HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santo Domingo

$235+ Cheap flights from Missouri to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Santo Domingo with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Santo Domingo

Keep the following information in mind while searching for Missouri to Santo Domingo flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$470
(Priceline)

One-way from

$235
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$573
Provider with most accurate pricing for Kansas City-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Kansas City-Santo Domingo Las Americas flights.
Search Deals
From Missouri to Santo Domingo Las Americas
Search Deals
One-way flight from Missouri to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2025
Search Deals

Find flight deals from Missouri to Santo Domingo

Cheapest flights from Missouri to Santo Domingo
Explore the most affordable flight options available from Missouri to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This FlightHub deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:43 pmMCI - SDQ
1 stop6h 27mSpirit Airlines
Mon 10/202:45 amSDQ - MCI
2 stops15h 53mSpirit Airlines
Deal found 3/31$468
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:59 pmMCI - SDQ
1 stop8h 51mDelta
Sun 5/112:41 pmSDQ - MCI
1 stop10h 18mDelta
Deal found 3/31$493
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/15:09 amMCI - SDQ
1 stop14h 17mAmerican Airlines
Tue 4/156:50 amSDQ - MCI
1 stop17h 12mAmerican Airlines
Deal found 3/30$504
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/136:00 amSTL - SDQ
1 stop6h 16mDelta
Tue 5/207:00 amSDQ - STL
2 stops14h 39mDelta
Deal found 3/30$519
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/136:20 pmSTL - SDQ
1 stop15h 55mAmerican Airlines
Tue 5/206:24 amSDQ - STL
1 stop16h 55mAmerican Airlines
Deal found 3/30$555
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/72:45 pmMCI - SDQ
1 stop10h 05mUnited Airlines
Tue 10/211:10 pmSDQ - MCI
1 stop10h 17mUnited Airlines
Deal found 3/31$583
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/54:57 pmSTL - SDQ
1 stop19h 25mFrontier
Fri 4/251:43 pmSDQ - STL
2 stops35h 21mFrontier
Deal found 3/30$642
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/510:40 amSTL - SDQ
2 stops14h 10mUnited Airlines
Fri 4/253:20 pmSDQ - STL
2 stops24h 25mUnited Airlines
Deal found 3/30$676
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/131:30 pmSTL - SDQ
3 stops26h 45mMultiple Airlines
Tue 5/203:35 pmSDQ - STL
3 stops45h 10mMultiple Airlines
Deal found 3/30$814

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Missouri

Fly to

Santo Domingo

Route

Depart

Return

Price

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 9/16

6:43 pm-2:10 am

1 stop6h 27m

Santo Domingo Las Americas

Mon 9/22

2:45 am-5:38 pm

2 stops15h 53m

$470

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 5/2

2:59 pm-12:50 am

1 stop8h 51m

Santo Domingo Las Americas

Sun 5/11

2:41 pm-11:59 pm

1 stop10h 18m

$493

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Thu 5/1

12:26 pm-10:40 pm

2 stops9h 14m

Santo Domingo Las Americas

Mon 5/12

6:24 am-10:38 pm

1 stop17h 14m

$508

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 5/13

6:00 am-1:16 pm

1 stop6h 16m

Santo Domingo Las Americas

Tue 5/20

7:00 am-8:39 pm

2 stops14h 39m

$519

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 5/13

6:20 pm-11:15 am

1 stop15h 55m

Santo Domingo Las Americas

Tue 5/20

6:24 am-10:19 pm

1 stop16h 55m

$555

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 5/14

6:40 pm-2:10 pm

2 stops18h 30m

Santo Domingo Las Americas

Wed 5/21

6:00 am-9:47 pm

2 stops16h 47m

$658

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 5/13

1:30 pm-5:15 pm

3 stops26h 45m

Santo Domingo Las Americas

Tue 5/20

3:35 pm-11:45 am

3 stops45h 10m

$814

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Sun 4/13

5:42 am-8:22 pm

2 stops13h 40m

$235

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 5/5

2:04 pm-9:45 pm

3 stops30h 41m

$264

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 5/1

6:00 am-1:15 pm

1 stop6h 15m

$306

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 11 results
1
2

Best time to book a flight from Missouri to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santo Domingo

What is the cheapest month to book a flight from Missouri to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SDQ?

Find hourly flight availability from Missouri to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santo Domingo as you normally would.

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated March 31, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Missouri to Santo Domingo to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Spirit Airlines
6.3
Okay
7,884 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

8.0

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Missouri?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Missouri. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • What are the cheapest airlines to fly from Missouri to Santo Domingo one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $235. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Missouri to Santo Domingo for a low price.

  • Can I find deals for flights from Missouri to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Missouri to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santo Domingo.

  • Can I find deals for business class flights from Missouri to Santo Domingo?

    Yes. Cheapflights offers flight deals from Missouri to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santiago de los Caballeros flights
John F Kennedy Intl to Punta Cana flights
John F Kennedy Intl to Santo Domingo flights
Newark to Punta Cana flights
Newark to Santiago de los Caballeros flights
Newark to Santo Domingo flights
LaGuardia to Punta Cana flights
Dulles Intl to Punta Cana flights
O'Hare Intl to Punta Cana flights
Boston to Punta Cana flights
Philadelphia to Punta Cana flights
Atlanta to Punta Cana flights
Dallas/Fort Worth to Punta Cana flights
LaGuardia to Santo Domingo flights
Boston to Santo Domingo flights
Hobby to Punta Cana flights
Baltimore to Punta Cana flights
Fort Lauderdale to Punta Cana flights
Orlando to Punta Cana flights
LaGuardia to Santiago de los Caballeros flights
Orlando to Santo Domingo flights
George Bush Intcntl to Punta Cana flights
Charlotte to Punta Cana flights
John F Kennedy Intl to Puerto Plata flights
Atlanta to Santo Domingo flights
Boston to Santiago de los Caballeros flights
Fort Lauderdale to Santo Domingo flights
Reagan-National to Punta Cana flights
Miami to Punta Cana flights
Miami to Santo Domingo flights
Los Angeles to Punta Cana flights
Midway to Punta Cana flights
Newark to Puerto Plata flights
Dallas/Fort Worth to Santo Domingo flights
Cleveland to Punta Cana flights
Minneapolis to Punta Cana flights
Philadelphia to Santo Domingo flights
Miami to Santiago de los Caballeros flights
Detroit to Punta Cana flights
Orlando to Santiago de los Caballeros flights
San Francisco to Punta Cana flights
Raleigh to Punta Cana flights
Baltimore to Santo Domingo flights
Dulles Intl to Santo Domingo flights
Tampa to Punta Cana flights
Atlantic City to Punta Cana flights
New Orleans to Punta Cana flights
Los Angeles to Santo Domingo flights
O'Hare Intl to Santo Domingo flights
Pittsburgh to Punta Cana flights

Top 4 airlines flying from Missouri to Santo Domingo

Discover the top 4 airlines that operate flights from Missouri to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$262Average$558FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$319Average$496FlexibilityNo cancel feeOn-time65%
FrontierCheapest$371Average$384FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$453Average$642FlexibilityNo cancel feeOn-time71%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.