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$55+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$183
(Mytrip)

One-way from

$55
(Frontier)

Good round-trip deal

$428 or less

Good one-way deal

$188 or less
Provider with most accurate pricing for Kansas City Downtown-San Diego flight deals.
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Provider most trusted by Cheapflights users for Kansas City Downtown-San Diego flights.
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From Missouri to San Diego
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One-way flight from Missouri to San Diego
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Price to beat on a round-trip flight from Missouri to San Diego.
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Price to beat on a one-way flight from Missouri to San Diego.
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Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/46:26 pmSTL - SAN
1 stop26h 52mFrontier
Fri 3/76:25 amSAN - STL
1 stop24h 51mFrontier
Deal found 2/20$183
This Spirit deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:04 pmMCI - SAN
1 stop12h 38mSpirit Airlines
Mon 5/56:15 amSAN - MCI
1 stop4h 44mSpirit Airlines
Deal found 2/19$184
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/43:06 pmMCI - SAN
1 stop10h 45mMultiple Airlines
Mon 4/76:25 amSAN - MCI
1 stop11h 12mMultiple Airlines
Deal found 2/19$198
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/154:29 pmSGF - SAN
1 stop8h 59mAmerican Airlines
Tue 4/223:28 pmSAN - SGF
1 stop6h 26mAmerican Airlines
Deal found 2/19$209
This Frontier deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/312:19 pmMCI - SAN
1 stop8h 18mFrontier
Mon 4/76:25 amSAN - MCI
1 stop11h 12mFrontier
Deal found 2/19$210
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/295:07 amMCI - SAN
1 stop6h 54mAmerican Airlines
Sun 5/410:33 pmSAN - MCI
1 stop7h 55mAmerican Airlines
Deal found 2/19$213
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/256:30 amMCI - SAN
1 stop8h 26mDelta
Thu 5/295:10 pmSAN - MCI
1 stop5h 10mDelta
Deal found 2/19$249
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/13:38 pmMCI - SAN
1 stop7h 02mUnited Airlines
Wed 4/27:09 amSAN - MCI
2 stops8h 36mUnited Airlines
Deal found 2/19$250
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/267:40 amSTL - SAN
1 stop6h 45mDelta
Mon 3/315:15 pmSAN - STL
1 stop5h 17mDelta
Deal found 2/19$277
This Expedia deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/23:11 pmSTL - SAN
2 stops18h 24mMultiple Airlines
Sat 4/59:46 pmSAN - STL
1 stop12h 30mMultiple Airlines
Deal found 2/20$283
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:11 pmSTL - SAN
2 stops32h 31mSpirit Airlines
Mon 4/218:14 amSAN - STL
3 stops31h 02mSpirit Airlines
Deal found 2/20$285
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/77:00 amSTL - SAN
1 stop8h 11mUnited Airlines
Wed 3/127:00 amSAN - STL
2 stops8h 11mUnited Airlines
Deal found 2/20$313

Find flights from Missouri to San Diego within your budget

Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 3/4

6:26 pm-7:18 pm

1 stop26h 52m

San Diego

Fri 3/7

6:25 am-9:16 am

1 stop24h 51m

$183

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 5/2

2:04 pm-12:42 am

1 stop12h 38m

San Diego

Mon 5/5

6:15 am-12:59 pm

1 stop4h 44m

$184

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 4/4

3:06 pm-11:51 pm

1 stop10h 45m

San Diego

Mon 4/7

6:25 am-7:37 pm

1 stop11h 12m

$198

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 4/15

4:29 pm-11:28 pm

1 stop8h 59m

San Diego

Tue 4/22

3:28 pm-11:54 pm

1 stop6h 26m

$209

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 4/3

12:19 pm-6:37 pm

1 stop8h 18m

San Diego

Mon 4/7

6:25 am-7:37 pm

1 stop11h 12m

$210

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 4/29

5:07 am-10:01 am

1 stop6h 54m

San Diego

Sun 5/4

10:33 pm-8:28 am

1 stop7h 55m

$213

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 3/18

6:35 am-2:36 pm

1 stop10h 01m

San Diego

Tue 3/18

10:00 pm-9:52 am

1 stop9h 52m

$249

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 4/1

3:38 pm-8:40 pm

1 stop7h 02m

San Diego

Wed 4/2

7:09 am-5:45 pm

2 stops8h 36m

$250

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 3/26

7:40 am-12:25 pm

1 stop6h 45m

San Diego

Mon 3/31

5:15 pm-12:32 am

1 stop5h 17m

$277

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 4/2

3:11 pm-7:35 am

2 stops18h 24m

San Diego

Sat 4/5

9:46 pm-12:16 pm

1 stop12h 30m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 43 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to San Diego

Get recent, data-driven insights about flights from Missouri to San Diego including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated February 20, 2025.
See what other customers who have flown with Southwest, Alaska Airlines and Delta from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Alaska Airlines
8.0
Very good
9,697 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,219 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,765 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.1

Comfort

8.1

Food

7.1

Crew

8.7

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $55 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $71 and American Airlines from $80 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $482, our data indicates the cheapest price to be $183. The most popular route (Kansas City - San Diego), is priced around $134.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado
Borrego Springs

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$100Average$197FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$122Average$206FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$208Average$416FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$298FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$377FlexibilityNo cancel feeOn-time69%
Alaska AirlinesCheapest$238Average$520FlexibilityNo cancel feeOn-time75%
SouthwestCheapest$253Average$467FlexibilityNo cancel feeOn-time63%
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