South Carolina

$185+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Feb 25 — Mar 41
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Cheap flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$365
(Mytrip)

One-way from

$185
(American Airlines)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
From Key West to South Carolina
One-way flight from Key West to South Carolina

Find flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2712:30 pmEYW - AGS
1 stop6h 19mDelta
Mon 9/111:35 amAGS - EYW
1 stop5h 40mDelta
Deal found 2/20$359
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/68:53 amEYW - CLT
2 stops30h 07mMultiple Airlines
Mon 3/1011:44 amCLT - EYW
2 stops26h 00mMultiple Airlines
Deal found 2/19$365
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/274:00 pmEYW - AGS
2 stops5h 25mAmerican Airlines
Mon 9/15:27 amAGS - EYW
1 stop5h 53mAmerican Airlines
Deal found 2/20$384
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:00 amEYW - SAV
1 stop6h 36mDelta
Tue 5/206:05 amSAV - EYW
2 stops13h 39mDelta
Deal found 2/20$433
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/147:40 pmEYW - CLT
2 stops21h 42mUnited Airlines
Tue 3/186:00 amCLT - EYW
2 stops12h 55mUnited Airlines
Deal found 2/19$438
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/187:29 pmEYW - SAV
1 stop4h 30mAmerican Airlines
Fri 4/251:10 pmSAV - EYW
1 stop5h 45mAmerican Airlines
Deal found 2/20$459
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:00 pmEYW - CHS
1 stop4h 08mDelta
Mon 8/2510:20 amCHS - EYW
1 stop6h 55mDelta
Deal found 2/19$459
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/227:30 pmEYW - CHS
1 stop4h 51mAmerican Airlines
Mon 8/255:35 amCHS - EYW
2 stops5h 23mAmerican Airlines
Deal found 2/19$464
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/66:10 pmEYW - CLT
1 stop14h 15mAmerican Airlines
Mon 3/1010:25 pmCLT - EYW
1 stop12h 48mAmerican Airlines
Deal found 2/19$472

Find flights from Key West to South Carolina within your budget

Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 3/6

8:53 am-3:00 pm

2 stops30h 07m

Charlotte Douglas

Mon 3/10

11:44 am-1:44 pm

2 stops26h 00m

$365

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 5/15

7:00 am-1:36 pm

1 stop6h 36m

Savannah/Hilton Head

Tue 5/20

6:05 am-7:44 pm

2 stops13h 39m

$433

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 3/14

7:40 pm-5:22 pm

2 stops21h 42m

Charlotte Douglas

Tue 3/18

6:00 am-6:55 pm

2 stops12h 55m

$438

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 4/18

7:29 pm-11:59 pm

1 stop4h 30m

Savannah/Hilton Head

Fri 4/25

1:10 pm-6:55 pm

1 stop5h 45m

$459

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 3/6

6:10 pm-8:25 am

1 stop14h 15m

Charlotte Douglas

Mon 3/10

10:25 pm-11:13 am

1 stop12h 48m

$472

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 3/7

11:36 am-10:00 pm

1 stop10h 24m

Charleston

Tue 3/11

6:17 am-3:25 pm

1 stop9h 08m

$497

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 3/26

7:55 am-2:17 pm

1 stop6h 22m

$185

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 3/18

10:55 am-11:59 pm

2 stops13h 04m

$213

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sun 3/30

8:53 am-5:02 pm

3 stops32h 09m

$233

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Wed 3/19

11:38 am-11:38 pm

1 stop12h 00m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 11 results
1
2

Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Key West to South Carolina

Get recent, data-driven insights about flights from Key West to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Key West to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 20, 2025.
8.0
Very good

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

8.0
Very good
8.0
Very good

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

8.0
Very good

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

8.0
Very good

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Key West to South Carolina one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $185. United Airlines flights start at $213 while deals on Delta start at $323 one-way.

  • What are the most popular routes from Key West to South Carolina?

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key West to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Key West to South Carolina

Discover the top 2 airlines that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$298FlexibilityNo cancel feeOn-timeN/A
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