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South America

$493+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated April 17, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$493
(Mytrip)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/18:35 pmTYS - CTG
1 stop16h 35mMultiple Airlines
Sun 6/81:15 pmCTG - TYS
1 stop18h 04mMultiple Airlines
Deal found 4/16$493
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/99:09 amTYS - LIM
3 stops19h 16mMultiple Airlines
Mon 6/162:50 amLIM - TYS
2 stops35h 35mMultiple Airlines
Deal found 4/16$591
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/97:44 pmTYS - LIM
1 stop10h 16mDelta
Tue 6/178:50 amLIM - TYS
2 stops14h 09mDelta
Deal found 4/16$657
This LATAM Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/157:07 amTYS - LIM
2 stops15h 33mLATAM Airlines
Sat 8/2312:15 amLIM - TYS
2 stops17h 02mLATAM Airlines
Deal found 4/16$670
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/145:46 pmTYS - LIM
2 stops30h 14mUnited Airlines
Sun 7/2012:40 amLIM - TYS
2 stops32h 37mUnited Airlines
Deal found 4/16$760
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/157:12 amTYS - LIM
1 stop16h 09mAmerican Airlines
Sun 8/2411:56 pmLIM - TYS
1 stop22h 26mAmerican Airlines
Deal found 4/16$777
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/52:48 pmTYS - SCL
2 stops16h 17mAmerican Airlines
Mon 8/189:55 pmSCL - TYS
2 stops19h 41mAmerican Airlines
Deal found 4/17$808
This StudentUniverse deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure StudentUniverse is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/315:45 amTYS - LIM
2 stops20h 40mCopa Airlines
Sat 6/71:20 pmLIM - TYS
2 stops20h 07mCopa Airlines
Deal found 4/16$823
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:59 pmTYS - GRU
2 stops31h 36mMultiple Airlines
Sat 5/314:50 pmGRU - TYS
2 stops27h 55mMultiple Airlines
Deal found 4/17$875
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/159:55 amTYS - GRU
1 stop22h 35mUnited Airlines
Sat 5/319:30 pmGRU - TYS
1 stop13h 57mUnited Airlines
Deal found 4/17$898
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/512:00 pmTYS - SCL
1 stop19h 00mDelta
Mon 8/188:40 pmSCL - TYS
1 stop16h 46mDelta
Deal found 4/17$944
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/175:45 amTYS - GRU
2 stops13h 15mDelta
Sat 5/2410:50 pmGRU - TYS
1 stop17h 27mDelta
Deal found 4/16$993

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 6/1

8:35 pm-12:10 pm

1 stop16h 35m

Cartagena Rafael Nunez

Sun 6/8

1:15 pm-8:19 am

1 stop18h 04m

$493

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/9

9:09 am-3:25 am

3 stops19h 16m

Lima J Chavez Intl

Mon 6/16

2:50 am-3:25 pm

2 stops35h 35m

$591

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/9

7:44 pm-5:00 am

1 stop10h 16m

Lima J Chavez Intl

Tue 6/17

8:50 am-11:59 pm

2 stops14h 09m

$657

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Fri 8/15

7:07 am-9:40 pm

2 stops15h 33m

Lima J Chavez Intl

Sat 8/23

12:15 am-6:17 pm

2 stops17h 02m

$670

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 7/14

5:46 pm-11:00 pm

2 stops30h 14m

Lima J Chavez Intl

Sun 7/20

12:40 am-10:17 am

2 stops32h 37m

$760

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Fri 8/15

7:12 am-10:21 pm

1 stop16h 09m

Lima J Chavez Intl

Sun 8/24

11:56 pm-11:22 pm

1 stop22h 26m

$777

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/5

2:48 pm-7:05 am

2 stops16h 17m

Santiago Arturo Merino Benitez

Mon 8/18

9:55 pm-5:36 pm

2 stops19h 41m

$808

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sat 5/31

5:45 am-1:25 am

2 stops20h 40m

Lima J Chavez Intl

Sat 6/7

1:20 pm-10:27 am

2 stops20h 07m

$823

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 5/15

8:59 pm-5:35 am

2 stops31h 36m

Sao Paulo Guarulhos Intl

Sat 5/31

4:50 pm-7:45 pm

2 stops27h 55m

$875

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 5/15

9:55 am-9:30 am

1 stop22h 35m

Sao Paulo Guarulhos Intl

Sat 5/31

9:30 pm-10:27 am

1 stop13h 57m

$898

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 25 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 17, 2025.
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,917 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,409 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,761 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to South America one-way?

    The cheapest airline one-way is LATAM Airlines, with whom users have recently found tickets for as low as $1,154. However, be on the lookout for offers from Delta and Air Canada, as they are both options that can get you from Knoxville to South America for a low price.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Lima J Chavez Intl, Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl or Knoxville McGhee Tyson - Armenia El Eden when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$392Average$752FlexibilityNo cancel feeOn-time71%
DeltaCheapest$399Average$884FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$590Average$753FlexibilityNo cancel feeOn-time81%

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