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South America

$96+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Apr 6 — Apr 131
Sun 4/6
Sun 4/13
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated April 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(Kiwi.com)

One-way from

$96
(CheapOair)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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From South Carolina to South America
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One-way flight from South Carolina to South America
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Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2025.

This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/104:46 pmCLT - CTG
1 stop20h 24mSpirit Airlines
Tue 5/131:15 pmCTG - CLT
1 stop7h 45mSpirit Airlines
Deal found 3/31$271
This eDestinos deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/266:58 amCLT - MDE
1 stop7h 17mSpirit Airlines
Sat 5/32:14 pmMDE - CLT
1 stop9h 13mSpirit Airlines
Deal found 3/30$322
This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/266:58 amCLT - BOG
1 stop7h 06mSpirit Airlines
Sat 5/31:59 pmBOG - CLT
1 stop9h 28mSpirit Airlines
Deal found 3/31$340
This Priceline deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/128:50 amCLT - BAQ
1 stop5h 56mSpirit Airlines
Wed 5/212:46 pmBAQ - CLT
2 stops24h 05mSpirit Airlines
Deal found 4/1$346
This Avianca Connect deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/16:58 amCLT - CTG
2 stops15h 27mMultiple Airlines
Sun 5/46:55 amCTG - CLT
2 stops16h 32mMultiple Airlines
Deal found 3/30$354
This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/276:58 amCLT - CLO
1 stop6h 57mSpirit Airlines
Thu 5/11:50 pmCLO - CLT
1 stop9h 37mSpirit Airlines
Deal found 3/31$357
This Avianca Connect deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:58 amCLT - BOG
1 stop12h 01mMultiple Airlines
Tue 5/69:00 amBOG - CLT
1 stop14h 27mMultiple Airlines
Deal found 3/31$365
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/79:45 pmCLT - MDE
1 stop16h 13mMultiple Airlines
Tue 5/207:41 pmMDE - CLT
2 stops25h 19mMultiple Airlines
Deal found 3/31$377
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/128:50 amCLT - BAQ
2 stops15h 46mMultiple Airlines
Wed 5/212:46 pmBAQ - CLT
1 stop22h 12mMultiple Airlines
Deal found 3/31$394
This Avianca Connect deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:58 amCLT - CLO
2 stops15h 20mMultiple Airlines
Sat 5/246:23 amCLO - CLT
2 stops14h 37mMultiple Airlines
Deal found 3/31$412
This United deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:00 amCLT - MDE
1 stop15h 10mUnited Airlines
Tue 6/312:15 amMDE - CLT
1 stop14h 44mUnited Airlines
Deal found 3/30$425
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/129:33 amCLT - BOG
1 stop10h 42mDelta
Tue 7/292:55 pmBOG - CLT
1 stop16h 42mDelta
Deal found 4/1$483

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sat 5/10

4:46 pm-12:10 pm

1 stop20h 24m

Cartagena Rafael Nunez

Tue 5/13

1:15 pm-10:00 pm

1 stop7h 45m

$271

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sat 4/26

6:58 am-1:15 pm

1 stop7h 17m

Medellín Jose Maria Cordova Intl

Sat 5/3

2:14 pm-12:27 am

1 stop9h 13m

$322

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Sat 4/26

6:58 am-1:04 pm

1 stop7h 06m

Bogotá El Dorado

Sat 5/3

1:59 pm-12:27 am

1 stop9h 28m

$340

CharlotteBarranquilla

CLT - BAQ

CLTBAQ

Charlotte Douglas

Mon 5/12

8:50 am-1:46 pm

1 stop5h 56m

Barranquilla E Cortissoz

Wed 5/21

2:46 pm-3:51 pm

2 stops24h 05m

$346

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 5/1

6:58 am-9:25 pm

2 stops15h 27m

Cartagena Rafael Nunez

Sun 5/4

6:55 am-12:27 am

2 stops16h 32m

$354

CharlotteCali

CLT - CLO

CLTCLO

Charlotte Douglas

Sun 4/27

6:58 am-12:55 pm

1 stop6h 57m

Cali Alfonso B. Aragon Intl

Thu 5/1

1:50 pm-12:27 am

1 stop9h 37m

$357

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Sat 5/3

6:58 am-5:59 pm

1 stop12h 01m

Bogotá El Dorado

Tue 5/6

9:00 am-12:27 am

1 stop14h 27m

$365

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 5/7

9:45 pm-12:58 pm

1 stop16h 13m

Medellín Jose Maria Cordova Intl

Tue 5/20

7:41 pm-10:00 pm

2 stops25h 19m

$377

CharlotteBarranquilla

CLT - BAQ

CLTBAQ

Charlotte Douglas

Mon 5/12

8:50 am-11:36 pm

2 stops15h 46m

Barranquilla E Cortissoz

Wed 5/21

2:46 pm-1:58 pm

1 stop22h 12m

$394

CharlotteCali

CLT - CLO

CLTCLO

Charlotte Douglas

Sat 5/3

6:58 am-9:18 pm

2 stops15h 20m

Cali Alfonso B. Aragon Intl

Sat 5/24

6:23 am-10:00 pm

2 stops14h 37m

$412

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 1, 2025.
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,400 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,754 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,615 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
GOL
7.3
Good
1,053 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Entertainment

7.9

Comfort

8.0

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $96 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Copa Airlines and Avianca, with prices starting from $285 and $297, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$199Average$410FlexibilityNo cancel feeOn-time65%
DeltaCheapest$355Average$862FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$405Average$788FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$879FlexibilityNo cancel feeOn-time81%
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