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Santo Domingo

$139+ Cheap flights from South Carolina to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDQ
Apr 7 — Apr 141
Mon 4/7
Mon 4/14
1 adult, Economy
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Cheap flight deals from South Carolina to Santo Domingo

Keep the following information in mind while searching for South Carolina to Santo Domingo flight deals. Data was last updated April 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$354
(Frontier)

One-way from

$139
(Booking.com)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
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From South Carolina to Santo Domingo Las Americas
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One-way flight from South Carolina to Santo Domingo Las Americas
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Find flight deals from South Carolina to Santo Domingo

Cheapest flights from South Carolina to Santo Domingo
Explore the most affordable flight options available from South Carolina to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2411:51 amCLT - SDQ
2 stops20h 22mFrontier
Sun 6/112:23 pmSDQ - CLT
1 stop9h 33mFrontier
Deal found 3/31$354
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/284:20 pmCLT - SDQ
2 stops29h 25mMultiple Airlines
Mon 5/54:44 pmSDQ - CLT
1 stop23h 54mMultiple Airlines
Deal found 3/31$364
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:43 pmCLT - SDQ
1 stop21h 17mSpirit Airlines
Mon 5/194:50 pmSDQ - CLT
1 stop29h 10mSpirit Airlines
Deal found 4/1$366
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/111:55 amCHS - SDQ
2 stops27h 54mSpirit Airlines
Mon 5/54:44 pmSDQ - CHS
1 stop16h 36mSpirit Airlines
Deal found 4/1$386
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/85:32 pmMYR - SDQ
1 stop22h 13mSpirit Airlines
Sat 5/173:50 pmSDQ - MYR
2 stops19h 09mSpirit Airlines
Deal found 3/31$400
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/311:07 amCHS - SDQ
2 stops34h 38mMultiple Airlines
Sun 5/113:35 pmSDQ - CHS
2 stops30h 34mMultiple Airlines
Deal found 4/1$419
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/15:25 pmCHS - SDQ
1 stop7h 25mDelta
Mon 5/57:00 amSDQ - CHS
1 stop9h 45mDelta
Deal found 4/1$431
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/176:00 amCHS - SDQ
1 stop12h 10mAmerican Airlines
Sun 6/2210:13 amSDQ - CHS
1 stop13h 45mAmerican Airlines
Deal found 4/1$436
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/86:00 amMYR - SDQ
3 stops34h 29mMultiple Airlines
Sat 5/173:50 pmSDQ - MYR
2 stops19h 09mMultiple Airlines
Deal found 3/31$442
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/167:00 amGSP - SDQ
1 stop13h 50mAmerican Airlines
Wed 7/232:35 pmSDQ - GSP
1 stop9h 23mAmerican Airlines
Deal found 4/1$465
This JetBlue deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/110:21 amCHS - SDQ
1 stop9h 37mJetBlue
Sun 5/41:24 amSDQ - CHS
1 stop8h 12mJetBlue
Deal found 4/1$467
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/178:24 pmSAV - SDQ
2 stops14h 51mAmerican Airlines
Sat 5/2412:15 pmSDQ - SAV
2 stops11h 41mAmerican Airlines
Deal found 4/1$479

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

South Carolina

Fly to

Santo Domingo

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 5/24

11:51 am-8:13 am

2 stops20h 22m

Santo Domingo Las Americas

Sun 6/1

12:23 pm-9:56 pm

1 stop9h 33m

$354

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 4/28

4:20 pm-9:45 pm

2 stops29h 25m

Santo Domingo Las Americas

Mon 5/5

4:44 pm-4:38 pm

1 stop23h 54m

$364

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 5/6

5:43 pm-3:00 pm

1 stop21h 17m

Santo Domingo Las Americas

Mon 5/19

4:50 pm-10:00 pm

1 stop29h 10m

$366

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 5/1

11:55 am-3:49 pm

2 stops27h 54m

Santo Domingo Las Americas

Mon 5/5

4:44 pm-9:20 am

1 stop16h 36m

$386

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 5/8

5:32 pm-3:45 pm

1 stop22h 13m

Santo Domingo Las Americas

Sat 5/17

3:50 pm-10:59 am

2 stops19h 09m

$400

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/3

11:07 am-9:45 pm

2 stops34h 38m

Santo Domingo Las Americas

Sun 5/11

3:35 pm-10:09 pm

2 stops30h 34m

$419

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 5/1

5:25 pm-12:50 am

1 stop7h 25m

Santo Domingo Las Americas

Mon 5/5

7:00 am-4:45 pm

1 stop9h 45m

$431

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/17

6:00 am-6:10 pm

1 stop12h 10m

Santo Domingo Las Americas

Sun 6/22

10:13 am-11:58 pm

1 stop13h 45m

$436

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 5/8

6:00 am-4:29 pm

3 stops34h 29m

Santo Domingo Las Americas

Sat 5/17

3:50 pm-10:59 am

2 stops19h 09m

$442

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 7/16

7:00 am-8:50 pm

1 stop13h 50m

Santo Domingo Las Americas

Wed 7/23

2:35 pm-11:58 pm

1 stop9h 23m

$465

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Showing 1-10 of 30 results
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Best time to book a flight from South Carolina to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santo Domingo

What is the cheapest month to book a flight from South Carolina to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SDQ?

Find hourly flight availability from South Carolina to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2025.

When flying from South Carolina to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated April 2, 2025.
See what other customers who have flown with Delta, Copa Airlines and United Airlines from South Carolina to Santo Domingo have to say. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,898 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,400 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,616 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
JetBlue
7.3
Good
2,922 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from South Carolina?

    If you book a flight to Santo Domingo from South Carolina, you will be flying to Las Americas, which is the city’s only airport. Santo Domingo Las Americas (SDQ) is located 17.5 mi from the center of Santo Domingo.

  • What are the cheapest airlines to fly from South Carolina to Santo Domingo one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $139. Users have also found prices from $173 and $204 on Spirit Airlines and American Airlines, respectively.

  • What are the most popular routes from South Carolina to Santo Domingo?

    The most popular route from South Carolina to Santo Domingo is Charlotte Douglas - Santo Domingo Las Americas. You may also consider Charleston - Santo Domingo Las Americas or Greenville - Santo Domingo Las Americas.

  • Can I find deals for flights from South Carolina to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santo Domingo.

  • Can I find deals for business class flights from South Carolina to Santo Domingo?

    Yes. Cheapflights offers flight deals from South Carolina to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Juan Dolio

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Alternative routes for South Carolina to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Detroit to Punta Cana flights
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Baltimore to Santo Domingo flights
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Dulles Intl to Santo Domingo flights
LaGuardia to Puerto Plata flights
Tampa to Punta Cana flights
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O'Hare Intl to Santo Domingo flights

Top 2 airlines flying from South Carolina to Santo Domingo

Discover the top 2 airlines that operate flights from South Carolina to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$320Average$548FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$663FlexibilityNo cancel feeOn-time71%

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