HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$51+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$96
(FlightHub)

One-way from

$51
(Cheapflightsfares)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Florida Keys to South Carolina
Search Deals
One-way flight from Florida Keys to South Carolina
Search Deals

Find flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/56:00 amMIA - CLT
Nonstop2h 09mSpirit Airlines
Sat 7/125:55 pmCLT - MIA
Nonstop2h 15mSpirit Airlines
Deal found 4/23$96
This Cheapflightsfares deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/86:00 amMIA - CLT
Nonstop2h 14mFrontier
Sun 5/119:04 amCLT - MIA
Nonstop2h 07mFrontier
Deal found 4/22$100
This Cheapflightsfares deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/68:59 amMIA - CLT
Nonstop2h 04mMultiple Airlines
Sun 6/89:07 amCLT - MIA
Nonstop2h 14mMultiple Airlines
Deal found 4/22$116
This Frontier deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/116:00 amMIA - MYR
1 stop8h 09mFrontier
Sat 5/1711:52 amMYR - MIA
1 stop11h 34mFrontier
Deal found 4/23$170
This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/167:00 amMIA - MYR
1 stop6h 47mSpirit Airlines
Sun 7/2012:18 pmMYR - MIA
1 stop6h 35mSpirit Airlines
Deal found 4/23$200
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/239:14 pmMIA - CHS
Nonstop1h 46mAmerican Airlines
Tue 5/277:30 amCHS - MIA
Nonstop1h 39mAmerican Airlines
Deal found 4/22$210
This Frontier deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/299:42 pmMIA - CHS
1 stop10h 23mFrontier
Mon 6/29:05 amCHS - MIA
1 stop8h 25mFrontier
Deal found 4/23$220
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/276:00 amMIA - CLT
Nonstop2h 09mAmerican Airlines
Tue 6/1010:25 pmCLT - MIA
Nonstop2h 04mAmerican Airlines
Deal found 4/22$225
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/97:30 pmMIA - CHS
1 stop4h 14mDelta
Sun 5/118:03 pmCHS - MIA
1 stop4h 34mDelta
Deal found 4/23$237
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/278:10 amMIA - CLT
1 stop4h 24mDelta
Tue 6/106:52 amCLT - MIA
1 stop4h 05mDelta
Deal found 4/21$239
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/255:30 amMIA - CAE
1 stop4h 48mDelta
Wed 7/95:40 amCAE - MIA
1 stop3h 43mDelta
Deal found 4/23$251
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:15 amMIA - CLT
1 stop7h 50mSouthwest
Wed 5/143:40 pmCLT - MIA
1 stop5h 55mSouthwest
Deal found 4/21$259

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Sat 7/5

6:00 am-8:09 am

Nonstop2h 09m

Charlotte Douglas

Sat 7/12

5:55 pm-8:10 pm

Nonstop2h 15m

$96

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 5/8

6:00 am-8:14 am

Nonstop2h 14m

Charlotte Douglas

Sun 5/11

9:04 am-11:11 am

Nonstop2h 07m

$100

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 6/6

8:59 am-11:03 am

Nonstop2h 04m

Charlotte Douglas

Sun 6/8

9:07 am-11:21 am

Nonstop2h 14m

$116

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

Sun 5/11

6:00 am-2:09 pm

1 stop8h 09m

Myrtle Beach Intl

Sat 5/17

11:52 am-11:26 pm

1 stop11h 34m

$170

MiamiMyrtle Beach

MIA - MYR

MIAMYR

Miami

Wed 7/16

7:00 am-1:47 pm

1 stop6h 47m

Myrtle Beach Intl

Sun 7/20

12:18 pm-6:53 pm

1 stop6h 35m

$200

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 5/23

9:14 pm-11:00 pm

Nonstop1h 46m

Charleston

Tue 5/27

7:30 am-9:09 am

Nonstop1h 39m

$210

MiamiCharleston

MIA - CHS

MIACHS

Miami

Thu 5/29

9:42 pm-8:05 am

1 stop10h 23m

Charleston

Mon 6/2

9:05 am-5:30 pm

1 stop8h 25m

$220

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Tue 5/27

6:00 am-8:09 am

Nonstop2h 09m

Charlotte Douglas

Tue 6/10

10:25 pm-12:29 am

Nonstop2h 04m

$225

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 5/9

7:30 pm-11:44 pm

1 stop4h 14m

Charleston

Sun 5/11

8:03 pm-12:37 am

1 stop4h 34m

$237

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Tue 5/27

8:10 am-12:34 pm

1 stop4h 24m

Charlotte Douglas

Tue 6/10

6:52 am-10:57 am

1 stop4h 05m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to South Carolina

What is the cheapest month to book a flight from Florida Keys to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to SC?

Find hourly flight availability from Florida Keys to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 24, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from Florida Keys to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,918 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,287 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,685 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
JetBlue
7.3
Good
2,924 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Food

7.1

Crew

8.5

Comfort

7.9

Boarding

8.2

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $51. However, be on the lookout for offers from Spirit Airlines and Delta, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Newark flights
Fort Lauderdale to LaGuardia flights
Miami to LaGuardia flights
Miami to Newark flights
Orlando to Dallas/Fort Worth flights
Miami to John F Kennedy Intl flights
Orlando to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Orlando to LaGuardia flights
Orlando to John F Kennedy Intl flights
Tampa to Newark flights
Orlando to Seattle flights
Tampa to John F Kennedy Intl flights
Tampa to Seattle flights
Fort Lauderdale to Las Vegas flights
West Palm Beach to John F Kennedy Intl flights
Orlando to Las Vegas flights
Miami to Los Angeles flights
Tampa to LaGuardia flights
Tampa to Las Vegas flights
Orlando to Los Angeles flights
Orlando to Boston flights
Orlando to Denver flights
Orlando to O'Hare Intl flights
Fort Lauderdale to O'Hare Intl flights
West Palm Beach to LaGuardia flights
Fort Lauderdale to Los Angeles flights
West Palm Beach to Newark flights
Miami to Seattle flights
Fort Lauderdale to Dallas/Fort Worth flights
Jacksonville to Newark flights
Orlando to Hobby flights
Miami to O'Hare Intl flights
Miami to Boston flights
Fort Lauderdale to Boston flights
Fort Lauderdale to Seattle flights
Fort Lauderdale to Atlanta flights
Tampa to Denver flights
Tampa to Dulles Intl flights
Tampa to O'Hare Intl flights
Tampa to Boston flights
Miami to Denver flights
Orlando to Philadelphia flights
Tampa to Reagan-National flights
Miami to Las Vegas flights
Tampa to Dallas/Fort Worth flights
Fort Lauderdale to Baltimore flights
Miami to Dallas/Fort Worth flights
Tampa to Baltimore flights
Fort Lauderdale to Philadelphia flights

Top 2 airlines flying from Florida Keys to South Carolina

Discover the top 2 airlines that operate flights from Florida Keys to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$592FlexibilityNo cancel feeOn-time71%
DeltaCheapest$298Average$445FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.