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$48+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$85
(FlightHub)

One-way from

$48
(Cheapflightsfares)

Popular in

March

Cheapest in

June

Average price

$344

Good round-trip deal

$136 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indianapolis to South Carolina
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One-way flight from Indianapolis to South Carolina
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Price to beat on a round-trip flight from Indianapolis to South Carolina.
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Find flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This FlightHub deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:36 pmIND - CLT
1 stop5h 04mSpirit Airlines
Mon 5/58:41 amCLT - IND
1 stop5h 00mSpirit Airlines
Deal found 2/18$85
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2112:44 pmIND - SAV
Nonstop1h 48mAllegiant Air
Fri 4/2510:00 amSAV - IND
Nonstop1h 54mAllegiant Air
Deal found 2/20$103
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/710:14 pmIND - CHS
1 stop11h 39mSpirit Airlines
Tue 3/112:59 pmCHS - IND
1 stop27h 04mSpirit Airlines
Deal found 2/19$106
This Frontier deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1011:22 amIND - CLT
1 stop6h 22mFrontier
Thu 3/138:08 amCLT - IND
1 stop7h 12mFrontier
Deal found 2/19$110
This Priceline deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/49:18 amIND - CLT
1 stop7h 14mMultiple Airlines
Tue 5/68:41 amCLT - IND
1 stop5h 00mMultiple Airlines
Deal found 2/20$111
This Cheapflightsfares deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/316:25 pmIND - MYR
Nonstop1h 43mAllegiant Air
Sat 6/79:51 pmMYR - IND
Nonstop1h 44mAllegiant Air
Deal found 2/19$112
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/31:17 pmIND - CHS
1 stop4h 51mMultiple Airlines
Fri 6/65:18 pmCHS - IND
Nonstop1h 50mMultiple Airlines
Deal found 2/20$121
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/23:58 pmIND - CHS
Nonstop1h 57mAllegiant Air
Fri 6/65:18 pmCHS - IND
Nonstop1h 50mAllegiant Air
Deal found 2/20$131
This Booking.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3110:51 amIND - MYR
1 stop6h 46mMultiple Airlines
Sat 6/79:51 pmMYR - IND
Nonstop1h 44mMultiple Airlines
Deal found 2/19$139
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2610:00 amIND - MYR
1 stop7h 36mSpirit Airlines
Mon 3/3110:27 pmMYR - IND
1 stop10h 31mSpirit Airlines
Deal found 2/20$146
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/36:45 amIND - SAV
1 stop16h 18mMultiple Airlines
Fri 3/72:05 pmSAV - IND
Nonstop1h 51mMultiple Airlines
Deal found 2/20$175
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2511:52 amIND - CLT
Nonstop1h 43mAmerican Airlines
Tue 3/254:40 pmCLT - IND
1 stop5h 37mAmerican Airlines
Deal found 2/19$223

Find flights from Indianapolis to South Carolina within your budget

Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 5/2

2:36 pm-7:40 pm

1 stop5h 04m

Charlotte Douglas

Mon 5/5

8:41 am-1:41 pm

1 stop5h 00m

$85

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Mon 4/21

12:44 pm-2:32 pm

Nonstop1h 48m

Savannah/Hilton Head

Fri 4/25

10:00 am-11:54 am

Nonstop1h 54m

$103

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Fri 3/7

10:14 pm-9:53 am

1 stop11h 39m

Charleston

Tue 3/11

2:59 pm-6:03 pm

1 stop27h 04m

$106

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 3/10

11:22 am-5:44 pm

1 stop6h 22m

Charlotte Douglas

Thu 3/13

8:08 am-3:20 pm

1 stop7h 12m

$110

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sun 5/4

9:18 am-4:32 pm

1 stop7h 14m

Charlotte Douglas

Tue 5/6

8:41 am-1:41 pm

1 stop5h 00m

$111

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 5/31

6:25 pm-8:08 pm

Nonstop1h 43m

Myrtle Beach Intl

Sat 6/7

9:51 pm-11:35 pm

Nonstop1h 44m

$112

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Tue 6/3

1:17 pm-6:08 pm

1 stop4h 51m

Charleston

Fri 6/6

5:18 pm-7:08 pm

Nonstop1h 50m

$121

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Mon 6/2

3:58 pm-5:55 pm

Nonstop1h 57m

Charleston

Fri 6/6

5:18 pm-7:08 pm

Nonstop1h 50m

$131

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 5/31

10:51 am-5:37 pm

1 stop6h 46m

Myrtle Beach Intl

Sat 6/7

9:51 pm-11:35 pm

Nonstop1h 44m

$139

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Wed 3/26

10:00 am-5:36 pm

1 stop7h 36m

Myrtle Beach Intl

Mon 3/31

10:27 pm-8:58 am

1 stop10h 31m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Indianapolis to South Carolina

Get recent, data-driven insights about flights from Indianapolis to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Indianapolis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 20, 2025.
Get a feel of what it's like to fly with Southwest, Alaska Airlines and Delta from Indianapolis to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,692 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $48. However, be on the lookout for offers from Delta and Frontier, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charlotte Douglas or Indianapolis - Myrtle Beach Intl, Indianapolis - Charleston is the most popular route from Indianapolis to South Carolina.

  • What are the cheapest flights from Indianapolis to South Carolina?

    On average you can expect to pay $162 for a flight from Indianapolis to South Carolina. The cheapest flight overall is $123 while the most popular route, (Indianapolis - Charleston) is currently priced at $106.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$86Average$165FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$110Average$183FlexibilityNo cancel feeOn-time65%
DeltaCheapest$216Average$339FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$350FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$238Average$384FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$257Average$371FlexibilityNo cancel feeOn-time63%
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