What are the cheapest airlines to fly from Saint Paul to South America one-way?

The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $293. However, be on the lookout for offers from American Airlines and Avianca, as they are both options that can get you from Saint Paul to South America for a low price.

What are the most popular routes from Saint Paul to South America?

Most travelers choose Minneapolis St Paul - Lima J Chavez Intl, Minneapolis St Paul - Rio de Janeiro Santos Dumont or Minneapolis St Paul - Rio de Janeiro–Galeão Intl when deciding on the best route from Saint Paul to South America.

What are the most popular airlines that fly from Saint Paul to South America?

Before booking your flight from Saint Paul to South America check out the most popular airlines for this route: American Airlines, Avianca or Delta.

What is the cheapest month to fly from Saint Paul to South America?

Flights from Saint Paul to South America lean towards being more expensive in December. Prices are generally better when you fly from Saint Paul to South America in November, with the cheapest ticket starting at $1,020.

Can I find deals for flights from Saint Paul to South America that include hotel bookings?

Yes. In addition to deals on Saint Paul to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Saint Paul to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Saint Paul to South America.

Can I find deals for business class flights from Saint Paul to South America?

Yes. Cheapflights offers flight deals from Saint Paul to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$665+ Flights from Saint Paul to South America

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Cheap flight deals from Saint Paul to South America

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$441 (Mytrip)
One-way from	$227 (Kiwi.com)
Popular in	December
Cheapest in	November
Average price	$1,261

Provider with most accurate pricing for Minneapolis St Paul-Sao Paulo (SAO) flight deals.

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Provider most trusted by Cheapflights users for Minneapolis St Paul-Sao Paulo (SAO) flights.

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From Saint Paul to South America

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One-way flight from Saint Paul to South America

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High demand for flights, 1% potential price rise

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Cheapest flight prices on average. 1% potential price decrease ($23 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Saint Paul to South America

Cheapest flights from Saint Paul to South America
Explore the most affordable flight options available from Saint Paul to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Fri 5/92:42 pmMSP - MDE

1 stop22h 16mMultiple Airlines

Fri 5/161:53 pmMDE - MSP

1 stop24h 37mMultiple Airlines

Deal found 4/16

$441

Sun 5/112:30 pmMSP - MDE

2 stops22h 28mSpirit Airlines

Sat 5/172:13 pmMDE - MSP

2 stops23h 15mSpirit Airlines

Deal found 4/16

$465

Wed 5/76:30 amMSP - UIO

2 stops29h 10mMultiple Airlines

Mon 5/127:09 amUIO - MSP

2 stops15h 31mMultiple Airlines

Deal found 4/16

$585

Tue 9/2310:01 amMSP - LIM

2 stops14h 34mMultiple Airlines

Tue 11/42:55 amLIM - MSP

2 stops13h 36mMultiple Airlines

Deal found 4/17

$597

Wed 10/226:32 pmMSP - GEO

2 stops28h 08mUnited Airlines

Thu 10/3012:30 amGEO - MSP

1 stop13h 22mUnited Airlines

Deal found 4/17

$613

Sun 8/316:46 amMSP - GEO

1 stop14h 24mAmerican Airlines

Thu 10/307:25 amGEO - MSP

1 stop17h 33mAmerican Airlines

Deal found 4/16

$623

Sun 8/316:32 pmMSP - MDE

2 stops26h 38mUnited Airlines

Sun 9/79:45 amMDE - MSP

2 stops37h 40mUnited Airlines

Deal found 4/16

$627

Sun 8/177:30 pmMSP - MDE

2 stops17h 10mAmerican Airlines

Wed 8/272:50 pmMDE - MSP

1 stop8h 58mAmerican Airlines

Deal found 4/17

$630

Thu 10/237:15 amMSP - MDE

2 stops32h 07mDelta

Sun 11/211:48 amMDE - MSP

2 stops13h 34mDelta

Deal found 4/17

$647

Thu 5/298:24 amMSP - GYE

3 stops32h 56mMultiple Airlines

Mon 6/1611:05 amGYE - MSP

2 stops30h 41mMultiple Airlines

Deal found 4/16

$669

Mon 5/266:48 amMSP - GEO

1 stop26h 52mMultiple Airlines

Tue 6/33:13 amGEO - MSP

2 stops19h 31mMultiple Airlines

Deal found 4/16

$703

Wed 10/17:15 amMSP - UIO

2 stops16h 05mLATAM Airlines

Wed 10/811:20 pmUIO - MSP

1 stop12h 23mLATAM Airlines

Deal found 4/17

$711

Best flights from Saint Paul to South America
Discover carefully curated flight deals from Saint Paul to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2025.

