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$126+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or April, booked 89 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(American Airlines)

One-way from

$126
(American Airlines)

Popular in

October

Cheapest in

February

Average price

$344
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
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From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
Search Deals

Find flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:20 amTYS - SNA
1 stop8h 21mAmerican Airlines
Wed 5/286:45 amSNA - TYS
1 stop7h 46mAmerican Airlines
Deal found 4/22$229
This Booking.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/295:30 pmTYS - SNA
1 stop20h 41mFrontier
Wed 6/412:01 pmSNA - TYS
1 stop25h 28mFrontier
Deal found 4/22$238
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/204:14 pmTYS - SNA
1 stop8h 46mUnited Airlines
Tue 5/2711:35 amSNA - TYS
1 stop7h 53mUnited Airlines
Deal found 4/22$251
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:00 amTYS - SNA
2 stops11h 21mMultiple Airlines
Thu 5/296:45 amSNA - TYS
1 stop27h 39mMultiple Airlines
Deal found 4/22$275
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/107:00 amTYS - SNA
1 stop6h 55mDelta
Tue 6/172:35 pmSNA - TYS
1 stop6h 24mDelta
Deal found 4/21$277
This Alaska Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:20 amTYS - SNA
2 stops11h 59mAlaska Airlines
Wed 8/65:49 pmSNA - TYS
2 stops14h 58mAlaska Airlines
Deal found 4/22$514

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 5/24

5:20 am-10:41 am

1 stop8h 21m

Santa Ana J. Wayne/Orange Cnty

Wed 5/28

6:45 am-5:31 pm

1 stop7h 46m

$229

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 5/29

5:30 pm-11:11 am

1 stop20h 41m

Santa Ana J. Wayne/Orange Cnty

Wed 6/4

12:01 pm-4:29 pm

1 stop25h 28m

$238

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 5/20

4:14 pm-10:00 pm

1 stop8h 46m

Santa Ana J. Wayne/Orange Cnty

Tue 5/27

11:35 am-10:28 pm

1 stop7h 53m

$251

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 5/22

6:00 am-2:21 pm

2 stops11h 21m

Santa Ana J. Wayne/Orange Cnty

Thu 5/29

6:45 am-1:24 pm

1 stop27h 39m

$275

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 6/10

7:00 am-10:55 am

1 stop6h 55m

Santa Ana J. Wayne/Orange Cnty

Tue 6/17

2:35 pm-11:59 pm

1 stop6h 24m

$277

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 5/7

5:20 am-2:19 pm

2 stops11h 59m

Santa Ana J. Wayne/Orange Cnty

Wed 8/6

5:49 pm-11:47 am

2 stops14h 58m

$514

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 5/7

8:30 am-2:21 pm

2 stops32h 51m

$191

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 5/7

12:08 pm-5:32 pm

1 stop8h 24m

$201

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 5/6

5:05 am-9:34 am

1 stop7h 29m

$246

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 5/3

5:15 am-4:35 pm

2 stops14h 20m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Showing 1-10 of 12 results
1
2

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on April 18, 2025.

Booking 21 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in June is currently the most expensive (average of $409). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

Find hourly flight availability from Knoxville to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

When flying from Knoxville to Santa Ana, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 19% versus a flight in the afternoon.

Rainfall in Santa Ana by month

Plan your trip to Santa Ana by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santa Ana ranges from 0.0 - 3.1 inches per month. February is typically the wettest month, when rainfall can reach 3.1 in. July is typically the driest time to visit Santa Ana when rainfall is around 0.0 in.

Temperature in Santa Ana by month

Plan your trip to Santa Ana by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santa Ana, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated April 22, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Delta and United Airlines from Knoxville to Santa Ana to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,911 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,683 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Frontier
6.0
Okay
3,283 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Entertainment

7.1

Food

7.1

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Santa Ana round-trip?

    Flying on American Airlines is currently your cheapest option to Santa Ana, with prices starting at $229. Additional round-trip tickets that might be worth considering are offered by Frontier and United Airlines, with the lowest prices starting at $238 and $251, respectively. You may be able to fly from Knoxville to Santa Ana for 44% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Santa Ana one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $126. United Airlines flights start at $176 while deals on Delta start at $201 one-way.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in June is currently the most expensive (average of $409). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$246Average$415FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$535FlexibilityNo cancel feeOn-time69%
DeltaCheapest$287Average$402FlexibilityNo cancel feeOn-timeN/A

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