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South Carolina

$87+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$160
(Frontier)

One-way from

$87
(FlightHub)

Popular in

March

Cheapest in

August

Average price

$396

Good round-trip deal

$307 or less

Good one-way deal

$138 or less
Provider with most accurate pricing for Kansas City-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Myrtle Beach Intl flights.
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From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Price to beat on a one-way flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Frontier deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:45 pmSTL - CLT
1 stop12h 09mFrontier
Sat 5/176:42 pmCLT - STL
1 stop6h 24mFrontier
Deal found 4/23$160
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2510:10 amSTL - CLT
1 stop8h 47mMultiple Airlines
Fri 5/309:01 pmCLT - STL
1 stop27h 43mMultiple Airlines
Deal found 4/23$207
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/243:58 pmSTL - CAE
1 stop5h 25mAmerican Airlines
Mon 5/266:10 amCAE - STL
1 stop5h 33mAmerican Airlines
Deal found 4/22$224
This Cheapflightsfares deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2011:00 amMCI - MYR
1 stop6h 53mSpirit Airlines
Tue 6/2411:25 amMYR - MCI
1 stop11h 36mSpirit Airlines
Deal found 4/22$226
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/73:40 pmSTL - CAE
1 stop6h 16mDelta
Tue 5/136:05 amCAE - STL
1 stop6h 43mDelta
Deal found 4/22$254
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/206:47 pmSTL - CLT
Nonstop1h 54mAmerican Airlines
Wed 5/218:30 pmCLT - STL
Nonstop1h 56mAmerican Airlines
Deal found 4/23$255
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:35 amMCI - CLT
1 stop7h 40mSouthwest
Sun 8/319:55 amCLT - MCI
1 stop7h 55mSouthwest
Deal found 4/22$260
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/245:25 amMCI - CLT
1 stop5h 59mAmerican Airlines
Tue 7/11:01 pmCLT - MCI
1 stop8h 33mAmerican Airlines
Deal found 4/23$262
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/187:00 amSTL - CHS
1 stop6h 52mAmerican Airlines
Wed 5/216:09 pmCHS - STL
1 stop4h 17mAmerican Airlines
Deal found 4/24$262
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/165:46 amMCI - CLT
1 stop15h 16mSpirit Airlines
Sun 5/189:45 pmCLT - MCI
1 stop17h 05mSpirit Airlines
Deal found 4/23$263
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:46 amMCI - CLT
1 stop9h 05mMultiple Airlines
Sun 5/255:27 pmCLT - MCI
1 stop26h 37mMultiple Airlines
Deal found 4/23$264
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/310:30 amSTL - CLT
Nonstop1h 50mSouthwest
Wed 6/41:55 pmCLT - STL
2 stops7h 05mSouthwest
Deal found 4/23$270

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 5/15

5:45 pm-6:54 am

1 stop12h 09m

Charlotte Douglas

Sat 5/17

6:42 pm-12:06 am

1 stop6h 24m

$160

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sun 5/25

10:10 am-7:57 pm

1 stop8h 47m

Charlotte Douglas

Fri 5/30

9:01 pm-11:44 pm

1 stop27h 43m

$207

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Sat 5/24

3:58 pm-10:23 pm

1 stop5h 25m

Columbia Metropolitan

Mon 5/26

6:10 am-10:43 am

1 stop5h 33m

$224

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Fri 6/20

11:00 am-6:53 pm

1 stop6h 53m

Myrtle Beach Intl

Tue 6/24

11:25 am-10:01 pm

1 stop11h 36m

$226

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 5/7

3:40 pm-10:56 pm

1 stop6h 16m

Columbia Metropolitan

Tue 5/13

6:05 am-11:48 am

1 stop6h 43m

$254

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 5/20

6:47 pm-9:41 pm

Nonstop1h 54m

Charlotte Douglas

Wed 5/21

8:30 pm-9:26 pm

Nonstop1h 56m

$255

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Tue 6/24

5:25 am-12:24 pm

1 stop5h 59m

Charlotte Douglas

Tue 7/1

1:01 pm-8:34 pm

1 stop8h 33m

$262

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Sun 5/18

7:00 am-2:52 pm

1 stop6h 52m

Charleston

Wed 5/21

6:09 pm-9:26 pm

1 stop4h 17m

$262

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Fri 5/16

5:46 am-10:02 pm

1 stop15h 16m

Charlotte Douglas

Sun 5/18

9:45 pm-1:50 pm

1 stop17h 05m

$263

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Sat 5/24

5:46 am-3:51 pm

1 stop9h 05m

Charlotte Douglas

Sun 5/25

5:27 pm-7:04 pm

1 stop26h 37m

$264

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 24, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,918 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,286 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,685 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $87. Users have also found prices from $96 and $110 on Frontier and Southwest, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$119Average$244FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$162Average$417FlexibilityNo cancel feeOn-time71%
DeltaCheapest$209Average$369FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$436FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$276Average$406FlexibilityNo cancel feeOn-time63%

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