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$42+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/8. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
feb. 25 — mar. 41
mar. 2/25
mar. 3/4
1 adult, Economy
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Cheap flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated febrero 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$69
(Justfly.com)

One-way from

$42
(FlightHub)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
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From Florida Keys to South Carolina
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One-way flight from Florida Keys to South Carolina
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Find flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 20, 2025.

This Justfly.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/149:24 amMIA - CLT
Nonstop2h 15mMultiple Airlines
dom. 3/167:36 pmCLT - MIA
Nonstop2h 15mMultiple Airlines
Deal found 2/19$69
This Frontier deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/1712:08 pmMIA - CLT
Nonstop2h 18mFrontier
lun. 4/218:13 pmCLT - MIA
Nonstop2h 10mFrontier
Deal found 2/19$73
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/69:24 amMIA - CLT
Nonstop2h 15mSpirit Airlines
mar. 3/187:24 pmCLT - MIA
Nonstop2h 06mSpirit Airlines
Deal found 2/19$74
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/2010:17 amMIA - CHS
2 stops30h 44mMultiple Airlines
lun. 3/2410:28 amCHS - MIA
2 stops29h 06mMultiple Airlines
Deal found 2/19$131
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/119:35 pmMIA - CHS
1 stop16h 29mSpirit Airlines
vie. 3/1410:48 amCHS - MIA
2 stops21h 41mSpirit Airlines
Deal found 2/19$149
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/43:53 pmMIA - MYR
1 stop6h 40mSpirit Airlines
mar. 3/115:45 amMYR - MIA
1 stop7h 43mSpirit Airlines
Deal found 2/20$159
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/136:01 amMIA - CLT
Nonstop2h 11mAmerican Airlines
lun. 3/178:30 pmCLT - MIA
Nonstop2h 20mAmerican Airlines
Deal found 2/19$197
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/1410:00 pmMIA - CHS
Nonstop1h 41mAmerican Airlines
jue. 4/177:18 pmCHS - MIA
Nonstop1h 42mAmerican Airlines
Deal found 2/20$197
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/142:30 pmMIA - CAE
1 stop5h 09mAmerican Airlines
sáb. 5/178:14 pmCAE - MIA
1 stop4h 19mAmerican Airlines
Deal found 2/20$199
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/2811:08 amMIA - SAV
2 stops12h 06mMultiple Airlines
lun. 3/3112:35 pmSAV - MIA
2 stops26h 59mMultiple Airlines
Deal found 2/20$226
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 3/85:00 amMIA - SAV
1 stop6h 00mSouthwest
lun. 3/1012:55 pmSAV - MIA
1 stop7h 40mSouthwest
Deal found 2/19$232
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/287:55 pmMIA - SAV
1 stop20h 58mDelta
lun. 3/317:55 pmSAV - MIA
1 stop4h 50mDelta
Deal found 2/20$236

Find flights from Florida Keys to South Carolina within your budget

Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 20, 2025.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

vie. 3/14

9:24 am-11:39 am

Nonstop2h 15m

Charlotte Douglas

dom. 3/16

7:36 pm-9:51 pm

Nonstop2h 15m

$69

MiamiCharlotte

MIA - CLT

MIACLT

Miami

jue. 4/17

12:08 pm-2:26 pm

Nonstop2h 18m

Charlotte Douglas

lun. 4/21

8:13 pm-10:23 pm

Nonstop2h 10m

$73

MiamiCharlotte

MIA - CLT

MIACLT

Miami

jue. 3/6

9:24 am-11:39 am

Nonstop2h 15m

Charlotte Douglas

mar. 3/18

7:24 pm-9:30 pm

Nonstop2h 06m

$74

MiamiCharleston

MIA - CHS

MIACHS

Miami

jue. 3/20

10:17 am-5:01 pm

2 stops30h 44m

Charleston

lun. 3/24

10:28 am-3:34 pm

2 stops29h 06m

$131

MiamiCharleston

MIA - CHS

MIACHS

Miami

mar. 3/11

9:35 pm-2:04 pm

1 stop16h 29m

Charleston

vie. 3/14

10:48 am-8:29 am

2 stops21h 41m

$149

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

mar. 3/4

3:53 pm-10:33 pm

1 stop6h 40m

Myrtle Beach Intl

mar. 3/11

5:45 am-1:28 pm

1 stop7h 43m

$159

MiamiCharlotte

MIA - CLT

MIACLT

Miami

jue. 3/13

6:01 am-8:12 am

Nonstop2h 11m

Charlotte Douglas

lun. 3/17

8:30 pm-10:50 pm

Nonstop2h 20m

$197

MiamiCharleston

MIA - CHS

MIACHS

Miami

lun. 4/14

10:00 pm-11:41 pm

Nonstop1h 41m

Charleston

jue. 4/17

7:18 pm-9:00 pm

Nonstop1h 42m

$197

MiamiColumbia

MIA - CAE

MIACAE

Miami

mié. 5/14

2:30 pm-7:39 pm

1 stop5h 09m

Columbia Metropolitan

sáb. 5/17

8:14 pm-12:33 am

1 stop4h 19m

$199

MiamiSavannah

MIA - SAV

MIASAV

Miami

vie. 3/28

11:08 am-11:14 pm

2 stops12h 06m

Savannah/Hilton Head

lun. 3/31

12:35 pm-3:34 pm

2 stops26h 59m

$226

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 60 results
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2
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Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Florida Keys to South Carolina

Get recent, data-driven insights about flights from Florida Keys to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest time of day to fly from EOA to SC?

Find hourly flight availability from Florida Keys to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated febrero 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated febrero 20, 2025.
Peruse reviews from past customers who have flown with Southwest, Alaska Airlines and Delta from Florida Keys to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,692 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

JetBlue
7.4
Good
3,070 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $42. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Florida Keys to South Carolina

Discover the top 2 airlines that operate flights from Florida Keys to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$298FlexibilityNo cancel feeOn-timeN/A
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