What are the cheapest airlines to fly from Missouri to San Diego one-way?

One-way options have recently been found by users for as low as $53 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $88 and Delta from $125 one-way.

What are the most popular routes from Missouri to San Diego?

While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

What are the cheapest flights from Missouri to San Diego?

Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $397, our data indicates the cheapest price to be $158. The most popular route (Kansas City - San Diego), is priced around $140.

What are the most popular airlines that fly from Missouri to San Diego?

Before booking your flight from Missouri to San Diego check out the most popular airlines for this route: American Airlines, Delta or Frontier.

How far in advance should I book a flight from Missouri to San Diego?

Users have found that booking a flight from Missouri to San Diego at least 54 days early can save you up to 24% on average compared to booking a flight this week. If booking 54 days before your flight isn’t an option for you, users have found flights from Missouri to San Diego for as little as $266 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $478 for flights departing within the next 3 days.

What is the cheapest month to fly from Missouri to San Diego?

The best pricing can be found in the month of August. Prices to San Diego from Missouri average $313. You can even find prices in August for less than $313, as users have found deals to San Diego from as low as $142. The month of March appears to be one of the more expensive times to travel to San Diego from Missouri. Flying in the targeted month can save you up to 19%.

What airport do you fly into for flights to San Diego from Missouri?

For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

Can I find deals for flights from Missouri to San Diego that include hotel bookings?

Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to San Diego?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

Can I find deals for business class flights from Missouri to San Diego?

Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$53+ Flights from Missouri to San Diego

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Diego

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$176 (Cheapflightsfares)
One-way from	$53 (FlightHub)
Popular in	March
Cheapest in	August
Average price	$332
Good round-trip deal	$454 or less
Good one-way deal	$204 or less

Provider with most accurate pricing for Kansas City-San Diego flight deals.

Search Deals

Provider most trusted by Cheapflights users for Kansas City-San Diego flights.

Search Deals

From Missouri to San Diego

Search Deals

One-way flight from Missouri to San Diego

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($24 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Price to beat on a round-trip flight from Missouri to San Diego.

Search Deals

Price to beat on a one-way flight from Missouri to San Diego.

