What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

For one-way options, check prices for Frontier. According to our data, you can fly for as low as $117. Users have also found prices from $119 and $129 on American Airlines and Delta, respectively.

What is the cheapest month to book a flight from Florida Keys to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to San Francisco (average of $276). Flying from Florida Keys to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How far in advance should I book a flight from Florida Keys to San Francisco?

When searching for a good deal, it’s best to be prepared for potential fluctuations in price. We recommend booking at least 16 days in advance, which can save you up to 42% on flights from Florida Keys to San Francisco compared to booking the week you need them. Waiting 16 days out may not be for everyone, so we have options available for flights within the next two weeks, with the lowest price starting at $292. For sooner than that we have options available in the next 3 days from $428.

What is the cheapest month to fly from Florida Keys to San Francisco?

Our data shows that January tends to be the cheapest month to fly to San Francisco from Florida Keys. Users have commonly found prices around $333 for the month, but tickets can be as low as $148. Due to multiple factors, prepare for potentially higher prices in June.

What airport do you fly into for flights to San Francisco from Florida Keys?

Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florida Keys to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

Can I find deals for business class flights from Florida Keys to San Francisco?

Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$117+ Flights from Florida Keys to San Francisco

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Florida Keys to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$198 (CheapOair)
One-way from	$117 (CheapOair)

Provider with most accurate pricing for Key West-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Key West-San Francisco flights.

Search Deals

From Florida Keys to San Francisco

Search Deals

One-way flight from Florida Keys to San Francisco

Search Deals

Find flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Thu 4/242:30 pmMIA - SFO

1 stop11h 38mFrontier

Tue 4/293:33 pmSFO - MIA

1 stop10h 48mFrontier

Deal found 4/16

$198

Wed 5/145:00 pmMIA - SFO

1 stop8h 47mUnited Airlines

Wed 5/217:00 amSFO - MIA

Nonstop5h 37mUnited Airlines

Deal found 4/16

$215

Wed 5/77:33 amMIA - SFO

Nonstop6h 19mAmerican Airlines

Fri 5/91:20 pmSFO - MIA

Nonstop5h 31mAmerican Airlines

Deal found 4/16

$219

Thu 5/86:25 pmEYW - SFO

1 stop8h 07mDelta

Sun 5/1111:59 pmSFO - EYW

1 stop7h 52mDelta

Deal found 4/17

$257

Tue 7/158:00 amMIA - SFO

1 stop10h 10mDelta

Mon 7/2112:40 amSFO - MIA

1 stop9h 50mDelta

Deal found 4/16

$257

Thu 5/81:39 pmEYW - SFO

1 stop9h 56mAmerican Airlines

Sat 5/1012:21 amSFO - EYW

2 stops9h 30mAmerican Airlines

Deal found 4/17

$262

Thu 5/297:10 amMIA - SFO

1 stop8h 14mMultiple Airlines

Mon 6/25:45 amSFO - MIA

1 stop20h 58mMultiple Airlines

Deal found 4/16

$266

Thu 9/116:07 pmMIA - SFO

1 stop18h 05mAlaska Airlines

Tue 9/238:49 pmSFO - MIA

1 stop17h 17mAlaska Airlines

Deal found 4/17

$267

Thu 8/148:00 amMIA - SFO

1 stop7h 10mSouthwest

Fri 8/225:00 amSFO - MIA

2 stops9h 20mSouthwest

Deal found 4/16

$328

Thu 6/198:53 amEYW - SFO

3 stops41h 00mMultiple Airlines

Tue 6/246:14 pmSFO - EYW

2 stops18h 45mMultiple Airlines

Deal found 4/17

$487

Sun 7/68:45 amEYW - SFO

1 stop28h 00mUnited Airlines

Tue 7/810:45 pmSFO - EYW

1 stop10h 57mUnited Airlines

Deal found 4/17

$532

Best flights from Florida Keys to San Francisco
Discover carefully curated flight deals from Florida Keys to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2025.

