HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$82+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$183
(Mytrip)

One-way from

$82
(FlightHub)

Good round-trip deal

$472 or less

Good one-way deal

$204 or less
Provider with most accurate pricing for Kansas City Downtown-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Kansas City Downtown-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/22:04 pmMCI - SAN
1 stop12h 38mSpirit Airlines
Tue 5/69:08 pmSAN - MCI
1 stop18h 37mSpirit Airlines
Deal found 3/26$183
This Booking.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/48:51 pmMCI - SAN
1 stop5h 22mMultiple Airlines
Thu 5/86:15 amSAN - MCI
1 stop10h 48mMultiple Airlines
Deal found 3/26$230
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/87:55 pmMCI - SAN
1 stop5h 48mAmerican Airlines
Mon 5/1210:39 pmSAN - MCI
1 stop7h 49mAmerican Airlines
Deal found 3/27$237
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:13 pmMCI - SAN
1 stop7h 36mDelta
Tue 12/3010:23 pmSAN - MCI
1 stop9h 15mDelta
Deal found 3/26$249
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/234:35 pmMCI - SAN
1 stop6h 47mUnited Airlines
Wed 4/302:27 pmSAN - MCI
2 stops7h 17mUnited Airlines
Deal found 3/26$254
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/186:40 amSTL - SAN
1 stop9h 16mDelta
Tue 6/2410:15 pmSAN - STL
1 stop9h 19mDelta
Deal found 3/27$257
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/157:09 amSGF - SAN
1 stop7h 34mAmerican Airlines
Tue 4/223:28 pmSAN - SGF
1 stop6h 26mAmerican Airlines
Deal found 3/28$264
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/51:41 pmSTL - SAN
2 stops8h 43mUnited Airlines
Fri 5/912:55 pmSAN - STL
1 stop6h 06mUnited Airlines
Deal found 3/27$268
This Sun Country Air deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sun Country Air is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/288:15 amSTL - SAN
1 stop10h 23mSun Country Air
Thu 5/16:05 pmSAN - STL
1 stop15h 26mSun Country Air
Deal found 3/26$275
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/96:51 pmSTL - SAN
1 stop7h 23mFrontier
Sun 4/136:25 amSAN - STL
1 stop24h 41mFrontier
Deal found 3/27$280
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/162:35 pmMCI - SAN
2 stops7h 10mSouthwest
Sun 4/204:40 pmSAN - MCI
1 stop6h 20mSouthwest
Deal found 3/26$294
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/3012:15 pmSTL - SAN
Nonstop3h 55mSouthwest
Mon 5/55:35 pmSAN - STL
1 stop5h 15mSouthwest
Deal found 3/26$297

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 5/2

2:04 pm-12:42 am

1 stop12h 38m

San Diego

Tue 5/6

9:08 pm-5:45 pm

1 stop18h 37m

$183

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sun 5/4

8:51 pm-12:13 am

1 stop5h 22m

San Diego

Thu 5/8

6:15 am-7:03 pm

1 stop10h 48m

$230

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 5/8

7:55 pm-11:43 pm

1 stop5h 48m

San Diego

Mon 5/12

10:39 pm-8:28 am

1 stop7h 49m

$237

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 6/17

3:42 pm-6:54 pm

1 stop5h 12m

San Diego

Tue 7/8

12:18 pm-11:53 pm

1 stop9h 35m

$249

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 4/23

4:35 pm-9:22 pm

1 stop6h 47m

San Diego

Wed 4/30

2:27 pm-11:44 pm

2 stops7h 17m

$254

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 6/18

6:40 am-1:56 pm

1 stop9h 16m

San Diego

Tue 6/24

10:15 pm-9:34 am

1 stop9h 19m

$257

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 4/15

8:18 am-12:51 pm

1 stop6h 33m

San Diego

Tue 4/22

2:41 pm-11:54 pm

1 stop7h 13m

$264

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 5/5

1:41 pm-8:24 pm

2 stops8h 43m

San Diego

Fri 5/9

12:55 pm-9:01 pm

1 stop6h 06m

$268

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 4/9

6:51 pm-12:14 am

1 stop7h 23m

San Diego

Sat 4/12

6:25 am-11:22 am

1 stop26h 57m

$270

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 4/28

8:15 am-4:38 pm

1 stop10h 23m

San Diego

Thu 5/1

6:05 pm-11:31 am

1 stop15h 26m

$275

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 45 results
1
2
3
...
5

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated March 28, 2025.
See what other customers who have flown with Southwest, Alaska Airlines and Delta from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Southwest
8.1
Very good
4,273 reviews
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Alaska Airlines
8.0
Very good
9,798 reviews
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Delta
8.0
Very good
7,896 reviews
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
United Airlines
7.4
Good
8,603 reviews
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Allegiant Air
7.3
Good
731 reviews
Southwest
8.1
Very good
4,273 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Entertainment

7.6

Comfort

8.1

Overall

8.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $82 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $115 and Delta from $119 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $393, our data indicates the cheapest price to be $146. The most popular route (Kansas City - San Diego), is priced around $164.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado
Borrego Springs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Las Vegas flights
Newark to Las Vegas flights
John F Kennedy Intl to Los Angeles flights
Newark to Los Angeles flights
LaGuardia to Las Vegas flights
O'Hare Intl to Las Vegas flights
LaGuardia to Los Angeles flights
Dallas/Fort Worth to Las Vegas flights
Seattle to Las Vegas flights
Newark to San Francisco flights
Denver to Las Vegas flights
Los Angeles to Las Vegas flights
Seattle to Los Angeles flights
Burbank to Las Vegas flights
Boston to Las Vegas flights
Dulles Intl to Las Vegas flights
San Francisco to Los Angeles flights
Boston to Los Angeles flights
Atlanta to Las Vegas flights
San Francisco to Las Vegas flights
John F Kennedy Intl to San Francisco flights
Hobby to Las Vegas flights
O'Hare Intl to Los Angeles flights
Dallas/Fort Worth to Los Angeles flights
San Jose to Los Angeles flights
Minneapolis to Las Vegas flights
John F Kennedy Intl to San Diego flights
Los Angeles to San Francisco flights
Reagan-National to Las Vegas flights
Seattle to San Diego flights
Reagan-National to Los Angeles flights
Los Angeles to San Jose flights
Newark to Burbank flights
Santa Ana to Las Vegas flights
Dulles Intl to Los Angeles flights
Newark to San Diego flights
Hobby to Los Angeles flights
George Bush Intcntl to Las Vegas flights
Los Angeles to Oakland flights
San Francisco to Ontario flights
LaGuardia to San Francisco flights
Dulles Intl to San Francisco flights
Baltimore to Las Vegas flights
Seattle to Santa Ana flights
Oakland to Las Vegas flights
Detroit to Las Vegas flights
Portland to Los Angeles flights
Seattle to Burbank flights
Oakland to Los Angeles flights
Baltimore to Los Angeles flights

Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$103Average$183FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$119Average$201FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$208Average$410FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$295FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$218Average$372FlexibilityNo cancel feeOn-time69%
Alaska AirlinesCheapest$236Average$248FlexibilityNo cancel feeOn-time75%
SouthwestCheapest$268Average$480FlexibilityNo cancel feeOn-time63%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.