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South Carolina

$160+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated April 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$319
(Delta)

One-way from

$160
(Mytrip)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
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From Key West to South Carolina
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One-way flight from Key West to South Carolina
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Find flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/272:35 pmEYW - AGS
1 stop4h 14mDelta
Mon 9/17:00 amAGS - EYW
1 stop3h 56mDelta
Deal found 4/22$319
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/272:00 pmEYW - AGS
2 stops7h 25mAmerican Airlines
Mon 9/15:27 amAGS - EYW
1 stop5h 53mAmerican Airlines
Deal found 4/22$324
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/16:00 pmEYW - CHS
1 stop4h 08mDelta
Tue 8/57:45 amCHS - EYW
1 stop5h 24mDelta
Deal found 4/22$382
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/112:50 pmEYW - CHS
1 stop7h 00mAmerican Airlines
Tue 8/511:14 amCHS - EYW
2 stops7h 47mAmerican Airlines
Deal found 4/22$387
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/123:17 pmEYW - CLT
Nonstop2h 21mAmerican Airlines
Wed 5/149:47 amCLT - EYW
Nonstop2h 23mAmerican Airlines
Deal found 4/21$569
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/128:45 amEYW - CLT
2 stops12h 36mUnited Airlines
Wed 5/146:35 amCLT - EYW
2 stops11h 30mUnited Airlines
Deal found 4/21$599
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/612:25 pmEYW - CLT
1 stop5h 45mDelta
Sat 5/107:00 amCLT - EYW
1 stop5h 56mDelta
Deal found 4/21$669

Cheapflights Fare Finder

Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Key West

Fly to

South Carolina

Route

Depart

Return

Price

Key WestAugusta

EYW - AGS

EYWAGS

Key West

Wed 8/27

2:35 pm-6:49 pm

1 stop4h 14m

Augusta Bush Field

Mon 9/1

7:00 am-10:56 am

1 stop3h 56m

$319

Key WestAugusta

EYW - AGS

EYWAGS

Key West

Wed 8/27

2:00 pm-9:25 pm

2 stops7h 25m

Augusta Bush Field

Mon 9/1

5:27 am-11:20 am

1 stop5h 53m

$324

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 8/1

6:00 pm-10:08 pm

1 stop4h 08m

Charleston

Tue 8/5

7:45 am-1:09 pm

1 stop5h 24m

$382

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 8/1

12:50 pm-7:50 pm

1 stop7h 00m

Charleston

Tue 8/5

11:14 am-7:01 pm

2 stops7h 47m

$387

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 5/12

3:17 pm-5:38 pm

Nonstop2h 21m

Charlotte Douglas

Wed 5/14

9:47 am-12:10 pm

Nonstop2h 23m

$569

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Mon 5/12

8:45 am-9:21 pm

2 stops12h 36m

Charlotte Douglas

Wed 5/14

6:35 am-6:05 pm

2 stops11h 30m

$599

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 5/6

12:25 pm-6:10 pm

1 stop5h 45m

Charlotte Douglas

Sat 5/10

7:00 am-12:56 pm

1 stop5h 56m

$669

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 5/22

10:30 am-10:59 pm

1 stop12h 29m

$160

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sat 5/24

7:30 am-1:40 pm

1 stop6h 10m

$230

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sat 5/24

5:24 pm-7:45 pm

Nonstop2h 21m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 11 results
1
2

Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina

What is the cheapest month to book a flight from Key West to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EYW to SC?

Find hourly flight availability from Key West to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

When flying from Key West to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 22, 2025.
Read through reviews of airlines operating flights from Key West to South Carolina, such as Delta, United Airlines and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,683 reviews
Delta
8.0
Very good
7,920 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Key West to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $230. American Airlines flights start at $255 while deals on United Airlines start at $282 one-way.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Augusta Bush Field, Key West - Charleston or Key West - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Key West to South Carolina (average of $217). Flying from Key West to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key West to South Carolina

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Top 2 airlines flying from Key West to South Carolina

Discover the top 2 airlines that operate flights from Key West to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$445FlexibilityNo cancel feeOn-timeN/A

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