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South America

$110+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated April 17, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$295
(Travelocity)

One-way from

$110
(Mytrip)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From South Carolina to South America
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One-way flight from South Carolina to South America
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Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Travelocity deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/276:58 amCLT - CTG
1 stop6h 09mSpirit Airlines
Sat 5/241:15 pmCTG - CLT
1 stop7h 45mSpirit Airlines
Deal found 4/16$295
This Avianca Connect deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/86:00 amCLT - BOG
1 stop16h 59mMultiple Airlines
Wed 5/1411:15 pmBOG - CLT
1 stop10h 48mMultiple Airlines
Deal found 4/15$317
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/159:02 pmCLT - BOG
1 stop17h 03mSpirit Airlines
Sun 5/182:07 pmBOG - CLT
1 stop28h 50mSpirit Airlines
Deal found 4/17$336
This CheapOair deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1711:23 amCLT - MDE
1 stop26h 35mSpirit Airlines
Sat 5/242:13 pmMDE - CLT
1 stop22h 45mSpirit Airlines
Deal found 4/17$371
This Avianca Connect deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/88:50 amCLT - CTG
2 stops13h 35mMultiple Airlines
Thu 5/156:55 amCTG - CLT
2 stops12h 02mMultiple Airlines
Deal found 4/16$386
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/174:46 pmCLT - MDE
2 stops21h 12mMultiple Airlines
Sat 5/246:00 amMDE - CLT
2 stops15h 00mMultiple Airlines
Deal found 4/17$406
This Avianca Connect deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:58 amCLT - CLO
2 stops16h 15mMultiple Airlines
Sat 5/244:24 amCLO - CLT
2 stops16h 36mMultiple Airlines
Deal found 4/16$408
This Expedia deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/129:02 pmCLT - CLO
1 stop17h 03mSpirit Airlines
Thu 5/152:00 pmCLO - CLT
2 stops25h 47mSpirit Airlines
Deal found 4/16$419
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3011:24 amCLT - MDE
2 stops9h 36mAmerican Airlines
Tue 10/75:50 amMDE - CLT
1 stop8h 52mAmerican Airlines
Deal found 4/17$429
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:30 amCLT - MDE
1 stop15h 35mUnited Airlines
Sat 11/810:45 amMDE - CLT
1 stop11h 07mUnited Airlines
Deal found 4/16$445
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/149:20 pmCLT - BOG
1 stop15h 00mAmerican Airlines
Mon 8/111:55 amBOG - CLT
1 stop14h 31mAmerican Airlines
Deal found 4/17$483
This Avianca Connect deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/168:50 amCLT - GYE
2 stops15h 30mMultiple Airlines
Thu 5/223:35 amGYE - CLT
2 stops14h 54mMultiple Airlines
Deal found 4/16$483

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sun 4/27

6:58 am-12:07 pm

1 stop6h 09m

Cartagena Rafael Nunez

Sat 5/24

1:15 pm-10:00 pm

1 stop7h 45m

$295

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Thu 5/8

6:00 am-9:59 pm

1 stop16h 59m

Bogotá El Dorado

Wed 5/14

11:15 pm-11:03 am

1 stop10h 48m

$317

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Thu 5/15

9:02 pm-1:05 pm

1 stop17h 03m

Bogotá El Dorado

Sun 5/18

2:07 pm-7:57 pm

1 stop28h 50m

$336

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sat 5/17

11:23 am-12:58 pm

1 stop26h 35m

Medellín Jose Maria Cordova Intl

Sat 5/24

2:13 pm-1:58 pm

1 stop22h 45m

$371

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 5/8

8:50 am-9:25 pm

2 stops13h 35m

Cartagena Rafael Nunez

Thu 5/15

6:55 am-7:57 pm

2 stops12h 02m

$386

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sat 5/17

4:46 pm-12:58 pm

2 stops21h 12m

Medellín Jose Maria Cordova Intl

Sat 5/24

6:00 am-10:00 pm

2 stops15h 00m

$406

CharlotteCali

CLT - CLO

CLTCLO

Charlotte Douglas

Wed 4/30

6:58 am-10:13 pm

2 stops16h 15m

Cali Alfonso B. Aragon Intl

Sat 5/24

4:24 am-10:00 pm

2 stops16h 36m

$408

CharlotteCali

CLT - CLO

CLTCLO

Charlotte Douglas

Mon 5/12

9:02 pm-1:05 pm

1 stop17h 03m

Cali Alfonso B. Aragon Intl

Thu 5/15

2:00 pm-4:47 pm

2 stops25h 47m

$419

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 7/16

5:10 pm-4:42 am

1 stop12h 32m

Medellín Jose Maria Cordova Intl

Tue 7/29

12:15 am-4:00 pm

1 stop14h 45m

$448

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Mon 7/14

9:20 pm-11:20 am

1 stop15h 00m

Bogotá El Dorado

Mon 8/11

1:55 am-5:26 pm

1 stop14h 31m

$483

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 17, 2025.
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,917 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,409 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,761 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
GOL
7.3
Good
1,060 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $110 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Copa Airlines and Avianca, with prices starting from $285 and $323, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$199Average$416FlexibilityNo cancel feeOn-time65%
DeltaCheapest$379Average$856FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$405Average$812FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$872FlexibilityNo cancel feeOn-time81%

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