What are the cheapest airlines flying from Santiago to San Francisco round-trip?

Currently priced at $555, Delta will fly you from Santiago to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and American Airlines - these airlines can fly you to your destination from $564 and $583, respectively. Delta is priced at 21% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Santiago to San Francisco one-way?

One-way options have recently been found by users for as low as $331 on Copa Airlines. Other airlines that offer cheap prices include Avianca from $438 and Delta from $452 one-way.

What is the cheapest day to fly from Santiago to San Francisco?

Travelers seeking maximum savings on their Santiago to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Santiago to San Francisco?

When booking a flight from Santiago to San Francisco, you may want to consider flying on American Airlines, Avianca or Copa Airlines as they are the most popular for this route.

What is the cheapest day to fly round-trip from Santiago to San Francisco?

Leaving on a Friday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 25% on the overall cost on flights from Santiago to San Francisco.

How far in advance should I book a flight from Santiago to San Francisco?

Users have found that booking a flight from Santiago to San Francisco at least 58 days early can save you up to 41% on average compared to booking a flight this week. If booking 58 days before your flight isn’t an option for you, users have found flights from Santiago to San Francisco for as little as $672 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $871 for flights departing within the next 3 days.

What is the cheapest month to fly from Santiago to San Francisco?

Flights from Santiago to San Francisco lean towards being more expensive in June. Prices are generally better when you fly from Santiago to San Francisco in March, with the cheapest ticket starting at $516.

Most accurate provider : When it comes to deals on Santiago-San Francisco flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

Can I find deals for business class flights from Santiago to San Francisco?

Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$331+ Flights from Santiago to San Francisco

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Find cheap flights from Santiago to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in March or November, booked 85 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Cheap flight deals from Santiago to San Francisco

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$555 (Delta)
One-way from	$331 (Copa Airlines)
Popular in	June
Cheapest in	March
Average price	$725

Provider with most accurate pricing for Santiago Arturo Merino Benitez-San Francisco flight deals.

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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-San Francisco flights.

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From Santiago Arturo Merino Benitez to San Francisco

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One-way flight from Santiago Arturo Merino Benitez to San Francisco

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($79 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Thu 8/2111:05 pmSCL - SFO

2 stops21h 14mDelta

Tue 9/211:30 amSFO - SCL

1 stop16h 30mDelta

Deal found 4/16

$555

Thu 10/3011:45 pmSCL - SFO

1 stop28h 32mAmerican Airlines

Wed 11/56:08 amSFO - SCL

1 stop20h 42mAmerican Airlines

Deal found 4/17

$563

Wed 7/1610:45 pmSCL - SFO

1 stop14h 12mLATAM Airlines

Mon 9/158:55 amSFO - SCL

1 stop17h 05mLATAM Airlines

Deal found 4/16

$564

Thu 8/212:23 amSCL - SFO

1 stop24h 17mCopa Airlines

Fri 9/121:28 amSFO - SCL

1 stop18h 12mCopa Airlines

Deal found 4/16

$572

Tue 7/159:39 pmSCL - SFO

2 stops26h 41mMultiple Airlines

Wed 8/276:00 amSFO - SCL

1 stop21h 00mMultiple Airlines

Deal found 4/17

$579

Thu 8/216:10 amSCL - SFO

2 stops19h 35mAvianca

Mon 9/112:05 amSFO - SCL

2 stops19h 25mAvianca

Deal found 4/16

$648

Best flights from Santiago to San Francisco
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2025.