Search Deals

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Fri 5/97:58 pmMCI - SAN

1 stop5h 58mSpirit Airlines

Wed 5/146:15 amSAN - MCI

1 stop9h 30mSpirit Airlines

Deal found 4/17

$176

Wed 5/287:39 pmMCI - SAN

1 stop5h 10mFrontier

Mon 6/210:57 amSAN - MCI

1 stop6h 09mFrontier

Deal found 4/17

$185

Thu 5/158:51 pmMCI - SAN

1 stop5h 22mMultiple Airlines

Sat 5/176:15 amSAN - MCI

1 stop9h 30mMultiple Airlines

Deal found 4/17

$188

Tue 6/175:41 pmMCI - SAN

1 stop7h 39mDelta

Fri 7/41:28 pmSAN - MCI

1 stop5h 39mDelta

Deal found 4/16

$249

Thu 8/286:00 amMCI - SAN

1 stop5h 17mUnited Airlines

Sat 8/301:58 pmSAN - MCI

2 stops7h 30mUnited Airlines

Deal found 4/17

$254

Tue 5/277:19 pmSTL - SAN

1 stop6h 34mDelta

Mon 6/210:30 pmSAN - STL

1 stop8h 30mDelta

Deal found 4/16

$257

Tue 5/63:08 pmSTL - SAN

1 stop9h 36mMultiple Airlines

Sun 5/118:54 pmSAN - STL

1 stop10h 15mMultiple Airlines

Deal found 4/17

$258

Fri 4/186:38 pmSTL - SAN

1 stop26h 38mFrontier

Tue 4/226:25 amSAN - STL

1 stop25h 36mFrontier

Deal found 4/15

$261

Fri 7/45:00 amSTL - SAN

1 stop6h 34mUnited Airlines

Tue 7/810:54 amSAN - STL

2 stops7h 42mUnited Airlines

Deal found 4/16

$262

Fri 4/256:30 pmMCI - SAN

1 stop5h 07mAmerican Airlines

Mon 4/283:28 pmSAN - MCI

1 stop5h 28mAmerican Airlines

Deal found 4/17

$267

Thu 5/83:01 pmSGF - SAN

1 stop7h 06mUnited Airlines

Sun 5/1112:13 pmSAN - SGF

1 stop8h 02mUnited Airlines

Deal found 4/15

$269

Sun 5/46:10 pmSTL - SAN

2 stops32h 32mSpirit Airlines

Fri 5/96:15 amSAN - STL

2 stops25h 00mSpirit Airlines

Deal found 4/17

$276

Best flights from Missouri to San Diego
Discover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2025.

Fri 5/97:58 pmMCI - SAN

1 stop5h 58mSpirit Airlines

Wed 5/146:15 amSAN - MCI

1 stop9h 30mSpirit Airlines

Deal found 4/17

$176

Wed 6/47:56 pmMCI - SAN

1 stop5h 18mFrontier

Sat 6/710:57 amSAN - MCI

1 stop22h 38mFrontier

Deal found 4/17

$181

Thu 5/158:51 pmMCI - SAN

1 stop5h 22mMultiple Airlines

Sat 5/176:15 amSAN - MCI

1 stop9h 30mMultiple Airlines

Deal found 4/17

$188

Tue 6/174:12 pmMCI - SAN

1 stop6h 35mDelta

Sun 6/226:15 amSAN - MCI

1 stop6h 29mDelta

Deal found 4/16

$249

Fri 7/45:00 amSTL - SAN

1 stop6h 34mUnited Airlines

Tue 7/810:54 amSAN - STL

2 stops7h 42mUnited Airlines

Deal found 4/16

$262

Thu 4/245:50 pmMCI - SAN

1 stop6h 30mSouthwest

Mon 4/283:35 pmSAN - MCI

1 stop7h 05mSouthwest

Deal found 4/16

$267

Wed 6/185:45 amMCI - SAN

1 stop5h 05mAmerican Airlines

Sat 6/2110:45 pmSAN - MCI

1 stop7h 52mAmerican Airlines

Deal found 4/16

$313

Thu 5/83:08 pmSTL - SAN

2 stops18h 28mAlaska Airlines

Mon 5/1211:54 amSAN - STL

1 stop10h 05mAlaska Airlines

Deal found 4/16

$335

Wed 5/286:00 amSTL - SAN

1 stop7h 16mDelta

Wed 6/45:02 pmSAN - STL

1 stop5h 31mDelta

Deal found 4/16

$257

Tue 5/63:08 pmSTL - SAN

1 stop9h 36mMultiple Airlines

Sun 5/118:54 pmSAN - STL

1 stop10h 15mMultiple Airlines

Deal found 4/17

$258

Thu 5/87:59 amJLN - SAN

1 stop7h 47mUnited Airlines

Wed 5/142:10 pmSAN - JLN

1 stop7h 35mUnited Airlines

Deal found 4/16

$264

Wed 4/236:58 pmSTL - SAN

1 stop7h 16mFrontier

Sun 4/278:50 pmSAN - STL

1 stop11h 11mFrontier

Deal found 4/17

$270

Last-minute flights from Missouri to San Diego
Discover last-minute flight deals from Missouri to San Diego. Data last updated April 17, 2025 and is based on user searches.

