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$115+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Apr 16 — Apr 231
Wed 4/16
Wed 4/23
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Diego are usually found in January or February, booked 67 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$244
(Mytrip)

One-way from

$115
(American Airlines)

Popular in

April

Cheapest in

January

Average price

$486
Provider with most accurate pricing for Knoxville McGhee Tyson-San Diego flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Diego flights.
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From Knoxville McGhee Tyson to San Diego
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One-way flight from Knoxville McGhee Tyson to San Diego
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Highest demand for flights based on searches. 13% potential increase in price ($63 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

This Mytrip deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2810:53 amTYS - SAN
2 stops36h 01mMultiple Airlines
Thu 5/16:15 amSAN - TYS
2 stops31h 10mMultiple Airlines
Deal found 4/10$244
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/37:00 amTYS - SAN
1 stop7h 43mUnited Airlines
Tue 5/69:30 pmSAN - TYS
1 stop9h 35mUnited Airlines
Deal found 4/10$251
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/195:14 amTYS - SAN
1 stop6h 43mAmerican Airlines
Sat 9/272:07 pmSAN - TYS
1 stop7h 06mAmerican Airlines
Deal found 4/10$270
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/157:07 amTYS - SAN
1 stop8h 38mDelta
Wed 7/1612:18 pmSAN - TYS
1 stop8h 29mDelta
Deal found 4/10$277
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/255:30 pmTYS - SAN
1 stop9h 29mFrontier
Thu 5/296:41 amSAN - TYS
1 stop6h 54mFrontier
Deal found 4/10$300
This Alaska Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:33 pmTYS - SAN
1 stop8h 21mAlaska Airlines
Mon 11/108:40 pmSAN - TYS
2 stops17h 48mAlaska Airlines
Deal found 4/11$509

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 4/28

10:53 am-7:54 pm

2 stops36h 01m

San Diego

Thu 5/1

6:15 am-4:25 pm

2 stops31h 10m

$244

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 5/3

7:00 am-11:43 am

1 stop7h 43m

San Diego

Tue 5/6

9:30 pm-10:05 am

1 stop9h 35m

$251

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 9/19

5:14 am-8:57 am

1 stop6h 43m

San Diego

Sat 9/27

2:07 pm-12:13 am

1 stop7h 06m

$270

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 7/15

7:07 am-12:45 pm

1 stop8h 38m

San Diego

Wed 7/16

12:18 pm-11:47 pm

1 stop8h 29m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 5/25

5:30 pm-11:59 pm

1 stop9h 29m

San Diego

Thu 5/29

6:41 am-4:35 pm

1 stop6h 54m

$300

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 7/13

6:37 pm-8:53 am

2 stops17h 16m

San Diego

Wed 7/16

7:00 am-11:50 pm

2 stops13h 50m

$747

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 5/30

7:50 pm-11:59 pm

1 stop7h 09m

$115

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 5/12

10:53 am-7:13 am

2 stops23h 20m

$121

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 7/9

11:30 am-6:13 pm

1 stop9h 43m

$139

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 5/10

7:00 am-2:56 pm

2 stops10h 56m

$176

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Compare providers for flights from Knoxville to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on April 4, 2025.

The best time to book flights from Knoxville to San Diego is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAN?

Find hourly flight availability from Knoxville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 11, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to San Diego in the evening. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Knoxville to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Diego flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 11, 2025.
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,851 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,910 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,636 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Frontier
6.0
Okay
3,277 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.1

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    United Airlines, at $251, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include American Airlines and Delta. United Airlines is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Diego one-way?

    One-way options have recently been found by users for as low as $115 on American Airlines. Other airlines that offer cheap prices include Delta from $139 and United Airlines from $176 one-way.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado
Borrego Springs

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Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$150Average$235FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$255Average$407FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$443FlexibilityNo cancel feeOn-time69%
DeltaCheapest$282Average$394FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$529FlexibilityNo cancel feeOn-time75%

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