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South Carolina

$60+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jan 6 — Jan 131
Mon 1/6
Mon 1/13
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to South Carolina (USSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 1, 2025.

Round-trip from

$224
(Mytrip)

One-way from

$60
(Frontier)
From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 1, 2025.

This Mytrip deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/147:17 pmDSM - CLT
1 stop10h 51mFrontier
Fri 2/218:08 amCLT - DSM
1 stop11h 09mFrontier
Deal found 12/31$224
This Mytrip deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/317:00 amDSM - SAV
1 stop14h 48mAllegiant Air
Sun 2/26:30 amSAV - DSM
1 stop8h 49mAllegiant Air
Deal found 12/31$230
This Mytrip deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/29:03 amDSM - CHS
2 stops12h 55mMultiple Airlines
Thu 2/67:15 amCHS - DSM
1 stop9h 35mMultiple Airlines
Deal found 12/31$233
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/152:06 pmDSM - CAE
1 stop7h 15mAmerican Airlines
Sat 2/227:35 amCAE - DSM
1 stop5h 45mAmerican Airlines
Deal found 12/31$248
This Delta deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/136:26 pmDSM - CAE
1 stop4h 13mDelta
Thu 2/206:50 amCAE - DSM
1 stop4h 50mDelta
Deal found 12/31$250
This Delta deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/225:33 amDSM - CLT
1 stop4h 36mDelta
Wed 1/294:59 pmCLT - DSM
1 stop5h 01mDelta
Deal found 12/30$278
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/182:06 pmDSM - CLT
Nonstop2h 20mAmerican Airlines
Tue 1/218:29 pmCLT - DSM
Nonstop2h 36mAmerican Airlines
Deal found 12/31$283
This Mytrip deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/173:29 pmDSM - CLT
2 stops22h 44mMultiple Airlines
Mon 2/247:17 amCLT - DSM
3 stops17h 14mMultiple Airlines
Deal found 12/30$296
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/155:55 amDSM - CHS
1 stop6h 40mAmerican Airlines
Sat 1/185:50 amCHS - DSM
1 stop7h 21mAmerican Airlines
Deal found 12/30$301
This Delta deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/126:30 amDSM - MYR
1 stop4h 41mDelta
Sat 2/1512:56 pmMYR - DSM
1 stop5h 16mDelta
Deal found 12/31$303
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/306:17 amDSM - HHH
1 stop7h 01mAmerican Airlines
Sun 2/96:05 pmHHH - DSM
1 stop5h 00mAmerican Airlines
Deal found 12/31$304
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/158:00 amDSM - CHS
1 stop5h 00mUnited Airlines
Sat 1/1810:00 amCHS - DSM
2 stops11h 32mUnited Airlines
Deal found 12/30$306

Find flights from Des Moines to South Carolina within your budget

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 1, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 2/14

7:17 pm-7:08 am

1 stop10h 51m

Charlotte Douglas

Fri 2/21

8:08 am-6:17 pm

1 stop11h 09m

$224

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Fri 1/31

7:00 am-10:48 pm

1 stop14h 48m

Savannah/Hilton Head

Sun 2/2

6:30 am-2:19 pm

1 stop8h 49m

$230

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 2/2

9:03 am-10:58 pm

2 stops12h 55m

Charleston

Thu 2/6

7:15 am-3:50 pm

1 stop9h 35m

$233

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 2/15

2:06 pm-10:21 pm

1 stop7h 15m

Columbia Metropolitan

Sat 2/22

7:35 am-12:20 pm

1 stop5h 45m

$248

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 2/13

6:26 pm-11:39 pm

1 stop4h 13m

Columbia Metropolitan

Thu 2/20

6:50 am-10:40 am

1 stop4h 50m

$250

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 1/22

5:33 am-11:09 am

1 stop4h 36m

Charlotte Douglas

Wed 1/29

4:59 pm-9:00 pm

1 stop5h 01m

$278

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 1/18

2:06 pm-5:26 pm

Nonstop2h 20m

Charlotte Douglas

Tue 1/21

8:29 pm-10:05 pm

Nonstop2h 36m

$283

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 2/17

3:29 pm-3:13 pm

2 stops22h 44m

Charlotte Douglas

Mon 2/24

7:17 am-11:31 pm

3 stops17h 14m

$296

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 1/15

5:55 am-1:35 pm

1 stop6h 40m

Charleston

Sat 1/18

5:50 am-12:11 pm

1 stop7h 21m

$301

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 2/12

6:30 am-12:11 pm

1 stop4h 41m

Myrtle Beach Intl

Sat 2/15

12:56 pm-5:12 pm

1 stop5h 16m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/31

Showing 1-10 of 40 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to South Carolina

Get recent, data-driven insights about flights from Des Moines to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 1, 2025.
Get a feel of what it's like to fly with Delta, American Airlines and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,699 reviews
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,537 reviews
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,973 reviews
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Allegiant Air
7.4
Good
806 reviews
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,699 reviews

Comfort

8.1

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $60. Users have also found prices from $169 and $178 on American Airlines and Delta, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Savannah/Hilton Head or Des Moines - Charleston as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to South Carolina

Discover the top 3 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$215Average$391FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$244Average$405FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$247Average$423FlexibilityNo cancel feeOn-time69%
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