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South Carolina

$58+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Apr 8 — Apr 151
Tue 4/8
Tue 4/15
1 adult, Economy
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Cheap flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated April 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$76
(FlightHub)

One-way from

$58
(Cheapflightsfares)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
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From Florida Keys to South Carolina
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One-way flight from Florida Keys to South Carolina
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Find flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2025.

This FlightHub deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/88:59 amMIA - CLT
Nonstop2h 04mSpirit Airlines
Mon 5/126:00 amCLT - MIA
Nonstop2h 04mSpirit Airlines
Deal found 4/2$76
This Cheapflightsfares deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/96:00 amMIA - CLT
Nonstop2h 14mMultiple Airlines
Sun 5/116:00 amCLT - MIA
Nonstop2h 04mMultiple Airlines
Deal found 4/1$86
This Cheapflightsfares deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1712:08 pmMIA - CLT
Nonstop2h 18mFrontier
Sun 4/208:53 amCLT - MIA
Nonstop2h 10mFrontier
Deal found 4/2$116
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/87:00 amMIA - CHS
1 stop15h 09mSpirit Airlines
Sat 5/106:00 amCHS - MIA
1 stop13h 58mSpirit Airlines
Deal found 4/1$174
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/127:00 amMIA - MYR
1 stop9h 44mSpirit Airlines
Thu 5/155:10 amMYR - MIA
1 stop14h 48mSpirit Airlines
Deal found 3/31$180
This CheapOair deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/46:00 amMIA - MYR
1 stop8h 09mFrontier
Sat 5/1011:52 amMYR - MIA
1 stop11h 34mFrontier
Deal found 4/2$190
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/168:09 amMIA - CHS
Nonstop1h 42mAmerican Airlines
Tue 4/227:18 pmCHS - MIA
Nonstop1h 42mAmerican Airlines
Deal found 4/2$197
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/95:05 pmMIA - MYR
1 stop5h 26mAmerican Airlines
Sun 5/117:54 pmMYR - MIA
1 stop4h 40mAmerican Airlines
Deal found 4/2$201
This Frontier deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/97:37 pmMIA - CHS
1 stop12h 30mFrontier
Mon 4/143:39 pmCHS - MIA
1 stop8h 56mFrontier
Deal found 4/1$208
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:00 amMIA - CHS
1 stop5h 27mDelta
Mon 4/218:23 pmCHS - MIA
1 stop4h 25mDelta
Deal found 4/2$217
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:24 amMIA - CLT
Nonstop2h 09mAmerican Airlines
Tue 6/105:17 amCLT - MIA
Nonstop2h 04mAmerican Airlines
Deal found 4/2$224
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/317:00 amMIA - AGS
1 stop6h 16mDelta
Wed 9/35:45 amAGS - MIA
1 stop5h 16mDelta
Deal found 4/2$226

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 5/8

8:59 am-11:03 am

Nonstop2h 04m

Charlotte Douglas

Mon 5/12

6:00 am-8:04 am

Nonstop2h 04m

$76

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 5/9

6:00 am-8:14 am

Nonstop2h 14m

Charlotte Douglas

Sun 5/11

6:00 am-8:04 am

Nonstop2h 04m

$86

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 4/18

8:00 am-10:18 am

Nonstop2h 18m

Charlotte Douglas

Sun 4/20

8:53 am-11:03 am

Nonstop2h 10m

$118

MiamiCharleston

MIA - CHS

MIACHS

Miami

Thu 5/8

7:00 am-10:09 pm

1 stop15h 09m

Charleston

Sat 5/10

6:00 am-7:58 pm

1 stop13h 58m

$174

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

Mon 5/12

7:00 am-4:44 pm

1 stop9h 44m

Myrtle Beach Intl

Thu 5/15

5:10 am-7:58 pm

1 stop14h 48m

$180

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

Sun 5/4

6:00 am-2:09 pm

1 stop8h 09m

Myrtle Beach Intl

Sat 5/10

11:52 am-11:26 pm

1 stop11h 34m

$190

MiamiCharleston

MIA - CHS

MIACHS

Miami

Wed 4/16

8:09 am-9:51 am

Nonstop1h 42m

Charleston

Tue 4/22

7:18 pm-9:00 pm

Nonstop1h 42m

$197

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

Fri 5/9

5:05 pm-10:31 pm

1 stop5h 26m

Myrtle Beach Intl

Sun 5/11

7:54 pm-12:34 am

1 stop4h 40m

$201

MiamiCharleston

MIA - CHS

MIACHS

Miami

Wed 4/9

7:37 pm-8:07 am

1 stop12h 30m

Charleston

Mon 4/14

3:39 pm-12:35 am

1 stop8h 56m

$208

MiamiCharleston

MIA - CHS

MIACHS

Miami

Thu 4/17

6:00 am-11:27 am

1 stop5h 27m

Charleston

Mon 4/21

8:23 pm-12:48 am

1 stop4h 25m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/2

Showing 1-10 of 60 results
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Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to South Carolina

What is the cheapest month to book a flight from Florida Keys to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to SC?

Find hourly flight availability from Florida Keys to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 3, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from Florida Keys to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Alaska Airlines
8.0
Very good
9,825 reviews
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Southwest
8.0
Very good
4,274 reviews
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Delta
8.0
Very good
7,897 reviews
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
United Airlines
7.4
Good
8,619 reviews
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
JetBlue
7.3
Good
2,920 reviews
Alaska Airlines
8.0
Very good
9,825 reviews

Crew

8.5

Food

7.1

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $58. However, be on the lookout for offers from Spirit Airlines and American Airlines, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Florida Keys to South Carolina

Discover the top 2 airlines that operate flights from Florida Keys to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$298FlexibilityNo cancel feeOn-timeN/A

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