What are the cheapest airlines to fly from San Diego to South America one-way?

The cheapest airlines for a one-way flight from San Diego to South America are Spirit Airlines ($129), Copa Airlines ($215), and American Airlines ($233).

What are the most popular routes from San Diego to South America?

The most popular route from San Diego to South America is San Diego - Medellín Jose Maria Cordova Intl. You may also consider San Diego - Lima J Chavez Intl or San Diego - Buenos Aires Ministro Pistarini.

What are the most popular airlines that fly from San Diego to South America?

The most popular airlines flying from San Diego to South America are American Airlines, Delta and LATAM Airlines. Something to consider prior to booking your flight.

How far in advance should I book a flight from San Diego to South America?

Find a great deal and save up to 5% by booking at least 24 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from San Diego to South America within the next two weeks, with the cheapest ticket starting at $750.

What is the cheapest month to fly from San Diego to South America?

February can be a great time to fly to South America from San Diego with a flight ticket averaging about $1,011. Cheapflights users have found deals in the month of February for as cheap as $728. The most expensive prices can be found in the month of December.

What airport do you fly from for flights from San Diego to South America?

Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.

Can I find deals for flights from San Diego to South America that include hotel bookings?

Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Diego to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.

Can I find deals for business class flights from San Diego to South America?

Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$534+ Flights from San Diego to South America

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from San Diego to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Diego to South America

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$403 (Copa Airlines)
One-way from	$129 (CheapOair)
Popular in	December
Cheapest in	February
Average price	$920

Provider with most accurate pricing for San Diego-Sao Paulo (SAO) flight deals.

Search Deals

Provider most trusted by Cheapflights users for San Diego-Sao Paulo (SAO) flights.

Search Deals

From San Diego to South America

Search Deals

One-way flight from San Diego to South America

Search Deals

Highest demand for flights based on searches. 8% potential increase in price ($89 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($17 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in March 2025

Search Deals

Find flight deals from San Diego to South America

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

Fri 9/199:03 pmSAN - MDE

1 stop9h 14mCopa Airlines

Sun 9/289:15 amMDE - SAN

1 stop10h 35mCopa Airlines

Deal found 3/25

$403

Mon 9/229:03 pmSAN - BOG

1 stop14h 26mCopa Airlines

Mon 9/296:10 amBOG - SAN

1 stop13h 40mCopa Airlines

Deal found 3/25

$411

Sun 5/49:08 pmSAN - MDE

2 stops13h 52mSpirit Airlines

Sun 5/111:53 pmMDE - SAN

2 stops19h 20mSpirit Airlines

Deal found 3/25

$438

Sun 9/79:03 pmSAN - LIM

1 stop16h 37mCopa Airlines

Sun 9/217:00 amLIM - SAN

1 stop12h 50mCopa Airlines

Deal found 3/25

$445

Sun 8/178:58 pmSAN - GRU

1 stop23h 12mCopa Airlines

Wed 10/15:25 amGRU - SAN

1 stop16h 32mCopa Airlines

Deal found 3/24

$447

Sat 5/105:43 pmSAN - BOG

2 stops17h 22mSpirit Airlines

Thu 5/152:07 pmBOG - SAN

2 stops19h 06mSpirit Airlines

Deal found 3/23

$461

Mon 4/289:08 pmSAN - MDE

3 stops19h 46mMultiple Airlines

Sat 5/32:14 pmMDE - SAN

3 stops43h 20mMultiple Airlines

Deal found 3/26

$474

Mon 4/147:00 amSAN - BOG

1 stop11h 25mMultiple Airlines

Wed 4/167:00 amBOG - SAN

1 stop13h 56mMultiple Airlines

Deal found 3/24

$491

Thu 5/86:15 amSAN - BOG

1 stop11h 00mDelta

Wed 5/219:00 amBOG - SAN

1 stop13h 08mDelta

Deal found 3/25

$513

Mon 4/146:15 amSAN - BOG

2 stops20h 39mUnited Airlines

Wed 4/168:30 amBOG - SAN

1 stop14h 52mUnited Airlines

Deal found 3/24

$517

Fri 7/410:43 amSAN - MDE

2 stops15h 59mUnited Airlines

Thu 7/109:45 amMDE - SAN

1 stop9h 54mUnited Airlines

Deal found 3/24

$533

Fri 4/187:35 pmSAN - CTG

3 stops35h 06mUnited Airlines

Sun 5/49:38 amCTG - SAN

2 stops32h 49mUnited Airlines

Deal found 3/24

$538

Best flights from San Diego to South America
Discover carefully curated flight deals from San Diego to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2025.

