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$55+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Jan 27 — Feb 31
Mon 1/27
Mon 2/3
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 22, 2025.

Round-trip from

$174
(CheapOair)

One-way from

$55
(Frontier)

Good round-trip deal

$343 or less

Good one-way deal

$168 or less
From Missouri to San Diego
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One-way flight from Missouri to San Diego
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Price to beat on a round-trip flight from Missouri to San Diego.
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Price to beat on a one-way flight from Missouri to San Diego.
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Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2025.

This CheapOair deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/87:04 pmSTL - SAN
1 stop17h 44mFrontier
Thu 3/136:25 amSAN - STL
1 stop24h 51mFrontier
Deal found 1/22$174
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/154:29 pmSGF - SAN
1 stop8h 57mAmerican Airlines
Tue 4/2210:30 amSAN - SGF
1 stop8h 07mAmerican Airlines
Deal found 1/20$209
This Gotogate deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/158:35 pmMCI - SAN
1 stop5h 45mFrontier
Mon 3/176:25 amSAN - MCI
1 stop11h 29mFrontier
Deal found 1/22$219
This Mytrip deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/197:24 pmMCI - SAN
1 stop6h 46mSpirit Airlines
Wed 2/263:00 pmSAN - MCI
2 stops21h 08mSpirit Airlines
Deal found 1/22$220
This Travelocity deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/197:04 pmSTL - SAN
1 stop7h 16mMultiple Airlines
Wed 2/266:15 amSAN - STL
2 stops15h 44mMultiple Airlines
Deal found 1/20$222
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/71:50 pmMCI - SAN
2 stops8h 03mUnited Airlines
Mon 2/101:45 pmSAN - MCI
1 stop6h 45mUnited Airlines
Deal found 1/22$232
This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/105:40 amMCI - SAN
1 stop4h 59mAmerican Airlines
Sat 2/1512:58 pmSAN - MCI
1 stop5h 20mAmerican Airlines
Deal found 1/22$238
This FlightHub deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1411:52 amMCI - SAN
1 stop13h 42mMultiple Airlines
Mon 3/176:25 amSAN - MCI
1 stop11h 29mMultiple Airlines
Deal found 1/22$240
This Delta deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/146:20 pmMCI - SAN
1 stop7h 38mDelta
Sun 2/166:25 amSAN - MCI
1 stop6h 18mDelta
Deal found 1/22$249
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/95:30 pmSTL - SAN
1 stop7h 00mUnited Airlines
Mon 2/107:35 amSAN - STL
1 stop8h 34mUnited Airlines
Deal found 1/22$272
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/166:59 pmSTL - SAN
1 stop6h 44mDelta
Fri 5/239:40 pmSAN - STL
1 stop9h 13mDelta
Deal found 1/21$277
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/67:45 amJLN - SAN
1 stop10h 03mUnited Airlines
Wed 2/128:35 amSAN - JLN
1 stop7h 20mUnited Airlines
Deal found 1/22$289

Find flights from Missouri to San Diego within your budget

Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 3/8

7:04 pm-10:48 am

1 stop17h 44m

San Diego

Thu 3/13

6:25 am-9:16 am

1 stop24h 51m

$174

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 4/15

4:29 pm-11:26 pm

1 stop8h 57m

San Diego

Tue 4/22

10:30 am-8:37 pm

1 stop8h 07m

$209

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 2/19

7:24 pm-12:10 am

1 stop6h 46m

San Diego

Wed 2/26

3:00 pm-2:08 pm

2 stops21h 08m

$220

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 2/19

7:04 pm-12:20 am

1 stop7h 16m

San Diego

Wed 2/26

6:15 am-11:59 pm

2 stops15h 44m

$222

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 2/7

1:50 pm-7:53 pm

2 stops8h 03m

San Diego

Mon 2/10

1:45 pm-10:30 pm

1 stop6h 45m

$232

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 2/10

5:40 am-8:39 am

1 stop4h 59m

San Diego

Sat 2/15

12:58 pm-8:18 pm

1 stop5h 20m

$238

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 3/14

11:52 am-11:34 pm

1 stop13h 42m

San Diego

Mon 3/17

6:25 am-7:54 pm

1 stop11h 29m

$240

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 2/14

6:20 pm-11:58 pm

1 stop7h 38m

San Diego

Sun 2/16

6:25 am-2:43 pm

1 stop6h 18m

$249

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 3/28

8:35 pm-12:20 am

1 stop5h 45m

San Diego

Mon 3/31

6:25 am-7:35 pm

1 stop11h 10m

$272

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sun 2/9

5:30 pm-10:30 pm

1 stop7h 00m

San Diego

Mon 2/10

7:35 am-6:09 pm

1 stop8h 34m

$272

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 39 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to San Diego

Get recent, data-driven insights about flights from Missouri to San Diego including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated January 22, 2025.
See what other customers who have flown with Southwest, United Airlines and Spirit Airlines from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,654 reviews
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Alaska Airlines
8.0
Very good
9,707 reviews
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,514 reviews
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,975 reviews
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,654 reviews

Crew

8.7

Entertainment

7.7

Food

7.2

Comfort

8.1

Boarding

8.2

Overall

8.1

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $55 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $84 and American Airlines from $114 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $510, our data indicates the cheapest price to be $212. The most popular route (Kansas City - San Diego), is priced around $150.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado
Borrego Springs

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$102Average$201FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$119Average$204FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$199Average$415FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$299FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$219Average$381FlexibilityNo cancel feeOn-time69%
Alaska AirlinesCheapest$238Average$520FlexibilityNo cancel feeOn-time75%
SouthwestCheapest$253Average$454FlexibilityNo cancel feeOn-time63%
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