What are the cheapest airlines to fly from St. Louis to South America one-way?

$136 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and LATAM Airlines, with prices starting from $323 and $337, respectively.

What are the most popular routes from St. Louis to South America?

The most popular flight routes from St. Louis to South America are Lambert-St Louis - Lima J Chavez Intl, Lambert-St Louis - Bogotá El Dorado and Lambert-St Louis - Medellín Jose Maria Cordova Intl.

What are the most popular airlines that fly from St. Louis to South America?

Consider American Airlines, Delta or LATAM Airlines when booking your flight. These represent the most popular airlines when flying from St. Louis to South America.

What is the cheapest month to fly from St. Louis to South America?

Due to multiple factors, expect to potentially pay more when booking in June. For low rates, April can be a great choice for travel to South America. Flights to South America from St. Louis in April are about $1,023 on average during April, but can be found for as low as $698.

What airport do you fly from for flights from St. Louis to South America?

Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

Can I find deals for flights from St. Louis to South America that include hotel bookings?

Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

Can I find deals for business class flights from St. Louis to South America?

Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$603+ Flights from St. Louis to South America

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Cheap flight deals from St. Louis to South America

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$459 (Kiwi.com)
One-way from	$136 (Mytrip)
Popular in	June
Cheapest in	April
Average price	$907

Provider with most accurate pricing for Lambert-St Louis-Sao Paulo (SAO) flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Sao Paulo (SAO) flights.

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From Lambert-St Louis to South America

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One-way flight from Lambert-St Louis to South America

Search Deals

Highest demand for flights based on searches. 0% potential increase in price ($6 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).

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Average for round-trip flights in March 2025

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Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Sat 4/124:57 pmSTL - MDE

1 stop20h 03mMultiple Airlines

Sat 4/191:55 pmMDE - STL

1 stop9h 51mMultiple Airlines

Deal found 3/27

$459

Mon 4/147:10 amSTL - BOG

2 stops20h 05mDelta

Wed 4/235:15 pmBOG - STL

2 stops16h 21mDelta

Deal found 3/28

$475

Mon 4/146:15 amSTL - BOG

1 stop13h 05mUnited Airlines

Tue 4/2212:14 amBOG - STL

2 stops14h 28mUnited Airlines

Deal found 3/28

$479

Sat 5/176:00 amSTL - CTG

1 stop7h 19mDelta

Thu 5/292:34 pmCTG - STL

1 stop9h 04mDelta

Deal found 3/27

$540

Sat 5/177:19 pmSTL - CTG

2 stops17h 06mAmerican Airlines

Thu 5/291:25 pmCTG - STL

1 stop8h 54mAmerican Airlines

Deal found 3/27

$544

Mon 4/216:00 amSTL - BOG

1 stop13h 15mLATAM Airlines

Sun 4/272:55 pmBOG - STL

1 stop27h 01mLATAM Airlines

Deal found 3/26

$545

Wed 7/165:00 amSTL - BOG

1 stop16h 17mAmerican Airlines

Wed 7/232:10 pmBOG - STL

1 stop10h 19mAmerican Airlines

Deal found 3/27

$564

Wed 6/119:50 amSTL - MDE

2 stops18h 52mUnited Airlines

Mon 6/3012:15 amMDE - STL

1 stop18h 38mUnited Airlines

Deal found 3/27

$570

Mon 3/315:24 pmSTL - CTG

2 stops29h 35mMultiple Airlines

Sat 4/51:12 pmCTG - STL

1 stop28h 40mMultiple Airlines

Deal found 3/26

$601

Sun 3/306:47 pmSTL - CTG

1 stop17h 20mSpirit Airlines

Sat 4/51:12 pmCTG - STL

1 stop28h 40mSpirit Airlines

Deal found 3/26

$605

Mon 3/318:40 amSTL - CTG

2 stops24h 01mUnited Airlines

Sat 4/59:38 amCTG - STL

2 stops35h 18mUnited Airlines

Deal found 3/26

$633

Tue 8/267:25 amSTL - LIM

1 stop14h 00mUnited Airlines

Sun 9/1412:40 amLIM - STL

1 stop18h 18mUnited Airlines

Deal found 3/26

$645

Best flights from St. Louis to South America
Discover carefully curated flight deals from St. Louis to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2025.

