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South America

$239+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Apr 20 — Apr 271
Sun 4/20
Sun 4/27
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated April 15, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$472
(Mytrip)

One-way from

$239
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$862
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
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From Des Moines to South America
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One-way flight from Des Moines to South America
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Highest demand for flights based on searches. 18% potential increase in price ($266 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($111 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

This Mytrip deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:30 amDSM - CTG
1 stop29h 40mMultiple Airlines
Tue 5/271:15 pmCTG - DSM
2 stops20h 27mMultiple Airlines
Deal found 4/15$472
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/184:22 pmDSM - CTG
2 stops21h 48mAmerican Airlines
Sat 8/231:55 pmCTG - DSM
1 stop8h 21mAmerican Airlines
Deal found 4/15$604
This Mytrip deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:00 amDSM - UIO
3 stops32h 21mMultiple Airlines
Thu 6/53:07 amUIO - DSM
3 stops38h 11mMultiple Airlines
Deal found 4/15$628
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:35 pmDSM - CTG
1 stop18h 44mDelta
Fri 6/65:15 amCTG - DSM
2 stops12h 35mDelta
Deal found 4/15$642
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:07 amDSM - GYE
2 stops29h 10mUnited Airlines
Fri 6/612:17 pmGYE - DSM
2 stops34h 15mUnited Airlines
Deal found 4/15$667
This Mytrip deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:30 amDSM - GYE
2 stops16h 50mMultiple Airlines
Thu 6/512:04 amGYE - DSM
3 stops41h 14mMultiple Airlines
Deal found 4/14$684
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:07 amDSM - UIO
1 stop17h 18mUnited Airlines
Thu 6/512:35 amUIO - DSM
1 stop21h 47mUnited Airlines
Deal found 4/15$699
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2410:15 amDSM - LIM
2 stops20h 10mDelta
Thu 9/412:15 pmLIM - DSM
2 stops21h 01mDelta
Deal found 4/15$709
This Mytrip deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/305:25 pmDSM - LIM
3 stops43h 00mMultiple Airlines
Thu 6/51:55 amLIM - DSM
3 stops39h 23mMultiple Airlines
Deal found 4/15$728
This LATAM Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/156:47 pmDSM - LIM
2 stops25h 28mLATAM Airlines
Tue 6/1712:05 amLIM - DSM
2 stops17h 57mLATAM Airlines
Deal found 4/15$733
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:30 amDSM - UIO
2 stops13h 30mDelta
Fri 6/611:20 pmUIO - DSM
2 stops13h 07mDelta
Deal found 4/15$750
This lastminute.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:35 pmDSM - UIO
1 stop25h 25mLATAM Airlines
Fri 6/67:09 pmUIO - DSM
2 stops39h 30mLATAM Airlines
Deal found 4/15$757

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Fri 5/23

6:30 am-12:10 pm

1 stop29h 40m

Cartagena Rafael Nunez

Tue 5/27

1:15 pm-9:42 am

2 stops20h 27m

$472

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Mon 8/18

4:22 pm-2:10 pm

2 stops21h 48m

Cartagena Rafael Nunez

Sat 8/23

1:55 pm-10:16 pm

1 stop8h 21m

$604

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Fri 5/30

6:00 am-2:21 pm

3 stops32h 21m

Quito Mariscal Sucr

Thu 6/5

3:07 am-5:18 pm

3 stops38h 11m

$628

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Fri 5/30

6:35 pm-1:19 pm

1 stop18h 44m

Cartagena Rafael Nunez

Fri 6/6

5:15 am-5:50 pm

2 stops12h 35m

$642

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Fri 5/30

6:07 am-11:17 am

2 stops29h 10m

Guayaquil Jose Joaquin de Olmedo

Fri 6/6

12:17 pm-10:32 pm

2 stops34h 15m

$667

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Fri 5/30

6:30 am-11:20 pm

2 stops16h 50m

Guayaquil Jose Joaquin de Olmedo

Thu 6/5

12:04 am-5:18 pm

3 stops41h 14m

$684

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Fri 5/30

6:07 am-11:25 pm

1 stop17h 18m

Quito Mariscal Sucr

Thu 6/5

12:35 am-10:22 pm

1 stop21h 47m

$699

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Fri 5/30

5:25 pm-12:25 pm

3 stops43h 00m

Lima J Chavez Intl

Thu 6/5

1:55 am-5:18 pm

3 stops39h 23m

$728

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Sun 6/15

6:47 pm-8:15 pm

2 stops25h 28m

Lima J Chavez Intl

Tue 6/17

12:05 am-6:02 pm

2 stops17h 57m

$733

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Fri 5/30

6:30 am-8:00 pm

2 stops13h 30m

Quito Mariscal Sucr

Fri 6/6

11:20 pm-12:27 pm

2 stops13h 07m

$750

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 40 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America

What is the cheapest month to book a flight from Des Moines to South America?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 15, 2025.
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,918 reviews
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
KLM
7.8
Good
1,323 reviews
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,408 reviews
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,758 reviews
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,658 reviews
Delta
8.0
Very good
7,918 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • What are the cheapest airlines to fly from Des Moines to South America one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $365. Users have also found prices from $468 and $551 on Delta and American Airlines, respectively.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Sao Paulo Guarulhos Intl, Des Moines - Buenos Aires Ministro Pistarini and Des Moines - Lima J Chavez Intl.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South America?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to South America

Discover the top 3 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$477Average$876FlexibilityNo cancel feeOn-time71%
DeltaCheapest$503Average$888FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$631Average$1,130FlexibilityNo cancel feeOn-time81%

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