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South America

$255+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
fev 27 — mar 61
qui 2/27
qui 3/6
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated fevereiro 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$533
(American Airlines)

One-way from

$255
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to South America
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One-way flight from Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on fevereiro 22, 2025.

This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 5/107:00 amTYS - CTG
1 stop8h 10mAmerican Airlines
sáb 6/141:55 pmCTG - TYS
2 stops19h 24mAmerican Airlines
Deal found 2/21$533
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/25:30 amTYS - LIM
2 stops17h 30mDelta
sáb 10/118:15 amLIM - TYS
2 stops14h 32mDelta
Deal found 2/21$619
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 4/287:15 amTYS - LIM
2 stops32h 20mMultiple Airlines
dom 5/181:15 amLIM - TYS
2 stops35h 47mMultiple Airlines
Deal found 2/20$647
This Avianca deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 4/159:55 amTYS - LIM
2 stops16h 50mAvianca
seg 4/212:50 amLIM - TYS
2 stops18h 32mAvianca
Deal found 2/22$650
This LATAM Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 7/1412:00 pmTYS - LIM
2 stops19h 25mLATAM Airlines
dom 7/2012:05 amLIM - TYS
2 stops22h 42mLATAM Airlines
Deal found 2/21$661
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 5/105:30 amTYS - CTG
1 stop8h 49mDelta
sáb 6/142:06 pmCTG - TYS
1 stop8h 41mDelta
Deal found 2/21$677
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 4/246:55 amTYS - LIM
1 stop14h 35mAmerican Airlines
ter 4/296:30 amLIM - TYS
1 stop15h 59mAmerican Airlines
Deal found 2/20$735
This United deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 4/110:40 amTYS - LIM
1 stop13h 20mUnited Airlines
seg 4/1412:40 amLIM - TYS
1 stop14h 11mUnited Airlines
Deal found 2/21$786
This LATAM Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 5/1011:55 amTYS - CTG
2 stops14h 13mLATAM Airlines
sex 6/133:42 amCTG - TYS
2 stops28h 31mLATAM Airlines
Deal found 2/21$815
This StudentUniverse deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure StudentUniverse is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 3/49:55 amTYS - GRU
2 stops18h 50mCopa Airlines
sex 3/73:15 amGRU - TYS
2 stops18h 19mCopa Airlines
Deal found 2/22$1,052
This LATAM Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 3/47:17 pmTYS - GRU
1 stop12h 18mLATAM Airlines
sáb 3/81:25 pmGRU - TYS
2 stops22h 49mLATAM Airlines
Deal found 2/22$1,059
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 3/47:40 pmTYS - GRU
1 stop11h 35mAmerican Airlines
sex 3/712:30 amGRU - TYS
1 stop24h 14mAmerican Airlines
Deal found 2/22$1,069

Find flights from Knoxville to South America within your budget

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated fevereiro 22, 2025.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

sáb 5/10

7:00 am-2:10 pm

1 stop8h 10m

Cartagena Rafael Nunez

sáb 6/14

1:55 pm-10:19 am

2 stops19h 24m

$533

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

seg 4/28

7:15 am-2:35 pm

2 stops32h 20m

Lima J Chavez Intl

dom 5/18

1:15 am-2:02 pm

2 stops35h 47m

$647

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

ter 4/15

9:55 am-1:45 am

2 stops16h 50m

Lima J Chavez Intl

seg 4/21

2:50 am-10:22 pm

2 stops18h 32m

$650

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

ter 4/15

7:00 am-8:20 pm

2 stops14h 20m

Lima J Chavez Intl

ter 4/22

8:50 am-11:48 pm

2 stops13h 58m

$655

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

seg 7/14

12:00 pm-6:25 am

2 stops19h 25m

Lima J Chavez Intl

dom 7/20

12:05 am-11:47 pm

2 stops22h 42m

$661

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

sáb 5/10

5:30 am-1:19 pm

1 stop8h 49m

Cartagena Rafael Nunez

sáb 6/14

2:06 pm-11:47 pm

1 stop8h 41m

$677

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

qui 4/24

6:55 am-8:30 pm

1 stop14h 35m

Lima J Chavez Intl

ter 4/29

6:30 am-11:29 pm

1 stop15h 59m

$735

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

ter 4/1

10:40 am-11:00 pm

1 stop13h 20m

Lima J Chavez Intl

seg 4/14

12:40 am-3:51 pm

1 stop14h 11m

$786

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

sáb 5/10

11:55 am-1:08 am

2 stops14h 13m

Cartagena Rafael Nunez

sex 6/13

3:42 am-9:13 am

2 stops28h 31m

$815

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

ter 3/4

9:55 am-6:45 am

2 stops18h 50m

Sao Paulo Guarulhos Intl

sex 3/7

3:15 am-7:34 pm

2 stops18h 19m

$1,052

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 26 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to South America

Get recent, data-driven insights about flights from Knoxville to South America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated fevereiro 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated fevereiro 22, 2025.
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,203 reviews
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines
7.6
Good
1,502 reviews
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,789 reviews
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,754 reviews
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,203 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to South America one-way?

    The cheapest airline one-way is Copa Airlines, with whom users have recently found tickets for as low as $311. However, be on the lookout for offers from American Airlines and LATAM Airlines, as they are both options that can get you from Knoxville to South America for a low price.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Lima J Chavez Intl, Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl or Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Knoxville to South America

Discover the top 4 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated fevereiro 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$392Average$700FlexibilityNo cancel feeOn-time71%
DeltaCheapest$399Average$1,004FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$575Average$656FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$948Average$1,167FlexibilityNo cancel feeOn-time69%
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