Fri 4/186:38 pmSTL - SAN

1 stop26h 38mFrontier

Tue 4/226:25 amSAN - STL

1 stop25h 36mFrontier

Deal found 4/15

$261

Wed 4/237:00 amMCI - SAN

1 stop9h 34mMultiple Airlines

Sun 4/276:25 amSAN - MCI

1 stop11h 25mMultiple Airlines

Deal found 4/17

$590

Thu 4/244:29 pmSGF - SAN

1 stop8h 59mAmerican Airlines

Sat 5/176:15 amSAN - SGF

1 stop8h 25mAmerican Airlines

Deal found 4/17

$315

Thu 4/245:10 pmSGF - SAN

2 stops8h 49mUnited Airlines

Sat 5/1712:55 pmSAN - SGF

1 stop5h 34mUnited Airlines

Deal found 4/17

$410

Fri 4/256:30 pmMCI - SAN

1 stop5h 07mAmerican Airlines

Mon 4/283:28 pmSAN - MCI

1 stop5h 28mAmerican Airlines

Deal found 4/17

$267

Fri 4/256:00 amMCI - SAN

1 stop5h 24mUnited Airlines

Mon 4/288:30 pmSAN - MCI

2 stops12h 02mUnited Airlines

Deal found 4/17

$362

Fri 4/254:59 pmMCI - SAN

2 stops19h 26mSpirit Airlines

Sun 4/276:15 amSAN - MCI

2 stops31h 11mSpirit Airlines

Deal found 4/17

$482

Sat 4/268:40 pmMCI - SAN

1 stop5h 34mFrontier

Sun 4/276:25 amSAN - MCI

1 stop11h 25mFrontier

Deal found 4/17

$270

Sat 4/266:00 amSTL - SAN

1 stop7h 00mDelta

Sat 5/38:00 amSAN - STL

1 stop8h 50mDelta

Deal found 4/16

$398

Sat 4/268:25 amSTL - SAN

2 stops8h 10mSouthwest

Sat 5/37:55 amSAN - STL

1 stop7h 50mSouthwest

Deal found 4/16

$403

Sat 4/266:30 amSTL - SAN

2 stops14h 39mAlaska Airlines

Sat 5/311:54 amSAN - STL

1 stop10h 05mAlaska Airlines

Deal found 4/16

$445

Mon 4/286:00 pmSTL - SAN

2 stops32h 42mMultiple Airlines

Tue 5/69:08 pmSAN - STL

2 stops34h 07mMultiple Airlines

Deal found 4/16

$339

One-way flights from Missouri to San Diego
Search for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated April 17, 2025.

