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$74+ Cheap flights from North Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheap flight deals from North Carolina to Panama

Keep the following information in mind while searching for North Carolina to Panama flight deals. Data was last updated April 22, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$189
(American Airlines)

One-way from

$74
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$541

Good round-trip deal

$373 or less

Good one-way deal

$176 or less
Provider with most accurate pricing for Charlotte Douglas-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Charlotte Douglas-Panama City Tocumen Intl flights.
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From North Carolina to Panama
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One-way flight from North Carolina to Panama
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Highest demand for flights based on searches. 16% potential increase in price ($114 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from North Carolina to Panama.
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Price to beat on a one-way flight from North Carolina to Panama.
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Find flight deals from North Carolina to Panama

Cheapest flights from North Carolina to Panama
Explore the most affordable flight options available from North Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/18:27 pmRDU - PTY
2 stops16h 52mAmerican Airlines
Sun 6/81:50 pmPTY - RDU
2 stops17h 10mAmerican Airlines
Deal found 4/22$189
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/246:00 amORF - PTY
1 stop8h 50mUnited Airlines
Thu 7/3110:00 amPTY - ORF
2 stops22h 41mUnited Airlines
Deal found 4/22$374
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:55 amGSO - PTY
1 stop6h 59mDelta
Wed 7/162:12 pmPTY - GSO
1 stop8h 47mDelta
Deal found 4/22$385
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/255:31 pmORF - PTY
2 stops20h 29mAmerican Airlines
Mon 6/303:20 pmPTY - ORF
2 stops22h 26mAmerican Airlines
Deal found 4/22$388
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2410:45 pmRDU - PTY
1 stop10h 26mMultiple Airlines
Sat 5/3110:25 amPTY - RDU
1 stop10h 33mMultiple Airlines
Deal found 4/22$400
This Avianca Connect deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/56:00 amCLT - PTY
2 stops16h 10mMultiple Airlines
Thu 6/121:30 pmPTY - CLT
2 stops17h 39mMultiple Airlines
Deal found 4/21$400
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:55 amORF - PTY
1 stop7h 00mDelta
Tue 5/62:20 pmPTY - ORF
1 stop8h 52mDelta
Deal found 4/22$403
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/16:00 amGSO - PTY
1 stop8h 50mUnited Airlines
Tue 7/89:45 amPTY - GSO
1 stop10h 09mUnited Airlines
Deal found 4/22$405
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/16:06 pmGSO - PTY
2 stops19h 54mAmerican Airlines
Tue 7/81:50 pmPTY - GSO
2 stops20h 06mAmerican Airlines
Deal found 4/22$420
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/158:52 pmAVL - PTY
2 stops16h 33mAmerican Airlines
Fri 10/241:50 pmPTY - AVL
2 stops20h 27mAmerican Airlines
Deal found 4/22$440
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/148:55 amCLT - PTY
1 stop6h 20mAmerican Airlines
Thu 7/171:50 pmPTY - CLT
2 stops15h 41mAmerican Airlines
Deal found 4/21$452
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/275:40 amILM - PTY
1 stop7h 39mAmerican Airlines
Wed 6/41:20 pmPTY - ILM
1 stop8h 44mAmerican Airlines
Deal found 4/22$455

Cheapflights Fare Finder

Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

North Carolina

Fly to

Panama

Route

Depart

Return

Price

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 6/1

8:27 pm-12:19 pm

2 stops16h 52m

Panama City Tocumen Intl

Sun 6/8

1:50 pm-8:00 am

2 stops17h 10m

$189

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 7/24

6:00 am-1:50 pm

1 stop8h 50m

Panama City Tocumen Intl

Thu 7/31

10:00 am-9:41 am

2 stops22h 41m

$374

GreensboroPanama City

GSO - PTY

GSOPTY

Greensboro/H. Point

Tue 7/8

6:55 am-12:54 pm

1 stop6h 59m

Panama City Tocumen Intl

Wed 7/16

2:12 pm-11:59 pm

1 stop8h 47m

$385

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 6/25

5:31 pm-1:00 pm

2 stops20h 29m

Panama City Tocumen Intl

Mon 6/30

3:20 pm-2:46 pm

2 stops22h 26m

$388

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sat 5/24

10:45 pm-8:11 am

1 stop10h 26m

Panama City Tocumen Intl

Sat 5/31

10:25 am-9:58 pm

1 stop10h 33m

$400

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 6/5

6:00 am-9:10 pm

2 stops16h 10m

Panama City Tocumen Intl

Thu 6/12

1:30 pm-8:09 am

2 stops17h 39m

$400

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Sat 5/3

6:55 am-12:55 pm

1 stop7h 00m

Panama City Tocumen Intl

Tue 5/6

2:20 pm-12:12 am

1 stop8h 52m

$403

GreensboroPanama City

GSO - PTY

GSOPTY

Greensboro/H. Point

Tue 7/1

6:00 am-1:50 pm

1 stop8h 50m

Panama City Tocumen Intl

Tue 7/8

9:45 am-8:54 pm

1 stop10h 09m

$405

GreensboroPanama City

GSO - PTY

GSOPTY

Greensboro/H. Point

Tue 7/1

4:09 pm-1:00 pm

2 stops21h 51m

Panama City Tocumen Intl

Tue 7/8

1:50 pm-10:50 pm

1 stop8h 00m

$420

AshevillePanama City

AVL - PTY

AVLPTY

Asheville Regional

Wed 10/15

8:52 pm-12:25 pm

2 stops16h 33m

Panama City Tocumen Intl

Fri 10/24

1:50 pm-11:17 am

2 stops20h 27m

$440

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 43 results
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Best time to book a flight from North Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Panama

What is the cheapest month to book a flight from North Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from North Carolina to Panama (average of $478). Flying from North Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to PA?

Find hourly flight availability from North Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 22, 2025.
Read through reviews of airlines operating flights from North Carolina to Panama, such as Delta, Copa Airlines and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,408 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,683 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,319 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this North Carolina to Panama flight route?

    Flights from North Carolina to Panama have been viewed 30 times in the past calendar month.

  • What are the cheapest airlines to fly from North Carolina to Panama one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $74. Users have also found prices from $215 and $215 on United Airlines and Delta, respectively.

  • Can I find deals for flights from North Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on North Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Panama.

  • Can I find deals for business class flights from North Carolina to Panama?

    Yes. Cheapflights offers flight deals from North Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from North Carolina to Panama (average of $478). Flying from North Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Dallas/Fort Worth to Panama City flights
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Top 4 airlines flying from North Carolina to Panama

Discover the top 4 airlines that operate flights from North Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$588FlexibilityNo cancel feeOn-time71%
DeltaCheapest$281Average$576FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$282Average$399FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$412Average$503FlexibilityNo cancel feeOn-time69%

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