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South Carolina

$166+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

One-way from

$166
(Mytrip)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
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From Key West to South Carolina
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One-way flight from Key West to South Carolina
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Find flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/271:27 pmEYW - AGS
1 stop5h 43mAmerican Airlines
Mon 9/15:27 amAGS - EYW
1 stop5h 53mAmerican Airlines
Deal found 3/31$319
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1710:23 amEYW - SAV
1 stop28h 09mAllegiant Air
Sun 4/2011:00 amSAV - EYW
1 stop23h 20mAllegiant Air
Deal found 3/31$344
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/168:00 amEYW - CHS
1 stop6h 06mAmerican Airlines
Tue 4/225:10 amCHS - EYW
1 stop6h 56mAmerican Airlines
Deal found 3/30$388
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/142:00 pmEYW - SAV
1 stop5h 02mAmerican Airlines
Tue 10/217:49 amSAV - EYW
1 stop5h 48mAmerican Airlines
Deal found 3/31$407
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/512:32 pmEYW - CLT
1 stop8h 45mAmerican Airlines
Tue 9/1610:28 pmCLT - EYW
1 stop13h 04mAmerican Airlines
Deal found 3/29$407
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:13 pmEYW - SAV
1 stop5h 44mDelta
Sat 4/198:30 amSAV - EYW
1 stop5h 35mDelta
Deal found 3/31$422
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1710:23 amEYW - SAV
3 stops36h 50mMultiple Airlines
Sun 4/2011:00 amSAV - EYW
1 stop23h 20mMultiple Airlines
Deal found 3/31$441
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:45 pmEYW - CLT
2 stops21h 41mUnited Airlines
Tue 9/1611:22 amCLT - EYW
2 stops26h 38mUnited Airlines
Deal found 3/29$512
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/49:51 amEYW - CHS
2 stops27h 28mMultiple Airlines
Sun 4/611:02 amCHS - EYW
3 stops29h 14mMultiple Airlines
Deal found 3/30$543
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/146:13 pmEYW - CHS
1 stop4h 33mDelta
Fri 4/1810:30 amCHS - EYW
1 stop6h 47mDelta
Deal found 3/30$637
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/146:13 pmEYW - CLT
1 stop5h 33mDelta
Fri 4/182:25 pmCLT - EYW
1 stop6h 05mDelta
Deal found 3/30$699

Cheapflights Fare Finder

Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestAugusta

EYW - AGS

EYWAGS

Key West

Wed 8/27

1:27 pm-7:10 pm

1 stop5h 43m

Augusta Bush Field

Mon 9/1

5:27 am-11:20 am

1 stop5h 53m

$319

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 4/17

10:23 am-2:32 pm

1 stop28h 09m

Savannah/Hilton Head

Sun 4/20

11:00 am-10:20 am

1 stop23h 20m

$344

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Wed 4/16

8:00 am-2:06 pm

1 stop6h 06m

Charleston

Tue 4/22

5:10 am-12:06 pm

1 stop6h 56m

$388

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 9/5

12:32 pm-9:17 pm

1 stop8h 45m

Charlotte Douglas

Tue 9/16

10:28 pm-11:32 am

1 stop13h 04m

$407

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Wed 7/9

7:31 pm-12:25 am

1 stop4h 54m

Savannah/Hilton Head

Sun 7/13

5:00 am-12:00 pm

1 stop7h 00m

$417

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Tue 4/15

6:13 pm-11:57 pm

1 stop5h 44m

Savannah/Hilton Head

Sat 4/19

8:30 am-2:05 pm

1 stop5h 35m

$422

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 4/17

10:23 am-11:13 pm

3 stops36h 50m

Savannah/Hilton Head

Sun 4/20

11:00 am-10:20 am

1 stop23h 20m

$441

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 9/5

6:45 pm-4:26 pm

2 stops21h 41m

Charlotte Douglas

Tue 9/16

11:22 am-2:00 pm

2 stops26h 38m

$512

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Mon 4/14

6:13 pm-10:46 pm

1 stop4h 33m

Charleston

Fri 4/18

10:30 am-5:17 pm

1 stop6h 47m

$637

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 4/14

6:13 pm-11:46 pm

1 stop5h 33m

Charlotte Douglas

Fri 4/18

2:25 pm-8:30 pm

1 stop6h 05m

$699

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 20 results
1
2

Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina

What is the cheapest month to book a flight from Key West to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

When flying from Key West to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 31, 2025.
Read through reviews of airlines operating flights from Key West to South Carolina, such as Delta, United Airlines and Allegiant Air. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Allegiant Air
7.3
Good
731 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Key West to South Carolina one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $220. Delta flights start at $220 while deals on Allegiant Air start at $222 one-way.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Charleston or Key West - Augusta Bush Field as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key West to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Key West to South Carolina

Discover the top 2 airlines that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$298FlexibilityNo cancel feeOn-timeN/A
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