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$115+ Cheap flights from Iowa to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Iowa to San Francisco

Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$238
(Frontier)

One-way from

$115
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$520
Provider with most accurate pricing for Des Moines-San Francisco flight deals.
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From Iowa to San Francisco
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One-way flight from Iowa to San Francisco
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Highest demand for flights based on searches. 3% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Iowa to San Francisco

Cheapest flights from Iowa to San Francisco
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/287:27 pmDSM - SFO
1 stop7h 06mFrontier
Wed 5/76:35 amSFO - DSM
1 stop9h 55mFrontier
Deal found 3/29$238
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:51 pmOMA - SFO
1 stop6h 26mAmerican Airlines
Tue 10/2112:46 pmSFO - OMA
1 stop8h 38mAmerican Airlines
Deal found 3/30$249
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/296:15 pmOMA - SFO
1 stop7h 36mDelta
Mon 8/412:40 amSFO - OMA
1 stop7h 28mDelta
Deal found 3/31$257
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/144:11 pmOMA - SFO
1 stop10h 33mFrontier
Fri 4/186:00 amSFO - OMA
1 stop6h 54mFrontier
Deal found 3/30$258
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/55:00 amMLI - SFO
1 stop9h 14mAmerican Airlines
Sat 7/1211:47 pmSFO - MLI
1 stop9h 06mAmerican Airlines
Deal found 3/30$259
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/168:16 pmCID - SFO
1 stop5h 53mFrontier
Sun 5/186:35 amSFO - CID
1 stop10h 23mFrontier
Deal found 3/30$268
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/158:20 pmOMA - SFO
1 stop5h 10mSouthwest
Tue 7/223:20 pmSFO - OMA
1 stop5h 10mSouthwest
Deal found 3/30$269
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/136:25 amCID - SFO
1 stop9h 04mDelta
Fri 5/2312:40 amSFO - CID
1 stop8h 37mDelta
Deal found 3/30$273
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:00 amOMA - SFO
1 stop5h 36mUnited Airlines
Sat 4/194:50 pmSFO - OMA
Nonstop3h 30mUnited Airlines
Deal found 3/30$279
This Hawaiian Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Hawaiian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:05 pmOMA - SFO
1 stop7h 13mHawaiian Airlines
Sun 11/166:00 amSFO - OMA
1 stop6h 12mHawaiian Airlines
Deal found 3/30$288
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/203:06 pmALO - SFO
1 stop7h 14mAmerican Airlines
Tue 9/236:10 amSFO - ALO
1 stop6h 26mAmerican Airlines
Deal found 3/31$289
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/235:50 amMLI - SFO
1 stop9h 55mDelta
Thu 4/246:00 amSFO - MLI
1 stop8h 20mDelta
Deal found 3/31$347

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.

Fly from

Iowa

Fly to

San Francisco

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 4/28

7:27 pm-12:33 am

1 stop7h 06m

San Francisco

Wed 5/7

6:35 am-6:30 pm

1 stop9h 55m

$238

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 7/5

5:00 am-10:30 am

1 stop7h 30m

San Francisco

Sat 7/12

5:41 am-3:22 pm

1 stop7h 41m

$249

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Tue 7/29

6:15 pm-11:51 pm

1 stop7h 36m

San Francisco

Tue 8/5

5:15 pm-12:03 am

1 stop4h 48m

$257

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Mon 4/14

4:11 pm-12:44 am

1 stop10h 33m

San Francisco

Fri 4/18

6:00 am-2:54 pm

1 stop6h 54m

$258

MolineSan Francisco

MLI - SFO

MLISFO

Moline Quad-City

Sat 7/5

5:00 am-12:14 pm

1 stop9h 14m

San Francisco

Sat 7/12

11:47 pm-10:53 am

1 stop9h 06m

$259

Cedar RapidsSan Francisco

CID - SFO

CIDSFO

Cedar Rapids

Fri 5/16

8:16 pm-12:09 am

1 stop5h 53m

San Francisco

Sun 5/18

6:35 am-6:58 pm

1 stop10h 23m

$268

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Tue 7/15

8:20 pm-11:30 pm

1 stop5h 10m

San Francisco

Tue 7/22

3:20 pm-10:30 pm

1 stop5h 10m

$269

Cedar RapidsSan Francisco

CID - SFO

CIDSFO

Cedar Rapids

Tue 5/13

6:25 am-1:29 pm

1 stop9h 04m

San Francisco

Sat 5/24

3:15 pm-11:01 pm

1 stop5h 46m

$273

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Thu 4/17

6:00 am-9:36 am

1 stop5h 36m

San Francisco

Sat 4/19

4:50 pm-10:20 pm

Nonstop3h 30m

$279

WaterlooSan Francisco

ALO - SFO

ALOSFO

Waterloo

Sat 9/20

3:06 pm-8:20 pm

1 stop7h 14m

San Francisco

Tue 9/23

6:10 am-2:36 pm

1 stop6h 26m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 46 results
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Best time to book a flight from Iowa to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Francisco

What is the cheapest month to book a flight from Iowa to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $276). Flying from Iowa to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SFO?

Find hourly flight availability from Iowa to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

When flying from Iowa to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 31, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from Iowa to San Francisco to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot
Alaska Airlines
8.0
Very good
9,818 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot
Southwest
8.0
Very good
4,276 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot
Delta
8.0
Very good
7,899 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot
United Airlines
7.4
Good
8,614 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,818 reviews

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.1

Boarding

8.2

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Seleste,Dec 2024

FAT - SAN

The attention and efficiency of the staff and the good handling of the pilot

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Iowa?

    San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Iowa to San Francisco.

  • What are the cheapest airlines to fly from Iowa to San Francisco one-way?

    $115 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and Frontier, with prices starting from $119 and $119, respectively.

  • What are the most popular routes from Iowa to San Francisco?

    The most popular route from Iowa to San Francisco is Omaha Eppley Airfield - San Francisco. You may also consider Des Moines - San Francisco or Cedar Rapids - San Francisco.

  • Can I find deals for flights from Iowa to San Francisco that include hotel bookings?

    Yes. In addition to deals on Iowa to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Francisco.

  • Can I find deals for business class flights from Iowa to San Francisco?

    Yes. Cheapflights offers flight deals from Iowa to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $276). Flying from Iowa to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Iowa?

Book flights to Iowa if you plan to visit one of these locations
Roseville
Mountain View
Santa Cruz
Turlock
Fairfield
South San Francisco
Manteca
Sausalito
Richmond
Watsonville
Hollister
Milpitas
Antioch
Hayward
Vallejo
Newark
Alameda
Sunnyvale
Campbell
Daly City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Iowa to San Francisco

Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$108Average$212FlexibilityNo cancel feeOn-time62%
DeltaCheapest$276Average$423FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$285Average$430FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$288Average$483FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$370Average$440FlexibilityNo cancel feeOn-time63%
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