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$259+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Find cheap flights from Mexico City to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in August or May, booked 83 days in advance, depart on a Sunday or Thursday and return on a Thursday

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$497
(Kiwi.com)

One-way from

$259
(Priceline)

Popular in

February

Cheapest in

August

Average price

$602

Good round-trip deal

$670 or less

Good one-way deal

$435 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flights.
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From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/192:00 amMEX - SCL
1 stop15h 24mCopa Airlines
Sun 6/111:28 amSCL - MEX
1 stop12h 37mCopa Airlines
Deal found 4/16$497
This Priceline deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1612:40 amMEX - SCL
1 stop19h 50mAvianca
Sat 5/242:30 pmSCL - MEX
1 stop14h 35mAvianca
Deal found 4/17$504
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/3010:05 pmMEX - SCL
1 stop12h 20mMultiple Airlines
Sat 5/310:10 pmSCL - MEX
1 stop15h 10mMultiple Airlines
Deal found 4/16$625
This Cheapflightsfares deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/238:20 pmMEX - SCL
Nonstop8h 05mLATAM Airlines
Sun 6/88:20 amSCL - MEX
Nonstop8h 35mLATAM Airlines
Deal found 4/16$656

Cheapflights Fare Finder

Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 5/19

2:00 am-7:24 pm

1 stop15h 24m

Santiago Arturo Merino Benitez

Sun 6/1

11:28 am-10:05 pm

1 stop12h 37m

$497

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 5/16

12:40 am-10:30 pm

1 stop19h 50m

Santiago Arturo Merino Benitez

Sat 5/24

2:30 pm-3:05 am

1 stop14h 35m

$504

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 4/30

10:05 pm-12:25 pm

1 stop12h 20m

Santiago Arturo Merino Benitez

Sat 5/3

10:10 pm-11:20 am

1 stop15h 10m

$625

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 5/23

8:20 pm-6:25 am

Nonstop8h 05m

Santiago Arturo Merino Benitez

Sun 6/8

8:20 am-2:55 pm

Nonstop8h 35m

$656

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 4/22

12:40 am-10:30 pm

1 stop19h 50m

$259

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 6/3

10:05 pm-4:01 am

1 stop27h 56m

$283

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 6/1

8:20 pm-6:40 am

Nonstop8h 20m

$547

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 4/28

1:40 am-7:24 pm

1 stop15h 44m

$560

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Compare providers for flights from Mexico City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in April.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on April 11, 2025.

The best time to book flights from Mexico City to Santiago is 83 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from Mexico City to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the evening.

What is the cheapest day to fly from Mexico City to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Santiago. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Mexico City to Santiago flight should consider departing on Sunday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 17, 2025.
Read through reviews of airlines operating flights from Mexico City to Santiago, such as Copa Airlines, LATAM Airlines and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,409 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Copa Airlines
7.6
Good
1,409 reviews
Copa Airlines
7.6
Good
1,409 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
LATAM Airlines
7.5
Good
1,761 reviews
Copa Airlines
7.6
Good
1,409 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Avianca
6.7
Okay
2,315 reviews
Copa Airlines
7.6
Good
1,409 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 5 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $497. Other airlines that can offer you cheap pricing are Avianca, from $504, and LATAM Airlines, from $656. Users have found that Copa Airlines is 21% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $259. LATAM Airlines flights start at $547 while deals on Copa Airlines start at $560 one-way.

  • What are the most reliable airlines from Mexico City to Santiago?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Santiago on time: WestJet (86%), Aeromexico (86%), LATAM Airlines (85%).

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $1,116, our data shows the cheapest flight currently is $320. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $511 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $752). Flying from Mexico City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
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Lastarria car rentals

Top 4 airlines flying from Mexico City to Santiago

Discover the top 4 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$347Average$677FlexibilityNo cancel feeOn-time70%
AviancaCheapest$364Average$589FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$460Average$721FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$510Average$686FlexibilityNo cancel feeOn-time81%

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