HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$46+ Cheap flights from Chicago (CHI) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Feb 27 — Mar 61
Thu 2/27
Thu 3/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Chicago to South Carolina with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Chicago to South Carolina

Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated February 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$95
(Cheapflightsfares)

One-way from

$46
(FlightHub)

Popular in

November

Cheapest in

September

Average price

$382

Good round-trip deal

$269 or less

Good one-way deal

$88 or less
Provider with most accurate pricing for Chicago (CHI)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago (CHI)-Myrtle Beach Intl flights.
Search Deals
From Chicago (CHI) to South Carolina
Search Deals
One-way flight from Chicago (CHI) to South Carolina
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2025
Search Deals
Price to beat on a round-trip flight from Chicago (CHI) to South Carolina.
Search Deals
Price to beat on a one-way flight from Chicago (CHI) to South Carolina.
Search Deals

Find flight deals from Chicago to South Carolina

Cheapest flights from Chicago to South Carolina
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:00 amORD - CLT
Nonstop2h 12mFrontier
Thu 5/2210:26 amCLT - ORD
Nonstop2h 02mFrontier
Deal found 2/21$95
This CheapOair deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/47:10 amORD - CLT
1 stop7h 03mMultiple Airlines
Thu 3/68:41 pmCLT - ORD
Nonstop2h 21mMultiple Airlines
Deal found 2/21$100
This Frontier deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/159:51 amMDW - CLT
1 stop10h 55mFrontier
Sun 5/185:22 pmCLT - MDW
1 stop6h 18mFrontier
Deal found 2/21$101
This Priceline deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/16:45 amORD - CLT
1 stop9h 17mSpirit Airlines
Tue 4/87:00 amCLT - ORD
1 stop9h 10mSpirit Airlines
Deal found 2/21$102
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/138:35 pmMDW - CLT
Nonstop1h 50mSouthwest
Mon 3/176:20 amCLT - MDW
Nonstop2h 00mSouthwest
Deal found 2/22$177
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/12:41 pmORD - CLT
Nonstop2h 11mUnited Airlines
Tue 4/810:43 amCLT - ORD
Nonstop2h 15mUnited Airlines
Deal found 2/21$177
This Cheapflightsfares deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/58:45 amORD - MYR
1 stop6h 49mSpirit Airlines
Thu 5/1511:05 amMYR - ORD
1 stop5h 37mSpirit Airlines
Deal found 2/21$178
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/710:28 amORD - CLT
Nonstop2h 05mAmerican Airlines
Mon 4/146:19 pmCLT - ORD
Nonstop2h 10mAmerican Airlines
Deal found 2/21$178
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:30 amORD - MYR
1 stop4h 07mDelta
Wed 5/1412:45 pmMYR - ORD
1 stop7h 39mDelta
Deal found 2/20$197
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/114:59 pmMDW - CLT
1 stop4h 01mDelta
Wed 3/199:40 amCLT - MDW
1 stop3h 56mDelta
Deal found 2/21$197
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/105:00 pmORD - CLT
1 stop5h 14mDelta
Wed 3/199:40 amCLT - ORD
1 stop4h 01mDelta
Deal found 2/21$197
This Cheapflightsfares deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/248:40 amMDW - SAV
Nonstop2h 05mAllegiant Air
Fri 4/46:30 amSAV - MDW
Nonstop2h 15mAllegiant Air
Deal found 2/21$199

Find flights from Chicago to South Carolina within your budget

Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.

