HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$413+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Nov 25 — Dec 21
Mon 11/25
Mon 12/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to South America with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to South America

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to South America (0SA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2024.

Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2024.

This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/304:44 pmTYS - CTG
2 stops20h 26mMultiple Airlines
Fri 1/310:06 pmCTG - TYS
2 stops24h 02mMultiple Airlines
Deal found 11/19$596
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/237:25 pmTYS - LIM
2 stops22h 15mMultiple Airlines
Mon 11/256:45 pmLIM - TYS
2 stops28h 27mMultiple Airlines
Deal found 11/19$976
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/296:26 pmTYS - CTG
2 stops19h 04mAmerican Airlines
Fri 1/32:30 pmCTG - TYS
2 stops19h 45mAmerican Airlines
Deal found 11/20$998
This CheapOair deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/167:59 pmTYS - GRU
2 stops31h 41mLATAM Airlines
Sat 1/1810:50 amGRU - TYS
2 stops48h 33mLATAM Airlines
Deal found 11/20$1,074
This LATAM Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/235:34 pmTYS - LIM
1 stop11h 26mLATAM Airlines
Mon 11/2512:10 pmLIM - TYS
1 stop11h 40mLATAM Airlines
Deal found 11/19$1,148
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/239:09 amTYS - LIM
2 stops14h 16mAmerican Airlines
Sun 11/2412:45 amLIM - TYS
2 stops15h 02mAmerican Airlines
Deal found 11/19$1,214
This Avianca deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2310:55 amTYS - GRU
2 stops16h 55mMultiple Airlines
Sun 11/241:50 amGRU - TYS
2 stops17h 05mMultiple Airlines
Deal found 11/19$1,282
This CheapOair deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/176:57 pmTYS - EZE
2 stops33h 03mLATAM Airlines
Tue 12/247:10 pmEZE - TYS
2 stops17h 49mLATAM Airlines
Deal found 11/18$1,494
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/177:00 amTYS - EZE
1 stop22h 20mUnited Airlines
Tue 12/2411:55 pmEZE - TYS
1 stop16h 05mUnited Airlines
Deal found 11/18$1,532
This KAYAK deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2811:40 amTYS - SCL
2 stops16h 45mLATAM Airlines
Sat 1/49:05 pmSCL - TYS
2 stops38h 18mLATAM Airlines
Deal found 11/20$1,544
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/164:10 pmTYS - GRU
2 stops15h 05mAmerican Airlines
Fri 1/1712:30 amGRU - TYS
1 stop23h 53mAmerican Airlines
Deal found 11/20$1,570
This Mytrip deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/179:50 amTYS - EZE
3 stops30h 20mMultiple Airlines
Tue 12/248:00 amEZE - TYS
3 stops36h 57mMultiple Airlines
Deal found 11/18$1,612

Find flights from Knoxville to South America within your budget

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,629,791 searches. Data last updated November 20, 2024.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Tue 2/4

8:05 pm-1:30 pm

2 stops17h 25m

Cartagena Rafael Nunez

Sun 2/9

2:30 pm-10:36 am

2 stops20h 06m

$497

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Mon 12/30

4:44 pm-1:10 pm

2 stops20h 26m

Cartagena Rafael Nunez

Fri 1/3

10:06 pm-10:08 pm

2 stops24h 02m

$596

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 2/20

7:05 am-8:50 am

1 stop23h 45m

Santiago Arturo Merino Benitez

Mon 3/10

9:45 pm-8:02 pm

1 stop23h 17m

$798

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sat 3/15

11:30 am-5:40 am

2 stops17h 10m

Sao Paulo Guarulhos Intl

Sat 3/22

7:35 am-11:45 pm

2 stops17h 10m

$942

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Fri 3/14

8:47 am-8:15 am

2 stops24h 28m

Lima J Chavez Intl

Sat 3/22

8:15 am-9:12 am

2 stops23h 57m

$943

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 2/22

5:15 pm-5:25 pm

2 stops22h 10m

Santiago Arturo Merino Benitez

Sun 3/9

4:00 pm-6:13 pm

2 stops27h 13m

$944

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/21

7:17 pm-3:00 pm

2 stops17h 43m

Santiago Arturo Merino Benitez

Sat 3/8

8:10 am-11:47 pm

2 stops17h 37m

$953

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 2/22

12:46 pm-7:50 am

2 stops17h 04m

Santiago Arturo Merino Benitez

Sun 3/9

10:45 pm-1:14 pm

1 stop15h 29m

$957

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sat 3/15

7:25 pm-5:00 am

1 stop10h 35m

Lima J Chavez Intl

Sat 3/22

1:00 pm-9:12 am

2 stops43h 12m

$1,006

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Mon 12/16

7:59 pm-5:40 am

2 stops31h 41m

Sao Paulo Guarulhos Intl

Sat 1/18

10:50 am-9:23 am

2 stops48h 33m

$1,074

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Showing 1-10 of 25 results
1
2
3

Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to South America

Get recent, data-driven insights about flights from Knoxville to South America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $355). Flying from Knoxville to South America in December is currently the most expensive (average of $488). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2024.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 20, 2024.
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,756 reviews
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,934 reviews
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
9,171 reviews
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Air Canada
7.0
Good
8,237 reviews
Delta
8.0
Very good
8,756 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to South America one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $413. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Knoxville to South America for a low price.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl, Knoxville McGhee Tyson - Cartagena Rafael Nunez or Knoxville McGhee Tyson - Lima J Chavez Intl when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $355). Flying from Knoxville to South America in December is currently the most expensive (average of $488). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to South America

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Nashville to Los Angeles flights
Nashville to Las Vegas flights
Nashville to Fort Lauderdale flights
Memphis to LaGuardia flights
Nashville to Orlando flights
Nashville to O'Hare Intl flights
Nashville to Seattle flights
Memphis to Las Vegas flights
Nashville to Reagan-National flights
Nashville to Denver flights
Nashville to Miami flights
Chattanooga to LaGuardia flights
Nashville to Dulles Intl flights
Memphis to Newark flights
Memphis to Miami flights
Nashville to Boston flights
Nashville to Heathrow flights
Nashville to Hobby flights
Memphis to John F Kennedy Intl flights
Memphis to Orlando flights
Nashville to Baltimore flights
Nashville to Dallas/Fort Worth flights
Knoxville to O'Hare Intl flights
Chattanooga to John F Kennedy Intl flights
Memphis to O'Hare Intl flights
Memphis to Denver flights
Nashville to Cancún flights
Nashville to San Francisco flights
Nashville to Salt Lake City flights
Memphis to Los Angeles flights
Nashville to Philadelphia flights
Nashville to George Bush Intcntl flights
Memphis to Hobby flights
Knoxville to LaGuardia flights
Nashville to Ontario flights
Knoxville to John F Kennedy Intl flights
Memphis to Atlanta flights
Chattanooga to Newark flights
Nashville to Sky Harbor Intl flights
Knoxville to Dulles Intl flights
Knoxville to Denver flights
Nashville to Vancouver Intl flights
Nashville to Austin flights
Knoxville to Reagan-National flights
Nashville to San Diego flights
Nashville to Charlotte flights
Nashville to Luis Munoz Marin Intl flights

Top 2 airlines flying from Knoxville to South America

Discover the top 2 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,629,791 searches. Data last updated November 20, 2024.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$378Average$800FlexibilityNo cancel feeOn-time71%
DeltaCheapest$399Average$1,099FlexibilityNo cancel feeOn-timeN/A
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
View all available airlines