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$364+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Apr 7 — Apr 141
Mon 4/7
Mon 4/14
1 adult, Economy
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Cheap flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated April 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$727
(Avianca Connect)

One-way from

$364
(Kiwi.com)

Popular in

September

Cheapest in

May

Average price

$922
Provider with most accurate pricing for Kansas City-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Santiago Arturo Merino Benitez flights.
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From Missouri to Santiago Arturo Merino Benitez
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One-way flight from Missouri to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 20% potential increase in price ($297 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($101 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

This Avianca Connect deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/125:46 amMCI - SCL
2 stops21h 29mMultiple Airlines
Mon 5/2611:55 pmSCL - MCI
2 stops23h 46mMultiple Airlines
Deal found 3/31$727
This FlightHub deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/295:45 amMCI - SCL
2 stops20h 45mLATAM Airlines
Mon 5/124:55 pmSCL - MCI
2 stops19h 12mLATAM Airlines
Deal found 3/30$764
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/13:35 pmSGF - SCL
1 stop14h 25mDelta
Mon 9/89:40 pmSCL - SGF
1 stop22h 28mDelta
Deal found 4/1$804
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:42 pmMCI - SCL
2 stops17h 43mDelta
Wed 10/298:15 amSCL - MCI
2 stops17h 42mDelta
Deal found 3/30$804
This LATAM Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2511:51 amSTL - SCL
1 stop18h 09mLATAM Airlines
Sat 10/410:10 pmSCL - STL
2 stops27h 29mLATAM Airlines
Deal found 4/1$844
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:00 amSTL - SCL
2 stops20h 00mDelta
Fri 11/2112:30 amSCL - STL
2 stops20h 32mDelta
Deal found 4/1$884
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/14:26 pmMCI - SCL
2 stops14h 39mAmerican Airlines
Sat 11/2211:45 pmSCL - MCI
1 stop13h 01mAmerican Airlines
Deal found 4/1$888
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1412:03 pmSTL - SCL
2 stops17h 52mAmerican Airlines
Mon 6/309:55 pmSCL - STL
2 stops18h 59mAmerican Airlines
Deal found 4/1$953
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1710:10 amSTL - SCL
3 stops35h 20mMultiple Airlines
Sat 5/248:40 pmSCL - STL
2 stops24h 03mMultiple Airlines
Deal found 4/1$1,082
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:37 pmMCI - SCL
2 stops35h 13mUnited Airlines
Tue 1/1310:45 pmSCL - MCI
2 stops23h 46mUnited Airlines
Deal found 3/31$1,154
This Air Canada deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amMCI - SCL
2 stops27h 10mAir Canada
Fri 1/99:00 amSCL - MCI
2 stops35h 21mAir Canada
Deal found 3/31$1,743
This StudentUniverse deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure StudentUniverse is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/148:00 amSTL - SCL
2 stops20h 04mCopa Airlines
Sun 6/292:24 amSCL - STL
2 stops32h 35mCopa Airlines
Deal found 4/1$1,766

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Missouri

Fly to

Santiago

Route

Depart

Return

Price

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 5/12

5:46 am-4:15 am

2 stops21h 29m

Santiago Arturo Merino Benitez

Mon 5/26

11:55 pm-10:41 pm

2 stops23h 46m

$727

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Tue 4/29

10:42 am-4:45 am

2 stops17h 03m

Santiago Arturo Merino Benitez

Mon 5/12

8:40 pm-11:07 am

1 stop15h 27m

$764

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Mon 9/1

6:00 am-5:30 am

2 stops22h 30m

Santiago Arturo Merino Benitez

Mon 9/8

9:40 pm-2:50 pm

1 stop19h 10m

$804

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 9/25

11:51 am-8:00 am

1 stop18h 09m

Santiago Arturo Merino Benitez

Sat 10/4

10:10 pm-11:39 pm

2 stops27h 29m

$844

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Thu 5/1

12:04 pm-6:55 am

2 stops17h 51m

Santiago Arturo Merino Benitez

Thu 5/15

9:00 pm-10:38 pm

1 stop26h 38m

$906

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 5/14

12:03 pm-6:55 am

2 stops17h 52m

Santiago Arturo Merino Benitez

Mon 6/30

9:55 pm-3:54 pm

2 stops18h 59m

$953

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 4/28

7:10 am-3:30 am

2 stops19h 20m

Santiago Arturo Merino Benitez

Sun 5/4

12:30 am-5:39 pm

2 stops18h 09m

$1,024

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 5/17

10:10 am-10:30 pm

3 stops35h 20m

Santiago Arturo Merino Benitez

Sat 5/24

8:40 pm-7:43 pm

2 stops24h 03m

$1,082

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 5/17

6:00 am-7:00 am

1 stop24h 00m

Santiago Arturo Merino Benitez

Fri 5/23

12:30 am-8:39 pm

2 stops21h 09m

$1,109

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 5/14

8:00 am-5:04 am

2 stops20h 04m

Santiago Arturo Merino Benitez

Sun 6/29

2:24 am-9:59 am

2 stops32h 35m

$1,766

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 19 results
1
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Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 2, 2025.
To help decide which airline to fly from Missouri to Santiago, see what other customers have to say about Delta, Copa Airlines and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,898 reviews
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,400 reviews
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,754 reviews
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,302 reviews
Delta
8.0
Very good
7,898 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • What are the cheapest airlines to fly from Missouri to Santiago one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $543. Users have also found prices from $583 and $16,699 on LATAM Airlines and British Airways, respectively.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Lambert-St Louis - Santiago Arturo Merino Benitez or Joplin - Santiago Arturo Merino Benitez, Kansas City - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$1,027FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$1,009FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$807Average$1,053FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

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