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South America

$553+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$553
(American Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/68:45 pmTYS - CTG
2 stops16h 25mAmerican Airlines
Sun 9/281:55 pmCTG - TYS
2 stops19h 35mAmerican Airlines
Deal found 3/27$553
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/205:30 amTYS - LIM
1 stop16h 40mDelta
Tue 8/2612:05 amLIM - TYS
2 stops17h 12mDelta
Deal found 3/27$595
This LATAM Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1412:00 pmTYS - LIM
2 stops19h 25mLATAM Airlines
Mon 7/211:30 pmLIM - TYS
2 stops20h 37mLATAM Airlines
Deal found 3/25$630
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2011:26 amTYS - LIM
2 stops11h 55mAmerican Airlines
Wed 8/276:55 amLIM - TYS
2 stops16h 22mAmerican Airlines
Deal found 3/27$703
This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/263:19 pmTYS - GRU
3 stops37h 16mMultiple Airlines
Sat 5/36:00 amGRU - TYS
3 stops39h 55mMultiple Airlines
Deal found 3/26$741
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/157:00 amTYS - LIM
1 stop17h 00mUnited Airlines
Sun 5/412:40 amLIM - TYS
2 stops32h 35mUnited Airlines
Deal found 3/26$756
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/511:06 amTYS - SCL
2 stops19h 59mAmerican Airlines
Mon 8/189:55 pmSCL - TYS
2 stops17h 50mAmerican Airlines
Deal found 3/27$758
This Avianca deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/47:00 amTYS - CTG
2 stops17h 36mAvianca
Mon 4/77:01 pmCTG - TYS
2 stops14h 04mAvianca
Deal found 3/27$829
This Avianca deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/157:00 amTYS - LIM
2 stops18h 35mAvianca
Mon 4/212:50 amLIM - TYS
2 stops18h 32mAvianca
Deal found 3/27$836
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/46:55 amTYS - GRU
1 stop21h 20mAmerican Airlines
Sun 5/2510:00 pmGRU - TYS
1 stop22h 56mAmerican Airlines
Deal found 3/26$889
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2610:40 amTYS - GRU
1 stop19h 55mUnited Airlines
Sat 5/39:50 pmGRU - TYS
2 stops25h 55mUnited Airlines
Deal found 3/26$943
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2610:25 amTYS - GRU
1 stop18h 15mDelta
Sat 5/310:50 pmGRU - TYS
1 stop15h 58mDelta
Deal found 3/26$989

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 9/6

8:45 pm-12:10 pm

2 stops16h 25m

Cartagena Rafael Nunez

Sun 9/28

1:55 pm-10:30 am

2 stops19h 35m

$553

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Wed 8/20

5:30 am-9:10 pm

1 stop16h 40m

Lima J Chavez Intl

Tue 8/26

12:05 am-6:17 pm

2 stops17h 12m

$595

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 7/14

12:00 pm-6:25 am

2 stops19h 25m

Lima J Chavez Intl

Mon 7/21

1:30 pm-11:07 am

2 stops20h 37m

$630

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Wed 8/20

11:26 am-10:21 pm

2 stops11h 55m

Lima J Chavez Intl

Wed 8/27

6:55 am-12:17 am

2 stops16h 22m

$703

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sat 4/26

3:19 pm-5:35 am

3 stops37h 16m

Sao Paulo Guarulhos Intl

Sat 5/3

6:00 am-8:55 pm

3 stops39h 55m

$741

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 4/15

7:00 am-11:00 pm

1 stop17h 00m

Lima J Chavez Intl

Sun 5/4

12:40 am-10:15 am

2 stops32h 35m

$756

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/5

11:06 am-7:05 am

2 stops19h 59m

Santiago Arturo Merino Benitez

Mon 8/18

9:55 pm-3:45 pm

2 stops17h 50m

$758

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 4/15

7:00 am-12:35 am

2 stops18h 35m

Lima J Chavez Intl

Mon 4/21

2:50 am-10:22 pm

2 stops18h 32m

$836

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 5/4

6:55 am-5:15 am

1 stop21h 20m

Sao Paulo Guarulhos Intl

Sun 5/25

10:00 pm-7:56 pm

1 stop22h 56m

$889

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sat 4/26

10:40 am-7:35 am

1 stop19h 55m

Sao Paulo Guarulhos Intl

Sat 5/3

9:50 pm-10:45 pm

2 stops25h 55m

$943

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 22 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated March 28, 2025.
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,896 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,750 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,395 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,603 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Lima J Chavez Intl, Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl or Knoxville McGhee Tyson - Armenia El Eden when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South America

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Top 4 airlines flying from Knoxville to South America

Discover the top 4 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$392Average$691FlexibilityNo cancel feeOn-time71%
DeltaCheapest$399Average$893FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$575Average$656FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$948Average$1,167FlexibilityNo cancel feeOn-time69%
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