Fri 5/92:42 pmMSP - MDE

1 stop22h 16mMultiple Airlines

Fri 5/161:53 pmMDE - MSP

1 stop24h 37mMultiple Airlines

Deal found 4/16

$441

Sun 5/112:30 pmMSP - MDE

2 stops22h 28mSpirit Airlines

Sat 5/172:13 pmMDE - MSP

2 stops23h 15mSpirit Airlines

Deal found 4/16

$465

Mon 6/96:10 amMSP - GEO

2 stops16h 11mAmerican Airlines

Wed 6/257:00 amGEO - MSP

2 stops17h 59mAmerican Airlines

Deal found 4/17

$617

Sun 8/316:32 pmMSP - MDE

2 stops26h 38mUnited Airlines

Sun 9/79:45 amMDE - MSP

2 stops37h 40mUnited Airlines

Deal found 4/17

$627

Sun 6/156:26 pmMSP - MDE

2 stops19h 24mDelta

Tue 6/249:18 pmMDE - MSP

2 stops20h 16mDelta

Deal found 4/16

$678

Wed 10/17:15 amMSP - UIO

2 stops16h 05mLATAM Airlines

Wed 10/811:20 pmUIO - MSP

1 stop12h 23mLATAM Airlines

Deal found 4/17

$711

Thu 9/1810:01 amMSP - LIM

2 stops15h 44mAvianca

Fri 10/32:50 amLIM - MSP

2 stops14h 35mAvianca

Deal found 4/17

$742

Mon 8/48:00 amMSP - SCL

2 stops20h 04mCopa Airlines

Mon 8/1811:27 amSCL - MSP

2 stops24h 01mCopa Airlines

Deal found 4/17

$936

Fri 5/91:10 pmMSP - GIG

2 stops27h 55mAir Canada

Tue 5/203:55 pmGIG - MSP

2 stops29h 44mAir Canada

Deal found 4/17

$1,119

Wed 5/76:30 amMSP - UIO

2 stops29h 10mMultiple Airlines

Mon 5/127:09 amUIO - MSP

2 stops15h 31mMultiple Airlines

Deal found 4/16

$585

Sun 8/177:30 pmMSP - MDE

2 stops17h 10mAmerican Airlines

Wed 8/275:45 amMDE - MSP

1 stop18h 03mAmerican Airlines

Deal found 4/16

$630

Tue 9/2310:01 amMSP - LIM

2 stops14h 34mMultiple Airlines

Tue 11/42:55 amLIM - MSP

2 stops13h 36mMultiple Airlines

Deal found 4/17

$597

Last-minute flights from Saint Paul to South America
Discover last-minute flight deals from Saint Paul to South America. Data last updated April 17, 2025 and is based on user searches.

