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$385+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Lambert-St Louis to Santiago Arturo Merino Benitez are usually found in October or May, booked 49 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$878
(American Airlines)

One-way from

$385
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$1,061
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
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From Lambert-St Louis to Santiago Arturo Merino Benitez
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One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 3% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/3010:08 amSTL - SCL
2 stops19h 52mAmerican Airlines
Wed 7/99:55 pmSCL - STL
2 stops20h 09mAmerican Airlines
Deal found 4/15$878
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/111:51 amSTL - SCL
2 stops17h 09mDelta
Sat 11/228:10 amSCL - STL
2 stops18h 29mDelta
Deal found 4/16$884
This LATAM Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:30 pmSTL - SCL
1 stop13h 30mLATAM Airlines
Fri 11/2112:30 amSCL - STL
2 stops20h 32mLATAM Airlines
Deal found 4/17$989
This Gotogate deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/307:30 amSTL - SCL
3 stops36h 15mMultiple Airlines
Wed 7/911:55 pmSCL - STL
2 stops21h 05mMultiple Airlines
Deal found 4/15$2,258
This Copa Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/288:10 amSTL - SCL
2 stops19h 54mCopa Airlines
Sun 6/812:13 amSCL - STL
2 stops20h 24mCopa Airlines
Deal found 4/16$2,465

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/30

10:08 am-7:00 am

2 stops19h 52m

Santiago Arturo Merino Benitez

Wed 7/9

9:55 pm-5:04 pm

2 stops20h 09m

$878

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 5/28

5:40 pm-7:35 am

3 stops36h 55m

Santiago Arturo Merino Benitez

Mon 6/9

3:40 pm-11:51 pm

2 stops33h 11m

$1,028

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/30

7:30 am-8:45 pm

3 stops36h 15m

Santiago Arturo Merino Benitez

Wed 7/9

11:55 pm-8:00 pm

2 stops21h 05m

$2,258

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 5/28

8:10 am-5:04 am

2 stops19h 54m

Santiago Arturo Merino Benitez

Sun 6/8

12:13 am-7:37 pm

2 stops20h 24m

$2,465

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 5/2

10:42 am-6:50 am

2 stops19h 08m

Santiago Arturo Merino Benitez

Fri 5/16

8:40 pm-8:56 am

1 stop13h 16m

$6,378

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 5/24

10:10 am-10:44 pm

3 stops59h 34m

$385

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 4/30

6:09 pm-6:55 am

1 stop11h 46m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

How far ahead should I book a flight from St. Louis to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santiago. Price data was last updated on April 11, 2025.

To ensure you get the cheapest price possible for a flight from St. Louis to Santiago, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SCL?

Find hourly flight availability from St. Louis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 9% on your trip compared to booking a flight in the morning.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 17, 2025.
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,916 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,409 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,761 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on American Airlines is currently your cheapest option to Santiago, with prices starting at $878. Additional round-trip tickets that might be worth considering are offered by LATAM Airlines and Copa Airlines, with the lowest prices starting at $1,028 and $2,465, respectively. These flights start at 12% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from St. Louis to Santiago

Discover the top 4 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$1,007FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$1,014FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$823Average$962FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

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