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$340+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$499
(Kiwi.com)

One-way from

$340
(Mytrip)

Popular in

June

Cheapest in

November
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
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From Des Moines to South America
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One-way flight from Des Moines to South America
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Highest demand for flights based on searches. 11% potential increase in price ($144 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($54 potential savings vs. average RT price).
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Find flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This United deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/18:00 amDSM - CTG
2 stops24h 43mUnited Airlines
Sat 5/319:38 amCTG - DSM
2 stops36h 44mUnited Airlines
Deal found 2/20$612
This United deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/58:00 amDSM - CTG
2 stops23h 39mMultiple Airlines
Mon 3/106:00 amCTG - DSM
2 stops32h 16mMultiple Airlines
Deal found 2/19$622
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/235:45 amDSM - UIO
1 stop14h 15mDelta
Tue 4/2911:20 pmUIO - DSM
1 stop18h 17mDelta
Deal found 2/19$641
This United deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/238:00 amDSM - UIO
2 stops15h 25mUnited Airlines
Mon 4/2812:35 amUIO - DSM
2 stops34h 05mUnited Airlines
Deal found 2/19$687
This KAYAK deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:25 pmDSM - UIO
1 stop25h 35mLATAM Airlines
Mon 4/2811:20 pmUIO - DSM
1 stop11h 21mLATAM Airlines
Deal found 2/19$697
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/15:45 amDSM - CTG
2 stops13h 47mDelta
Sat 5/312:34 pmCTG - DSM
1 stop22h 52mDelta
Deal found 2/20$724
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2211:27 amDSM - LIM
2 stops20h 48mDelta
Fri 3/2811:55 pmLIM - DSM
1 stop10h 45mDelta
Deal found 2/18$765
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/222:07 pmDSM - LIM
2 stops14h 03mAmerican Airlines
Thu 3/2712:45 amLIM - DSM
1 stop21h 49mAmerican Airlines
Deal found 2/18$769
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/53:46 pmDSM - GRU
2 stops35h 04mMultiple Airlines
Sun 3/166:00 amGRU - DSM
2 stops32h 42mMultiple Airlines
Deal found 2/20$791
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/116:30 pmDSM - GRU
1 stop13h 05mDelta
Wed 3/193:55 pmGRU - DSM
2 stops20h 45mDelta
Deal found 2/20$799
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/115:29 pmDSM - GRU
1 stop13h 01mAmerican Airlines
Tue 3/1812:30 amGRU - DSM
2 stops18h 06mAmerican Airlines
Deal found 2/20$803
This SmartFares deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/225:22 pmDSM - LIM
1 stop27h 33mLATAM Airlines
Fri 3/2811:55 pmLIM - DSM
1 stop10h 45mLATAM Airlines
Deal found 2/18$820

Find flights from Des Moines to South America within your budget

Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Thu 4/3

7:30 am-10:59 pm

2 stops15h 29m

Cartagena Rafael Nunez

Thu 4/10

1:12 pm-2:00 pm

1 stop24h 48m

$499

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sat 4/5

8:00 am-8:41 am

2 stops24h 41m

Cartagena Rafael Nunez

Sat 4/12

9:38 am-10:45 pm

2 stops37h 07m

$618

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Wed 4/23

5:45 am-8:00 pm

1 stop14h 15m

Quito Mariscal Sucr

Tue 4/29

11:20 pm-5:37 pm

1 stop18h 17m

$641

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sat 4/5

1:59 pm-12:35 pm

2 stops22h 36m

Cartagena Rafael Nunez

Sat 4/12

3:15 pm-1:13 pm

2 stops21h 58m

$666

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Wed 4/23

8:00 am-11:25 pm

2 stops15h 25m

Quito Mariscal Sucr

Mon 4/28

12:35 am-10:40 am

2 stops34h 05m

$687

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Tue 4/22

6:25 pm-8:00 pm

1 stop25h 35m

Quito Mariscal Sucr

Mon 4/28

11:20 pm-10:41 am

1 stop11h 21m

$697

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Thu 5/1

5:45 am-7:32 pm

2 stops13h 47m

Cartagena Rafael Nunez

Sat 5/31

2:34 pm-1:26 pm

1 stop22h 52m

$724

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Sat 3/22

5:45 am-9:45 pm

2 stops16h 00m

Lima J Chavez Intl

Thu 3/27

12:30 am-10:56 pm

2 stops22h 26m

$765

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Sat 3/22

2:07 pm-4:10 am

2 stops14h 03m

Lima J Chavez Intl

Thu 3/27

12:45 am-10:34 pm

1 stop21h 49m

$769

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 3/5

3:46 pm-5:50 am

2 stops35h 04m

Sao Paulo Guarulhos Intl

Sun 3/16

6:00 am-12:42 pm

2 stops32h 42m

$791

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 41 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to South America

Get recent, data-driven insights about flights from Des Moines to South America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to South America?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 20, 2025.
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,220 reviews
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines
7.6
Good
1,510 reviews
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,795 reviews
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,766 reviews
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,220 reviews

Comfort

8.0

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • What are the cheapest airlines to fly from Des Moines to South America one-way?

    For one-way options, check prices for Copa Airlines. According to our data, you can fly for as low as $414. Users have also found prices from $449 and $469 on United Airlines and LATAM Airlines, respectively.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Quito Mariscal Sucr, Des Moines - Santiago Arturo Merino Benitez and Des Moines - Buenos Aires Ministro Pistarini.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South America?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to South America

Discover the top 4 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$503Average$830FlexibilityNo cancel feeOn-time71%
DeltaCheapest$508Average$936FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$631Average$1,130FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$757Average$1,198FlexibilityNo cancel feeOn-time69%
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