Fly from

Chicago

Fly to

South Carolina

Route

Depart

Return

Price

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 5/15

8:00 am-11:12 am

Nonstop2h 12m

Charlotte Douglas

Thu 5/22

10:26 am-11:28 am

Nonstop2h 02m

$95

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 3/4

7:10 am-3:13 pm

1 stop7h 03m

Charlotte Douglas

Thu 3/6

8:41 pm-10:02 pm

Nonstop2h 21m

$100

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Thu 5/15

9:51 am-9:46 pm

1 stop10h 55m

Charlotte Douglas

Sun 5/18

5:22 pm-10:40 pm

1 stop6h 18m

$101

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 4/1

6:45 am-5:02 pm

1 stop9h 17m

Charlotte Douglas

Tue 4/8

7:00 am-3:10 pm

1 stop9h 10m

$102

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Thu 3/13

8:35 pm-11:25 pm

Nonstop1h 50m

Charlotte Douglas

Mon 3/17

6:20 am-7:20 am

Nonstop2h 00m

$177

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 4/1

2:41 pm-5:52 pm

Nonstop2h 11m

Charlotte Douglas

Tue 4/8

10:43 am-11:58 am

Nonstop2h 15m

$177

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Mon 4/7

10:28 am-1:33 pm

Nonstop2h 05m

Charlotte Douglas

Mon 4/14

6:19 pm-7:29 pm

Nonstop2h 10m

$178

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Mon 5/5

8:45 am-4:34 pm

1 stop6h 49m

Myrtle Beach Intl

Thu 5/15

11:05 am-3:42 pm

1 stop5h 37m

$178

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Tue 5/6

5:30 am-10:37 am

1 stop4h 07m

Myrtle Beach Intl

Wed 5/14

12:45 pm-7:24 pm

1 stop7h 39m

$197

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Tue 3/11

4:59 pm-10:00 pm

1 stop4h 01m

Charlotte Douglas

Tue 3/18

6:00 am-9:09 am

1 stop4h 09m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Chicago to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Chicago to South Carolina

Get recent, data-driven insights about flights from Chicago to South Carolina including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Chicago to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $217). Flying from Chicago to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHI to SC?

Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2025.

When flying from Chicago to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Chicago to South Carolina

Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 22, 2025.

The most flights from CHI to USSC are scheduled on a Thursday (20 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (8 on average).

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 22, 2025.
Get a feel of what it's like to fly with Southwest, Alaska Airlines and Delta from Chicago to South Carolina by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,395 reviews
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,700 reviews
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,203 reviews
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

JetBlue
7.4
Good
3,068 reviews
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,754 reviews
Southwest
8.1
Very good
4,395 reviews

Crew

8.7

Comfort

8.1

Overall

8.1

Food

7.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Chicago to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $46. Users have also found prices from $49 and $68 on Allegiant Air and Frontier, respectively.

  • What are the most popular routes from Chicago to South Carolina?

    When deciding which route to take from Chicago to South Carolina consider Chicago O'Hare Intl - Charleston, Chicago O'Hare Intl - Charlotte Douglas or Chicago O'Hare Intl - Savannah/Hilton Head as they are the most popular.

  • What are the most reliable airlines from Chicago to South Carolina?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Chicago to South Carolina on time: Air Canada (85%), Air New Zealand (85%), ANA (85%).

  • What are the cheapest flights from Chicago to South Carolina?

    On average you can expect to pay $363 for a flight from Chicago to South Carolina. The cheapest flight overall is $139 while the most popular route, (Chicago O'Hare Intl - Charleston) is currently priced at $120.

  • Can I find deals for flights from Chicago to South Carolina that include hotel bookings?

    Yes. In addition to deals on Chicago to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to South Carolina.

  • Can I find deals for business class flights from Chicago to South Carolina?

    Yes. Cheapflights offers flight deals from Chicago to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $217). Flying from Chicago to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Chicago to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to Miami flights
O'Hare Intl to Sky Harbor Intl flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Seattle flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Orlando flights
O'Hare Intl to Tampa flights
Midway to Las Vegas flights
O'Hare Intl to Denver flights
O'Hare Intl to San Francisco flights
O'Hare Intl to Newark flights
O'Hare Intl to New Orleans flights
O'Hare Intl to Dulles Intl flights
O'Hare Intl to Boston flights
O'Hare Intl to San Diego flights
O'Hare Intl to Reagan-National flights
O'Hare Intl to Fort Myers flights
O'Hare Intl to Honolulu flights
O'Hare Intl to Baltimore flights
Midway to Los Angeles flights
O'Hare Intl to Nashville flights
O'Hare Intl to Atlanta flights
O'Hare Intl to Santa Ana flights
O'Hare Intl to Austin flights
Midway to Newark flights
Midway to Dallas/Fort Worth flights
Midway to Miami flights
O'Hare Intl to Salt Lake City flights
O'Hare Intl to George Bush Intcntl flights
O'Hare Intl to Hobby flights
O'Hare Intl to Philadelphia flights
St. Louis to Seattle flights
O'Hare Intl to West Palm Beach flights
Midway to Hobby flights
O'Hare Intl to Ontario flights
Midway to Sky Harbor Intl flights
O'Hare Intl to Burbank flights
Midway to LaGuardia flights
O'Hare Intl to Charleston flights
St. Louis to Las Vegas flights
Midway to John F Kennedy Intl flights
O'Hare Intl to Portland flights
O'Hare Intl to Love Field flights
Midway to Orlando flights
Midway to New Orleans flights
O'Hare Intl to Charlotte flights

Top 5 airlines flying from Chicago to South Carolina

Discover the top 5 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$79Average$169FlexibilityNo cancel feeOn-time65%
DeltaCheapest$133Average$388FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$179Average$406FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$372FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$236Average$393FlexibilityNo cancel feeOn-time63%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.