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$264+ Cheap flights from South Carolina to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAF
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from South Carolina to Santa Fe

Cheapest flights from South Carolina to Santa Fe
Explore the most affordable flight options available from South Carolina to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:00 amCLT - SAF
1 stop6h 44mUnited Airlines
Thu 12/251:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/11$449
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:00 amCLT - SAF
1 stop6h 44mUnited Airlines
Tue 12/301:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/11$525
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:20 amCLT - SAF
2 stops12h 42mUnited Airlines
Thu 12/251:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/11$553
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:10 amCLT - SAF
1 stop6h 25mAmerican Airlines
Wed 12/3110:05 amSAF - CLT
1 stop7h 16mAmerican Airlines
Deal found 12/11$575
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:00 amCLT - SAF
1 stop6h 44mUnited Airlines
Fri 12/261:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/11$578
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:20 amCLT - SAF
2 stops11h 42mUnited Airlines
Thu 12/251:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/11$580
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:00 amCLT - SAF
1 stop6h 44mUnited Airlines
Wed 12/311:22 pmSAF - CLT
2 stops18h 41mUnited Airlines
Deal found 12/11$583
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:05 pmCHS - SAF
1 stop7h 54mUnited Airlines
Sun 12/217:00 amSAF - CHS
2 stops10h 18mUnited Airlines
Deal found 12/11$620
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:23 pmGSP - SAF
1 stop7h 35mAmerican Airlines
Tue 12/304:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Deal found 12/11$664
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:31 pmCHS - SAF
1 stop8h 27mAmerican Airlines
Wed 12/316:15 amSAF - CHS
1 stop6h 33mAmerican Airlines
Deal found 12/10$676
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:31 pmCHS - SAF
1 stop8h 27mAmerican Airlines
Tue 12/306:15 amSAF - CHS
2 stops11h 13mAmerican Airlines
Deal found 12/10$746
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:00 amGSP - SAF
1 stop8h 24mAmerican Airlines
Thu 12/256:15 amSAF - GSP
1 stop7h 18mAmerican Airlines
Deal found 12/11$792

Find flight deals from South Carolina to Santa Fe

Keep the following information in mind while searching for South Carolina to Santa Fe flight deals. Data was last updated December 12, 2025.

Round-trip from

$264
(American Airlines)
From South Carolina to Santa Fe
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from South Carolina to Santa Fe that are best for you.

Fly from

South Carolina

Fly to

Santa Fe

Route

Depart

Return

Price

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 2/7

4:44 pm-9:09 pm

1 stop6h 25m

Santa Fe

Mon 2/9

5:05 pm-12:40 am

1 stop5h 35m

$264

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 1/21

10:44 am-8:47 pm

2 stops12h 03m

Santa Fe

Wed 1/28

3:30 pm-10:59 pm

1 stop5h 29m

$354

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 1/10

6:10 am-4:56 pm

2 stops12h 46m

Santa Fe

Tue 1/13

1:16 pm-10:59 pm

1 stop7h 43m

$354

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sat 1/10

6:35 am-4:56 pm

2 stops12h 21m

Santa Fe

Tue 1/13

7:00 am-11:48 pm

2 stops14h 48m

$359

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Sat 1/10

10:30 am-4:56 pm

2 stops8h 26m

Santa Fe

Mon 1/12

10:45 am-11:44 pm

2 stops10h 59m

$379

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 3/7

5:15 am-9:46 am

1 stop6h 31m

Santa Fe

Wed 3/11

6:42 pm-5:56 am

1 stop9h 14m

$385

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Wed 3/4

3:45 pm-8:49 pm

1 stop7h 04m

Santa Fe

Sun 3/8

6:15 am-2:54 pm

1 stop6h 39m

$445

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Fri 1/16

7:32 am-12:29 pm

1 stop6h 57m

Santa Fe

Mon 1/19

6:31 pm-8:47 am

2 stops12h 16m

$473

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Mon 6/8

6:21 pm-9:53 pm

1 stop5h 32m

Santa Fe

Fri 6/19

5:01 pm-11:59 pm

1 stop4h 58m

$557

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sun 6/7

7:38 am-11:03 am

1 stop5h 25m

Santa Fe

Sun 6/14

5:01 pm-11:59 pm

1 stop4h 58m

$632

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 12 results
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Best time to book a flight from South Carolina to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santa Fe

What is the cheapest month to book a flight from South Carolina to Santa Fe?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAF?

Find hourly flight availability from South Carolina to Santa Fe. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from South Carolina to Santa Fe in the evening. Doing so could potentially save you 44% on the flight price compared to flying in the afternoon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from South Carolina?

    If you book a flight to Santa Fe from South Carolina, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • How long is the flight from South Carolina to Santa Fe?

    Airlines like American Airlines and United Airlines fly from South Carolina to Santa Fe in about 6h 25m. The time it takes to get you to your destination can typically vary by up to 5h 38m. The distance from South Carolina to Santa Fe is about 1411 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Santa Fe?

    While some choose either Greenville - Santa Fe or Charlotte Douglas - Santa Fe, Charleston - Santa Fe is the most popular route from South Carolina to Santa Fe.

  • Can I find deals for flights from South Carolina to Santa Fe that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santa Fe.

  • Can I find deals for business class flights from South Carolina to Santa Fe?

    Yes. Cheapflights offers flight deals from South Carolina to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santa Fe?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for South Carolina to Santa Fe

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Top airline flying from South Carolina to Santa Fe

Discover the top airline that operate flights from South Carolina to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$637FlexibilityNo cancel feeOn-time71%

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