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$101+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Mar 1 — Mar 81
Sat 3/1
Sat 3/8
1 adult, Economy
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Cheap flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated February 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$218
(Mytrip)

One-way from

$101
(FlightHub)

Popular in

January

Cheapest in

August

Average price

$327
Provider with most accurate pricing for Key West-San Diego flight deals.
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Provider most trusted by Cheapflights users for Key West-San Diego flights.
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From Florida Keys to San Diego
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One-way flight from Florida Keys to San Diego
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Highest demand for flights based on searches. 4% potential increase in price ($20 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($35 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 24, 2025.

This Mytrip deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/276:00 pmMIA - SAN
2 stops32h 51mSpirit Airlines
Wed 4/26:15 amSAN - MIA
2 stops24h 15mSpirit Airlines
Deal found 2/23$218
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/46:25 amMIA - SAN
1 stop8h 23mMultiple Airlines
Sat 3/155:39 pmSAN - MIA
1 stop9h 31mMultiple Airlines
Deal found 2/23$220
This eDestinos deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:00 amMIA - SAN
1 stop30h 39mFrontier
Mon 6/22:37 pmSAN - MIA
2 stops19h 22mFrontier
Deal found 2/23$237
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/21:03 pmEYW - SAN
1 stop10h 55mAmerican Airlines
Wed 4/97:30 amSAN - EYW
1 stop8h 25mAmerican Airlines
Deal found 2/24$249
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/37:54 pmMIA - SAN
Nonstop6h 14mAmerican Airlines
Mon 4/712:24 pmSAN - MIA
Nonstop4h 49mAmerican Airlines
Deal found 2/23$257
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/224:57 pmMIA - SAN
2 stops10h 02mUnited Airlines
Sun 4/279:30 pmSAN - MIA
1 stop10h 41mUnited Airlines
Deal found 2/23$295
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/102:51 pmMIA - SAN
1 stop8h 37mDelta
Wed 4/237:10 amSAN - MIA
1 stop11h 08mDelta
Deal found 2/24$338
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/41:50 pmMIA - SAN
1 stop8h 55mSouthwest
Wed 3/127:50 amSAN - MIA
2 stops10h 45mSouthwest
Deal found 2/22$378
This Mytrip deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/209:03 amEYW - SAN
3 stops42h 39mMultiple Airlines
Sun 4/276:15 amSAN - EYW
3 stops23h 46mMultiple Airlines
Deal found 2/24$463
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/23:05 pmEYW - SAN
3 stops30h 51mUnited Airlines
Wed 4/912:55 pmSAN - EYW
2 stops27h 00mUnited Airlines
Deal found 2/24$500
This Alaska Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/212:17 pmEYW - SAN
3 stops24h 14mAlaska Airlines
Wed 4/92:00 pmSAN - EYW
3 stops18h 41mAlaska Airlines
Deal found 2/24$2,524

Find flights from Florida Keys to San Diego within your budget

Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2025.

Fly from

Florida Keys

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 3/27

6:00 pm-11:51 pm

2 stops32h 51m

San Diego

Wed 4/2

6:15 am-9:30 am

2 stops24h 15m

$218

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 3/4

6:25 am-11:48 am

1 stop8h 23m

San Diego

Sat 3/15

5:39 pm-6:10 am

1 stop9h 31m

$220

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 4/2

1:03 pm-8:58 pm

1 stop10h 55m

San Diego

Wed 4/9

7:30 am-6:55 pm

1 stop8h 25m

$249

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 3/9

6:25 am-11:48 am

1 stop8h 23m

San Diego

Tue 3/11

12:38 pm-5:16 am

1 stop13h 38m

$250

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 4/3

7:54 pm-11:08 pm

Nonstop6h 14m

San Diego

Mon 4/7

12:24 pm-8:13 pm

Nonstop4h 49m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 4/22

4:57 pm-11:59 pm

2 stops10h 02m

San Diego

Sun 4/27

9:30 pm-11:11 am

1 stop10h 41m

$295

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 4/10

2:51 pm-8:28 pm

1 stop8h 37m

San Diego

Wed 4/23

7:10 am-9:18 pm

1 stop11h 08m

$338

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 3/4

1:50 pm-7:45 pm

1 stop8h 55m

San Diego

Wed 3/12

7:50 am-9:35 pm

2 stops10h 45m

$378

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Sun 4/20

9:03 am-12:42 am

3 stops42h 39m

San Diego

Sun 4/27

6:15 am-9:01 am

3 stops23h 46m

$463

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Wed 4/2

3:05 pm-6:56 pm

3 stops30h 51m

San Diego

Wed 4/9

12:55 pm-6:55 pm

2 stops27h 00m

$500

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 22 results
1
2
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Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Florida Keys to San Diego

Get recent, data-driven insights about flights from Florida Keys to San Diego including ideal travel times, pricing trends, and more.

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated February 24, 2025.
See what other customers who have flown with Southwest, Alaska Airlines and Delta from Florida Keys to San Diego have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Southwest
8.1
Very good
4,380 reviews
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Alaska Airlines
8.0
Very good
9,710 reviews
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Delta
8.0
Very good
8,175 reviews
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

United Airlines
7.4
Good
8,740 reviews
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,380 reviews

Comfort

8.1

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.7

Reviews

1 / 20

10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Florida Keys?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

  • What are the cheapest airlines to fly from Florida Keys to San Diego one-way?

    The cheapest airlines for a one-way flight from Florida Keys to San Diego are Spirit Airlines ($101), Frontier ($104), and American Airlines ($125).

  • Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

  • Can I find deals for business class flights from Florida Keys to San Diego?

    Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to San Diego (average of $286). Flying from Florida Keys to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado
Borrego Springs

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Alternative routes for Florida Keys to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida Keys to San Diego

Discover the top airline that operate flights from Florida Keys to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$306Average$447FlexibilityNo cancel feeOn-time71%
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