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South America

$533+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Jan 22 — Jan 291
Wed 1/22
Wed 1/29
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to South America (0SA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 17, 2025.

Round-trip from

$533
(American Airlines)
From Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 17, 2025.

This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/266:53 amTYS - CTG
1 stop6h 37mAmerican Airlines
Tue 4/17:35 amCTG - TYS
1 stop14h 19mAmerican Airlines
Deal found 1/16$533
This Avianca deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/279:55 amTYS - LIM
2 stops15h 50mMultiple Airlines
Mon 3/316:45 pmLIM - TYS
2 stops14h 20mMultiple Airlines
Deal found 1/16$615
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/276:53 amTYS - LIM
1 stop17h 32mAmerican Airlines
Mon 3/316:28 amLIM - TYS
1 stop15h 26mAmerican Airlines
Deal found 1/16$624
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/204:00 pmTYS - LIM
2 stops15h 25mDelta
Tue 7/2212:05 amLIM - TYS
2 stops17h 12mDelta
Deal found 1/16$645
This Mytrip deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/268:32 amTYS - GRU
2 stops21h 33mMultiple Airlines
Tue 3/47:25 pmGRU - TYS
2 stops26h 27mMultiple Airlines
Deal found 1/15$669
This LATAM Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/204:00 pmTYS - LIM
2 stops15h 25mLATAM Airlines
Thu 7/2412:00 pmLIM - TYS
1 stop10h 47mLATAM Airlines
Deal found 1/15$707
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/269:15 amTYS - GRU
1 stop22h 15mUnited Airlines
Tue 3/410:15 pmGRU - TYS
1 stop23h 47mUnited Airlines
Deal found 1/15$758
This Gotogate deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/225:45 amTYS - LIM
2 stops35h 55mAvianca
Mon 2/106:45 pmLIM - TYS
2 stops39h 59mAvianca
Deal found 1/15$827
This StudentUniverse deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure StudentUniverse is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/17:25 pmTYS - MVD
2 stops22h 35mLATAM Airlines
Tue 7/86:55 pmMVD - TYS
3 stops29h 52mLATAM Airlines
Deal found 1/16$906
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1412:54 pmTYS - GRU
2 stops18h 16mAmerican Airlines
Wed 3/1912:05 amGRU - TYS
2 stops16h 41mAmerican Airlines
Deal found 1/15$913
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/205:45 amTYS - LIM
2 stops18h 10mUnited Airlines
Sun 2/91:50 amLIM - TYS
2 stops32h 54mUnited Airlines
Deal found 1/15$924
This United deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/254:55 pmTYS - EZE
1 stop14h 25mUnited Airlines
Mon 4/79:00 pmEZE - TYS
1 stop24h 06mUnited Airlines
Deal found 1/15$975

Find flights from Knoxville to South America within your budget

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.

Fly from

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Fly to

Any airport

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 3/26

6:53 am-12:30 pm

1 stop6h 37m

Cartagena Rafael Nunez

Tue 4/1

7:35 am-10:54 pm

1 stop14h 19m

$533

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 3/27

9:55 am-12:45 am

2 stops15h 50m

Lima J Chavez Intl

Mon 3/31

6:45 pm-10:05 am

2 stops14h 20m

$615

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 3/27

6:53 am-11:25 pm

1 stop17h 32m

Lima J Chavez Intl

Mon 3/31

6:28 am-10:54 pm

1 stop15h 26m

$624

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 2/26

8:32 am-8:05 am

2 stops21h 33m

Sao Paulo Guarulhos Intl

Tue 3/4

7:25 pm-7:52 pm

2 stops26h 27m

$669

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 3/27

5:00 pm-5:00 am

1 stop13h 00m

Lima J Chavez Intl

Sun 3/30

12:05 am-6:38 pm

2 stops17h 33m

$709

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 2/26

9:15 am-9:30 am

1 stop22h 15m

Sao Paulo Guarulhos Intl

Tue 3/4

10:15 pm-8:02 pm

1 stop23h 47m

$758

KnoxvilleMontevideo

TYS - MVD

TYSMVD

Knoxville McGhee Tyson

Tue 7/1

7:25 pm-7:00 pm

2 stops22h 35m

Montevideo Carrasco

Tue 7/8

6:55 pm-11:47 pm

3 stops29h 52m

$906

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 3/14

12:54 pm-8:10 am

2 stops18h 16m

Sao Paulo Guarulhos Intl

Wed 3/19

12:05 am-3:46 pm

2 stops16h 41m

$913

KnoxvilleBuenos Aires

TYS - EZE

TYSEZE

Knoxville McGhee Tyson

Tue 3/25

4:55 pm-8:20 am

1 stop14h 25m

Buenos Aires Ministro Pistarini

Mon 4/7

9:00 pm-8:06 pm

1 stop24h 06m

$975

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/21

7:25 pm-8:50 am

2 stops35h 25m

Santiago Arturo Merino Benitez

Fri 2/28

10:45 pm-4:54 pm

2 stops20h 09m

$1,058

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/16

Showing 1-10 of 25 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to South America

Get recent, data-driven insights about flights from Knoxville to South America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 17, 2025.
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,511 reviews
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,849 reviews
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,965 reviews
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Air Canada
7.0
Good
8,587 reviews
Delta
8.0
Very good
8,511 reviews

Food

7.3

Crew

8.6

Comfort

8.0

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini, Knoxville McGhee Tyson - Lima J Chavez Intl or Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$391Average$857FlexibilityNo cancel feeOn-time71%
DeltaCheapest$399Average$1,041FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$575Average$627FlexibilityNo cancel feeOn-time81%
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