Fri 9/199:03 pmSAN - MDE

1 stop9h 14mCopa Airlines

Sun 9/289:15 amMDE - SAN

1 stop10h 35mCopa Airlines

Deal found 3/25

$403

Sun 5/49:08 pmSAN - MDE

2 stops13h 52mSpirit Airlines

Sun 5/111:53 pmMDE - SAN

2 stops19h 20mSpirit Airlines

Deal found 3/25

$438

Mon 4/289:08 pmSAN - MDE

3 stops19h 46mMultiple Airlines

Sat 5/32:14 pmMDE - SAN

3 stops43h 20mMultiple Airlines

Deal found 3/26

$474

Thu 5/87:40 pmSAN - BOG

2 stops21h 40mUnited Airlines

Tue 5/2012:14 amBOG - SAN

1 stop15h 43mUnited Airlines

Deal found 3/25

$513

Wed 4/96:15 amSAN - BOG

1 stop11h 00mLATAM Airlines

Tue 4/152:55 pmBOG - SAN

1 stop21h 12mLATAM Airlines

Deal found 3/25

$540

Wed 4/97:08 pmSAN - BOG

2 stops19h 07mDelta

Tue 4/152:55 pmBOG - SAN

1 stop21h 12mDelta

Deal found 3/25

$545

Thu 5/296:20 amSAN - BOG

2 stops14h 10mAmerican Airlines

Tue 7/16:30 amBOG - SAN

2 stops14h 50mAmerican Airlines

Deal found 3/25

$589

Sun 5/258:39 pmSAN - CTG

1 stop15h 26mJetBlue

Sat 5/313:29 pmCTG - SAN

1 stop19h 41mJetBlue

Deal found 3/25

$665

Fri 5/28:10 amSAN - GRU

1 stop21h 35mAir Canada

Sat 5/179:00 pmGRU - SAN

1 stop26h 45mAir Canada

Deal found 3/24

$680

Sun 9/79:03 pmSAN - LIM

1 stop20h 12mCopa Airlines

Sat 9/202:35 amLIM - SAN

1 stop17h 15mCopa Airlines

Deal found 3/25

$445

Wed 5/77:25 pmSAN - MDE

3 stops15h 05mAvianca

Tue 5/133:15 amMDE - SAN

2 stops16h 36mAvianca

Deal found 3/25

$909

Sat 5/105:43 pmSAN - BOG

2 stops17h 22mSpirit Airlines

Thu 5/152:07 pmBOG - SAN

2 stops19h 06mSpirit Airlines

Deal found 3/23

$461

Last-minute flights from San Diego to South America
Discover last-minute flight deals from San Diego to South America. Data last updated March 26, 2025 and is based on user searches.