Thu 4/242:54 pmMSP - UIO

2 stops29h 06mMultiple Airlines

Thu 5/111:20 pmUIO - MSP

2 stops25h 13mMultiple Airlines

Deal found 4/15

$888

Thu 4/249:14 amMSP - UIO

1 stop9h 51mLATAM Airlines

Thu 5/111:20 pmUIO - MSP

1 stop11h 20mLATAM Airlines

Deal found 4/16

$1,057

Thu 4/246:33 amMSP - UIO

2 stops14h 23mAmerican Airlines

Thu 5/16:00 amUIO - MSP

2 stops18h 03mAmerican Airlines

Deal found 4/16

$1,094

Thu 4/2410:00 amMSP - UIO

2 stops14h 34mAvianca

Wed 4/302:30 amUIO - MSP

2 stops15h 04mAvianca

Deal found 4/16

$1,145

Thu 4/242:05 pmMSP - UIO

1 stop9h 20mUnited Airlines

Wed 4/3012:35 amUIO - MSP

1 stop22h 18mUnited Airlines

Deal found 4/16

$1,701

Fri 4/259:00 amMSP - GYE

3 stops22h 30mMultiple Airlines

Tue 4/298:50 amGYE - MSP

3 stops28h 50mMultiple Airlines

Deal found 4/16

$742

Sat 4/2611:38 amMSP - LIM

2 stops12h 57mMultiple Airlines

Tue 5/66:45 pmLIM - MSP

2 stops16h 02mMultiple Airlines

Deal found 4/16

$622

Sat 4/266:00 amMSP - LIM

1 stop14h 30mAmerican Airlines

Tue 5/66:30 amLIM - MSP

1 stop16h 16mAmerican Airlines

Deal found 4/17

$1,149

Sat 4/267:45 amMSP - LIM

1 stop15h 15mUnited Airlines

Fri 5/912:40 amLIM - MSP

1 stop15h 14mUnited Airlines

Deal found 4/17

$1,275

Wed 5/76:30 amMSP - UIO

2 stops29h 10mMultiple Airlines

Mon 5/127:09 amUIO - MSP

2 stops15h 31mMultiple Airlines

Deal found 4/16

$585

Fri 5/92:42 pmMSP - MDE

1 stop22h 16mMultiple Airlines

Fri 5/161:53 pmMDE - MSP

1 stop24h 37mMultiple Airlines

Deal found 4/16

$441

Fri 5/910:00 amMSP - GIG

2 stops30h 40mMultiple Airlines

Wed 5/1410:00 amGIG - MSP

2 stops32h 01mMultiple Airlines

Deal found 4/17

$849

One-way flights from Saint Paul to South America
Search for one-way flight options from Saint Paul to South America. Find affordable one-way fares based on user searches. Data last updated April 17, 2025.

Fri 4/256:00 amMSP - MDE

2 stops28h 35mMultiple Airlines

Deal found 4/15

$227

Wed 5/146:36 amMSP - UIO

2 stops15h 49mMultiple Airlines

Deal found 4/16

$228

Mon 6/25:54 amMSP - GYE

2 stops14h 31mMultiple Airlines

Deal found 4/17

$245

Thu 4/242:45 pmMSP - MDE

2 stops22h 30mSpirit Airlines

Deal found 4/15

$293

Wed 6/118:24 amMSP - LIM

2 stops33h 16mMultiple Airlines

Deal found 4/16

$300

Sat 5/177:42 amMSP - SCL

2 stops19h 53mMultiple Airlines

Deal found 4/15

$354

Tue 7/226:12 amMSP - UIO

1 stop18h 33mAmerican Airlines

Deal found 4/16

$408

Tue 5/2010:00 amMSP - GYE

2 stops22h 35mAvianca

Deal found 4/16

$453

Wed 5/1410:12 amMSP - UIO

1 stop9h 48mDelta

Deal found 4/16

$468

Sat 6/216:36 amMSP - EZE

3 stops36h 54mMultiple Airlines

Deal found 4/17

$472

Tue 4/228:00 amMSP - MDE

1 stop13h 10mUnited Airlines

Deal found 4/15

$520

Tue 5/610:00 amMSP - UIO

1 stop10h 00mLATAM Airlines

Deal found 4/16

$522

Cheapflights Fare Finder

Use the filters below to find and compare flights from Saint Paul to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MinneapolisMedellín

