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$159+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Feb 9 — Feb 161
Sun 2/9
Sun 2/16
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Panama (PA0). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$383
(United Airlines)

One-way from

$159
(Delta)

Popular in

March

Cheapest in

May

Average price

$732
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From South Carolina to Panama
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One-way flight from South Carolina to Panama
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Highest demand for flights based on searches. 19% potential increase in price ($148 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2025.

This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/46:35 amGSP - PTY
1 stop13h 03mUnited Airlines
Tue 2/118:55 amPTY - GSP
1 stop13h 01mUnited Airlines
Deal found 2/3$383
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/46:23 pmGSP - PTY
2 stops19h 06mAmerican Airlines
Tue 2/112:35 pmPTY - GSP
2 stops19h 24mAmerican Airlines
Deal found 2/3$388
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/246:40 amCLT - PTY
1 stop13h 39mMultiple Airlines
Wed 3/512:03 pmPTY - CLT
1 stop11h 52mMultiple Airlines
Deal found 2/3$417
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2610:11 amGSP - PTY
1 stop10h 16mDelta
Sat 5/37:27 amPTY - GSP
1 stop7h 59mDelta
Deal found 2/3$423
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:20 amCHS - PTY
1 stop13h 17mUnited Airlines
Sun 5/1810:55 pmPTY - CHS
1 stop8h 56mUnited Airlines
Deal found 2/3$423
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/208:22 pmCHS - PTY
2 stops19h 10mAmerican Airlines
Tue 3/253:30 pmPTY - CHS
2 stops19h 39mAmerican Airlines
Deal found 2/4$428
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1912:32 pmCHS - PTY
1 stop7h 55mDelta
Sun 5/47:27 amPTY - CHS
1 stop10h 51mDelta
Deal found 2/2$443
This Avianca Connect deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/49:45 amMYR - PTY
2 stops14h 35mMultiple Airlines
Tue 3/113:19 amPTY - MYR
2 stops13h 17mMultiple Airlines
Deal found 2/4$474
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:20 amCLT - PTY
1 stop8h 54mUnited Airlines
Fri 4/2510:00 amPTY - CLT
1 stop10h 59mUnited Airlines
Deal found 2/4$487
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/164:25 pmCAE - PTY
2 stops20h 50mAmerican Airlines
Wed 5/211:20 pmPTY - CAE
2 stops19h 45mAmerican Airlines
Deal found 2/3$492
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/208:37 pmCLT - PTY
1 stop17h 18mDelta
Fri 4/252:20 pmPTY - CLT
1 stop23h 34mDelta
Deal found 2/4$494
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/46:00 amCLT - PTY
1 stop7h 30mAmerican Airlines
Tue 3/113:30 pmPTY - CLT
1 stop15h 42mAmerican Airlines
Deal found 2/4$507

Find flights from South Carolina to Panama within your budget

Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 3/19

7:04 am-6:38 pm

1 stop12h 34m

Panama City Tocumen Intl

Wed 3/26

7:55 am-11:15 pm

1 stop14h 20m

$383

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/24

6:01 pm-1:30 pm

2 stops19h 29m

Panama City Tocumen Intl

Mon 3/10

1:05 pm-12:00 pm

2 stops21h 55m

$388

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 2/24

6:40 am-8:19 pm

1 stop13h 39m

Panama City Tocumen Intl

Wed 3/5

12:03 pm-11:55 pm

1 stop11h 52m

$417

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/26

10:11 am-7:27 pm

1 stop10h 16m

Panama City Tocumen Intl

Sat 5/3

7:27 am-4:26 pm

1 stop7h 59m

$423

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 5/15

6:20 am-6:37 pm

1 stop13h 17m

Panama City Tocumen Intl

Sun 5/18

10:55 pm-8:51 am

1 stop8h 56m

$423

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 3/20

8:22 pm-2:32 pm

2 stops19h 10m

Panama City Tocumen Intl

Tue 3/25

3:30 pm-12:09 pm

2 stops19h 39m

$428

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 4/19

12:32 pm-7:27 pm

1 stop7h 55m

Panama City Tocumen Intl

Sun 5/4

7:27 am-7:18 pm

1 stop10h 51m

$443

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 3/4

9:45 am-12:20 am

2 stops14h 35m

Panama City Tocumen Intl

Tue 3/11

3:19 am-5:36 pm

2 stops13h 17m

$474

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 4/22

6:20 am-2:14 pm

1 stop8h 54m

Panama City Tocumen Intl

Fri 4/25

10:00 am-9:59 pm

1 stop10h 59m

$487

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Fri 5/16

4:25 pm-12:15 pm

2 stops20h 50m

Panama City Tocumen Intl

Wed 5/21

1:20 pm-10:05 am

2 stops19h 45m

$492

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/4

Showing 1-10 of 35 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Panama

Get recent, data-driven insights about flights from South Carolina to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 4, 2025.
Read through reviews of airlines operating flights from South Carolina to Panama, such as Delta, United Airlines and American Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,408 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,408 reviews
Delta
8.0
Very good
8,408 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,887 reviews
Delta
8.0
Very good
8,408 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,408 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Avianca
6.9
Okay
2,511 reviews
Delta
8.0
Very good
8,408 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Panama one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $159. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from South Carolina to Panama for a low price.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$392FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$284Average$570FlexibilityNo cancel feeOn-time71%
DeltaCheapest$331Average$628FlexibilityNo cancel feeOn-timeN/A
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