Thu 4/242:30 pmMIA - SFO

1 stop11h 38mFrontier

Tue 4/293:33 pmSFO - MIA

1 stop10h 48mFrontier

Deal found 4/16

$198

Wed 5/145:00 pmMIA - SFO

1 stop8h 47mUnited Airlines

Wed 5/217:00 amSFO - MIA

Nonstop5h 37mUnited Airlines

Deal found 4/16

$215

Wed 5/77:33 amMIA - SFO

Nonstop6h 19mAmerican Airlines

Fri 5/91:20 pmSFO - MIA

Nonstop5h 31mAmerican Airlines

Deal found 4/16

$219

Thu 5/86:25 pmEYW - SFO

1 stop8h 07mDelta

Sun 5/1111:59 pmSFO - EYW

1 stop7h 52mDelta

Deal found 4/17

$257

Thu 5/297:10 amMIA - SFO

1 stop8h 14mMultiple Airlines

Mon 6/25:45 amSFO - MIA

1 stop20h 58mMultiple Airlines

Deal found 4/16

$266

Thu 7/32:00 pmMIA - SFO

1 stop10h 50mSouthwest

Sun 7/65:15 amSFO - MIA

2 stops9h 25mSouthwest

Deal found 4/16

$328

Tue 7/158:00 amMIA - SFO

1 stop10h 10mDelta

Mon 7/2112:40 amSFO - MIA

1 stop9h 50mDelta

Deal found 4/16

$257

Thu 5/81:39 pmEYW - SFO

1 stop9h 56mAmerican Airlines

Sat 5/1012:21 amSFO - EYW

2 stops9h 30mAmerican Airlines

Deal found 4/17

$262

Thu 6/198:53 amEYW - SFO

3 stops41h 00mMultiple Airlines

Tue 6/246:14 pmSFO - EYW

2 stops18h 45mMultiple Airlines

Deal found 4/17

$487

Sun 7/68:45 amEYW - SFO

1 stop28h 00mUnited Airlines

Tue 7/810:45 pmSFO - EYW

1 stop10h 57mUnited Airlines

Deal found 4/17

$532

Last-minute flights from Florida Keys to San Francisco
Discover last-minute flight deals from Florida Keys to San Francisco. Data last updated April 17, 2025 and is based on user searches.

Wed 4/233:30 pmMIA - SFO

2 stops10h 50mSouthwest

Wed 4/308:10 amSFO - MIA

1 stop10h 20mSouthwest

Deal found 4/16

$338

Wed 4/238:27 amMIA - SFO

2 stops16h 12mAlaska Airlines

Mon 4/288:09 pmSFO - MIA

1 stop17h 52mAlaska Airlines

Deal found 4/17

$567

Thu 4/242:30 pmMIA - SFO

1 stop11h 38mFrontier

Tue 4/293:33 pmSFO - MIA

1 stop10h 48mFrontier

Deal found 4/16

$198

Thu 4/247:34 amMIA - SFO

Nonstop6h 17mAmerican Airlines

Tue 4/2911:37 pmSFO - MIA

Nonstop5h 23mAmerican Airlines

Deal found 4/16

$297

Thu 4/248:05 amMIA - SFO

1 stop9h 44mDelta

Mon 4/2812:47 amSFO - MIA

1 stop10h 05mDelta

Deal found 4/16

$317

Thu 4/248:30 amMIA - SFO

Nonstop6h 31mUnited Airlines

Sun 4/279:01 pmSFO - MIA

1 stop11h 10mUnited Airlines

Deal found 4/16

$351

Thu 4/246:01 pmMIA - SFO

2 stops25h 29mMultiple Airlines

Tue 4/293:33 pmSFO - MIA

1 stop10h 48mMultiple Airlines

Deal found 4/16

$452

Wed 5/77:33 amMIA - SFO

Nonstop6h 19mAmerican Airlines

Fri 5/91:20 pmSFO - MIA

Nonstop5h 31mAmerican Airlines

Deal found 4/16

$219

Wed 5/78:45 amEYW - SFO

2 stops13h 58mUnited Airlines

Fri 5/912:10 amSFO - EYW

2 stops10h 50mUnited Airlines

Deal found 4/17

$595

Thu 5/86:25 pmEYW - SFO

1 stop8h 07mDelta

Sun 5/1111:59 pmSFO - EYW

1 stop7h 52mDelta

Deal found 4/17

$257

Thu 5/81:39 pmEYW - SFO

1 stop9h 56mAmerican Airlines

Sat 5/1012:21 amSFO - EYW

2 stops9h 30mAmerican Airlines

Deal found 4/17

$262

Wed 5/145:00 pmMIA - SFO

1 stop8h 47mUnited Airlines

Wed 5/217:00 amSFO - MIA

Nonstop5h 37mUnited Airlines

Deal found 4/16

$215

One-way flights from Florida Keys to San Francisco
Search for one-way flight options from Florida Keys to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 17, 2025.