Mon 3/3112:40 pmSAN - GIG

2 stops30h 15mMultiple Airlines

Mon 4/75:00 pmGIG - SAN

2 stops22h 48mMultiple Airlines

Deal found 3/23

$809

Mon 3/317:35 pmSAN - LIM

2 stops25h 25mUnited Airlines

Wed 4/912:40 amLIM - SAN

1 stop15h 10mUnited Airlines

Deal found 3/25

$1,055

Mon 3/312:40 pmSAN - GIG

1 stop15h 35mLATAM Airlines

Mon 4/79:00 pmGIG - SAN

1 stop17h 11mLATAM Airlines

Deal found 3/23

$1,111

Tue 4/18:30 pmSAN - EZE

2 stops27h 39mCopa Airlines

Tue 4/223:54 amEZE - SAN

2 stops22h 39mCopa Airlines

Deal found 3/25

$1,208

Tue 4/110:26 amSAN - EZE

1 stop17h 34mUnited Airlines

Wed 4/239:00 pmEZE - SAN

1 stop23h 27mUnited Airlines

Deal found 3/25

$1,245

Thu 4/36:15 amSAN - BOG

3 stops28h 49mSpirit Airlines

Fri 4/181:59 pmBOG - SAN

2 stops22h 26mSpirit Airlines

Deal found 3/25

$538

Thu 4/310:00 amSAN - BOG

2 stops16h 54mUnited Airlines

Thu 4/1712:14 amBOG - SAN

1 stop12h 53mUnited Airlines

Deal found 3/25

$541

Fri 4/410:15 pmSAN - LIM

1 stop22h 10mAmerican Airlines

Fri 4/186:30 amLIM - SAN

1 stop18h 08mAmerican Airlines

Deal found 3/25

$960

Fri 4/44:05 pmSAN - LIM

2 stops21h 35mCopa Airlines

Thu 4/172:40 amLIM - SAN

2 stops21h 53mCopa Airlines

Deal found 3/25

$1,050

Fri 4/410:55 amSAN - LIM

1 stop18h 35mDelta

Thu 4/1712:50 amLIM - SAN

1 stop18h 02mDelta

Deal found 3/25

$1,075

Fri 4/46:15 pmSAN - CUZ

2 stops17h 30mLATAM Airlines

Sun 4/136:15 pmCUZ - SAN

2 stops18h 07mLATAM Airlines

Deal found 3/25

$1,131

Sat 4/510:15 pmSAN - MDE

1 stop12h 40mAmerican Airlines

Fri 4/116:00 amMDE - SAN

1 stop18h 38mAmerican Airlines

Deal found 3/25

$723

One-way flights from San Diego to South America
Search for one-way flight options from San Diego to South America. Find affordable one-way fares based on user searches. Data last updated March 26, 2025.

