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South Carolina

$117+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$220
(CheapOair)

One-way from

$117
(Mytrip)

Popular in

December

Cheapest in

September

Average price

$401
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/118:17 pmDSM - CLT
1 stop21h 40mFrontier
Sun 4/1310:20 pmCLT - DSM
1 stop21h 59mFrontier
Deal found 3/27$220
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:28 pmDSM - SAV
1 stop7h 45mAllegiant Air
Mon 5/512:34 pmSAV - DSM
1 stop10h 24mAllegiant Air
Deal found 3/27$229
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/106:45 amDSM - CAE
1 stop6h 22mAmerican Airlines
Sat 5/178:45 pmCAE - DSM
1 stop4h 13mAmerican Airlines
Deal found 3/26$249
This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/194:43 pmDSM - CLT
2 stops22h 08mMultiple Airlines
Thu 5/2211:58 amCLT - DSM
1 stop25h 48mMultiple Airlines
Deal found 3/26$261
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/132:01 pmDSM - CLT
Nonstop2h 22mAmerican Airlines
Wed 5/2812:04 pmCLT - DSM
Nonstop2h 24mAmerican Airlines
Deal found 3/26$284
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/116:30 amDSM - CAE
2 stops7h 28mDelta
Sun 5/185:44 amCAE - DSM
2 stops7h 43mDelta
Deal found 3/27$289
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/236:45 amDSM - CHS
1 stop6h 03mAmerican Airlines
Tue 4/296:28 amCHS - DSM
1 stop6h 27mAmerican Airlines
Deal found 3/27$297
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/106:30 amDSM - GSP
1 stop4h 16mDelta
Sat 5/1712:30 pmGSP - DSM
1 stop5h 33mDelta
Deal found 3/27$297
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/106:10 amDSM - MYR
1 stop5h 22mAmerican Airlines
Wed 6/185:03 pmMYR - DSM
1 stop7h 49mAmerican Airlines
Deal found 3/27$297
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/195:45 amDSM - SAV
1 stop6h 51mDelta
Tue 4/227:00 amSAV - DSM
1 stop7h 24mDelta
Deal found 3/27$297
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/117:07 amDSM - HHH
1 stop6h 08mAmerican Airlines
Wed 7/165:50 pmHHH - DSM
1 stop6h 11mAmerican Airlines
Deal found 3/27$299
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/117:36 pmDSM - MYR
2 stops23h 17mMultiple Airlines
Sun 5/185:32 pmMYR - DSM
1 stop23h 21mMultiple Airlines
Deal found 3/27$300

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 4/11

8:17 pm-6:57 pm

1 stop21h 40m

Charlotte Douglas

Sun 4/13

10:20 pm-7:19 pm

1 stop21h 59m

$220

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Fri 5/2

2:28 pm-11:13 pm

1 stop7h 45m

Savannah/Hilton Head

Mon 5/5

12:34 pm-9:58 pm

1 stop10h 24m

$229

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 5/10

6:45 am-2:07 pm

1 stop6h 22m

Columbia Metropolitan

Sat 5/17

8:45 pm-11:58 pm

1 stop4h 13m

$249

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 5/19

4:43 pm-3:51 pm

2 stops22h 08m

Charlotte Douglas

Thu 5/22

11:58 am-12:46 pm

1 stop25h 48m

$261

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 5/13

2:01 pm-5:23 pm

Nonstop2h 22m

Charlotte Douglas

Wed 5/28

12:04 pm-1:28 pm

Nonstop2h 24m

$284

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sun 5/11

6:30 am-2:58 pm

2 stops7h 28m

Columbia Metropolitan

Sun 5/18

5:44 am-12:27 pm

2 stops7h 43m

$289

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 5/10

6:30 am-11:46 am

1 stop4h 16m

Greenville

Sat 5/17

12:30 pm-5:03 pm

1 stop5h 33m

$297

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 4/23

6:45 am-1:48 pm

1 stop6h 03m

Charleston

Tue 4/29

6:28 am-11:55 am

1 stop6h 27m

$297

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 4/19

5:45 am-1:36 pm

1 stop6h 51m

Savannah/Hilton Head

Tue 4/22

7:00 am-1:24 pm

1 stop7h 24m

$297

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/10

6:10 am-12:32 pm

1 stop5h 22m

Myrtle Beach Intl

Wed 6/18

5:03 pm-11:52 pm

1 stop7h 49m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 46 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 28, 2025.
Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.1
Very good
4,274 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,897 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,603 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
731 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Entertainment

7.6

Overall

8.1

Crew

8.7

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $126. Users have also found prices from $149 and $154 on Delta and American Airlines, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Los Angeles flights
Omaha to O'Hare Intl flights
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Omaha to San Francisco flights
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Omaha to Salt Lake City flights
Des Moines to Dallas/Fort Worth flights
Omaha to Miami flights
Moline to Denver flights
Omaha to John F Kennedy Intl flights
Omaha to LaGuardia flights
Des Moines to Hobby flights
Des Moines to Dulles Intl flights
Des Moines to O'Hare Intl flights
Des Moines to Reagan-National flights
Omaha to Sky Harbor Intl flights
Omaha to Atlanta flights
Des Moines to Atlanta flights
Omaha to George Bush Intcntl flights
Omaha to Reagan-National flights
Omaha to San Diego flights
Omaha to Newark flights
Omaha to Love Field flights
Moline to Orlando flights
Omaha to Philadelphia flights
Des Moines to San Francisco flights
Omaha to Nashville flights
Des Moines to Newark flights
Omaha to Boston flights
Des Moines to George Bush Intcntl flights
Cedar Rapids to Reagan-National flights
Moline to Dallas/Fort Worth flights
Des Moines to Los Angeles flights
Des Moines to Baltimore flights

Top 3 airlines flying from Des Moines to South Carolina

Discover the top 3 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$392FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$424FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$400FlexibilityNo cancel feeOn-time71%
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