What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?

Our cheapest airline available from Panama City to Santiago de los Caballeros is American Airlines. Our recent data shows that you can find tickets from as low as $1,133 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $1,333 and $1,651 round-trip.

What is the cheapest day to fly from Panama City to Santiago de los Caballeros?

Travelers seeking maximum savings on their Panama City to Santiago de los Caballeros flight should consider departing on Thursday mornings when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Panama City to Santiago de los Caballeros?

Users have found that leaving on a Wednesday can be a cost-effective option. It’s possible to save up to 6% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City to Santiago de los Caballeros?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, April can be a great choice for travel to Santiago de los Caballeros. Flights to Santiago de los Caballeros from Panama City in April are about $487 on average during April, but can be found for as low as $313.

What is the cheapest time of day to fly from PTY to STI?

When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

How can I find direct flights from Panama City to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$479+ Save on Flights from Panama City to Santiago de los Caballeros

Q: How far in advance should I book a flight from Panama City to Santiago de los Caballeros?

Travelers have found it’s best to book a flight 50 days in advance to save up to 8% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 50 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Panama City to Santiago de los Caballeros 1-2 weeks in advance for as low as $340, or $598 for flights within the next 24 hours.

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Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

The best prices from Panama City Tocumen Intl to Santiago de los Caballeros are usually found in April or May, booked 62 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Panama City to Santiago de los Caballeros

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$1,133 (American Airlines)
One-way from	$479 (Kiwi.com)
Popular in	March
Cheapest in	April
Average price	$702
Good one-way deal	$464 or less

Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.

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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.

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From Panama City Tocumen Intl to Santiago de los Caballeros

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One-way flight from Panama City Tocumen Intl to Santiago de los Caballeros

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Highest demand for flights based on searches. 29% potential increase in price ($199 potential increase over avg. RT price).

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Cheapest flight prices on average. 11% potential price decrease ($51 potential savings vs. average RT price).

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Average for round-trip flights in February 2025

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Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago de los Caballeros.

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Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2月 21, 2025.

火 5/271:20 pmPTY - STI

1 stop48h 40mAmerican Airlines

日 6/13:50 pmSTI - PTY

1 stop21h 25mAmerican Airlines

Deal found 2/20

$1,133

日 2/2310:15 pmPTY - STI

2 stops19h 08mMultiple Airlines

水 2/2610:59 amSTI - PTY

1 stop10h 20mMultiple Airlines

Deal found 2/20

$1,220

月 3/33:27 pmPTY - STI

2 stops26h 17mDelta

月 3/101:27 pmSTI - PTY

2 stops24h 28mDelta

Deal found 2/19

$1,333

木 7/177:55 amPTY - STI

2 stops16h 51mUnited Airlines

金 7/252:07 pmSTI - PTY

2 stops25h 07mUnited Airlines

Deal found 2/19

$1,651

Best flights from Panama City to Santiago de los Caballeros
Discover carefully curated flight deals from Panama City to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 2月 21, 2025.

火 5/271:20 pmPTY - STI

1 stop48h 40mAmerican Airlines

日 6/13:50 pmSTI - PTY

1 stop21h 25mAmerican Airlines

Deal found 2/20

$1,133

月 3/33:27 pmPTY - STI

2 stops26h 17mDelta

月 3/108:05 pmSTI - PTY

2 stops17h 50mDelta

Deal found 2/21

$1,333

木 7/177:55 amPTY - STI

2 stops16h 51mUnited Airlines

金 7/252:07 pmSTI - PTY

2 stops25h 07mUnited Airlines

Deal found 2/19

$1,651

火 5/271:20 pmPTY - STI

1 stop24h 40mMultiple Airlines

日 6/13:50 pmSTI - PTY

2 stops43h 42mMultiple Airlines

Deal found 2/20

$3,304

Last-minute flights from Panama City to Santiago de los Caballeros
Discover last-minute flight deals from Panama City to Santiago de los Caballeros. Data last updated 2月 21, 2025 and is based on user searches.