Sat 4/124:57 pmSTL - MDE

1 stop20h 03mMultiple Airlines

Sat 4/191:55 pmMDE - STL

1 stop9h 51mMultiple Airlines

Deal found 3/27

$459

Mon 4/147:10 amSTL - BOG

2 stops20h 05mDelta

Wed 4/235:15 pmBOG - STL

2 stops16h 21mDelta

Deal found 3/27

$475

Mon 4/146:15 amSTL - BOG

1 stop13h 05mUnited Airlines

Tue 4/2212:14 amBOG - STL

2 stops15h 33mUnited Airlines

Deal found 3/27

$479

Sat 5/177:19 pmSTL - CTG

2 stops17h 06mAmerican Airlines

Thu 5/291:25 pmCTG - STL

1 stop8h 54mAmerican Airlines

Deal found 3/27

$544

Mon 4/216:00 amSTL - BOG

1 stop13h 15mLATAM Airlines

Sun 4/272:55 pmBOG - STL

1 stop27h 01mLATAM Airlines

Deal found 3/26

$545

Sat 4/269:39 amSTL - LIM

2 stops16h 06mAvianca

Fri 5/26:45 pmLIM - STL

2 stops15h 13mAvianca

Deal found 3/26

$772

Mon 5/122:30 pmSTL - SDU

2 stops23h 20mAir Canada

Tue 5/271:05 pmSDU - STL

2 stops25h 31mAir Canada

Deal found 3/27

$780

Fri 8/224:19 pmSTL - GIG

2 stops24h 46mGOL

Fri 9/56:00 amGIG - STL

2 stops19h 01mGOL

Deal found 3/27

$1,016

Sat 5/176:00 amSTL - CTG

1 stop7h 19mDelta

Thu 5/292:34 pmCTG - STL

1 stop9h 04mDelta

Deal found 3/27

$540

Wed 6/119:50 amSTL - MDE

2 stops18h 52mUnited Airlines

Mon 6/3012:15 amMDE - STL

1 stop18h 38mUnited Airlines

Deal found 3/27

$570

Mon 4/149:50 amSTL - BOG

3 stops32h 09mMultiple Airlines

Wed 4/2312:16 pmBOG - STL

3 stops28h 59mMultiple Airlines

Deal found 3/27

$691

Sat 7/126:00 amSTL - LIM

2 stops16h 00mLATAM Airlines

Wed 7/2311:40 pmLIM - STL

2 stops23h 59mLATAM Airlines

Deal found 3/26

$693

Last-minute flights from St. Louis to South America
Discover last-minute flight deals from St. Louis to South America. Data last updated March 28, 2025 and is based on user searches.

Sun 3/306:47 pmSTL - CTG

1 stop17h 20mSpirit Airlines

Sat 4/51:12 pmCTG - STL

1 stop28h 40mSpirit Airlines

Deal found 3/26

$605

Mon 3/315:24 pmSTL - CTG

2 stops29h 35mMultiple Airlines

Sat 4/51:12 pmCTG - STL

1 stop28h 40mMultiple Airlines

Deal found 3/26

$601

Mon 3/318:40 amSTL - CTG

2 stops24h 01mUnited Airlines

Sat 4/59:38 amCTG - STL

2 stops35h 18mUnited Airlines

Deal found 3/26

$633

Tue 4/18:25 amSTL - MDE

2 stops23h 53mCopa Airlines

Tue 5/611:29 amMDE - STL

2 stops22h 29mCopa Airlines

Deal found 3/27

$651

Wed 4/210:19 amSTL - SCL

2 stops18h 11mDelta

Wed 4/910:35 amSCL - STL

2 stops24h 01mDelta

Deal found 3/27

$824

Wed 4/210:19 amSTL - SCL

1 stop19h 41mMultiple Airlines

Tue 4/812:35 amSCL - STL

2 stops39h 37mMultiple Airlines

Deal found 3/27

$1,240

Wed 4/26:00 amSTL - SCL

3 stops29h 55mLATAM Airlines

Wed 4/97:40 amSCL - STL

3 stops35h 27mLATAM Airlines

Deal found 3/26

$1,436

Wed 4/28:25 amSTL - SCL

2 stops19h 39mCopa Airlines

Tue 4/812:19 amSCL - STL

2 stops19h 59mCopa Airlines

Deal found 3/26

$3,076

Sat 4/124:57 pmSTL - MDE

1 stop20h 03mMultiple Airlines

Sat 4/191:55 pmMDE - STL

1 stop9h 51mMultiple Airlines

Deal found 3/27

$459

Mon 4/147:10 amSTL - BOG

2 stops20h 05mDelta

Wed 4/235:15 pmBOG - STL

2 stops16h 21mDelta

Deal found 3/28

$475

Mon 4/146:15 amSTL - BOG

1 stop13h 05mUnited Airlines

Tue 4/2212:14 amBOG - STL

2 stops14h 28mUnited Airlines

Deal found 3/28

$479

Mon 4/149:50 amSTL - BOG

3 stops32h 09mMultiple Airlines

Wed 4/2312:16 pmBOG - STL

3 stops28h 59mMultiple Airlines

Deal found 3/27

$691

One-way flights from St. Louis to South America
Search for one-way flight options from St. Louis to South America. Find affordable one-way fares based on user searches. Data last updated March 28, 2025.

