What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

Currently priced at $351, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $356 and $620, respectively. You may be able to fly from Myrtle Beach to San Francisco for 22% less than the average price by searching for these airlines.

What are the cheapest airlines to fly from Myrtle Beach to San Francisco one-way?

$176 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $179 and $314, respectively.

What is the cheapest day to fly from Myrtle Beach to San Francisco?

Travelers seeking maximum savings on their Myrtle Beach to San Francisco flight should consider departing on Tuesday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Myrtle Beach to San Francisco?

Departing on a Wednesday is a good option for securing a great price. You can expect to save up to 32% when planning your travel around this day of the week.

How far in advance should I book a flight from Myrtle Beach to San Francisco?

To save on the cost of your flight from Myrtle Beach to San Francisco, book at least 9 days before your planned departure. Booking around this time can save you about 201% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $235 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $798.

What is the cheapest month to fly from Myrtle Beach to San Francisco?

Our data shows that April tends to be the cheapest month to fly to San Francisco from Myrtle Beach. Users have commonly found prices around $452 for the month, but tickets can be as low as $245. Due to multiple factors, prepare for potentially higher prices in June.

Most accurate provider : When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

Can I find deals for business class flights from Myrtle Beach to San Francisco?

Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$176+ Flights from Myrtle Beach to San Francisco

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Find cheap flights from Myrtle Beach to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Myrtle Beach Intl to San Francisco are usually found in April or September, booked 8 days in advance, depart on a Thursday or Tuesday and return on a Wednesday

Cheap flight deals from Myrtle Beach to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$351 (Delta)
One-way from	$176 (Delta)
Popular in	June
Cheapest in	April
Average price	$506

Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.

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From Myrtle Beach Intl to San Francisco

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One-way flight from Myrtle Beach Intl to San Francisco

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($54 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).

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Average for round-trip flights in March 2025

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Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Mon 4/142:55 pmMYR - SFO

1 stop8h 42mDelta

Wed 4/166:00 amSFO - MYR

1 stop9h 07mDelta

Deal found 3/24

$351

Mon 4/144:42 pmMYR - SFO

1 stop9h 59mAmerican Airlines

Wed 4/1611:32 amSFO - MYR

2 stops9h 12mAmerican Airlines

Deal found 3/24

$356

Thu 9/188:25 amMYR - SFO

2 stops11h 00mSouthwest

Sun 9/216:20 amSFO - MYR

1 stop6h 35mSouthwest

Deal found 3/23

$428

Sat 8/211:35 amMYR - SFO

2 stops14h 35mUnited Airlines

Sat 8/97:03 pmSFO - MYR

2 stops16h 32mUnited Airlines

Deal found 3/24

$620

Best flights from Myrtle Beach to San Francisco
Discover carefully curated flight deals from Myrtle Beach to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 25, 2025.

Mon 4/142:55 pmMYR - SFO

1 stop8h 42mDelta

Wed 4/166:00 amSFO - MYR

1 stop9h 07mDelta

Deal found 3/24

$351

Mon 4/144:42 pmMYR - SFO

1 stop9h 59mAmerican Airlines

Wed 4/1611:32 amSFO - MYR

2 stops9h 12mAmerican Airlines

Deal found 3/24

$356

Sat 8/211:35 amMYR - SFO

2 stops14h 35mUnited Airlines

Sat 8/97:03 pmSFO - MYR

2 stops16h 32mUnited Airlines

Deal found 3/24

$620

Last-minute flights from Myrtle Beach to San Francisco
Discover last-minute flight deals from Myrtle Beach to San Francisco. Data last updated March 25, 2025 and is based on user searches.

