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South Carolina

$155+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jan 22 — Jan 291
Wed 1/22
Wed 1/29
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to South Carolina (USSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 17, 2025.

Round-trip from

$214
(American Airlines)

One-way from

$155
(American Airlines)
From Knoxville McGhee Tyson to South Carolina
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One-way flight from Knoxville McGhee Tyson to South Carolina
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Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 17, 2025.

This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/256:00 pmTYS - MYR
1 stop4h 28mAmerican Airlines
Sat 3/17:43 pmMYR - TYS
1 stop4h 14mAmerican Airlines
Deal found 1/15$214
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/265:45 amTYS - MYR
1 stop4h 30mDelta
Mon 3/36:59 pmMYR - TYS
1 stop4h 48mDelta
Deal found 1/15$219
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/29:16 pmTYS - CHS
2 stops25h 43mMultiple Airlines
Wed 3/510:48 amCHS - TYS
1 stop9h 04mMultiple Airlines
Deal found 1/16$227
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/117:17 pmTYS - CLT
1 stop21h 49mAmerican Airlines
Wed 2/126:22 pmCLT - TYS
Nonstop1h 13mAmerican Airlines
Deal found 1/15$239
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/39:15 amTYS - CLT
1 stop7h 59mMultiple Airlines
Fri 2/79:40 pmCLT - TYS
2 stops16h 59mMultiple Airlines
Deal found 1/16$245
This Mytrip deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/111:57 amTYS - MYR
2 stops9h 30mMultiple Airlines
Fri 2/76:11 amMYR - TYS
1 stop8h 17mMultiple Airlines
Deal found 1/15$253
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2212:12 pmTYS - SAV
1 stop9h 59mMultiple Airlines
Mon 2/246:14 pmSAV - TYS
2 stops24h 30mMultiple Airlines
Deal found 1/16$292
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1212:08 pmTYS - CAE
1 stop4h 11mDelta
Tue 2/186:50 amCAE - TYS
1 stop4h 33mDelta
Deal found 1/15$309
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/55:45 amTYS - CHS
1 stop3h 43mDelta
Wed 2/52:41 pmCHS - TYS
1 stop3h 56mDelta
Deal found 1/16$309
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2212:46 pmTYS - HHH
1 stop4h 45mAmerican Airlines
Wed 2/266:01 pmHHH - TYS
1 stop3h 17mAmerican Airlines
Deal found 1/16$344
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/75:53 pmTYS - CHS
1 stop4h 19mAmerican Airlines
Tue 3/119:07 amCHS - TYS
1 stop5h 06mAmerican Airlines
Deal found 1/16$359
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/228:00 amTYS - SAV
1 stop8h 57mDelta
Mon 2/246:50 pmSAV - TYS
1 stop21h 19mDelta
Deal found 1/16$365

Find flights from Knoxville to South Carolina within your budget

Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.

Fly from

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Fly to

Any airport

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 2/25

6:00 pm-10:28 pm

1 stop4h 28m

Myrtle Beach Intl

Sat 3/1

7:43 pm-11:57 pm

1 stop4h 14m

$214

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 2/26

5:45 am-10:15 am

1 stop4h 30m

Myrtle Beach Intl

Mon 3/3

6:59 pm-11:47 pm

1 stop4h 48m

$219

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 3/2

9:16 pm-10:59 pm

2 stops25h 43m

Charleston

Wed 3/5

10:48 am-7:52 pm

1 stop9h 04m

$227

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 2/11

7:17 pm-5:06 pm

1 stop21h 49m

Charlotte Douglas

Wed 2/12

6:22 pm-7:35 pm

Nonstop1h 13m

$239

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/3

9:15 am-5:14 pm

1 stop7h 59m

Charlotte Douglas

Fri 2/7

9:40 pm-2:39 pm

2 stops16h 59m

$245

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sat 2/22

12:12 pm-10:11 pm

1 stop9h 59m

Savannah/Hilton Head

Mon 2/24

6:14 pm-6:44 pm

2 stops24h 30m

$292

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 2/12

12:08 pm-4:19 pm

1 stop4h 11m

Columbia Metropolitan

Tue 2/18

6:50 am-11:23 am

1 stop4h 33m

$309

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 2/1

5:45 am-11:08 am

1 stop5h 23m

Charleston

Wed 2/5

5:35 am-9:16 am

1 stop3h 41m

$309

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 5/16

8:00 am-5:19 pm

1 stop9h 19m

Myrtle Beach Intl

Tue 5/20

5:00 am-6:54 pm

2 stops13h 54m

$316

KnoxvilleHilton Head Island

TYS - HHH

TYSHHH

Knoxville McGhee Tyson

Sat 2/22

12:46 pm-5:31 pm

1 stop4h 45m

Hilton Head Island

Wed 2/26

6:01 pm-9:18 pm

1 stop3h 17m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 33 results
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Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to South Carolina

Get recent, data-driven insights about flights from Knoxville to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 17, 2025.
Get a feel of what it's like to fly with American Airlines, United Airlines and Delta from Knoxville to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,511 reviews

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,511 reviews
Delta
8.0
Very good
8,511 reviews

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,965 reviews
Delta
8.0
Very good
8,511 reviews

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.4
Good
801 reviews
Delta
8.0
Very good
8,511 reviews

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,511 reviews

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to South Carolina one-way?

    $155 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $184 and $250, respectively.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Charlotte Douglas. You may also consider Knoxville McGhee Tyson - Savannah/Hilton Head or Knoxville McGhee Tyson - Charleston.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to South Carolina

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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$484FlexibilityNo cancel feeOn-time71%
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