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South Carolina

$79+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Apr 21 — Apr 281
Mon 4/21
Mon 4/28
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated April 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$160
(Frontier)

One-way from

$79
(Cheapflightsfares)

Popular in

April

Cheapest in

September

Average price

$418
Provider with most accurate pricing for Buffalo-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Myrtle Beach Intl flights.
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From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 16, 2025.

This Frontier deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/99:51 amBUF - CLT
1 stop5h 40mFrontier
Sun 5/1110:36 pmCLT - BUF
1 stop10h 25mFrontier
Deal found 4/15$160
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/71:36 pmBUF - CLT
1 stop7h 49mAmerican Airlines
Sat 6/710:45 pmCLT - BUF
Nonstop1h 53mAmerican Airlines
Deal found 4/15$197
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/247:11 pmBUF - GSP
1 stop4h 35mAmerican Airlines
Sat 5/316:36 pmGSP - BUF
1 stop5h 38mAmerican Airlines
Deal found 4/15$217
This JetBlue deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/910:33 amBUF - CHS
1 stop7h 30mJetBlue
Thu 6/1211:00 amCHS - BUF
1 stop8h 30mJetBlue
Deal found 4/15$223
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/185:30 amBUF - CAE
1 stop5h 15mAmerican Airlines
Wed 5/216:09 pmCAE - BUF
1 stop4h 42mAmerican Airlines
Deal found 4/15$227
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/612:05 pmBUF - CAE
1 stop4h 54mDelta
Sun 6/811:18 amCAE - BUF
1 stop7h 11mDelta
Deal found 4/15$228
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/103:55 pmBUF - SAV
1 stop6h 35mDelta
Sat 5/175:30 amSAV - BUF
1 stop5h 43mDelta
Deal found 4/14$229
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:17 amBUF - HHH
1 stop4h 58mAmerican Airlines
Wed 5/216:20 pmHHH - BUF
1 stop5h 54mAmerican Airlines
Deal found 4/16$229
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/105:46 pmBUF - SAV
2 stops6h 10mAmerican Airlines
Sat 5/178:24 pmSAV - BUF
1 stop3h 50mAmerican Airlines
Deal found 4/14$234
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:05 amBUF - HHH
2 stops9h 15mDelta
Wed 5/214:00 pmHHH - BUF
1 stop7h 13mDelta
Deal found 4/16$234
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/217:11 pmBUF - CHS
1 stop5h 04mAmerican Airlines
Sun 5/258:43 pmCHS - BUF
1 stop3h 31mAmerican Airlines
Deal found 4/15$235
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/202:55 pmBUF - GSP
1 stop5h 15mSouthwest
Sat 5/246:35 pmGSP - BUF
1 stop4h 35mSouthwest
Deal found 4/15$237

Cheapflights Fare Finder

Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 16, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Fri 5/9

9:51 am-3:31 pm

1 stop5h 40m

Charlotte Douglas

Sun 5/11

10:36 pm-9:01 am

1 stop10h 25m

$160

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Sat 6/7

1:36 pm-9:25 pm

1 stop7h 49m

Charlotte Douglas

Sat 6/7

10:45 pm-12:38 am

Nonstop1h 53m

$197

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Sat 5/24

7:11 pm-11:46 pm

1 stop4h 35m

Greenville

Sat 5/31

8:35 pm-12:14 am

1 stop3h 39m

$217

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 6/9

10:33 am-6:03 pm

1 stop7h 30m

Charleston

Thu 6/12

11:00 am-7:30 pm

1 stop8h 30m

$223

BuffaloColumbia

BUF - CAE

BUFCAE

Buffalo

Sun 5/18

5:30 am-10:45 am

1 stop5h 15m

Columbia Metropolitan

Wed 5/21

6:09 pm-10:51 pm

1 stop4h 42m

$227

BuffaloColumbia

BUF - CAE

BUFCAE

Buffalo

Fri 6/6

12:05 pm-4:59 pm

1 stop4h 54m

Columbia Metropolitan

Sun 6/8

11:18 am-6:29 pm

1 stop7h 11m

$228

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 5/10

3:55 pm-10:30 pm

1 stop6h 35m

Savannah/Hilton Head

Sat 5/17

5:30 am-11:13 am

1 stop5h 43m

$229

BuffaloHilton Head Island

BUF - HHH

BUFHHH

Buffalo

Wed 5/14

5:17 am-10:15 am

1 stop4h 58m

Hilton Head Island

Wed 5/21

6:20 pm-12:14 am

1 stop5h 54m

$229

BuffaloHilton Head Island

BUF - HHH

BUFHHH

Buffalo

Wed 5/14

6:05 am-3:20 pm

2 stops9h 15m

Hilton Head Island

Wed 5/21

4:00 pm-11:13 pm

1 stop7h 13m

$234

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 5/10

5:46 pm-11:56 pm

2 stops6h 10m

Savannah/Hilton Head

Sat 5/17

8:24 pm-12:14 am

1 stop3h 50m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 57 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Buffalo to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 16, 2025.
Read through reviews of airlines operating flights from Buffalo to South Carolina, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,282 reviews
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,916 reviews
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,665 reviews
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
JetBlue
7.3
Good
2,926 reviews
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,282 reviews

Food

7.1

Overall

8.0

Crew

8.6

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are Frontier ($79), American Airlines ($114), and Delta ($115).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Charleston or Buffalo - Myrtle Beach Intl, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$191Average$273FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$196Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$317FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$218Average$412FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$234Average$381FlexibilityNo cancel feeOn-time69%

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