Tue 5/136:45 pmMCI - SAN

1 stop7h 11mSpirit Airlines

Deal found 4/17

$53

Wed 5/287:39 pmMCI - SAN

1 stop5h 10mFrontier

Deal found 4/17

$88

Sat 5/178:15 pmSTL - SAN

1 stop5h 58mFrontier

Deal found 4/16

$88

Wed 6/49:13 pmSGF - SAN

1 stop12h 00mMultiple Airlines

Deal found 4/17

$118

Sat 6/146:40 amMCI - SAN

1 stop7h 42mDelta

Deal found 4/17

$125

Tue 5/206:45 amSTL - SAN

1 stop9h 40mDelta

Deal found 4/15

$129

Tue 6/31:42 pmSTL - SAN

2 stops8h 54mUnited Airlines

Deal found 4/16

$134

Fri 6/277:15 pmSTL - SAN

1 stop5h 50mSouthwest

Deal found 4/16

$139

Sat 5/1710:10 amSTL - SAN

2 stops23h 03mSpirit Airlines

Deal found 4/16

$147

Sun 5/48:00 amSTL - SAN

1 stop11h 03mSun Country Air

Deal found 4/16

$148

Sun 5/48:51 pmMCI - SAN

2 stops15h 34mMultiple Airlines

Deal found 4/17

$149

Fri 5/26:50 pmMCI - SAN

1 stop6h 10mSouthwest

Deal found 4/17

$153

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 5/9

7:58 pm-11:56 pm

1 stop5h 58m

San Diego

Wed 5/14

6:15 am-5:45 pm

1 stop9h 30m

$176

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 6/4

7:56 pm-11:14 pm

1 stop5h 18m

San Diego

Sat 6/7

10:57 am-11:35 am

1 stop22h 38m

$181

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 5/15

8:51 pm-12:13 am

1 stop5h 22m

San Diego

Sat 5/17

6:15 am-5:45 pm

1 stop9h 30m

$188

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 6/17

5:20 pm-10:24 pm

1 stop7h 04m

San Diego

Thu 6/19

10:30 pm-9:04 am

1 stop8h 34m

$249

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 5/27

7:19 pm-11:53 pm

1 stop6h 34m

San Diego

Mon 6/2

10:30 pm-9:00 am

1 stop8h 30m

$257

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 5/3

4:09 pm-8:26 pm

1 stop6h 17m

San Diego

Wed 5/7

2:10 pm-11:24 pm

1 stop7h 14m

$258

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 5/6

3:08 pm-10:44 pm

1 stop9h 36m

San Diego

Sun 5/11

8:54 pm-9:09 am

1 stop10h 15m

$258

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 7/4

5:00 am-9:34 am

1 stop6h 34m

San Diego

Tue 7/8

10:54 am-8:36 pm

2 stops7h 42m

$262

JoplinSan Diego

JLN - SAN

JLNSAN

Joplin

Thu 5/8

7:59 am-1:46 pm

1 stop7h 47m

San Diego

Wed 5/14

2:10 pm-11:45 pm

1 stop7h 35m

$264

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Thu 5/8

3:01 pm-8:07 pm

1 stop7h 06m

San Diego

Sun 5/11

12:13 pm-10:15 pm

1 stop8h 02m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 41 results

...

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Rainfall in San Diego by month

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

See what other customers who have flown with Alaska Airlines, Southwest and Delta from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Alaska Airlines

8.0

Very good

9,882 reviews

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Southwest

8.0

Very good

4,280 reviews

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Delta

8.0

Very good

7,917 reviews

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

United Airlines

7.4

Good

8,667 reviews

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Allegiant Air

7.3

Good

734 reviews

Alaska Airlines

8.0

Very good

9,882 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

What airport do you fly into for flights to San Diego from Missouri?
For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.
What are the cheapest airlines to fly from Missouri to San Diego one-way?
One-way options have recently been found by users for as low as $53 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $88 and Delta from $125 one-way.
What are the most popular routes from Missouri to San Diego?
While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.
What are the cheapest flights from Missouri to San Diego?
Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $397, our data indicates the cheapest price to be $158. The most popular route (Kansas City - San Diego), is priced around $140.
Can I find deals for flights from Missouri to San Diego that include hotel bookings?
Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to San Diego?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.
Can I find deals for business class flights from Missouri to San Diego?
Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to San Diego?
Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

El Cajon

Chula Vista

Lemon Grove

National City

Imperial Beach

La Mesa

Alpine

Poway

Santee

Coronado

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from Missouri to San Diego

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$110	Average$186	FlexibilityNo cancel fee	On-time62%
Spirit Airlines	Cheapest$114	Average$205	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$208	Average$397	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$218	Average$281	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$218	Average$365	FlexibilityNo cancel fee	On-time69%
Alaska Airlines	Cheapest$236	Average$248	FlexibilityNo cancel fee	On-time75%
Southwest	Cheapest$266	Average$481	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$53+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated April 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San DiegoExplore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

Reviews of airlines servicing San Diego

See what other customers who have flown with Alaska Airlines, Southwest and Delta from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to San Diego from Missouri?

What are the cheapest airlines to fly from Missouri to San Diego one-way?

What are the most popular routes from Missouri to San Diego?

What are the cheapest flights from Missouri to San Diego?

Can I find deals for flights from Missouri to San Diego that include hotel bookings?

How can I find direct flights from Missouri to San Diego?

Can I find deals for business class flights from Missouri to San Diego?

What is the cheapest month to book a flight from Missouri to San Diego?

Traveling to a place near Missouri?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Missouri to San Diego

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.