HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$134+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$218
(Mytrip)

One-way from

$134
(Mytrip)

Popular in

December

Cheapest in

September

Average price

$316
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Des Moines to South Carolina
Search Deals
One-way flight from Des Moines to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Mytrip deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:28 pmDSM - CHS
1 stop18h 44mMultiple Airlines
Mon 5/510:32 amCHS - DSM
1 stop12h 26mMultiple Airlines
Deal found 4/15$218
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/96:13 pmDSM - CLT
1 stop14h 52mAmerican Airlines
Sat 5/1012:42 pmCLT - DSM
Nonstop2h 22mAmerican Airlines
Deal found 4/17$226
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/17:25 amDSM - CAE
1 stop8h 07mAmerican Airlines
Mon 5/58:45 pmCAE - DSM
1 stop4h 13mAmerican Airlines
Deal found 4/17$259
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/168:30 amDSM - CLT
1 stop10h 27mMultiple Airlines
Sun 5/189:02 pmCLT - DSM
1 stop19h 51mMultiple Airlines
Deal found 4/16$270
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:35 amDSM - MYR
1 stop5h 48mDelta
Sat 5/103:10 pmMYR - DSM
1 stop6h 56mDelta
Deal found 4/17$271
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/121:31 pmDSM - MYR
1 stop5h 22mMultiple Airlines
Fri 5/168:21 pmMYR - DSM
2 stops25h 59mMultiple Airlines
Deal found 4/16$275
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/71:12 pmDSM - CHS
1 stop8h 38mAmerican Airlines
Sat 5/176:10 pmCHS - DSM
1 stop6h 48mAmerican Airlines
Deal found 4/15$284
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/172:01 pmDSM - SAV
1 stop4h 53mAmerican Airlines
Sat 5/248:24 pmSAV - DSM
1 stop4h 34mAmerican Airlines
Deal found 4/16$284
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/77:01 amDSM - CHS
1 stop6h 15mDelta
Sat 5/176:37 amCHS - DSM
2 stops6h 50mDelta
Deal found 4/15$289
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/204:26 pmDSM - MYR
1 stop6h 36mAmerican Airlines
Sat 9/278:04 pmMYR - DSM
1 stop4h 39mAmerican Airlines
Deal found 4/17$297
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/316:35 pmDSM - SAV
1 stop4h 06mDelta
Sat 6/75:30 amSAV - DSM
1 stop6h 11mDelta
Deal found 4/16$297
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/33:38 pmDSM - CHS
1 stop4h 54mUnited Airlines
Fri 6/66:30 amCHS - DSM
1 stop4h 50mUnited Airlines
Deal found 4/17$303

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 5/9

6:13 pm-10:05 am

1 stop14h 52m

Charlotte Douglas

Sat 5/10

12:42 pm-2:04 pm

Nonstop2h 22m

$226

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 5/1

7:25 am-4:32 pm

1 stop8h 07m

Columbia Metropolitan

Mon 5/5

8:45 pm-11:58 pm

1 stop4h 13m

$259

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 5/16

8:30 am-7:57 pm

1 stop10h 27m

Charlotte Douglas

Sun 5/18

9:02 pm-3:53 pm

1 stop19h 51m

$270

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 5/7

5:35 am-12:23 pm

1 stop5h 48m

Myrtle Beach Intl

Sat 5/10

3:10 pm-9:06 pm

1 stop6h 56m

$271

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 5/12

1:31 pm-7:53 pm

1 stop5h 22m

Myrtle Beach Intl

Fri 5/16

8:21 pm-9:20 pm

2 stops25h 59m

$275

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 5/17

2:01 pm-7:54 pm

1 stop4h 53m

Savannah/Hilton Head

Sat 5/24

8:24 pm-11:58 pm

1 stop4h 34m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 6/3

2:01 pm-10:04 pm

1 stop7h 03m

Charleston

Thu 6/5

7:04 pm-12:06 am

1 stop6h 02m

$287

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 5/31

6:35 pm-11:44 pm

1 stop4h 09m

Charleston

Sat 6/7

11:55 am-5:03 pm

1 stop6h 08m

$297

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 5/31

6:35 pm-11:41 pm

1 stop4h 06m

Savannah/Hilton Head

Sat 6/7

5:30 am-10:41 am

1 stop6h 11m

$297

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 9/20

4:26 pm-12:02 am

1 stop6h 36m

Myrtle Beach Intl

Sat 9/27

8:04 pm-11:43 pm

1 stop4h 39m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 39 results
1
2
3
4

Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 17, 2025.
Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,916 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
733 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $136. Users have also found prices from $136 and $148 on American Airlines and Allegiant Air, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Seattle flights
Des Moines to Denver flights
Cedar Rapids to Denver flights
Omaha to O'Hare Intl flights
Omaha to Dallas/Fort Worth flights
Omaha to Orlando flights
Cedar Rapids to Dallas/Fort Worth flights
Des Moines to Seattle flights
Cedar Rapids to Seattle flights
Omaha to Las Vegas flights
Omaha to Sky Harbor Intl flights
Omaha to Denver flights
Des Moines to Dallas/Fort Worth flights
Des Moines to LaGuardia flights
Omaha to John F Kennedy Intl flights
Cedar Rapids to Sky Harbor Intl flights
Des Moines to Sky Harbor Intl flights
Des Moines to Orlando flights
Moline to Denver flights
Des Moines to John F Kennedy Intl flights
Omaha to Atlanta flights
Omaha to LaGuardia flights
Des Moines to O'Hare Intl flights
Moline to Dallas/Fort Worth flights
Omaha to Los Angeles flights
Omaha to Newark flights
Cedar Rapids to Orlando flights
Omaha to San Diego flights
Des Moines to Las Vegas flights
Omaha to Hobby flights
Omaha to Miami flights
Omaha to Salt Lake City flights
Des Moines to Reagan-National flights
Des Moines to Dulles Intl flights
Omaha to Boston flights
Omaha to San Francisco flights
Omaha to Reagan-National flights
Des Moines to Atlanta flights
Moline to Orlando flights
Omaha to Dulles Intl flights
Omaha to George Bush Intcntl flights
Cedar Rapids to Las Vegas flights
Des Moines to Salt Lake City flights
Cedar Rapids to Reagan-National flights
Omaha to Nashville flights
Des Moines to Hobby flights
Des Moines to George Bush Intcntl flights
Cedar Rapids to Miami flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to San Francisco flights

Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$471FlexibilityNo cancel feeOn-time69%
DeltaCheapest$248Average$387FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$399FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$376Average$447FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.