Sat 5/1010:10 amSTL - BOG

1 stop26h 55mSpirit Airlines

Deal found 3/26

$136

Sat 4/265:41 pmSTL - CTG

2 stops18h 26mMultiple Airlines

Deal found 3/26

$150

Sat 5/1010:10 amSTL - BOG

2 stops12h 45mMultiple Airlines

Deal found 3/26

$170

Sat 4/54:57 pmSTL - MDE

2 stops29h 29mMultiple Airlines

Deal found 3/27

$218

Sun 3/306:47 pmSTL - CTG

1 stop17h 20mSpirit Airlines

Deal found 3/26

$238

Sun 8/317:37 pmSTL - MDE

1 stop17h 32mSpirit Airlines

Deal found 3/27

$314

Thu 6/195:27 pmSTL - BOG

2 stops17h 28mDelta

Deal found 3/27

$323

Sat 4/266:00 amSTL - CTG

1 stop7h 12mLATAM Airlines

Deal found 3/26

$337

Mon 5/265:45 pmSTL - LIM

2 stops35h 21mMultiple Airlines

Deal found 3/27

$355

Sun 8/315:30 pmSTL - MDE

2 stops27h 40mUnited Airlines

Deal found 3/27

$364

Mon 5/266:20 pmSTL - LIM

1 stop9h 50mAmerican Airlines

Deal found 3/27

$409

Sun 5/45:45 pmSTL - EZE

3 stops43h 35mMultiple Airlines

Deal found 3/27

$409

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 4/12

4:57 pm-1:00 pm

1 stop20h 03m

Medellín Jose Maria Cordova Intl

Sat 4/19

1:55 pm-11:46 pm

1 stop9h 51m

$459

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/14

7:10 am-3:15 am

2 stops20h 05m

Bogotá El Dorado

Wed 4/23

5:15 pm-9:36 am

2 stops16h 21m

$475

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/14

6:15 am-7:20 pm

1 stop13h 05m

Bogotá El Dorado

Tue 4/22

12:14 am-2:42 pm

2 stops14h 28m

$479

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 5/17

6:00 am-1:19 pm

1 stop7h 19m

Cartagena Rafael Nunez

Thu 5/29

2:34 pm-11:38 pm

1 stop9h 04m

$540

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 5/17

7:19 pm-12:25 pm

2 stops17h 06m

Cartagena Rafael Nunez

Thu 5/29

1:25 pm-10:19 pm

1 stop8h 54m

$544

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/21

6:00 am-7:15 pm

1 stop13h 15m

Bogotá El Dorado

Sun 4/27

2:55 pm-5:56 pm

1 stop27h 01m

$545

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Wed 7/16

5:00 am-9:17 pm

1 stop16h 17m

Bogotá El Dorado

Wed 7/23

2:10 pm-12:29 am

1 stop10h 19m

$564

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 6/11

9:50 am-4:42 am

2 stops18h 52m

Medellín Jose Maria Cordova Intl

Mon 6/30

12:15 am-6:53 pm

1 stop18h 38m

$570

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Tue 8/26

7:25 am-9:25 pm

1 stop14h 00m

Lima J Chavez Intl

Sun 9/14

12:40 am-6:58 pm

1 stop18h 18m

$645

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Tue 8/26

9:00 am-5:00 am

1 stop20h 00m

Lima J Chavez Intl

Tue 9/9

11:20 pm-3:58 pm

1 stop16h 38m

$669

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 50 results

...

Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SA?

When flying from St. Louis to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,896 reviews

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines

7.5

Good

1,750 reviews

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.5

Good

1,395 reviews

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,603 reviews

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

GOL

7.3

Good

1,052 reviews

Delta

8.0

Very good

7,896 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What airport do you fly from for flights from St. Louis to South America?
Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.
What are the cheapest airlines to fly from St. Louis to South America one-way?
$136 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and LATAM Airlines, with prices starting from $323 and $337, respectively.
What are the most popular routes from St. Louis to South America?
The most popular flight routes from St. Louis to South America are Lambert-St Louis - Lima J Chavez Intl, Lambert-St Louis - Bogotá El Dorado and Lambert-St Louis - Medellín Jose Maria Cordova Intl.
Can I find deals for flights from St. Louis to South America that include hotel bookings?
Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.
Can I find deals for business class flights from St. Louis to South America?
Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to South America?
Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

St. Louis to South America flights

Top 5 airlines flying from St. Louis to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$273	Average$396	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$289	Average$900	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$389	Average$871	FlexibilityNo cancel fee	On-time81%
United Airlines	Cheapest$399	Average$900	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$463	Average$886	FlexibilityNo cancel fee	On-time71%

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$136+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to South America with Cheapflights

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3. Compare prices and book

Cheap flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated March 28, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South AmericaExplore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

What is the cheapest time of day to fly from STL to SA?

Find hourly flight availability from St. Louis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

Reviews of airlines servicing South America

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from St. Louis to South America?

What are the cheapest airlines to fly from St. Louis to South America one-way?

What are the most popular routes from St. Louis to South America?

Can I find deals for flights from St. Louis to South America that include hotel bookings?

How can I find direct flights from St. Louis to South America?

Can I find deals for business class flights from St. Louis to South America?

What is the cheapest month to book a flight from St. Louis to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from St. Louis to South America

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Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.