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Santa Cruz de la Sierra

$184+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — VVI
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in August or November, booked 66 days in advance, depart on a Thursday or Monday and return on a Monday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$355
(Avianca)

One-way from

$184
(Priceline)

Popular in

January

Cheapest in

August

Average price

$544
Provider with most accurate pricing for Panama City Tocumen Intl-Santa Cruz de la Sierra Viru Viru Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santa Cruz de la Sierra Viru Viru Intl flights.
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From Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 14% potential increase in price ($81 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/211:05 amPTY - VVI
1 stop13h 45mAvianca
Sun 4/132:55 amVVI - PTY
1 stop14h 35mAvianca
Deal found 2/20$355
This Copa Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/149:43 pmPTY - VVI
Nonstop4h 57mCopa Airlines
Sat 3/1512:51 amVVI - PTY
Nonstop4h 50mCopa Airlines
Deal found 2/20$356
This Gotogate deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/205:25 pmPTY - VVI
1 stop7h 25mMultiple Airlines
Tue 5/277:00 pmVVI - PTY
2 stops22h 30mMultiple Airlines
Deal found 2/19$691

Find flights from Panama City to Santa Cruz de la Sierra within your budget

Customize your flight search to find flights from Panama City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Panama City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 4/2

11:05 am-1:50 am

1 stop13h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/13

2:55 am-4:30 pm

1 stop14h 35m

$355

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Fri 3/14

9:43 pm-3:40 am

Nonstop4h 57m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/15

12:51 am-4:41 am

Nonstop4h 50m

$356

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 5/20

5:25 pm-1:50 am

1 stop7h 25m

Santa Cruz de la Sierra Viru Viru Intl

Tue 5/27

7:00 pm-4:30 pm

2 stops22h 30m

$691

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 3/26

11:25 am-2:00 am

1 stop13h 35m

$184

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 3/25

3:19 am-7:25 am

2 stops27h 06m

$424

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 3/10

4:04 pm-10:04 pm

Nonstop5h 00m

$648

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

  • Most accurate provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City to Santa Cruz de la Sierra

Get recent, data-driven insights about flights from Panama City to Santa Cruz de la Sierra including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on February 14, 2025.

The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 66 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to VVI?

Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

It’s optimal to fly from Panama City to Santa Cruz de la Sierra in the morning. By choosing this option you can save up to 13% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated February 20, 2025.
Copa Airlines
7.6
Good
1,510 reviews

Food

6.9

Boarding

7.8

Comfort

7.4

Overall

7.6

Crew

8.1

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Copa Airlines
7.6
Good
1,510 reviews
Copa Airlines
7.6
Good
1,510 reviews

Food

6.9

Boarding

7.8

Comfort

7.4

Overall

7.6

Crew

8.1

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Avianca
6.8
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,510 reviews

Food

6.9

Boarding

7.8

Comfort

7.4

Overall

7.6

Crew

8.1

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Panama City to Santa Cruz de la Sierra is Avianca. Our recent data shows that you can find tickets from as low as $355 on this airline. An additional option worth looking into is Copa Airlines, starting at $356. Avianca is priced at 27% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest flights from Panama City to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $418. While the most popular route (Panama City Tocumen Intl - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $356 on average our data indicates $544 when flying from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Panama City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
Cochabamba car rentals

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Panama City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$338Average$358FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$414Average$544FlexibilityNo cancel feeOn-time70%
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