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South America

$265+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated February 20, 2025.

Round-trip from

$433
(Kiwi.com)

One-way from

$265
(Kiwi.com)
From Missouri to South America
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One-way flight from Missouri to South America
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/610:20 amMCI - BOG
2 stops26h 44mSpirit Airlines
Tue 3/111:59 pmBOG - MCI
1 stop25h 45mSpirit Airlines
Deal found 2/20$433
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/66:11 pmSTL - MDE
1 stop18h 58mSpirit Airlines
Sat 5/102:14 pmMDE - STL
1 stop28h 18mSpirit Airlines
Deal found 2/20$442
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/610:20 amMCI - BOG
1 stop8h 50mMultiple Airlines
Tue 3/111:59 pmBOG - MCI
1 stop25h 45mMultiple Airlines
Deal found 2/20$473
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/610:25 amMCI - BOG
1 stop11h 45mAmerican Airlines
Mon 3/1012:10 amBOG - MCI
1 stop9h 34mAmerican Airlines
Deal found 2/20$518
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2011:00 amMCI - BOG
1 stop8h 30mLATAM Airlines
Thu 3/279:00 amBOG - MCI
1 stop11h 07mLATAM Airlines
Deal found 2/19$519
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2011:00 amMCI - BOG
1 stop8h 30mDelta
Thu 3/276:50 amBOG - MCI
2 stops17h 14mDelta
Deal found 2/19$523
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/206:05 amMCI - BOG
1 stop16h 30mUnited Airlines
Wed 3/261:30 amBOG - MCI
2 stops12h 57mUnited Airlines
Deal found 2/19$548
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/265:22 pmSTL - MDE
1 stop19h 29mMultiple Airlines
Sun 6/11:46 pmMDE - STL
1 stop9h 51mMultiple Airlines
Deal found 2/19$587
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/305:45 amMCI - UIO
1 stop14h 15mDelta
Tue 5/1311:20 pmUIO - MCI
1 stop10h 11mDelta
Deal found 2/20$606
This United deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:20 amMCI - UIO
1 stop17h 05mUnited Airlines
Mon 5/1212:35 amUIO - MCI
1 stop18h 04mUnited Airlines
Deal found 2/20$607
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2010:19 amSTL - MDE
2 stops13h 49mDelta
Sun 3/231:18 pmMDE - STL
2 stops19h 56mDelta
Deal found 2/20$616
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/46:20 pmSTL - MDE
1 stop18h 20mAmerican Airlines
Thu 7/245:50 amMDE - STL
1 stop17h 14mAmerican Airlines
Deal found 2/20$619

Find flights from Missouri to South America within your budget

Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Thu 3/6

10:20 am-2:04 pm

2 stops26h 44m

Bogotá El Dorado

Tue 3/11

1:59 pm-3:44 pm

1 stop25h 45m

$433

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 5/6

6:11 pm-1:09 pm

1 stop18h 58m

Medellín Jose Maria Cordova Intl

Sat 5/10

2:14 pm-6:32 pm

1 stop28h 18m

$442

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Thu 3/6

10:20 am-8:10 pm

1 stop8h 50m

Bogotá El Dorado

Tue 3/11

1:59 pm-3:44 pm

1 stop25h 45m

$473

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Thu 3/6

10:25 am-11:10 pm

1 stop11h 45m

Bogotá El Dorado

Mon 3/10

12:10 am-9:44 am

1 stop9h 34m

$518

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Thu 3/20

8:15 am-8:20 pm

2 stops12h 05m

Bogotá El Dorado

Thu 3/27

6:50 am-12:04 am

2 stops17h 14m

$523

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Thu 3/20

6:05 am-10:35 pm

1 stop16h 30m

Bogotá El Dorado

Wed 3/26

1:30 am-2:27 pm

2 stops12h 57m

$548

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Mon 5/26

5:22 pm-12:51 pm

1 stop19h 29m

Medellín Jose Maria Cordova Intl

Sun 6/1

1:46 pm-11:37 pm

1 stop9h 51m

$587

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Sat 6/21

4:15 pm-8:10 pm

2 stops27h 55m

Bogotá El Dorado

Tue 7/1

11:00 am-11:53 pm

2 stops12h 53m

$606

Kansas CityQuito

MCI - UIO

MCIUIO

Kansas City

Wed 4/30

5:45 am-8:00 pm

1 stop14h 15m

Quito Mariscal Sucr

Tue 5/13

11:20 pm-9:31 am

1 stop10h 11m

$606

Kansas CityQuito

MCI - UIO

MCIUIO

Kansas City

Wed 4/30

6:20 am-11:25 pm

1 stop17h 05m

Quito Mariscal Sucr

Mon 5/12

12:35 am-6:39 pm

1 stop18h 04m

$607

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 46 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to South America

Get recent, data-driven insights about flights from Missouri to South America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 20, 2025.
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,219 reviews
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines
7.6
Good
1,510 reviews
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,795 reviews
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,765 reviews
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,219 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $279 is the cheapest one-way deal found within the past few days, from Copa Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $313 and $323, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South America

Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$269Average$437FlexibilityNo cancel feeOn-time65%
DeltaCheapest$289Average$870FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$370Average$890FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$389Average$947FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$399Average$921FlexibilityNo cancel feeOn-time71%
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