HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$338+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
feb. 4 — feb. 111
mar. 2/4
mar. 2/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Santiago with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 30, 2025.

Round-trip from

$824
(Delta)

One-way from

$338
(Kiwi.com)
From Missouri to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Missouri to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 30, 2025.

This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/47:15 amSTL - SCL
1 stop21h 35mAmerican Airlines
mar. 11/1110:30 pmSCL - STL
1 stop20h 09mAmerican Airlines
Deal found 1/29$804
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/206:00 amSGF - SCL
1 stop22h 20mDelta
jue. 3/2711:15 pmSCL - SGF
1 stop17h 30mDelta
Deal found 1/29$824
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/46:00 amSTL - SCL
2 stops19h 30mDelta
lun. 11/1012:30 amSCL - STL
2 stops20h 33mDelta
Deal found 1/29$824
This LATAM Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/46:00 amSTL - SCL
2 stops21h 00mLATAM Airlines
lun. 11/1012:30 amSCL - STL
3 stops26h 09mLATAM Airlines
Deal found 1/29$828
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/16:42 pmMCI - SCL
2 stops18h 18mDelta
sáb. 11/228:10 amSCL - MCI
2 stops18h 43mDelta
Deal found 1/30$884
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/33:50 pmSTL - SCL
1 stop17h 20mMultiple Airlines
mié. 2/53:29 pmSCL - STL
3 stops26h 14mMultiple Airlines
Deal found 1/30$962
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/124:29 pmSTL - SCL
1 stop13h 21mUnited Airlines
dom. 3/239:45 pmSCL - STL
2 stops42h 38mUnited Airlines
Deal found 1/30$985
This FlightHub deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/33:56 pmMCI - SCL
1 stop12h 24mLATAM Airlines
mar. 4/112:25 amSCL - MCI
2 stops21h 42mLATAM Airlines
Deal found 1/30$1,024
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/2511:30 amMCI - SCL
2 stops42h 20mUnited Airlines
mié. 3/269:45 pmSCL - MCI
1 stop13h 50mUnited Airlines
Deal found 1/30$1,038
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/1611:52 amMCI - SCL
3 stops32h 23mMultiple Airlines
dom. 3/235:47 amSCL - MCI
3 stops36h 30mMultiple Airlines
Deal found 1/30$1,105
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/165:23 pmMCI - SCL
1 stop13h 12mAmerican Airlines
dom. 3/2310:44 pmSCL - MCI
1 stop13h 00mAmerican Airlines
Deal found 1/30$1,144
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/128:40 amSGF - SCL
1 stop21h 55mAmerican Airlines
sáb. 3/2210:44 pmSCL - SGF
1 stop27h 08mAmerican Airlines
Deal found 1/30$1,172

Find flights from Missouri to Santiago within your budget

Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

jue. 3/20

6:00 am-6:20 am

1 stop22h 20m

Santiago Arturo Merino Benitez

jue. 3/27

11:15 pm-2:45 pm

1 stop17h 30m

$824

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mié. 3/12

4:29 pm-7:50 am

1 stop13h 21m

Santiago Arturo Merino Benitez

dom. 3/23

9:45 pm-2:23 pm

2 stops42h 38m

$985

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom. 6/1

4:00 pm-8:55 am

2 stops15h 55m

Santiago Arturo Merino Benitez

sáb. 6/14

8:40 pm-3:58 pm

1 stop20h 18m

$1,018

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

lun. 3/3

3:56 pm-7:20 am

1 stop12h 24m

Santiago Arturo Merino Benitez

mar. 4/1

12:25 am-8:07 pm

2 stops21h 42m

$1,024

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

mar. 2/25

11:30 am-8:50 am

2 stops42h 20m

Santiago Arturo Merino Benitez

mié. 3/26

9:45 pm-9:35 am

1 stop13h 50m

$1,038

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mié. 3/5

10:26 am-5:40 am

2 stops16h 14m

Santiago Arturo Merino Benitez

dom. 3/16

4:00 pm-11:31 pm

2 stops33h 31m

$1,044

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

dom. 3/16

11:52 am-10:15 pm

3 stops32h 23m

Santiago Arturo Merino Benitez

dom. 3/23

5:47 am-4:17 pm

3 stops36h 30m

$1,105

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

dom. 3/16

5:23 pm-8:35 am

1 stop13h 12m

Santiago Arturo Merino Benitez

dom. 3/23

10:44 pm-9:44 am

1 stop13h 00m

$1,144

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

mar. 2/25

5:07 pm-3:00 pm

2 stops18h 53m

Santiago Arturo Merino Benitez

mar. 3/25

12:25 am-8:07 pm

2 stops21h 42m

$1,164

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

mié. 3/12

8:40 am-8:35 am

1 stop21h 55m

Santiago Arturo Merino Benitez

sáb. 3/22

10:44 pm-11:52 pm

1 stop27h 08m

$1,172

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/30

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Santiago

Get recent, data-driven insights about flights from Missouri to Santiago including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated enero 30, 2025.
To help decide which airline to fly from Missouri to Santiago, see what other customers have to say about Delta, Copa Airlines and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,454 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines
7.6
Good
1,617 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines
7.5
Good
1,838 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,913 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • What are the cheapest airlines to fly from Missouri to Santiago one-way?

    For one-way options, check prices for Air Canada. According to our data, you can fly for as low as $445. Users have also found prices from $542 and $543 on American Airlines and Delta, respectively.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Kansas City - Santiago Arturo Merino Benitez or Springfield-Branson - Santiago Arturo Merino Benitez, Lambert-St Louis - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santiago flights
Miami to Santiago flights
Los Angeles to Santiago flights
Newark to Santiago flights
LaGuardia to Santiago flights
Dulles Intl to Santiago flights
Dallas/Fort Worth to Santiago flights
O'Hare Intl to Santiago flights
Baltimore to Santiago flights
San Francisco to Santiago flights
Reagan-National to Santiago flights
Atlanta to Santiago flights
Orlando to Santiago flights
Seattle to Santiago flights
Tampa to Santiago flights
Fort Lauderdale to Santiago flights
Boston to Santiago flights
Midway to Santiago flights
Austin to Santiago flights
Ontario to Santiago flights
Hobby to Santiago flights
Denver to Santiago flights
George Bush Intcntl to Santiago flights
Portland to Santiago flights
Love Field to Santiago flights
St. Louis to Santiago flights
Salt Lake City to Santiago flights
Raleigh to Santiago flights
Charleston to Santiago flights
Nashville to Santiago flights
Miami to Punta Arenas flights
Sky Harbor Intl to Santiago flights
Tucson to Santiago flights
Detroit to Santiago flights
San Diego to Santiago flights
Cincinnati to Santiago flights
Charlotte to Santiago flights
Cleveland to Santiago flights
Minneapolis to Santiago flights
O'Hare Intl to Punta Arenas flights
West Palm Beach to Santiago flights
Philadelphia to Santiago flights
San Jose to Santiago flights
New Orleans to Santiago flights
San Antonio to Santiago flights
Seattle to Puerto Montt flights
Denver to Punta Arenas flights
San Francisco to Punta Arenas flights
Sacramento to Santiago flights
Albuquerque to Santiago flights

Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$706Average$1,036FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$985FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$807Average$1,092FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.