日 2/2310:15 pmPTY - STI

2 stops19h 08mMultiple Airlines

水 2/2610:59 amSTI - PTY

1 stop10h 20mMultiple Airlines

Deal found 2/20

$1,220

月 3/33:27 pmPTY - STI

2 stops26h 17mDelta

月 3/101:27 pmSTI - PTY

2 stops24h 28mDelta

Deal found 2/19

$1,333

One-way flights from Panama City to Santiago de los Caballeros
Search for one-way flight options from Panama City to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated 2月 21, 2025.

水 4/236:34 pmPTY - STI

2 stops19h 02mMultiple Airlines

Deal found 2/20

$479

Find flights from Panama City to Santiago de los Caballeros within your budget

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

火 5/27

1:20 pm-3:00 pm

1 stop48h 40m

Santiago de los Caballeros

日 6/1

3:50 pm-12:15 pm

1 stop21h 25m

$1,133

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

月 3/3

3:27 pm-6:44 pm

2 stops26h 17m

Santiago de los Caballeros

月 3/10

1:27 pm-12:55 pm

2 stops24h 28m

$1,333

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

木 7/17

7:55 am-1:46 am

2 stops16h 51m

Santiago de los Caballeros

金 7/25

2:07 pm-2:14 pm

2 stops25h 07m

$1,651

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

火 5/27

1:20 pm-3:00 pm

1 stop24h 40m

Santiago de los Caballeros

日 6/1

3:50 pm-10:32 am

2 stops43h 42m

$3,304

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

水 4/23

6:34 pm-2:36 pm

2 stops19h 02m

$479

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City to Santiago de los Caballeros

Get recent, data-driven insights about flights from Panama City to Santiago de los Caballeros including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Panama City to Santiago de los Caballeros?

The price you pay for your flight from Panama City to Santiago de los Caballeros may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $631). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Santiago de los Caballeros by month

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

Temperature in Santiago de los Caballeros by month

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Santiago de los Caballeros

Delta

8.0

Very good

8,219 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

Delta

8.0

Very good

8,219 reviews

Delta

8.0

Very good

8,219 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

United Airlines

7.4

Good

8,765 reviews

Delta

8.0

Very good

8,219 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

8,219 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

Related info for your journey

What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?
Our cheapest airline available from Panama City to Santiago de los Caballeros is American Airlines. Our recent data shows that you can find tickets from as low as $1,133 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $1,333 and $1,651 round-trip.
What are the cheapest flights from Panama City to Santiago de los Caballeros?
While on average a flight from Panama City to Santiago de los Caballeros is generally $464, our data shows the cheapest flight currently is $464. When looking at the most popular route, (Panama City Tocumen Intl - Santiago de los Caballeros), you can expect to pay $1,295 for that flight.
Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.
Can I find deals for business class flights from Panama City to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $631). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Panama City to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$313	Average$340	FlexibilityNo cancel fee	On-time70%

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$479+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

The best prices from Panama City Tocumen Intl to Santiago de los Caballeros are usually found in April or May, booked 62 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Panama City to Santiago de los Caballeros

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good one-way deal

Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los CaballerosExplore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2月 21, 2025.

Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2月 21, 2025.

Find flights from Panama City to Santiago de los Caballeros within your budget

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.

Travel insights for flights from Panama City to Santiago de los Caballeros

Get recent, data-driven insights about flights from Panama City to Santiago de los Caballeros including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Panama City to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago de los Caballeros. Price data was last updated on February 14, 2025.

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Rainfall in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average rainfall totals by month.

Temperature in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average temperature totals by month.

Reviews of airlines servicing Santiago de los Caballeros

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?

What are the cheapest flights from Panama City to Santiago de los Caballeros?

Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Panama City to Santiago de los Caballeros?

Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Panama City to Santiago de los Caballeros

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Travel Smart

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2月 21, 2025.