Sat 5/105:43 pmSAN - BOG

2 stops17h 22mSpirit Airlines

Deal found 3/25

$129

Tue 4/16:15 amSAN - CTG

3 stops27h 52mSpirit Airlines

Deal found 3/24

$189

Fri 5/95:43 pmSAN - BOG

3 stops27h 32mMultiple Airlines

Deal found 3/25

$200

Tue 5/209:52 pmSAN - CTG

2 stops12h 18mMultiple Airlines

Deal found 3/25

$213

Sun 8/178:58 pmSAN - GRU

1 stop23h 12mCopa Airlines

Deal found 3/24

$215

Thu 5/86:15 amSAN - BOG

1 stop14h 15mAmerican Airlines

Deal found 3/25

$233

Wed 4/306:15 amSAN - MDE

3 stops31h 47mMultiple Airlines

Deal found 3/26

$234

Wed 4/3010:15 pmSAN - MDE

1 stop20h 00mAmerican Airlines

Deal found 3/26

$243

Sat 4/197:35 pmSAN - CTG

3 stops35h 06mUnited Airlines

Deal found 3/24

$244

Sat 5/318:20 pmSAN - CTG

1 stop15h 45mJetBlue

Deal found 3/24

$255

Sun 6/226:41 pmSAN - MDE

1 stop24h 29mUnited Airlines

Deal found 3/25

$259

Mon 5/59:08 pmSAN - LIM

3 stops26h 37mMultiple Airlines

Deal found 3/25

$278

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Fri 9/19

9:03 pm-8:17 am

1 stop9h 14m

Medellín Jose Maria Cordova Intl

Sun 9/28

9:15 am-5:50 pm

1 stop10h 35m

$403

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Sun 5/4

9:08 pm-1:00 pm

2 stops13h 52m

Medellín Jose Maria Cordova Intl

Sun 5/11

1:53 pm-7:13 am

2 stops19h 20m

$438

San DiegoLima

SAN - LIM

SANLIM

San Diego

Sun 9/7

9:03 pm-7:15 pm

1 stop20h 12m

Lima J Chavez Intl

Sat 9/20

2:35 am-5:50 pm

1 stop17h 15m

$445

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Sat 5/10

5:43 pm-1:05 pm

2 stops17h 22m

Bogotá El Dorado

Thu 5/15

2:07 pm-7:13 am

2 stops19h 06m

$461

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Mon 4/28

9:08 pm-6:54 pm

3 stops19h 46m

Medellín Jose Maria Cordova Intl

Sat 5/3

2:14 pm-7:34 am

3 stops43h 20m

$474

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Mon 4/14

7:00 am-8:25 pm

1 stop11h 25m

Bogotá El Dorado

Wed 4/16

7:00 am-6:56 pm

1 stop13h 56m

$491

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Thu 5/8

7:40 pm-7:20 pm

2 stops21h 40m

Bogotá El Dorado

Tue 5/20

12:14 am-1:57 pm

1 stop15h 43m

$513

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Fri 7/4

10:43 am-4:42 am

2 stops15h 59m

Medellín Jose Maria Cordova Intl

Thu 7/10

9:45 am-5:39 pm

1 stop9h 54m

$533

San DiegoCartagena

SAN - CTG

SANCTG

San Diego

Fri 4/18

5:48 pm-8:41 am

2 stops36h 53m

Cartagena Rafael Nunez

Sun 5/4

9:38 am-4:27 pm

2 stops32h 49m

$538

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Wed 4/9

6:15 am-7:15 pm

1 stop11h 00m

Bogotá El Dorado

Tue 4/15

2:55 pm-10:07 am

1 stop21h 12m

$540

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 60 results

...

Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SA?

When flying from San Diego to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Alaska Airlines

8.0

Very good

9,789 reviews

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Delta

8.0

Very good

7,891 reviews

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Copa Airlines

7.6

Good

1,393 reviews

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

LATAM Airlines

7.5

Good

1,749 reviews

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

United Airlines

7.4

Good

8,608 reviews

Alaska Airlines

8.0

Very good

9,789 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

What airport do you fly from for flights from San Diego to South America?
Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.
What are the cheapest airlines to fly from San Diego to South America one-way?
The cheapest airlines for a one-way flight from San Diego to South America are Spirit Airlines ($129), Copa Airlines ($215), and American Airlines ($233).
What are the most popular routes from San Diego to South America?
The most popular route from San Diego to South America is San Diego - Medellín Jose Maria Cordova Intl. You may also consider San Diego - Lima J Chavez Intl or San Diego - Buenos Aires Ministro Pistarini.
Can I find deals for flights from San Diego to South America that include hotel bookings?
Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Diego to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.
Can I find deals for business class flights from San Diego to South America?
Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Diego to South America?
Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from San Diego to South America

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$395	Average$974	FlexibilityNo cancel fee	On-time69%
Spirit Airlines	Cheapest$406	Average$453	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$433	Average$958	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$446	Average$860	FlexibilityNo cancel fee	On-time70%
LATAM Airlines	Cheapest$449	Average$936	FlexibilityNo cancel fee	On-time81%
Delta	Cheapest$449	Average$982	FlexibilityNo cancel fee	On-timeN/A
Air Canada	Cheapest$957	Average$1,084	FlexibilityNo cancel fee	On-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$129+ Cheap flights from San Diego (SAN) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Diego to South America with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from San Diego to South America

Keep the following information in mind while searching for San Diego to South America flight deals. Data was last updated March 26, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Diego to South America

Cheapest flights from San Diego to South AmericaExplore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to South America that are best for you.

Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

What is the cheapest time of day to fly from SAN to SA?

Find hourly flight availability from San Diego to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2025.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

Reviews of airlines servicing South America

Related info for your journey

Find useful and relevant information for your journey from San Diego to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from San Diego to South America?

What are the cheapest airlines to fly from San Diego to South America one-way?

What are the most popular routes from San Diego to South America?

Can I find deals for flights from San Diego to South America that include hotel bookings?

How can I find direct flights from San Diego to South America?

Can I find deals for business class flights from San Diego to South America?

What is the cheapest month to book a flight from San Diego to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from San Diego to South America

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.