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South America

$269+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BOG
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$544
(Avianca Connect)

One-way from

$269
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Sao Paulo (SAO) flights.
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From Mississippi to South America
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One-way flight from Mississippi to South America
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Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This Avianca Connect deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/245:00 amMEM - CTG
2 stops17h 54mMultiple Airlines
Tue 7/296:06 amCTG - MEM
2 stops16h 51mMultiple Airlines
Deal found 3/31$544
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:14 pmMEM - GIG
2 stops29h 21mMultiple Airlines
Wed 5/211:20 pmGIG - MEM
3 stops30h 09mMultiple Airlines
Deal found 3/30$601
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/85:14 pmMEM - GRU
2 stops18h 01mMultiple Airlines
Mon 5/1210:00 amGRU - MEM
2 stops32h 19mMultiple Airlines
Deal found 3/31$641
This United deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/127:00 amMEM - LIM
1 stop16h 00mUnited Airlines
Fri 11/141:50 amLIM - MEM
1 stop17h 14mUnited Airlines
Deal found 3/31$645
This LATAM Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:45 amMEM - LIM
2 stops25h 15mLATAM Airlines
Fri 10/1712:05 amLIM - MEM
2 stops22h 43mLATAM Airlines
Deal found 3/30$661
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/123:35 pmMEM - LIM
2 stops14h 50mDelta
Fri 11/1412:10 amLIM - MEM
2 stops19h 07mDelta
Deal found 3/31$665
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/245:41 pmMEM - CTG
1 stop20h 29mAmerican Airlines
Tue 7/291:25 pmCTG - MEM
1 stop10h 41mAmerican Airlines
Deal found 3/31$770
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:00 amMEM - GRU
1 stop23h 30mUnited Airlines
Thu 5/2210:20 pmGRU - MEM
1 stop14h 42mUnited Airlines
Deal found 3/31$809
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/45:45 pmMEM - LIM
1 stop10h 25mAmerican Airlines
Sat 7/1211:45 pmLIM - MEM
1 stop17h 16mAmerican Airlines
Deal found 3/30$834
This LATAM Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/812:32 pmMEM - GRU
1 stop15h 08mLATAM Airlines
Mon 5/128:15 amGRU - MEM
2 stops17h 01mLATAM Airlines
Deal found 3/31$859
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/245:45 amMEM - CTG
1 stop7h 07mDelta
Mon 7/283:46 amCTG - MEM
2 stops14h 30mDelta
Deal found 3/31$915
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/147:00 amMOB - EZE
1 stop23h 00mUnited Airlines
Wed 5/219:00 pmEZE - MOB
1 stop16h 43mUnited Airlines
Deal found 3/30$1,046

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Mississippi

Fly to

South America

Route

Depart

Return

Price

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Thu 7/24

5:00 am-10:54 pm

2 stops17h 54m

Cartagena Rafael Nunez

Tue 7/29

6:06 am-10:57 pm

2 stops16h 51m

$544

MemphisRio de Janeiro

MEM - GIG

MEMGIG

Memphis

Wed 5/14

5:14 pm-12:35 am

2 stops29h 21m

Rio de Janeiro–Galeão Intl

Wed 5/21

1:20 pm-5:29 pm

3 stops30h 09m

$601

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Thu 5/8

5:14 pm-1:15 pm

2 stops18h 01m

Sao Paulo Guarulhos Intl

Mon 5/12

10:00 am-4:19 pm

2 stops32h 19m

$641

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Thu 5/15

8:00 am-9:30 am

1 stop23h 30m

Sao Paulo Guarulhos Intl

Thu 5/22

10:20 pm-11:02 am

1 stop14h 42m

$809

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 7/4

6:25 am-9:45 pm

2 stops15h 20m

Lima J Chavez Intl

Fri 7/11

12:05 am-8:26 pm

2 stops20h 21m

$820

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Thu 7/24

5:45 am-7:32 pm

2 stops13h 47m

Cartagena Rafael Nunez

Mon 7/28

3:46 am-6:16 pm

2 stops14h 30m

$822

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 7/4

5:45 pm-4:10 am

1 stop10h 25m

Lima J Chavez Intl

Sat 7/12

11:45 pm-5:01 pm

1 stop17h 16m

$834

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Thu 5/8

5:58 pm-9:00 am

1 stop13h 02m

Sao Paulo Guarulhos Intl

Mon 5/12

10:50 pm-11:27 am

1 stop14h 37m

$859

MobileBuenos Aires

MOB - EZE

MOBEZE

Mobile

Wed 5/14

7:00 am-8:00 am

1 stop23h 00m

Buenos Aires Ministro Pistarini

Wed 5/21

9:00 pm-11:43 am

1 stop16h 43m

$1,046

MemphisBuenos Aires

MEM - EZE

MEMEZE

Memphis

Thu 5/15

8:00 am-8:00 am

2 stops22h 00m

Buenos Aires Ministro Pistarini

Thu 5/22

9:00 pm-4:25 pm

1 stop21h 25m

$1,055

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 33 results
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Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest month to book a flight from Mississippi to South America?

Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated March 31, 2025.
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,754 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air Canada
7.0
Good
9,004 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Crew

8.5

Comfort

8.0

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Mississippi to South America one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $390. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Mississippi to South America for a low price.

  • Can I find deals for flights from Mississippi to South America that include hotel bookings?

    Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

  • Can I find deals for business class flights from Mississippi to South America?

    Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South America?

    Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to South America

Discover the top 2 airlines that operate flights from Mississippi to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$528Average$692FlexibilityNo cancel feeOn-time69%
DeltaCheapest$583Average$674FlexibilityNo cancel feeOn-timeN/A
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