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South America

$331+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/5. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Mar 31 — Apr 71
Mon 3/31
Mon 4/7
1 adult, Economy
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Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated March 26, 2025.

Round-trip from

$493
(Delta)

One-way from

$331
(Delta)
From Panama City NW Florida Beaches to South America
Search Deals
One-way flight from Panama City NW Florida Beaches to South America
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/101:30 pmECP - BOG
2 stops22h 30mDelta
Sat 9/275:00 amBOG - ECP
2 stops17h 41mDelta
Deal found 3/25$493
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/78:50 amECP - BOG
1 stop10h 30mUnited Airlines
Tue 5/1312:14 amBOG - ECP
1 stop16h 05mUnited Airlines
Deal found 3/25$518
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/32:39 pmECP - BOG
2 stops20h 41mAmerican Airlines
Tue 7/226:30 amBOG - ECP
2 stops11h 55mAmerican Airlines
Deal found 3/24$539
This United deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:30 amECP - GYE
2 stops19h 35mUnited Airlines
Tue 6/38:31 amGYE - ECP
2 stops37h 29mUnited Airlines
Deal found 3/25$625
This United deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/166:30 amECP - GYE
2 stops16h 50mMultiple Airlines
Sat 8/163:35 amGYE - ECP
2 stops15h 24mMultiple Airlines
Deal found 3/25$992
This United deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/56:15 amECP - LPB
2 stops18h 55mMultiple Airlines
Mon 4/73:25 pmLPB - ECP
3 stops29h 44mMultiple Airlines
Deal found 3/25$1,146
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/99:12 amECP - COR
2 stops18h 58mDelta
Fri 5/167:45 amCOR - ECP
2 stops28h 04mDelta
Deal found 3/25$2,595
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/281:12 pmECP - CUZ
3 stops18h 57mAmerican Airlines
Sun 3/305:17 pmCUZ - ECP
3 stops20h 44mAmerican Airlines
Deal found 3/24$3,028

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 9/10

1:30 pm-12:00 pm

2 stops22h 30m

Bogotá El Dorado

Sat 9/27

5:00 am-10:41 pm

2 stops17h 41m

$493

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 5/7

8:50 am-7:20 pm

1 stop10h 30m

Bogotá El Dorado

Tue 5/13

12:14 am-4:19 pm

1 stop16h 05m

$518

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 9/10

11:38 am-10:03 pm

1 stop10h 25m

Bogotá El Dorado

Sat 9/27

11:42 pm-10:34 am

1 stop10h 52m

$535

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 5/22

6:30 am-2:05 am

2 stops19h 35m

Guayaquil Jose Joaquin de Olmedo

Tue 6/3

8:31 am-10:00 pm

2 stops37h 29m

$625

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 8/16

6:30 am-11:20 pm

2 stops16h 50m

Guayaquil Jose Joaquin de Olmedo

Sat 8/16

3:35 am-6:59 pm

2 stops15h 24m

$992

Panama CityLa Paz

ECP - LPB

ECPLPB

Panama City NW Florida Beaches

Sat 4/5

6:15 am-2:10 am

2 stops18h 55m

La Paz El Alto Intl

Mon 4/7

3:25 pm-8:09 pm

3 stops29h 44m

$1,146

Panama CityCordoba

ECP - COR

ECPCOR

Panama City NW Florida Beaches

Fri 5/9

9:12 am-6:10 am

2 stops18h 58m

Cordoba Pajas Blancas

Fri 5/16

7:45 am-9:49 am

2 stops28h 04m

$2,595

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Thu 6/5

7:15 am-7:15 pm

1 stop12h 00m

$331

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated March 26, 2025.
Delta
8.0
Very good
7,891 reviews

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
Delta
8.0
Very good
7,891 reviews
Delta
8.0
Very good
7,891 reviews

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
United Airlines
7.4
Good
8,608 reviews
Delta
8.0
Very good
7,891 reviews

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,891 reviews

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Bogotá El Dorado, Panama City NW Florida Beaches - Bucaramanga Palo Negro and Panama City NW Florida Beaches - Cusco Velazco Astete.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to South America

Discover the top 2 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$448Average$574FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$620FlexibilityNo cancel feeOn-timeN/A
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