

Food

7.1

Overall

8.1

Crew

8.7

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $62. Users have also found prices from $74 and $127 on Spirit Airlines and American Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$119Average$237FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$168Average$424FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$396FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$430FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$306Average$410FlexibilityNo cancel feeOn-time63%
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