South Carolina

$60+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Dec 27 — Jan 31
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Cheap flight deals from Missouri to South Carolina

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to South Carolina (USSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 22, 2024.

Round-trip from

$120
(FlightHub)

One-way from

$60
(Mytrip)
From Missouri to South Carolina
One-way flight from Missouri to South Carolina

Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2024.

This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:32 amMCI - CLT
1 stop10h 23mAmerican Airlines
Tue 12/318:20 pmCLT - MCI
Nonstop2h 36mAmerican Airlines
Deal found 12/21$269
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:17 pmSTL - CAE
1 stop5h 42mDelta
Tue 1/76:00 amCAE - STL
1 stop7h 32mDelta
Deal found 12/21$283
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:03 amSTL - CAE
1 stop4h 38mAmerican Airlines
Tue 1/711:08 amCAE - STL
2 stops6h 12mAmerican Airlines
Deal found 12/21$313
This FlightHub deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/235:45 pmSTL - CLT
1 stop22h 55mFrontier
Sun 1/58:55 pmCLT - STL
1 stop27h 45mFrontier
Deal found 12/21$353
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:49 pmMCI - CLT
1 stop4h 41mDelta
Sat 1/46:25 pmCLT - MCI
1 stop6h 31mDelta
Deal found 12/21$392
This Southwest deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/216:10 pmMCI - CLT
1 stop4h 55mSouthwest
Sat 12/288:40 pmCLT - MCI
1 stop4h 45mSouthwest
Deal found 12/20$415
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/282:27 pmSTL - CHS
1 stop4h 11mAmerican Airlines
Wed 1/19:10 amCHS - STL
1 stop5h 27mAmerican Airlines
Deal found 12/21$496
This Delta deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/295:45 amMCI - CAE
1 stop6h 54mDelta
Wed 1/16:29 pmCAE - MCI
1 stop6h 30mDelta
Deal found 12/20$498
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2911:35 amMCI - SAV
1 stop10h 05mSouthwest
Sun 1/56:25 amSAV - MCI
1 stop5h 25mSouthwest
Deal found 12/21$531
This Booking.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/257:11 pmMCI - MYR
2 stops14h 20mSpirit Airlines
Fri 12/276:00 amMYR - MCI
2 stops13h 05mSpirit Airlines
Deal found 12/21$534
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/306:40 pmMCI - CHS
1 stop4h 18mDelta
Mon 1/67:00 amCHS - MCI
1 stop7h 53mDelta
Deal found 12/21$546
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/238:00 amMCI - CAE
1 stop7h 26mUnited Airlines
Thu 12/266:15 amCAE - MCI
1 stop5h 31mUnited Airlines
Deal found 12/21$559

Find flights from Missouri to South Carolina within your budget

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2024.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 1/15

6:46 pm-6:15 pm

1 stop22h 29m

Charlotte Douglas

Thu 1/23

7:15 pm-9:16 am

1 stop15h 01m

$120

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 1/16

4:28 pm-11:28 pm

1 stop6h 00m

Charlotte Douglas

Thu 1/23

7:15 pm-9:16 am

1 stop15h 01m

$157

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Thu 1/16

4:28 pm-10:58 pm

1 stop5h 30m

Charleston

Thu 1/23

7:15 am-2:43 pm

1 stop8h 28m

$185

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 1/9

4:28 pm-11:28 pm

1 stop6h 00m

Charlotte Douglas

Mon 1/13

8:55 pm-2:43 pm

2 stops18h 48m

$194

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Mon 1/6

7:11 pm-10:31 am

2 stops14h 20m

Myrtle Beach Intl

Fri 1/10

6:11 am-10:56 am

1 stop5h 45m

$213

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Thu 2/6

11:05 am-7:50 pm

1 stop7h 45m

Charlotte Douglas

Mon 2/10

6:10 am-2:55 pm

1 stop9h 45m

$220

Kansas CityCharleston

MCI - CHS

MCICHS

Kansas City

Fri 1/31

4:04 pm-8:50 pm

1 stop27h 46m

Charleston

Sun 2/2

5:16 pm-2:55 pm

1 stop22h 39m

$235

Kansas CityColumbia

MCI - CAE

MCICAE

Kansas City

Tue 2/25

1:33 pm-8:35 pm

1 stop6h 02m

Columbia Metropolitan

Sat 3/1

1:00 pm-5:41 pm

1 stop5h 41m

$248

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Thu 2/6

1:35 pm-10:43 pm

1 stop8h 08m

Columbia Metropolitan

Sun 2/9

8:23 am-11:46 am

1 stop4h 23m

$248

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Sat 6/7

4:20 pm-7:40 pm

Nonstop2h 20m

Charlotte Douglas

Sat 6/14

8:55 am-10:33 am

Nonstop2h 38m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to South Carolina

Get recent, data-driven insights about flights from Missouri to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 22, 2024.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 22, 2024.
Read reviews from past customers who have flown Frontier, American Airlines and Delta from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

8.1
Very good
4,804 reviews
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

8.0
Very good
8,594 reviews
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

7.4
Good
9,028 reviews
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

7.2
Good
10,000 reviews
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

6.3
Okay
8,111 reviews
8.1
Very good
4,804 reviews

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Overall

8.1

Crew

8.7

Food

7.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Missouri to South Carolina flight route?

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $60. Users have also found prices from $90 and $127 on Spirit Airlines and American Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2024.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$119Average$236FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$173Average$413FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$372FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$303Average$458FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$306Average$409FlexibilityNo cancel feeOn-time63%
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