Tue 4/811:54 amMYR - SFO

1 stop9h 13mUnited Airlines

Sat 4/127:05 pmSFO - MYR

2 stops16h 38mUnited Airlines

Deal found 3/24

$716

Mon 4/142:55 pmMYR - SFO

1 stop8h 42mDelta

Wed 4/166:00 amSFO - MYR

1 stop9h 07mDelta

Deal found 3/24

$351

Mon 4/144:42 pmMYR - SFO

1 stop9h 59mAmerican Airlines

Wed 4/1611:32 amSFO - MYR

2 stops9h 12mAmerican Airlines

Deal found 3/24

$356

One-way flights from Myrtle Beach to San Francisco
Search for one-way flight options from Myrtle Beach to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 25, 2025.

Mon 5/52:30 pmMYR - SFO

1 stop8h 45mDelta

Deal found 3/23

$176

Wed 8/136:34 pmMYR - SFO

1 stop7h 06mAmerican Airlines

Deal found 3/23

$179

Thu 5/85:32 pmMYR - SFO

3 stops26h 41mMultiple Airlines

Deal found 3/23

$202

Mon 5/264:55 pmMYR - SFO

1 stop10h 04mUnited Airlines

Deal found 3/23

$314

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 4/14

2:55 pm-8:37 pm

1 stop8h 42m

San Francisco

Wed 4/16

6:00 am-6:07 pm

1 stop9h 07m

$351

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 4/14

4:42 pm-11:41 pm

1 stop9h 59m

San Francisco

Wed 4/16

11:32 am-11:44 pm

2 stops9h 12m

$356

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 9/18

8:25 am-4:25 pm

2 stops11h 00m

San Francisco

Sun 9/21

6:20 am-3:55 pm

1 stop6h 35m

$428

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 8/2

11:35 am-11:10 pm

2 stops14h 35m

San Francisco

Sat 8/9

7:03 pm-2:35 pm

2 stops16h 32m

$620

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 5/5

2:30 pm-8:15 pm

1 stop8h 45m

$176

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 8/13

6:34 pm-10:40 pm

1 stop7h 06m

$179

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 5/8

5:32 pm-5:13 pm

3 stops26h 41m

$202

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 5/26

4:55 pm-11:59 pm

1 stop10h 04m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/23

Compare providers for flights from Myrtle Beach to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in March.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

How far ahead should I book a flight from Myrtle Beach to San Francisco?

The best time to book flights from Myrtle Beach to San Francisco is 8 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $398). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SFO?

One of the essential ways to save on airfare from Myrtle Beach to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight at noon could potentially save you up to 8% on airfare.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,890 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,605 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?
Currently priced at $351, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $356 and $620, respectively. You may be able to fly from Myrtle Beach to San Francisco for 22% less than the average price by searching for these airlines.
What are the cheapest airlines to fly from Myrtle Beach to San Francisco one-way?
$176 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $179 and $314, respectively.
Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.
Can I find deals for business class flights from Myrtle Beach to San Francisco?
Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $398). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Turlock

Fairfield

South San Francisco

Manteca

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Richmond

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Hollister

Milpitas

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Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Myrtle Beach to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$250	Average$424	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$306	Average$456	FlexibilityNo cancel fee	On-time71%

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$176+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Myrtle Beach Intl to San Francisco are usually found in April or September, booked 8 days in advance, depart on a Thursday or Tuesday and return on a Wednesday

Cheap flight deals from Myrtle Beach to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San FranciscoExplore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Compare providers for flights from Myrtle Beach to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in March.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

How far ahead should I book a flight from Myrtle Beach to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Myrtle Beach to San Francisco. Price data was last updated on March 21, 2025.

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

What is the cheapest time of day to fly from MYR to SFO?

Find hourly flight availability from Myrtle Beach to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 25, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

What are the cheapest airlines to fly from Myrtle Beach to San Francisco one-way?

Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

How can I find direct flights from Myrtle Beach to San Francisco?

Can I find deals for business class flights from Myrtle Beach to San Francisco?

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Traveling to a place near Myrtle Beach?

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Alternative routes for Myrtle Beach to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Myrtle Beach to San Francisco

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Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.