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South Carolina

$39+ Cheap flights from Indiana to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Indiana to South Carolina

Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$122
(Cheapflightsfares)

One-way from

$46
(FlightHub)

Popular in

March

Cheapest in

June

Average price

$400

Good round-trip deal

$106 or less

Good one-way deal

$103 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indiana to South Carolina
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One-way flight from Indiana to South Carolina
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Highest demand for flights based on searches. 13% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Price to beat on a round-trip flight from Indiana to South Carolina.
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Price to beat on a one-way flight from Indiana to South Carolina.
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Find flight deals from Indiana to South Carolina

Cheapest flights from Indiana to South Carolina
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/87:47 amORD - MYR
1 stop10h 38mSpirit Airlines
Sat 5/1711:32 amMYR - ORD
Nonstop2h 10mSpirit Airlines
Deal found 3/31$122
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/155:36 amORD - CLT
1 stop10h 02mSpirit Airlines
Fri 4/184:20 pmCLT - ORD
1 stop6h 06mSpirit Airlines
Deal found 3/30$128
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:51 amORD - CLT
1 stop7h 34mMultiple Airlines
Sun 5/412:01 pmCLT - ORD
Nonstop2h 33mMultiple Airlines
Deal found 3/30$136
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/27:59 amORD - CLT
Nonstop2h 08mFrontier
Sun 5/412:01 pmCLT - ORD
Nonstop2h 33mFrontier
Deal found 3/31$142
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:45 amCVG - CLT
1 stop12h 11mFrontier
Fri 5/1610:36 amCLT - CVG
1 stop8h 25mFrontier
Deal found 3/31$158
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/19:51 amMDW - CLT
1 stop10h 55mFrontier
Fri 5/210:36 amCLT - MDW
1 stop10h 57mFrontier
Deal found 3/31$158
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/126:45 pmMDW - CLT
Nonstop1h 50mSouthwest
Wed 5/146:40 pmCLT - MDW
Nonstop2h 15mSouthwest
Deal found 3/31$197
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1310:34 amORD - CLT
Nonstop2h 07mAmerican Airlines
Tue 5/208:30 pmCLT - ORD
Nonstop2h 13mAmerican Airlines
Deal found 3/30$197
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/136:00 amMDW - CLT
1 stop6h 36mDelta
Tue 5/2011:24 amCLT - MDW
1 stop4h 56mDelta
Deal found 3/30$217
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:10 amORD - CLT
1 stop4h 01mDelta
Tue 5/202:21 pmCLT - ORD
1 stop5h 27mDelta
Deal found 3/30$217
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/138:05 amORD - CAE
1 stop5h 02mAmerican Airlines
Wed 5/148:45 pmCAE - ORD
1 stop4h 26mAmerican Airlines
Deal found 3/31$224
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/116:12 amORD - MYR
1 stop6h 44mAmerican Airlines
Tue 7/155:16 pmMYR - ORD
Nonstop2h 33mAmerican Airlines
Deal found 3/30$227

Cheapflights Fare Finder

Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.

Fly from

Indiana

Fly to

South Carolina

Route

Depart

Return

Price

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Thu 5/8

7:47 am-7:25 pm

1 stop10h 38m

Myrtle Beach Intl

Sat 5/17

11:32 am-12:42 pm

Nonstop2h 10m

$122

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 4/15

5:36 am-4:38 pm

1 stop10h 02m

Charlotte Douglas

Fri 4/18

4:20 pm-9:26 pm

1 stop6h 06m

$128

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Wed 4/30

6:51 am-3:25 pm

1 stop7h 34m

Charlotte Douglas

Sun 5/4

12:01 pm-1:34 pm

Nonstop2h 33m

$136

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Fri 5/2

7:59 am-11:07 am

Nonstop2h 08m

Charlotte Douglas

Sun 5/4

12:01 pm-1:34 pm

Nonstop2h 33m

$142

CincinnatiCharlotte

CVG - CLT

CVGCLT

Cincinnati Cinci./N. Kentucky

Thu 5/15

5:45 am-5:56 pm

1 stop12h 11m

Charlotte Douglas

Fri 5/16

10:36 am-7:01 pm

1 stop8h 25m

$158

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Thu 5/1

9:51 am-9:46 pm

1 stop10h 55m

Charlotte Douglas

Mon 5/5

10:46 am-8:33 pm

1 stop10h 47m

$158

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Mon 5/12

6:45 pm-9:35 pm

Nonstop1h 50m

Charlotte Douglas

Wed 5/14

6:40 pm-7:55 pm

Nonstop2h 15m

$197

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 5/13

10:34 am-1:41 pm

Nonstop2h 07m

Charlotte Douglas

Tue 5/20

8:30 pm-9:43 pm

Nonstop2h 13m

$197

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Tue 5/13

6:00 am-1:36 pm

1 stop6h 36m

Charlotte Douglas

Tue 5/20

11:24 am-3:20 pm

1 stop4h 56m

$217

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 5/13

7:10 am-12:11 pm

1 stop4h 01m

Charlotte Douglas

Tue 5/20

2:21 pm-6:48 pm

1 stop5h 27m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to South Carolina

What is the cheapest month to book a flight from Indiana to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SC?

Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

When flying from Indiana to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 31, 2025.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Alaska Airlines, Southwest and Delta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Alaska Airlines
8.0
Very good
9,818 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Southwest
8.0
Very good
4,277 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Delta
8.0
Very good
7,899 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Avelo Airlines
7.5
Good
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
United Airlines
7.4
Good
8,614 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Food

7.1

Overall

8.0

Boarding

8.2

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to South Carolina flight route?

    This flight path from Indiana to South Carolina was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Indiana to South Carolina one-way?

    $46 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Frontier and Southwest, with prices starting from $78 and $89, respectively.

  • Can I find deals for flights from Indiana to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indiana to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to South Carolina.

  • Can I find deals for business class flights from Indiana to South Carolina?

    Yes. Cheapflights offers flight deals from Indiana to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Indiana to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indiana to South Carolina

Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$86Average$152FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$107Average$185FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$198Average$406FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$198Average$386FlexibilityNo cancel feeOn-time69%
DeltaCheapest$198Average$344FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$276Average$379FlexibilityNo cancel feeOn-time63%
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