HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$110+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated April 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$204
(American Airlines)

One-way from

$110
(Mytrip)

Popular in

December

Cheapest in

September

Average price

$316
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2811:30 amCID - SAV
2 stops7h 24mAmerican Airlines
Fri 5/306:11 pmSAV - CID
1 stop4h 52mAmerican Airlines
Deal found 4/22$204
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/302:00 pmCID - CHS
2 stops9h 15mAmerican Airlines
Mon 6/26:09 pmCHS - CID
1 stop4h 54mAmerican Airlines
Deal found 4/21$229
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1812:32 pmDSM - CLT
1 stop26h 05mMultiple Airlines
Wed 5/219:45 pmCLT - DSM
2 stops26h 42mMultiple Airlines
Deal found 4/22$237
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:25 amCID - SAV
1 stop6h 49mDelta
Sat 5/244:51 pmSAV - CID
1 stop6h 25mDelta
Deal found 4/21$243
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/28:35 amDSM - CHS
1 stop12h 34mMultiple Airlines
Thu 6/52:03 pmCHS - DSM
1 stop25h 42mMultiple Airlines
Deal found 4/22$247
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/205:35 amDSM - SAV
1 stop4h 48mDelta
Sat 5/244:51 pmSAV - DSM
1 stop6h 39mDelta
Deal found 4/22$271
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/35:55 amCID - CHS
1 stop4h 32mDelta
Tue 5/66:03 pmCHS - CID
1 stop6h 04mDelta
Deal found 4/21$284
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/316:00 amOMA - SAV
1 stop5h 42mAmerican Airlines
Sun 9/77:38 amSAV - OMA
1 stop6h 22mAmerican Airlines
Deal found 4/20$285
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/284:22 pmDSM - CHS
1 stop6h 55mAmerican Airlines
Sun 8/317:31 amCHS - DSM
1 stop7h 40mAmerican Airlines
Deal found 4/22$287
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/303:47 pmDSM - SAV
1 stop5h 51mAmerican Airlines
Thu 7/312:50 pmSAV - DSM
1 stop4h 25mAmerican Airlines
Deal found 4/22$287
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/267:21 pmDSM - SAV
2 stops24h 24mAllegiant Air
Thu 5/298:15 amSAV - DSM
1 stop29h 31mAllegiant Air
Deal found 4/22$296
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:30 pmDSM - CHS
1 stop4h 11mDelta
Tue 10/72:05 pmCHS - DSM
1 stop6h 48mDelta
Deal found 4/21$297

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Wed 5/28

11:30 am-7:54 pm

2 stops7h 24m

Savannah/Hilton Head

Fri 5/30

6:11 pm-10:03 pm

1 stop4h 52m

$204

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 5/30

2:00 pm-12:15 am

2 stops9h 15m

Charleston

Mon 6/2

6:09 pm-10:03 pm

1 stop4h 54m

$229

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sun 5/18

12:32 pm-3:37 pm

1 stop26h 05m

Charlotte Douglas

Wed 5/21

9:45 pm-11:27 pm

2 stops26h 42m

$237

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Wed 5/14

6:25 am-2:14 pm

1 stop6h 49m

Savannah/Hilton Head

Sat 5/24

4:51 pm-10:16 pm

1 stop6h 25m

$243

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 6/2

8:35 am-10:09 pm

1 stop12h 34m

Charleston

Thu 6/5

2:03 pm-2:45 pm

1 stop25h 42m

$247

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Tue 5/20

5:35 am-11:23 am

1 stop4h 48m

Savannah/Hilton Head

Sat 5/24

4:51 pm-10:30 pm

1 stop6h 39m

$271

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Sat 5/3

5:55 am-11:27 am

1 stop4h 32m

Charleston

Wed 5/7

6:24 pm-11:00 pm

1 stop5h 36m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 8/28

4:22 pm-12:17 am

1 stop6h 55m

Charleston

Sun 8/31

7:31 am-2:11 pm

1 stop7h 40m

$287

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Mon 6/30

3:47 pm-10:38 pm

1 stop5h 51m

Savannah/Hilton Head

Thu 7/3

12:50 pm-4:15 pm

1 stop4h 25m

$287

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Mon 5/26

7:21 pm-8:45 pm

2 stops24h 24m

Savannah/Hilton Head

Thu 5/29

8:15 am-12:46 pm

1 stop29h 31m

$296

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

When flying from Iowa to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 22, 2025.
Read through reviews of airlines operating flights from Iowa to South Carolina, such as Alaska Airlines, Southwest and Delta. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,911 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,287 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,683 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $110. However, be on the lookout for offers from Delta and Frontier, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
Newark to Fort Lauderdale flights
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Miami flights
LaGuardia to Fort Lauderdale flights
Newark to Miami flights
Dallas/Fort Worth to Seattle flights
Newark to Las Vegas flights
Newark to Los Angeles flights
Dallas/Fort Worth to John F Kennedy Intl flights
LaGuardia to Miami flights
San Francisco to John F Kennedy Intl flights
Los Angeles to Seattle flights
Los Angeles to Newark flights
Newark to Orlando flights
LaGuardia to O'Hare Intl flights
Los Angeles to Honolulu flights
John F Kennedy Intl to O'Hare Intl flights
John F Kennedy Intl to Dallas/Fort Worth flights
Dallas/Fort Worth to O'Hare Intl flights
Seattle to Los Angeles flights
John F Kennedy Intl to San Francisco flights
John F Kennedy Intl to Las Vegas flights
John F Kennedy Intl to Fort Lauderdale flights
Newark to Seattle flights
San Francisco to Newark flights
John F Kennedy Intl to Seattle flights
John F Kennedy Intl to Orlando flights
Dallas/Fort Worth to LaGuardia flights
Dallas/Fort Worth to Newark flights
Newark to O'Hare Intl flights
Newark to Dallas/Fort Worth flights
LaGuardia to Atlanta flights
O'Hare Intl to LaGuardia flights
Los Angeles to LaGuardia flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to John F Kennedy Intl flights
Seattle to John F Kennedy Intl flights
Dallas/Fort Worth to Las Vegas flights
Newark to San Francisco flights
LaGuardia to Dallas/Fort Worth flights
Atlanta to LaGuardia flights
Seattle to Newark flights
Seattle to Las Vegas flights
LaGuardia to Orlando flights
O'Hare Intl to Las Vegas flights
John F Kennedy Intl to Hobby flights
LaGuardia to Los Angeles flights
Los Angeles to Boston flights
Newark to Denver flights

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$384FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$227Average$423FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$355FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$376Average$447FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.