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South America

$136+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated March 28, 2025.

Round-trip from

$382
(FlightHub)

One-way from

$136
(Mytrip)
From Missouri to South America
Search Deals
One-way flight from Missouri to South America
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This FlightHub deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/92:45 pmMCI - MDE
2 stops22h 30mSpirit Airlines
Wed 5/211:53 pmMDE - MCI
1 stop8h 48mSpirit Airlines
Deal found 3/28$382
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/284:23 pmMCI - MDE
1 stop20h 37mMultiple Airlines
Sat 5/102:34 pmMDE - MCI
2 stops43h 57mMultiple Airlines
Deal found 3/27$453
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/124:57 pmSTL - MDE
1 stop20h 03mMultiple Airlines
Sat 4/191:55 pmMDE - STL
1 stop9h 51mMultiple Airlines
Deal found 3/27$459
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/147:10 amSTL - BOG
2 stops20h 05mDelta
Wed 4/235:15 pmBOG - STL
2 stops16h 21mDelta
Deal found 3/28$475
This United deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/146:15 amSTL - BOG
1 stop13h 05mUnited Airlines
Tue 4/2212:14 amBOG - STL
2 stops14h 28mUnited Airlines
Deal found 3/28$479
This Travelocity deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/216:00 amSTL - BOG
1 stop13h 15mLATAM Airlines
Sun 4/272:55 pmBOG - STL
1 stop27h 01mLATAM Airlines
Deal found 3/26$545
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/165:00 amSTL - BOG
1 stop16h 17mAmerican Airlines
Wed 7/232:10 pmBOG - STL
1 stop10h 19mAmerican Airlines
Deal found 3/27$564
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/119:50 amSTL - MDE
2 stops18h 52mUnited Airlines
Mon 6/3012:15 amMDE - STL
1 stop18h 38mUnited Airlines
Deal found 3/27$570
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/25:25 amMCI - BOG
1 stop17h 05mAmerican Airlines
Tue 7/812:25 amBOG - MCI
1 stop9h 28mAmerican Airlines
Deal found 3/26$587
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/83:05 pmMCI - MDE
1 stop13h 37mUnited Airlines
Tue 7/1512:15 amMDE - MCI
1 stop11h 48mUnited Airlines
Deal found 3/27$590
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/21:09 pmMCI - BOG
2 stops21h 46mDelta
Wed 7/99:00 amBOG - MCI
1 stop14h 53mDelta
Deal found 3/26$591
This KAYAK deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/215:28 pmMCI - BOG
2 stops23h 07mLATAM Airlines
Tue 7/17:00 amBOG - MCI
2 stops15h 42mLATAM Airlines
Deal found 3/27$606

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Fri 5/9

2:45 pm-1:15 pm

2 stops22h 30m

Medellín Jose Maria Cordova Intl

Wed 5/21

1:53 pm-10:41 pm

1 stop8h 48m

$382

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Mon 4/28

4:23 pm-1:00 pm

1 stop20h 37m

Medellín Jose Maria Cordova Intl

Sat 5/10

2:34 pm-10:31 am

2 stops43h 57m

$453

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 4/12

4:57 pm-1:00 pm

1 stop20h 03m

Medellín Jose Maria Cordova Intl

Sat 4/19

1:55 pm-11:46 pm

1 stop9h 51m

$459

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/14

7:10 am-3:15 am

2 stops20h 05m

Bogotá El Dorado

Wed 4/23

5:15 pm-9:36 am

2 stops16h 21m

$475

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/14

6:15 am-7:20 pm

1 stop13h 05m

Bogotá El Dorado

Tue 4/22

12:14 am-2:42 pm

2 stops14h 28m

$479

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 4/21

6:00 am-7:15 pm

1 stop13h 15m

Bogotá El Dorado

Sun 4/27

2:55 pm-5:56 pm

1 stop27h 01m

$545

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Wed 7/16

5:00 am-9:17 pm

1 stop16h 17m

Bogotá El Dorado

Wed 7/23

2:10 pm-12:29 am

1 stop10h 19m

$564

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 6/11

9:50 am-4:42 am

2 stops18h 52m

Medellín Jose Maria Cordova Intl

Mon 6/30

12:15 am-6:53 pm

1 stop18h 38m

$570

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Wed 7/2

5:25 am-10:30 pm

1 stop17h 05m

Bogotá El Dorado

Tue 7/8

12:25 am-9:53 am

1 stop9h 28m

$587

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Tue 7/8

3:05 pm-4:42 am

1 stop13h 37m

Medellín Jose Maria Cordova Intl

Tue 7/15

12:15 am-12:03 pm

1 stop11h 48m

$590

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 54 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated March 28, 2025.
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,896 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,750 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,603 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air Canada
7.0
Good
8,986 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $136 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $310 and $323, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South America

Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$265Average$434FlexibilityNo cancel feeOn-time65%
DeltaCheapest$289Average$899FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$389Average$943FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$396Average$898FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$441Average$919FlexibilityNo cancel feeOn-time71%
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