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South Carolina

$85+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$160
(CheapOair)

One-way from

$85
(Cheapflightsfares)

Good round-trip deal

$372 or less

Good one-way deal

$138 or less
Provider with most accurate pricing for Kansas City Downtown-Myrtle Beach Intl flight deals.
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From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Price to beat on a one-way flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/165:55 pmSTL - CLT
1 stop22h 57mFrontier
Mon 5/194:21 pmCLT - STL
1 stop8h 45mFrontier
Deal found 3/27$160
This Cheapflightsfares deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/246:10 pmSTL - CLT
1 stop5h 17mSpirit Airlines
Thu 5/16:58 amCLT - STL
1 stop11h 17mSpirit Airlines
Deal found 3/26$193
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/54:05 pmSTL - CHS
1 stop5h 41mDelta
Tue 5/612:32 pmCHS - STL
1 stop4h 54mDelta
Deal found 3/28$209
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/246:10 pmSTL - CLT
1 stop5h 17mMultiple Airlines
Mon 4/284:21 pmCLT - STL
1 stop8h 43mMultiple Airlines
Deal found 3/27$212
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:10 pmSTL - CHS
1 stop23h 25mSpirit Airlines
Thu 4/2410:25 amCHS - STL
1 stop7h 50mSpirit Airlines
Deal found 3/27$219
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/283:48 pmMCI - CHS
1 stop4h 16mDelta
Tue 6/36:37 amCHS - MCI
1 stop6h 33mDelta
Deal found 3/27$223
This Cheapflightsfares deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/810:15 amMCI - MYR
1 stop7h 15mSpirit Airlines
Tue 5/136:00 amMYR - MCI
1 stop8h 50mSpirit Airlines
Deal found 3/27$226
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/34:23 pmMCI - CLT
1 stop16h 13mSpirit Airlines
Fri 5/99:02 pmCLT - MCI
1 stop14h 29mSpirit Airlines
Deal found 3/27$244
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/312:19 pmMCI - CLT
1 stop8h 10mFrontier
Sun 4/610:20 pmCLT - MCI
1 stop22h 17mFrontier
Deal found 3/27$248
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/66:39 pmSGF - CAE
1 stop4h 15mAmerican Airlines
Sat 5/105:24 amCAE - SGF
1 stop6h 20mAmerican Airlines
Deal found 3/26$249
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/184:59 pmMCI - CHS
1 stop16h 13mSpirit Airlines
Fri 4/2510:32 amCHS - MCI
1 stop6h 32mSpirit Airlines
Deal found 3/25$253
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/301:59 pmSTL - CHS
1 stop4h 59mAmerican Airlines
Tue 6/312:45 pmCHS - STL
1 stop7h 44mAmerican Airlines
Deal found 3/26$253

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 5/16

5:55 pm-5:52 pm

1 stop22h 57m

Charlotte Douglas

Mon 5/19

4:21 pm-12:06 am

1 stop8h 45m

$160

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 4/24

6:10 pm-12:27 am

1 stop5h 17m

Charlotte Douglas

Thu 5/1

6:58 am-5:15 pm

1 stop11h 17m

$193

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Mon 5/5

4:05 pm-10:46 pm

1 stop5h 41m

Charleston

Tue 5/6

12:32 pm-4:26 pm

1 stop4h 54m

$209

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 4/24

6:10 pm-12:27 am

1 stop5h 17m

Charlotte Douglas

Mon 4/28

4:21 pm-12:04 am

1 stop8h 43m

$212

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Tue 4/15

6:10 pm-6:35 pm

1 stop23h 25m

Charleston

Thu 4/24

10:25 am-5:15 pm

1 stop7h 50m

$219

Kansas CityCharleston

MCI - CHS

MCICHS

Kansas City

Wed 5/28

3:48 pm-9:04 pm

1 stop4h 16m

Charleston

Tue 6/3

6:37 am-12:10 pm

1 stop6h 33m

$223

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Thu 5/8

10:15 am-6:30 pm

1 stop7h 15m

Myrtle Beach Intl

Tue 5/13

6:00 am-1:50 pm

1 stop8h 50m

$226

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Sat 5/3

4:23 pm-9:36 am

1 stop16h 13m

Charlotte Douglas

Fri 5/9

9:02 pm-10:31 am

1 stop14h 29m

$244

SpringfieldColumbia

SGF - CAE

SGFCAE

Springfield-Branson

Tue 5/6

6:39 pm-11:54 pm

1 stop4h 15m

Columbia Metropolitan

Sat 5/10

5:24 am-10:44 am

1 stop6h 20m

$249

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Thu 4/10

12:34 pm-9:29 pm

1 stop7h 55m

Charlotte Douglas

Sun 4/13

10:20 pm-7:37 pm

1 stop22h 17m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 28, 2025.
Read reviews from past customers who have flown Southwest, Alaska Airlines and Delta from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.1
Very good
4,273 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Alaska Airlines
8.0
Very good
9,798 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,896 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,603 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
731 reviews
Southwest
8.1
Very good
4,273 reviews

Entertainment

7.6

Overall

8.1

Food

7.1

Comfort

8.1

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $85. Users have also found prices from $90 and $105 on Frontier and Delta, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$119Average$235FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$164Average$422FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$434FlexibilityNo cancel feeOn-time69%
DeltaCheapest$230Average$380FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$276Average$408FlexibilityNo cancel feeOn-time63%
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