MSP - MDE

MSPMDE

Minneapolis St Paul

Fri 5/9

2:42 pm-12:58 pm

1 stop22h 16m

Medellín Jose Maria Cordova Intl

Fri 5/16

1:53 pm-2:30 pm

1 stop24h 37m

$441

MinneapolisMedellín

MSP - MDE

MSPMDE

Minneapolis St Paul

Sun 5/11

2:30 pm-12:58 pm

2 stops22h 28m

Medellín Jose Maria Cordova Intl

Sat 5/17

2:13 pm-1:28 pm

2 stops23h 15m

$465

MinneapolisQuito

MSP - UIO

MSPUIO

Minneapolis St Paul

Wed 5/7

6:30 am-11:40 am

2 stops29h 10m

Quito Mariscal Sucr

Mon 5/12

7:09 am-10:40 pm

2 stops15h 31m

$585

MinneapolisLima

MSP - LIM

MSPLIM

Minneapolis St Paul

Tue 9/23

10:01 am-12:35 am

2 stops14h 34m

Lima J Chavez Intl

Tue 11/4

2:55 am-3:31 pm

2 stops13h 36m

$597

MinneapolisGeorgetown

MSP - GEO

MSPGEO

Minneapolis St Paul

Mon 6/9

6:10 am-11:21 pm

1 stop16h 11m

Georgetown Cheddi Jagan Intl

Wed 6/25

7:00 am-11:59 pm

2 stops17h 59m

$617

MinneapolisMedellín

MSP - MDE

MSPMDE

Minneapolis St Paul

Sun 8/31

6:32 pm-9:10 pm

2 stops26h 38m

Medellín Jose Maria Cordova Intl

Sun 9/7

9:45 am-11:25 pm

2 stops37h 40m

$627

MinneapolisMedellín

MSP - MDE

MSPMDE

Minneapolis St Paul

Sun 8/17

7:30 pm-12:40 pm

2 stops17h 10m

Medellín Jose Maria Cordova Intl

Wed 8/27

5:45 am-11:48 pm

1 stop18h 03m

$630

MinneapolisGuayaquil

MSP - GYE

MSPGYE

Minneapolis St Paul

Thu 5/29

8:24 am-5:20 pm

3 stops32h 56m

Guayaquil Jose Joaquin de Olmedo

Mon 6/16

11:05 am-5:46 pm

2 stops30h 41m

$669

MinneapolisMedellín

MSP - MDE

MSPMDE

Minneapolis St Paul

Sun 6/15

6:26 pm-1:50 pm

2 stops19h 24m

Medellín Jose Maria Cordova Intl

Tue 6/24

9:18 pm-5:34 pm

2 stops20h 16m

$678

MinneapolisGeorgetown

MSP - GEO

MSPGEO

Minneapolis St Paul

Mon 5/26

6:48 am-10:40 am

1 stop26h 52m

Georgetown Cheddi Jagan Intl

Tue 6/3

3:13 am-9:44 pm

2 stops19h 31m

$703

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 55 results

...

Best time to book a flight from Saint Paul to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Saint Paul with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Saint Paul to South America

What is the cheapest month to book a flight from Saint Paul to South America?

Currently, May is the cheapest month in which you can book a flight from Saint Paul to South America (average of $359). Flying from Saint Paul to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA1 to SA?

When flying from Saint Paul to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,916 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.6

Good

1,409 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines

7.5

Good

1,761 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,667 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What are the cheapest airlines to fly from Saint Paul to South America one-way?
The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $293. However, be on the lookout for offers from American Airlines and Avianca, as they are both options that can get you from Saint Paul to South America for a low price.
What are the most popular routes from Saint Paul to South America?
Most travelers choose Minneapolis St Paul - Lima J Chavez Intl, Minneapolis St Paul - Rio de Janeiro Santos Dumont or Minneapolis St Paul - Rio de Janeiro–Galeão Intl when deciding on the best route from Saint Paul to South America.
Can I find deals for flights from Saint Paul to South America that include hotel bookings?
Yes. In addition to deals on Saint Paul to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Saint Paul to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Saint Paul to South America.
Can I find deals for business class flights from Saint Paul to South America?
Yes. Cheapflights offers flight deals from Saint Paul to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Saint Paul to South America?
Currently, May is the cheapest month in which you can book a flight from Saint Paul to South America (average of $359). Flying from Saint Paul to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from Saint Paul to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$328	Average$460	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$342	Average$1,166	FlexibilityNo cancel fee	On-timeN/A
Avianca	Cheapest$487	Average$700	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$527	Average$1,197	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$587	Average$1,036	FlexibilityNo cancel fee	On-time71%
LATAM Airlines	Cheapest$663	Average$1,146	FlexibilityNo cancel fee	On-time81%
Air Canada	Cheapest$840	Average$1,284	FlexibilityNo cancel fee	On-time67%

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$227+ Cheap flights from Saint Paul, MN to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Saint Paul to South America with Cheapflights

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3. Compare prices and book

Cheap flight deals from Saint Paul to South America

Keep the following information in mind while searching for Saint Paul to South America flight deals. Data was last updated April 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Saint Paul to South America

Cheapest flights from Saint Paul to South AmericaExplore the most affordable flight options available from Saint Paul to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Explore the most affordable flight options available from Saint Paul to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Saint Paul to South America that are best for you.

Best time to book a flight from Saint Paul to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Saint Paul with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Saint Paul to South America

What is the cheapest month to book a flight from Saint Paul to South America?

What is the cheapest time of day to fly from SA1 to SA?

Find hourly flight availability from Saint Paul to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

Reviews of airlines servicing South America

Related info for your journey

Find useful and relevant information for your journey from Saint Paul to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines to fly from Saint Paul to South America one-way?

What are the most popular routes from Saint Paul to South America?

Can I find deals for flights from Saint Paul to South America that include hotel bookings?

How can I find direct flights from Saint Paul to South America?

Can I find deals for business class flights from Saint Paul to South America?

What is the cheapest month to book a flight from Saint Paul to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Saint Paul to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Saint Paul to South America

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Cheapest flights from Saint Paul to South America
Explore the most affordable flight options available from Saint Paul to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.