$174+ Cheap flights from South Carolina to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from South Carolina to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Panama
Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated April 24, 2025.
Most accurate provider | AranGrant 3 stars |
|---|---|
Most trusted provider | AranGrant 3 stars |
Round-trip from | $349 (United Airlines) |
One-way from | $174 (Delta) |
Popular in | March |
Cheapest in | June |
Average price | $776 |
Find flight deals from South Carolina to Panama
Cheapest flights from South Carolina to PanamaExplore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca Connect deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Tue 6/10
7:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
Tue 6/17
10:00 am-10:00 pm
1 stop11h 00m
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Tue 6/10
7:04 pm-1:00 pm
2 stops18h 56m
Panama City Tocumen Intl
Tue 6/17
1:50 pm-10:23 am
2 stops19h 33m
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Thu 8/14
5:30 am-12:54 pm
1 stop8h 24m
Panama City Tocumen Intl
Fri 8/22
2:12 pm-11:44 pm
1 stop8h 32m
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Wed 8/13
5:45 am-12:54 pm
1 stop8h 09m
Panama City Tocumen Intl
Tue 8/19
2:12 pm-11:45 pm
1 stop8h 33m
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Wed 8/13
6:26 pm-2:15 pm
2 stops20h 49m
Panama City Tocumen Intl
Tue 8/19
3:16 pm-12:27 am
1 stop8h 11m
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Thu 8/14
7:00 am-4:12 pm
1 stop10h 12m
Panama City Tocumen Intl
Fri 8/22
3:20 pm-3:46 pm
1 stop23h 26m
SavannahPanama City
SAV - PTY
SAVPTY
Savannah/Hilton Head
Tue 7/15
6:15 am-1:50 pm
1 stop8h 35m
Panama City Tocumen Intl
Mon 9/15
10:00 am-9:59 pm
1 stop10h 59m
SavannahPanama City
SAV - PTY
SAVPTY
Savannah/Hilton Head
Tue 7/15
6:00 am-12:54 pm
1 stop7h 54m
Panama City Tocumen Intl
Mon 9/15
1:50 pm-11:27 am
2 stops20h 37m
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Mon 6/2
6:00 am-9:10 pm
2 stops16h 10m
Panama City Tocumen Intl
Thu 6/26
1:30 pm-8:09 am
2 stops17h 39m
ColumbiaPanama City
CAE - PTY
CAEPTY
Columbia Metropolitan
Wed 6/11
7:46 pm-1:00 pm
2 stops18h 14m
Panama City Tocumen Intl
Tue 6/17
1:50 pm-10:12 am
2 stops19h 22m
Best time to book a flight from South Carolina to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama
What is the cheapest month to book a flight from South Carolina to Panama?
Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to PA?
Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.
Rainfall in Panama by month
Plan your trip to Panama by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.
Temperature in Panama by month
Plan your trip to Panama by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 24, 2025.
Read through reviews of airlines operating flights from South Carolina to Panama, such as Delta, United Airlines and American Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
Comfort
Boarding
Entertainment
Crew
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Food
Comfort
Boarding
Entertainment
Crew
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Food
Comfort
Boarding
Entertainment
Crew
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Food
Comfort
Boarding
Entertainment
Crew
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Food
Comfort
Boarding
Entertainment
Crew
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from South Carolina to Panama
Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$281 | Average$403 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$331 | Average$603 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$351 | Average$557 | FlexibilityNo cancel fee | On-time71% |