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$105+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Feb 28 — Mar 71
Fri 2/28
Fri 3/7
1 adult, Economy
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Cheap flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated February 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$203
(United Airlines)

One-way from

$105
(Frontier)
Provider with most accurate pricing for Key West-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Key West-San Francisco flights.
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From Florida Keys to San Francisco
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One-way flight from Florida Keys to San Francisco
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Find flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2025.

This Frontier deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/276:00 amMIA - SFO
1 stop12h 14mFrontier
Tue 6/34:04 pmSFO - MIA
1 stop10h 20mFrontier
Deal found 2/23$200
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/268:40 amMIA - SFO
1 stop10h 04mUnited Airlines
Tue 4/110:35 pmSFO - MIA
Nonstop5h 43mUnited Airlines
Deal found 2/22$203
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/87:34 amMIA - SFO
Nonstop6h 17mAmerican Airlines
Tue 4/1511:37 pmSFO - MIA
Nonstop5h 23mAmerican Airlines
Deal found 2/23$213
This Expedia deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/110:36 amMIA - SFO
1 stop15h 08mMultiple Airlines
Tue 4/87:40 amSFO - MIA
1 stop8h 19mMultiple Airlines
Deal found 2/22$219
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/712:50 pmEYW - SFO
1 stop8h 39mAmerican Airlines
Sat 5/1010:00 pmSFO - EYW
1 stop11h 10mAmerican Airlines
Deal found 2/23$257
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/106:10 pmMIA - SFO
1 stop9h 12mDelta
Mon 3/319:30 pmSFO - MIA
1 stop8h 50mDelta
Deal found 2/22$257
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/34:25 pmMIA - SFO
2 stops11h 05mSouthwest
Tue 4/810:40 amSFO - MIA
1 stop7h 55mSouthwest
Deal found 2/23$272
This JetBlue deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/311:58 amMIA - SFO
1 stop13h 27mJetBlue
Sun 4/610:21 pmSFO - MIA
1 stop11h 52mJetBlue
Deal found 2/22$292
This Alaska Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/177:52 pmMIA - SFO
1 stop16h 58mAlaska Airlines
Sat 3/227:55 pmSFO - MIA
1 stop18h 07mAlaska Airlines
Deal found 2/21$363
This Trip.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/33:05 pmEYW - SFO
2 stops36h 39mMultiple Airlines
Sun 4/66:00 amSFO - EYW
2 stops25h 10mMultiple Airlines
Deal found 2/22$392
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/183:59 pmEYW - SFO
1 stop10h 01mUnited Airlines
Sat 3/229:51 pmSFO - EYW
1 stop18h 04mUnited Airlines
Deal found 2/22$409
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/76:00 pmEYW - SFO
1 stop8h 38mDelta
Fri 5/912:40 amSFO - EYW
2 stops13h 33mDelta
Deal found 2/22$1,006

Find flights from Florida Keys to San Francisco within your budget

Customize your flight search to find flights from Florida Keys to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2025.

Fly from

Florida Keys

Fly to

San Francisco

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 3/26

8:40 am-3:44 pm

1 stop10h 04m

San Francisco

Tue 4/1

10:35 pm-7:18 am

Nonstop5h 43m

$203

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sun 3/16

6:25 am-12:43 am

1 stop21h 18m

San Francisco

Sun 3/30

12:15 am-10:53 am

1 stop7h 38m

$204

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 4/8

7:34 am-10:51 am

Nonstop6h 17m

San Francisco

Tue 4/15

11:37 pm-8:00 am

Nonstop5h 23m

$213

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 4/1

10:36 am-10:44 pm

1 stop15h 08m

San Francisco

Tue 4/8

7:40 am-6:59 pm

1 stop8h 19m

$219

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Mon 3/10

6:10 pm-12:22 am

1 stop9h 12m

San Francisco

Mon 3/31

9:30 pm-9:20 am

1 stop8h 50m

$257

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/7

12:50 pm-6:29 pm

1 stop8h 39m

San Francisco

Sat 5/10

10:00 pm-12:10 pm

1 stop11h 10m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 4/3

4:25 pm-12:30 am

2 stops11h 05m

San Francisco

Tue 4/8

10:40 am-9:35 pm

1 stop7h 55m

$272

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 4/3

11:58 am-10:25 pm

1 stop13h 27m

San Francisco

Sun 4/6

10:21 pm-1:13 pm

1 stop11h 52m

$292

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Mon 3/17

7:52 pm-9:50 am

1 stop16h 58m

San Francisco

Sat 3/22

7:55 pm-5:02 pm

1 stop18h 07m

$363

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 4/3

3:05 pm-12:44 am

2 stops36h 39m

San Francisco

Sun 4/6

6:00 am-10:10 am

2 stops25h 10m

$392

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/23

Showing 1-10 of 23 results
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Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Florida Keys to San Francisco

Get recent, data-driven insights about flights from Florida Keys to San Francisco including ideal travel times, pricing trends, and more.

What is the cheapest time of day to fly from EOA to SFO?

Find hourly flight availability from Florida Keys to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 23, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Francisco as you normally would.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 23, 2025.
Get a feel of what it's like to fly with Southwest, Alaska Airlines and Delta from Florida Keys to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

Southwest
8.1
Very good
4,385 reviews
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

Alaska Airlines
8.0
Very good
9,706 reviews
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

Delta
8.0
Very good
8,187 reviews
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

JetBlue
7.4
Good
3,065 reviews
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

United Airlines
7.4
Good
8,746 reviews
Southwest
8.1
Very good
4,385 reviews

Boarding

8.2

Comfort

8.1

Food

7.1

Crew

8.7

Entertainment

7.6

Overall

8.1

Reviews

1 / 20

8.0
Excellent

Christine,Aug 2024

DEN - LGB

No issues. I needed pre boarding and I was able to get it without issue

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Florida Keys?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $105. Users have also found prices from $114 and $120 on American Airlines and United Airlines, respectively.

  • Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

  • Can I find deals for business class flights from Florida Keys to San Francisco?

    Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to San Francisco (average of $276). Flying from Florida Keys to San Francisco in June is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
Roseville
Mountain View
Turlock
Santa Cruz
Fairfield
Manteca
Sausalito
Watsonville
Hayward
Richmond
Hollister
South San Francisco
Antioch
Milpitas
Vallejo
Newark
Alameda
Campbell
Pacific Grove
Sunnyvale

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florida Keys to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida Keys to San Francisco

Discover the top airline that operate flights from Florida Keys to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$317Average$608FlexibilityNo cancel feeOn-time71%
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