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South Carolina

$46+ Cheap flights from Indiana to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Indiana to South Carolina

Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$93
(Kiwi.com)

One-way from

$46
(FlightHub)

Popular in

March

Cheapest in

June

Average price

$344

Good round-trip deal

$136 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indiana to South Carolina
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One-way flight from Indiana to South Carolina
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Highest demand for flights based on searches. 11% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Price to beat on a round-trip flight from Indiana to South Carolina.
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Find flight deals from Indiana to South Carolina

Cheapest flights from Indiana to South Carolina
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:00 amORD - CLT
Nonstop2h 12mMultiple Airlines
Sun 5/186:32 pmCLT - ORD
1 stop5h 38mMultiple Airlines
Deal found 2/20$93
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/18:00 amORD - CLT
Nonstop2h 12mFrontier
Sun 5/412:07 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 2/20$97
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/295:10 pmORD - CLT
1 stop5h 11mSpirit Airlines
Mon 6/26:32 pmCLT - ORD
1 stop5h 38mSpirit Airlines
Deal found 2/19$99
This Frontier deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/199:25 amMDW - CLT
1 stop9h 21mFrontier
Wed 3/268:46 pmCLT - MDW
1 stop12h 30mFrontier
Deal found 2/19$100
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/25:10 amORD - MYR
1 stop11h 26mSpirit Airlines
Sun 4/66:00 amMYR - ORD
1 stop26h 34mSpirit Airlines
Deal found 2/19$176
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/195:30 amMDW - MYR
1 stop4h 05mSouthwest
Sat 4/263:30 pmMYR - MDW
1 stop7h 15mSouthwest
Deal found 2/18$177
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/197:05 pmMDW - CLT
Nonstop1h 45mSouthwest
Wed 3/268:05 amCLT - MDW
Nonstop2h 00mSouthwest
Deal found 2/19$177
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/87:00 amORD - MYR
2 stops14h 10mSouthwest
Tue 3/117:50 amMYR - ORD
2 stops14h 40mSouthwest
Deal found 2/20$184
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/288:40 amMDW - SAV
Nonstop2h 05mAllegiant Air
Mon 3/316:30 amSAV - MDW
Nonstop2h 20mAllegiant Air
Deal found 2/20$195
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/285:30 amORD - MYR
1 stop4h 07mDelta
Sat 5/34:46 pmMYR - ORD
1 stop5h 30mDelta
Deal found 2/20$197
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/44:59 pmMDW - MYR
1 stop5h 50mDelta
Tue 4/86:00 amMYR - MDW
1 stop4h 07mDelta
Deal found 2/18$197
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/171:33 pmORD - CLT
Nonstop1h 59mAmerican Airlines
Fri 3/2111:19 amCLT - ORD
Nonstop2h 13mAmerican Airlines
Deal found 2/20$197

Find flights from Indiana to South Carolina within your budget

Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Indiana

Fly to

South Carolina

Route

Depart

Return

Price

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 5/15

8:00 am-11:12 am

Nonstop2h 12m

Charlotte Douglas

Sun 5/18

6:32 pm-11:10 pm

1 stop5h 38m

$93

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 5/1

8:00 am-11:12 am

Nonstop2h 12m

Charlotte Douglas

Sun 5/4

12:07 pm-1:20 pm

Nonstop2h 13m

$97

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 5/29

5:10 pm-11:21 pm

1 stop5h 11m

Charlotte Douglas

Mon 6/2

6:32 pm-11:10 pm

1 stop5h 38m

$99

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 3/19

9:25 am-7:46 pm

1 stop9h 21m

Charlotte Douglas

Wed 3/26

8:46 pm-8:16 am

1 stop12h 30m

$100

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Mon 3/3

7:13 pm-8:36 am

1 stop12h 23m

Myrtle Beach Intl

Fri 3/7

10:37 pm-9:07 am

1 stop11h 30m

$175

ChicagoMyrtle Beach

MDW - MYR

MDWMYR

Chicago Midway

Sat 4/19

5:30 am-10:35 am

1 stop4h 05m

Myrtle Beach Intl

Sat 4/26

3:30 pm-9:45 pm

1 stop7h 15m

$177

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 3/19

7:05 pm-9:50 pm

Nonstop1h 45m

Charlotte Douglas

Wed 3/26

8:05 am-9:05 am

Nonstop2h 00m

$177

ChicagoSavannah

MDW - SAV

MDWSAV

Chicago Midway

Fri 3/28

8:40 am-11:45 am

Nonstop2h 05m

Savannah/Hilton Head

Mon 3/31

6:30 am-7:50 am

Nonstop2h 20m

$195

ChicagoMyrtle Beach

MDW - MYR

MDWMYR

Chicago Midway

Fri 4/4

4:59 pm-11:49 pm

1 stop5h 50m

Myrtle Beach Intl

Tue 4/8

6:00 am-9:07 am

1 stop4h 07m

$197

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Mon 3/17

1:33 pm-4:32 pm

Nonstop1h 59m

Charlotte Douglas

Fri 3/21

11:19 am-12:32 pm

Nonstop2h 13m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Indiana to South Carolina

Get recent, data-driven insights about flights from Indiana to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Indiana to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SC?

Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Indiana to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 20, 2025.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Southwest, Delta and JetBlue. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

JetBlue
7.4
Good
3,070 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to South Carolina flight route?

    This flight path from Indiana to South Carolina was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Indiana to South Carolina one-way?

    $46 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Allegiant Air and Southwest, with prices starting from $49 and $59, respectively.

  • Can I find deals for flights from Indiana to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indiana to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to South Carolina.

  • Can I find deals for business class flights from Indiana to South Carolina?

    Yes. Cheapflights offers flight deals from Indiana to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indiana to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indiana to South Carolina

Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$86Average$161FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$110Average$183FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$198Average$417FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$347FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$383FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$257Average$371FlexibilityNo cancel feeOn-time63%
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