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$81+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Feb 27 — Mar 61
Thu 2/27
Thu 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated February 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$243
(Frontier)

One-way from

$81
(Frontier)

Popular in

December

Cheapest in

September

Average price

$366
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2025.

This Frontier deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/287:17 pmDSM - CLT
1 stop10h 51mFrontier
Mon 3/38:08 amCLT - DSM
1 stop11h 06mFrontier
Deal found 2/20$243
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/113:23 pmDSM - CLT
1 stop4h 12mAmerican Airlines
Fri 3/148:30 pmCLT - DSM
Nonstop2h 34mAmerican Airlines
Deal found 2/21$253
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/16:20 amDSM - CHS
1 stop5h 00mDelta
Tue 4/152:05 pmCHS - DSM
1 stop6h 09mDelta
Deal found 2/21$257
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/175:59 pmDSM - CLT
1 stop4h 35mDelta
Mon 3/245:21 pmCLT - DSM
1 stop4h 59mDelta
Deal found 2/21$263
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/77:30 amDSM - CLT
1 stop16h 02mMultiple Airlines
Mon 4/147:00 amCLT - DSM
1 stop8h 00mMultiple Airlines
Deal found 2/21$266
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/262:07 pmDSM - CHS
1 stop4h 25mAmerican Airlines
Sat 3/296:53 amCHS - DSM
1 stop6h 12mAmerican Airlines
Deal found 2/21$277
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/76:26 pmDSM - SAV
1 stop4h 31mDelta
Mon 3/106:54 pmSAV - DSM
1 stop5h 02mDelta
Deal found 2/21$277
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/83:34 pmDSM - SAV
1 stop4h 30mUnited Airlines
Wed 3/127:15 amSAV - DSM
2 stops11h 41mUnited Airlines
Deal found 2/21$282
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2912:30 pmDSM - GSP
1 stop4h 03mDelta
Sat 4/57:00 amGSP - DSM
1 stop4h 37mDelta
Deal found 2/21$297
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/116:30 pmDSM - MYR
1 stop4h 19mDelta
Mon 3/176:46 pmMYR - DSM
1 stop5h 10mDelta
Deal found 2/20$297
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/292:07 pmDSM - GSP
1 stop6h 12mAmerican Airlines
Sat 4/55:28 amGSP - DSM
2 stops6h 53mAmerican Airlines
Deal found 2/21$302
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:40 amDSM - MYR
2 stops8h 53mAmerican Airlines
Sat 5/175:00 amMYR - DSM
2 stops7h 13mAmerican Airlines
Deal found 2/21$307

Find flights from Des Moines to South Carolina within your budget

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 3/22

2:07 pm-5:30 pm

Nonstop2h 23m

Charlotte Douglas

Sat 3/29

9:25 pm-10:56 pm

Nonstop2h 31m

$243

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 4/1

6:20 am-12:20 pm

1 stop5h 00m

Charleston

Tue 4/15

2:05 pm-7:14 pm

1 stop6h 09m

$257

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 3/17

5:59 pm-11:34 pm

1 stop4h 35m

Charlotte Douglas

Mon 3/24

5:21 pm-9:20 pm

1 stop4h 59m

$263

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 4/7

7:30 am-12:32 am

1 stop16h 02m

Charlotte Douglas

Mon 4/14

7:00 am-2:00 pm

1 stop8h 00m

$266

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 3/26

2:07 pm-7:32 pm

1 stop4h 25m

Charleston

Sat 3/29

6:53 am-12:05 pm

1 stop6h 12m

$277

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Fri 3/7

6:26 pm-11:57 pm

1 stop4h 31m

Savannah/Hilton Head

Mon 3/10

6:54 pm-10:56 pm

1 stop5h 02m

$277

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 3/8

3:34 pm-9:04 pm

1 stop4h 30m

Savannah/Hilton Head

Wed 3/12

7:15 am-5:56 pm

2 stops11h 41m

$282

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 3/29

12:30 pm-5:33 pm

1 stop4h 03m

Greenville

Sat 4/5

7:00 am-10:37 am

1 stop4h 37m

$297

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 3/11

6:30 pm-11:49 pm

1 stop4h 19m

Myrtle Beach Intl

Mon 3/17

6:46 pm-10:56 pm

1 stop5h 10m

$297

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 3/29

2:07 pm-9:19 pm

1 stop6h 12m

Greenville

Sat 4/5

5:28 am-11:21 am

2 stops6h 53m

$302

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 42 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to South Carolina

Get recent, data-driven insights about flights from Des Moines to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 22, 2025.
Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,395 reviews
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,212 reviews
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,759 reviews
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Frontier
6.0
Okay
3,352 reviews
Southwest
8.1
Very good
4,395 reviews

Comfort

8.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $81. Users have also found prices from $122 and $132 on American Airlines and Delta, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Savannah/Hilton Head or Des Moines - Charleston as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Love Field flights

Top 3 airlines flying from Des Moines to South Carolina

Discover the top 3 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$387FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$247Average$393FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$424FlexibilityNo cancel feeOn-time69%
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