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$161+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Apr 7 — Apr 141
Mon 4/7
Mon 4/14
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated April 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$364
(American Airlines)

One-way from

$161
(Delta)

Popular in

March

Cheapest in

June

Average price

$776
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From South Carolina to Panama
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One-way flight from South Carolina to Panama
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Highest demand for flights based on searches. 23% potential increase in price ($180 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/58:35 pmGSP - PTY
2 stops16h 44mAmerican Airlines
Thu 5/81:20 pmPTY - GSP
2 stops18h 13mAmerican Airlines
Deal found 4/2$364
This United deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/54:12 pmGSP - PTY
1 stop23h 02mUnited Airlines
Thu 5/83:20 pmPTY - GSP
1 stop29h 55mUnited Airlines
Deal found 4/2$375
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/106:30 amGSP - PTY
1 stop7h 35mDelta
Tue 6/172:20 pmPTY - GSP
1 stop8h 35mDelta
Deal found 4/2$383
This United deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/87:00 amCHS - PTY
1 stop12h 37mUnited Airlines
Mon 5/1210:00 amPTY - CHS
1 stop10h 40mUnited Airlines
Deal found 3/31$387
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:30 pmCHS - PTY
2 stops18h 49mAmerican Airlines
Thu 5/221:20 pmPTY - CHS
2 stops9h 55mAmerican Airlines
Deal found 3/30$410
This Avianca Connect deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:00 amCLT - PTY
2 stops16h 10mMultiple Airlines
Sun 5/1810:05 pmPTY - CLT
2 stops20h 24mMultiple Airlines
Deal found 4/1$411
This United deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/46:30 amSAV - PTY
1 stop8h 20mUnited Airlines
Wed 6/117:55 amPTY - SAV
1 stop13h 04mUnited Airlines
Deal found 4/2$415
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:13 amCLT - PTY
1 stop13h 24mUnited Airlines
Tue 4/297:55 amPTY - CLT
1 stop13h 04mUnited Airlines
Deal found 3/31$417
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/47:11 amSAV - PTY
1 stop6h 08mAmerican Airlines
Wed 6/111:50 pmPTY - SAV
2 stops20h 46mAmerican Airlines
Deal found 4/2$420
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:45 pmCAE - PTY
2 stops17h 34mAmerican Airlines
Thu 5/221:20 pmPTY - CAE
2 stops23h 47mAmerican Airlines
Deal found 4/1$424
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/163:56 pmMYR - PTY
2 stops21h 23mAmerican Airlines
Fri 5/231:20 pmPTY - MYR
2 stops18h 10mAmerican Airlines
Deal found 4/1$428
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/16:01 amCLT - PTY
1 stop7h 14mAmerican Airlines
Thu 5/81:20 pmPTY - CLT
2 stops16h 08mAmerican Airlines
Deal found 4/1$433

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 5/5

8:35 pm-12:19 pm

2 stops16h 44m

Panama City Tocumen Intl

Thu 5/8

1:20 pm-8:33 am

2 stops18h 13m

$364

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 5/5

4:12 pm-2:14 pm

1 stop23h 02m

Panama City Tocumen Intl

Thu 5/8

3:20 pm-10:15 pm

1 stop29h 55m

$375

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 6/10

6:30 am-1:05 pm

1 stop7h 35m

Panama City Tocumen Intl

Tue 6/17

2:20 pm-11:55 pm

1 stop8h 35m

$383

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 5/8

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 5/12

10:00 am-9:40 pm

1 stop10h 40m

$387

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 5/15

6:30 pm-12:19 pm

2 stops18h 49m

Panama City Tocumen Intl

Thu 5/22

1:20 pm-12:15 am

2 stops9h 55m

$410

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 5/15

6:00 am-9:10 pm

2 stops16h 10m

Panama City Tocumen Intl

Sun 5/18

10:05 pm-7:29 pm

2 stops20h 24m

$411

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Wed 6/4

6:30 am-1:50 pm

1 stop8h 20m

Panama City Tocumen Intl

Wed 6/11

7:55 am-9:59 pm

1 stop13h 04m

$415

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 4/22

6:13 am-6:37 pm

1 stop13h 24m

Panama City Tocumen Intl

Tue 4/29

7:55 am-9:59 pm

1 stop13h 04m

$417

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Wed 6/4

7:11 am-12:19 pm

1 stop6h 08m

Panama City Tocumen Intl

Wed 6/11

1:50 pm-11:36 am

2 stops20h 46m

$420

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Thu 5/15

7:45 pm-12:19 pm

2 stops17h 34m

Panama City Tocumen Intl

Thu 5/22

1:20 pm-2:07 pm

2 stops23h 47m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 31 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 2, 2025.
Read through reviews of airlines operating flights from South Carolina to Panama, such as Delta, United Airlines and American Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Food

7.3

Comfort

8.0

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Food

7.3

Comfort

8.0

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,615 reviews
Delta
8.0
Very good
7,899 reviews

Food

7.3

Comfort

8.0

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Food

7.3

Comfort

8.0

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,301 reviews
Delta
8.0
Very good
7,899 reviews

Food

7.3

Comfort

8.0

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Panama one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $161. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from South Carolina to Panama for a low price.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$281Average$396FlexibilityNo cancel feeOn-time69%
DeltaCheapest$331Average$623FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$351Average$560FlexibilityNo cancel feeOn-time71%

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