Tue 4/226:00 amMIA - SFO

1 stop11h 38mFrontier

Deal found 4/16

$117

Wed 5/147:30 pmMIA - SFO

Nonstop6h 22mAmerican Airlines

Deal found 4/16

$119

Tue 6/35:35 amMIA - SFO

1 stop7h 40mDelta

Deal found 4/15

$129

Sun 5/118:35 amMIA - SFO

Nonstop6h 30mUnited Airlines

Deal found 4/16

$130

Fri 6/1312:15 pmMIA - SFO

2 stops13h 38mMultiple Airlines

Deal found 4/17

$163

Thu 5/15:20 pmEYW - SFO

1 stop8h 31mAmerican Airlines

Deal found 4/17

$190

Tue 7/152:40 pmMIA - SFO

2 stops11h 50mSouthwest

Deal found 4/16

$204

Tue 5/136:01 pmMIA - SFO

2 stops18h 31mAlaska Airlines

Deal found 4/17

$222

Sat 7/128:45 amEYW - SFO

1 stop27h 37mUnited Airlines

Deal found 4/17

$257

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 4/24

2:30 pm-11:08 pm

1 stop11h 38m

San Francisco

Tue 4/29

3:33 pm-5:21 am

1 stop10h 48m

$198

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 5/14

5:00 pm-10:47 pm

1 stop8h 47m

San Francisco

Wed 5/21

7:00 am-3:37 pm

Nonstop5h 37m

$215

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 5/7

7:33 am-10:52 am

Nonstop6h 19m

San Francisco

Fri 5/9

1:20 pm-9:51 pm

Nonstop5h 31m

$219

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/8

6:25 pm-11:32 pm

1 stop8h 07m

San Francisco

Sun 5/11

11:59 pm-10:51 am

1 stop7h 52m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 7/15

8:00 am-3:10 pm

1 stop10h 10m

San Francisco

Mon 7/21

12:40 am-1:30 pm

1 stop9h 50m

$257

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/8

1:39 pm-8:35 pm

1 stop9h 56m

San Francisco

Sat 5/10

12:21 am-12:51 pm

2 stops9h 30m

$262

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 5/29

7:10 am-12:24 pm

1 stop8h 14m

San Francisco

Mon 6/2

5:45 am-5:43 am

1 stop20h 58m

$266

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 7/3

2:00 pm-9:50 pm

1 stop10h 50m

San Francisco

Sun 7/6

5:15 am-5:40 pm

2 stops9h 25m

$328

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 6/19

8:53 am-10:53 pm

3 stops41h 00m

San Francisco

Tue 6/24

6:14 pm-3:59 pm

2 stops18h 45m

$487

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sun 7/6

8:45 am-9:45 am

1 stop28h 00m

San Francisco

Tue 7/8

10:45 pm-12:42 pm

1 stop10h 57m

$532

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 19 results

Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco

What is the cheapest time of day to fly from EOA to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Francisco as you normally would.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Alaska Airlines, Southwest and Delta from Florida Keys to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Alaska Airlines

8.0

Very good

9,887 reviews

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Southwest

8.0

Very good

4,280 reviews

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Delta

8.0

Very good

7,916 reviews

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

United Airlines

7.4

Good

8,667 reviews

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

American Airlines

7.2

Good

10,000 reviews

Alaska Airlines

8.0

Very good

9,887 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

What airport do you fly into for flights to San Francisco from Florida Keys?
Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.
What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?
For one-way options, check prices for Frontier. According to our data, you can fly for as low as $117. Users have also found prices from $119 and $129 on American Airlines and Delta, respectively.
Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?
Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florida Keys to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.
Can I find deals for business class flights from Florida Keys to San Francisco?
Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florida Keys to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Florida Keys to San Francisco (average of $276). Flying from Florida Keys to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

Santa Cruz

Turlock

South San Francisco

Fairfield

Manteca

Sausalito

Richmond

Watsonville

Hollister

Milpitas

Antioch

Vallejo

Newark

Hayward

Alameda

Sunnyvale

Livermore

Campbell

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Florida Keys to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$355	Average$608	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$117+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florida Keys to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated April 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Find flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San FranciscoExplore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco

What is the cheapest time of day to fly from EOA to SFO?

Find hourly flight availability from Florida Keys to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Alaska Airlines, Southwest and Delta from Florida Keys to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to San Francisco from Florida Keys?

What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

How can I find direct flights from Florida Keys to San Francisco?

Can I find deals for business class flights from Florida Keys to San Francisco?

What is the cheapest month to book a flight from Florida Keys to San Francisco?

Traveling to a place near Florida Keys?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Florida Keys to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.