$60+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to South Carolina (USSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.
Round-trip from | $120 (CheapOair) |
|---|---|
One-way from | $60 (Cheapflightsfares) |
Good round-trip deal | $469 or less |
Find flight deals from Missouri to South Carolina
Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.
This CheapOair deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This CheapOair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This CheapOair deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This CheapOair deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Find flights from Missouri to South Carolina within your budget
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
Fly from
Fly to
Route
Depart
Return
Price
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 2/22
5:20 pm-7:08 am
1 stop12h 48m
Charlotte Douglas
Tue 2/25
8:08 am-11:43 pm
1 stop16h 35m
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 2/20
4:00 pm-11:41 pm
1 stop6h 41m
Charlotte Douglas
Mon 2/24
8:52 pm-2:42 pm
1 stop18h 50m
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 2/20
4:00 pm-11:41 pm
1 stop6h 41m
Charlotte Douglas
Sun 2/23
7:54 pm-9:16 am
1 stop14h 22m
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 2/18
4:00 pm-10:16 pm
2 stops29h 16m
Charleston
Tue 2/25
7:15 am-2:42 pm
1 stop8h 27m
SpringfieldSavannah
SGF - SAV
SGFSAV
Springfield-Branson
Wed 2/12
6:39 pm-11:52 pm
1 stop4h 13m
Savannah/Hilton Head
Wed 2/19
6:30 am-10:52 am
1 stop5h 22m
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 2/4
3:48 pm-5:15 pm
1 stop24h 27m
Charleston
Thu 2/6
7:15 am-2:43 pm
1 stop8h 28m
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Sat 2/15
12:15 pm-8:36 am
1 stop19h 21m
Myrtle Beach Intl
Wed 2/19
8:08 am-12:55 pm
1 stop5h 47m
SpringfieldSavannah
SGF - SAV
SGFSAV
Springfield-Branson
Tue 2/18
3:05 pm-9:59 pm
1 stop5h 54m
Savannah/Hilton Head
Tue 2/25
5:00 pm-9:44 pm
1 stop5h 44m
Kansas CityCharleston
MCI - CHS
MCICHS
Kansas City
Thu 3/6
5:12 pm-9:53 am
2 stops15h 41m
Charleston
Sat 3/8
10:48 am-3:44 pm
1 stop5h 56m
SpringfieldSavannah
SGF - SAV
SGFSAV
Springfield-Branson
Wed 4/9
3:27 pm-9:18 pm
1 stop4h 51m
Savannah/Hilton Head
Wed 4/16
12:26 pm-6:11 pm
1 stop6h 45m
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Travel insights for flights from Missouri to South Carolina
Get recent, data-driven insights about flights from Missouri to South Carolina including ideal travel times, pricing trends, and more.
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Rainfall in South Carolina by month
Plan your trip to South Carolina by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.
Temperature in South Carolina by month
Plan your trip to South Carolina by taking into account the average temperature totals by month.
If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 21, 2025.
Read reviews from past customers who have flown Delta, United Airlines and Frontier from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$119 | Average$236 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$173 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$397 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$431 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$317 | Average$408 | FlexibilityNo cancel fee | On-time63% |