What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

Currently priced at $307, United Airlines will fly you from Panama City, Florida to San Francisco and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $312 and $343, respectively. United Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

$154 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $204 and $208, respectively.

What is the cheapest day to fly from Panama City, Florida to San Francisco?

Travelers seeking maximum savings on their Panama City, Florida to San Francisco flight should consider departing on Saturday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Panama City, Florida to San Francisco?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Panama City, Florida to San Francisco.

What is the cheapest day to fly round-trip from Panama City, Florida to San Francisco?

Flights from Panama City, Florida to San Francisco are found to be more expensive on Sunday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to San Francisco.

What is the cheapest month to fly from Panama City, Florida to San Francisco?

September is one of the best times of the year to fly to San Francisco from Panama City, Florida. Prices for September average $433 per person but you can even find prices for as low as $295. The most expensive prices can be found in the month of May. Opting for a September flight can save you 62% on your journey compared to booking in May

Most accurate provider : When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$154+ Flights from Panama City, FL to San Francisco

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1. Tell us where you want to go

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Cheap flight deals from Panama City to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$307 (United Airlines)
One-way from	$154 (American Airlines)
Popular in	May
Cheapest in	September
Average price	$391

Provider with most accurate pricing for Panama City NW Florida Beaches-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Francisco flights.

Search Deals

From Panama City NW Florida Beaches to San Francisco

Search Deals

One-way flight from Panama City NW Florida Beaches to San Francisco

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($61 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($25 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Wed 4/301:15 pmECP - SFO

1 stop8h 17mUnited Airlines

Mon 5/512:43 amSFO - ECP

1 stop9h 42mUnited Airlines

Deal found 4/9

$307

Wed 4/303:38 pmECP - SFO

2 stops9h 01mAmerican Airlines

Mon 5/512:24 amSFO - ECP

1 stop8h 39mAmerican Airlines

Deal found 4/9

$312

Tue 5/135:30 pmECP - SFO

1 stop7h 28mDelta

Fri 5/169:35 pmSFO - ECP

1 stop8h 41mDelta

Deal found 4/10

$343

Thu 8/2110:40 amECP - SFO

1 stop8h 00mSouthwest

Thu 8/284:20 pmSFO - ECP

2 stops15h 35mSouthwest

Deal found 4/11

$382

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2025.

Wed 4/301:15 pmECP - SFO

1 stop8h 17mUnited Airlines

Mon 5/512:43 amSFO - ECP

1 stop9h 42mUnited Airlines

Deal found 4/9

$307

Wed 4/303:38 pmECP - SFO

2 stops9h 01mAmerican Airlines

Mon 5/512:24 amSFO - ECP

1 stop8h 39mAmerican Airlines

Deal found 4/9

$312

Tue 5/135:30 pmECP - SFO

1 stop7h 28mDelta

Fri 5/169:35 pmSFO - ECP

1 stop8h 41mDelta

Deal found 4/10

$343

Thu 8/2110:40 amECP - SFO

1 stop8h 00mSouthwest

Thu 8/284:20 pmSFO - ECP

2 stops15h 35mSouthwest

Deal found 4/11

$382

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated April 11, 2025 and is based on user searches.

Wed 4/301:15 pmECP - SFO

1 stop8h 17mUnited Airlines

Mon 5/512:43 amSFO - ECP

1 stop9h 42mUnited Airlines

Deal found 4/9

$307

Wed 4/303:38 pmECP - SFO

2 stops9h 01mAmerican Airlines

Mon 5/512:24 amSFO - ECP

1 stop8h 39mAmerican Airlines

Deal found 4/9

$312

Sun 5/44:40 pmECP - SFO

2 stops10h 05mSouthwest

Thu 5/89:55 amSFO - ECP

2 stops10h 10mSouthwest

Deal found 4/10

$682

Tue 5/135:30 pmECP - SFO

1 stop7h 28mDelta

Fri 5/169:35 pmSFO - ECP

1 stop8h 41mDelta

Deal found 4/10

$343

One-way flights from Panama City to San Francisco
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 11, 2025.

Wed 4/302:27 pmECP - SFO

1 stop8h 38mAmerican Airlines

Deal found 4/9

$154

Wed 7/23:04 pmECP - SFO

1 stop8h 57mUnited Airlines

Deal found 4/10

$204

Tue 7/16:00 amECP - SFO

2 stops18h 17mDelta

Deal found 4/10

$208

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/30

1:15 pm-7:32 pm

1 stop8h 17m

San Francisco

Mon 5/5

12:43 am-12:25 pm

1 stop9h 42m

$307

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/30

3:38 pm-10:39 pm

2 stops9h 01m

San Francisco

Mon 5/5

12:24 am-11:03 am

1 stop8h 39m

$312

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Tue 5/13

5:30 pm-10:58 pm

1 stop7h 28m

San Francisco

Fri 5/16

9:35 pm-8:16 am

1 stop8h 41m

$343

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Thu 8/21

10:40 am-4:40 pm

1 stop8h 00m

San Francisco

Thu 8/28

4:20 pm-9:55 am

2 stops15h 35m

$382

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 4/30

2:27 pm-9:05 pm

1 stop8h 38m

$154

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 7/2

3:04 pm-10:01 pm

1 stop8h 57m

$204

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Tue 7/1

6:00 am-10:17 pm

2 stops18h 17m

$208

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/9

Compare providers for flights from Panama City to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SFO?

Unlike at noon, when flights are generally more expensive, you can save up to 23% on flights from Panama City, Florida to San Francisco by exploring options for tickets in the evening.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Southwest

8.0

Very good

4,279 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Delta

8.0

Very good

7,911 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

United Airlines

7.4

Good

8,636 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?
Currently priced at $307, United Airlines will fly you from Panama City, Florida to San Francisco and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $312 and $343, respectively. United Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?
$154 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $204 and $208, respectively.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$296	Average$441	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$311	Average$431	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$360	Average$411	FlexibilityNo cancel fee	On-time71%

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$154+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in April.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

What is the cheapest time of day to fly from ECP to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 11, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Traveling to a place near Panama City?

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Alternative routes for Panama City to San Francisco

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Top 3 airlines flying from Panama City to San Francisco

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Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.