HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$54+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Dec 23 — Dec 301
Mon 12/23
Mon 12/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 18, 2024.

Round-trip from

$195
(Trip.com)

One-way from

$54
(Frontier)
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2024.

This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/275:09 amMCI - SAN
1 stop5h 46mAmerican Airlines
Sat 1/116:40 amSAN - MCI
1 stop8h 03mAmerican Airlines
Deal found 12/17$263
This CheapOair deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/239:29 pmSTL - SAN
1 stop14h 27mFrontier
Tue 12/316:25 amSAN - STL
1 stop23h 48mFrontier
Deal found 12/16$334
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/195:00 amSGF - SAN
1 stop7h 02mAmerican Airlines
Sat 2/16:40 amSAN - SGF
1 stop7h 55mAmerican Airlines
Deal found 12/17$353
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/316:15 amMCI - SAN
1 stop10h 21mDelta
Fri 1/35:10 pmSAN - MCI
1 stop5h 28mDelta
Deal found 12/17$357
This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/316:00 pmSTL - SAN
1 stop7h 40mAmerican Airlines
Tue 1/76:33 amSAN - STL
1 stop5h 09mAmerican Airlines
Deal found 12/18$357
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/245:20 amMCI - SAN
1 stop5h 54mUnited Airlines
Thu 12/263:36 pmSAN - MCI
1 stop7h 07mUnited Airlines
Deal found 12/16$371
This CheapOair deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/312:20 pmMCI - SAN
1 stop25h 07mSpirit Airlines
Sun 1/56:06 pmSAN - MCI
1 stop17h 12mSpirit Airlines
Deal found 12/17$381
This CheapOair deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1810:46 pmMCI - SAN
1 stop25h 26mMultiple Airlines
Wed 12/256:25 amSAN - MCI
1 stop5h 13mMultiple Airlines
Deal found 12/17$431
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/197:45 amSGF - SAN
2 stops11h 52mUnited Airlines
Sat 2/18:35 amSAN - SGF
2 stops11h 39mUnited Airlines
Deal found 12/17$443
This Trip.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2212:00 pmSTL - SAN
1 stop23h 16mMultiple Airlines
Mon 1/66:25 amSAN - STL
1 stop13h 51mMultiple Airlines
Deal found 12/17$446
This United Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:33 pmSTL - SAN
1 stop18h 14mUnited Airlines
Tue 1/710:30 pmSAN - STL
2 stops11h 46mUnited Airlines
Deal found 12/18$500
This Cheapflightsfares deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/228:28 pmMCI - SAN
1 stop5h 26mFrontier
Mon 12/236:25 amSAN - MCI
1 stop5h 13mFrontier
Deal found 12/17$526

Find flights from Missouri to San Diego within your budget

Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2024.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 3/8

6:59 pm-10:48 am

1 stop17h 49m

San Diego

Thu 3/13

4:06 pm-9:16 am

1 stop15h 10m

$196

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 1/7

2:49 pm-10:33 pm

1 stop9h 44m

San Diego

Thu 1/9

10:35 am-7:34 pm

1 stop6h 59m

$197

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 1/6

10:46 pm-11:51 am

2 stops15h 05m

San Diego

Wed 1/8

2:22 pm-10:10 am

3 stops17h 48m

$204

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 1/14

7:00 am-12:29 pm

1 stop7h 29m

San Diego

Tue 1/21

7:25 am-5:00 pm

1 stop7h 35m

$216

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 1/9

5:19 pm-11:58 pm

1 stop8h 39m

San Diego

Sun 1/12

4:30 pm-11:46 pm

1 stop5h 16m

$218

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 1/13

6:39 pm-12:16 am

1 stop7h 37m

San Diego

Wed 1/15

8:55 pm-5:39 pm

2 stops18h 44m

$221

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 1/13

2:59 pm-8:20 am

2 stops19h 21m

San Diego

Sat 1/18

4:26 pm-2:04 pm

1 stop19h 38m

$235

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 1/6

2:38 pm-11:54 pm

1 stop11h 16m

San Diego

Fri 1/10

6:25 am-5:43 pm

1 stop9h 18m

$238

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 1/6

4:30 pm-9:26 pm

1 stop6h 56m

San Diego

Wed 1/15

10:15 am-8:31 pm

2 stops8h 16m

$241

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 2/28

3:21 pm-11:59 pm

1 stop10h 38m

San Diego

Mon 3/3

7:00 am-11:59 pm

1 stop14h 59m

$248

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 40 results
1
2
3
4

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to San Diego

Get recent, data-driven insights about flights from Missouri to San Diego including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $266). Flying from Missouri to San Diego in March is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2024.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated December 18, 2024.
See what other customers who have flown with Delta, Spirit Airlines and United Airlines from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,848 reviews
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Alaska Airlines
8.0
Very good
9,552 reviews
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,604 reviews
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
9,059 reviews
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,848 reviews

Crew

8.7

Food

7.2

Entertainment

7.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $54 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $69 and American Airlines from $84 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $444, our data indicates the cheapest price to be $216. The most popular route (Kansas City - San Diego), is priced around $113.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $266). Flying from Missouri to San Diego in March is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Los Angeles flights
Newark to Los Angeles flights
John F Kennedy Intl to Las Vegas flights
Dallas/Fort Worth to Las Vegas flights
Newark to Las Vegas flights
Seattle to Las Vegas flights
John F Kennedy Intl to San Francisco flights
Seattle to Los Angeles flights
San Francisco to Las Vegas flights
O'Hare Intl to Las Vegas flights
LaGuardia to Los Angeles flights
O'Hare Intl to Los Angeles flights
Dallas/Fort Worth to Los Angeles flights
Minneapolis to Las Vegas flights
Los Angeles to Las Vegas flights
San Francisco to Los Angeles flights
Atlanta to Las Vegas flights
Dulles Intl to Las Vegas flights
Hobby to Las Vegas flights
Denver to Las Vegas flights
LaGuardia to Las Vegas flights
Boston to Los Angeles flights
Santa Ana to Las Vegas flights
Reagan-National to Los Angeles flights
Los Angeles to San Francisco flights
Newark to San Francisco flights
Baltimore to Las Vegas flights
Hobby to Los Angeles flights
Burbank to Las Vegas flights
San Jose to Las Vegas flights
Baltimore to Los Angeles flights
George Bush Intcntl to Las Vegas flights
Detroit to Las Vegas flights
Boston to Las Vegas flights
Dulles Intl to Los Angeles flights
Oakland to Las Vegas flights
Philadelphia to Las Vegas flights
Portland to Los Angeles flights
George Bush Intcntl to Los Angeles flights
Dallas/Fort Worth to San Francisco flights
Seattle to San Diego flights
Love Field to Las Vegas flights
Dallas/Fort Worth to Ontario flights
Austin to Las Vegas flights
Atlanta to Los Angeles flights
Reagan-National to Las Vegas flights
Midway to Las Vegas flights
Newark to Burbank flights
Seattle to San Francisco flights
John F Kennedy Intl to San Diego flights

Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2024.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$113Average$201FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$121Average$198FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$198Average$414FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$384FlexibilityNo cancel feeOn-time69%
DeltaCheapest$218Average$298FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$247Average$520FlexibilityNo cancel feeOn-time75%
SouthwestCheapest$268Average$456FlexibilityNo cancel feeOn-time63%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.