Thu 6/511:05 pmSCL - SFO

2 stops22h 51mDelta

Wed 6/189:35 amSFO - SCL

1 stop18h 10mDelta

Deal found 4/16

$555

Wed 7/1610:45 pmSCL - SFO

1 stop14h 12mLATAM Airlines

Mon 9/158:55 amSFO - SCL

1 stop17h 05mLATAM Airlines

Deal found 4/16

$564

Tue 7/159:39 pmSCL - SFO

2 stops26h 41mMultiple Airlines

Wed 8/276:00 amSFO - SCL

1 stop21h 00mMultiple Airlines

Deal found 4/17

$579

Tue 7/159:55 pmSCL - SFO

1 stop23h 52mAmerican Airlines

Wed 8/279:49 amSFO - SCL

2 stops18h 16mAmerican Airlines

Deal found 4/16

$583

Mon 5/512:24 amSCL - SFO

1 stop26h 16mCopa Airlines

Tue 5/137:52 pmSFO - SCL

1 stop20h 32mCopa Airlines

Deal found 4/16

$628

Mon 5/262:30 pmSCL - SFO

2 stops36h 25mAvianca

Sun 6/112:05 amSFO - SCL

2 stops25h 10mAvianca

Deal found 4/16

$815

Last-minute flights from Santiago to San Francisco
Discover last-minute flight deals from Santiago to San Francisco. Data last updated April 17, 2025 and is based on user searches.

Thu 4/172:30 amSCL - SFO

1 stop19h 00mCopa Airlines

Sat 4/261:40 amSFO - SCL

1 stop22h 07mCopa Airlines

Deal found 4/16

$628

Tue 4/223:35 amSCL - SFO

3 stops36h 19mMultiple Airlines

Fri 5/26:10 amSFO - SCL

2 stops21h 40mMultiple Airlines

Deal found 4/16

$1,130

Wed 4/239:55 pmSCL - SFO

2 stops22h 13mAmerican Airlines

Fri 5/210:10 amSFO - SCL

2 stops17h 45mAmerican Airlines

Deal found 4/16

$889

Wed 4/238:40 pmSCL - SFO

1 stop16h 45mLATAM Airlines

Fri 5/26:00 amSFO - SCL

1 stop22h 00mLATAM Airlines

Deal found 4/16

$891

Wed 4/2312:19 amSCL - SFO

1 stop26h 21mCopa Airlines

Mon 5/191:37 amSFO - SCL

1 stop14h 47mCopa Airlines

Deal found 4/17

$1,336

Sat 4/266:10 amSCL - SFO

2 stops19h 35mAvianca

Thu 5/12:30 amSFO - SCL

2 stops17h 00mAvianca

Deal found 4/16

$1,962

Sat 4/2610:45 pmSCL - SFO

1 stop21h 41mDelta

Sat 5/39:10 amSFO - SCL

1 stop18h 35mDelta

Deal found 4/15

$3,766

Thu 5/1511:00 amSCL - SFO

2 stops39h 59mMultiple Airlines

Wed 5/286:05 amSFO - SCL

1 stop20h 45mMultiple Airlines

Deal found 4/15

$717

Thu 5/227:40 pmSCL - SFO

2 stops19h 05mLATAM Airlines

Thu 5/2912:40 pmSFO - SCL

1 stop14h 20mLATAM Airlines

Deal found 4/16

$686

Mon 5/2610:55 pmSCL - SFO

1 stop23h 05mDelta

Mon 6/26:15 amSFO - SCL

1 stop21h 45mDelta

Deal found 4/16

$705

Mon 5/262:30 pmSCL - SFO

2 stops36h 25mAvianca

Sun 6/112:05 amSFO - SCL

2 stops25h 10mAvianca

Deal found 4/16

$815

Thu 5/299:00 pmSCL - SFO

2 stops22h 59mAmerican Airlines

Mon 6/210:10 amSFO - SCL

2 stops17h 45mAmerican Airlines

Deal found 4/17

$737

One-way flights from Santiago to San Francisco
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 17, 2025.

