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South Carolina

$100+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Mar 31 — Apr 71
Mon 3/31
Mon 4/7
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated March 26, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$194
(Mytrip)

One-way from

$100
(Delta)

Popular in

November

Cheapest in

December

Average price

$430
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
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From Knoxville McGhee Tyson to South Carolina
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One-way flight from Knoxville McGhee Tyson to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/119:29 pmTYS - SAV
1 stop20h 25mAllegiant Air
Fri 4/1812:34 pmSAV - TYS
1 stop8h 41mAllegiant Air
Deal found 3/25$194
This Mytrip deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/58:00 amTYS - CLT
1 stop9h 36mMultiple Airlines
Tue 4/811:45 amCLT - TYS
1 stop24h 15mMultiple Airlines
Deal found 3/24$195
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/97:15 amTYS - CHS
1 stop14h 54mMultiple Airlines
Mon 5/126:00 amCHS - TYS
1 stop6h 00mMultiple Airlines
Deal found 3/25$196
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/111:29 pmTYS - MYR
1 stop18h 25mMultiple Airlines
Mon 4/146:15 amMYR - TYS
1 stop16h 37mMultiple Airlines
Deal found 3/25$206
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/104:11 pmTYS - MYR
1 stop3h 03mDelta
Tue 6/177:59 pmMYR - TYS
1 stop3h 55mDelta
Deal found 3/25$214
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/117:54 pmTYS - MYR
1 stop2h 37mAmerican Airlines
Fri 5/235:00 amMYR - TYS
1 stop3h 24mAmerican Airlines
Deal found 3/25$229
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/119:29 pmTYS - SAV
1 stop20h 25mMultiple Airlines
Fri 4/1812:34 pmSAV - TYS
2 stops30h 55mMultiple Airlines
Deal found 3/25$233
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/297:32 pmTYS - CLT
1 stop16h 22mAmerican Airlines
Wed 4/302:35 pmCLT - TYS
Nonstop1h 15mAmerican Airlines
Deal found 3/24$255
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/207:00 amTYS - CAE
1 stop2h 42mDelta
Wed 4/2312:23 pmCAE - TYS
1 stop3h 51mDelta
Deal found 3/25$287
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/195:30 amTYS - CHS
1 stop5h 57mDelta
Sat 4/266:45 amCHS - TYS
1 stop2h 55mDelta
Deal found 3/25$287
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/255:00 pmTYS - SAV
1 stop4h 00mDelta
Tue 4/2910:23 amSAV - TYS
1 stop5h 51mDelta
Deal found 3/26$357
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/107:54 pmTYS - CHS
1 stop4h 03mAmerican Airlines
Tue 4/156:08 pmCHS - TYS
1 stop5h 37mAmerican Airlines
Deal found 3/25$357

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Fri 4/11

9:29 pm-5:54 pm

1 stop20h 25m

Savannah/Hilton Head

Fri 4/18

12:34 pm-9:15 pm

1 stop8h 41m

$194

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 4/5

8:00 am-5:36 pm

1 stop9h 36m

Charlotte Douglas

Tue 4/8

11:45 am-12:00 pm

1 stop24h 15m

$195

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 5/9

7:15 am-10:09 pm

1 stop14h 54m

Charleston

Mon 5/12

6:00 am-12:00 pm

1 stop6h 00m

$196

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 4/11

1:29 pm-7:54 am

1 stop18h 25m

Myrtle Beach Intl

Mon 4/14

6:15 am-10:52 pm

1 stop16h 37m

$206

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 6/10

4:11 pm-7:14 pm

1 stop3h 03m

Myrtle Beach Intl

Tue 6/17

7:59 pm-11:54 pm

1 stop3h 55m

$214

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sun 5/11

7:54 pm-10:31 pm

1 stop2h 37m

Myrtle Beach Intl

Fri 5/23

5:00 am-8:24 am

1 stop3h 24m

$229

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Fri 4/11

9:29 pm-5:54 pm

1 stop20h 25m

Savannah/Hilton Head

Fri 4/18

12:34 pm-7:29 pm

2 stops30h 55m

$233

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 4/29

7:32 pm-11:54 am

1 stop16h 22m

Charlotte Douglas

Wed 4/30

2:35 pm-3:50 pm

Nonstop1h 15m

$255

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Sun 4/20

7:00 am-9:42 am

1 stop2h 42m

Columbia Metropolitan

Wed 4/23

12:23 pm-4:14 pm

1 stop3h 51m

$287

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 4/19

5:30 am-11:27 am

1 stop5h 57m

Charleston

Sat 4/26

6:45 am-9:40 am

1 stop2h 55m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 33 results
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Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 26, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,891 reviews

Comfort

8.0

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,891 reviews
Delta
8.0
Very good
7,891 reviews

Comfort

8.0

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,608 reviews
Delta
8.0
Very good
7,891 reviews

Comfort

8.0

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
730 reviews
Delta
8.0
Very good
7,891 reviews

Comfort

8.0

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,891 reviews

Comfort

8.0

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to South Carolina one-way?

    $100 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $144 and $243, respectively.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Charleston. You may also consider Knoxville McGhee Tyson - Myrtle Beach Intl or Knoxville McGhee Tyson - Savannah/Hilton Head.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$495FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$384FlexibilityNo cancel feeOn-timeN/A
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