Sat 5/102:24 amSCL - SFO

1 stop24h 16mCopa Airlines

Deal found 4/16

$331

Thu 5/222:30 pmSCL - SFO

3 stops53h 59mMultiple Airlines

Deal found 4/16

$385

Thu 5/226:10 amSCL - SFO

2 stops19h 35mAvianca

Deal found 4/16

$438

Sun 6/18:40 pmSCL - SFO

1 stop20h 25mDelta

Deal found 4/16

$452

Sun 5/114:55 pmSCL - SFO

2 stops30h 14mLATAM Airlines

Deal found 4/17

$456

Sat 4/269:55 pmSCL - SFO

1 stop27h 59mAmerican Airlines

Deal found 4/17

$1,385

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 6/5

11:05 pm-6:56 pm

2 stops22h 51m

San Francisco

Wed 6/18

9:35 am-6:45 am

1 stop18h 10m

$555

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 7/16

10:45 pm-9:57 am

1 stop14h 12m

San Francisco

Mon 9/15

8:55 am-6:00 am

1 stop17h 05m

$564

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 7/15

9:39 pm-9:20 pm

2 stops26h 41m

San Francisco

Wed 8/27

6:00 am-6:00 am

1 stop21h 00m

$579

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 7/15

9:55 pm-6:47 pm

1 stop23h 52m

San Francisco

Wed 8/27

9:49 am-7:05 am

2 stops18h 16m

$583

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 5/5

12:24 am-11:40 pm

1 stop26h 16m

San Francisco

Tue 5/13

7:52 pm-7:24 pm

1 stop20h 32m

$628

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 5/26

2:30 pm-11:55 pm

2 stops36h 25m

San Francisco

Sun 6/1

12:05 am-4:15 am

2 stops25h 10m

$815

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 5/10

2:24 am-11:40 pm

1 stop24h 16m

$331

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 5/22

2:30 pm-5:29 pm

3 stops53h 59m

$385

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 5/22

6:10 am-10:45 pm

2 stops19h 35m

$438

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 6/1

8:40 pm-2:05 pm

1 stop20h 25m

$452

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 12 results

Compare providers for flights from Santiago to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in April.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy3 stars	Trust Score*3 stars
Cheapflightsfares	Price Accuracy3 stars	Trust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 85 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the evening, which is usually more expensive.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Santiago to San Francisco, such as Delta, Copa Airlines and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,917 reviews

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Copa Airlines

7.6

Good

1,409 reviews

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

LATAM Airlines

7.5

Good

1,761 reviews

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca

6.7

Okay

2,315 reviews

Delta

8.0

Very good

7,917 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Santiago to San Francisco round-trip?
Currently priced at $555, Delta will fly you from Santiago to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and American Airlines - these airlines can fly you to your destination from $564 and $583, respectively. Delta is priced at 21% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Santiago to San Francisco one-way?
One-way options have recently been found by users for as low as $331 on Copa Airlines. Other airlines that offer cheap prices include Avianca from $438 and Delta from $452 one-way.
Can I find deals for flights from Santiago to San Francisco that include hotel bookings?
Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.
Can I find deals for business class flights from Santiago to San Francisco?
Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Turlock

South San Francisco

Fairfield

Manteca

Sausalito

Richmond

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Hollister

Milpitas

Antioch

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Alameda

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Livermore

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Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Santiago to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$474	Average$733	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$509	Average$658	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$513	Average$872	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$533	Average$706	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$536	Average$710	FlexibilityNo cancel fee	On-time81%
American Airlines	Cheapest$611	Average$875	FlexibilityNo cancel fee	On-time71%

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$331+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in March or November, booked 85 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Cheap flight deals from Santiago to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Compare providers for flights from Santiago to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in April.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on April 11, 2025.

What is the cheapest month to book a flight from Santiago to San Francisco?

What is the cheapest time of day to fly from SCL to SFO?

Find hourly flight availability from Santiago to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Santiago to San Francisco, such as Delta, Copa Airlines and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santiago to San Francisco round-trip?

What are the cheapest airlines to fly from Santiago to San Francisco one-way?

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

How can I find direct flights from Santiago to San Francisco?

Can I find deals for business class flights from Santiago to San Francisco?

What is the cheapest month to book a flight from Santiago to San Francisco?

Traveling to a place near Santiago?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santiago to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Santiago to San Francisco

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Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.